| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD 18 . ^^^ Furthermore , Syk phosphorylation was attenuated by blockade of both low affinity Fcgamma receptors and CD 18 . ^^^ |
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| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis of CD 18 immunoprecipitates allowed us to identify p 72 ( syk ) as one of these proteins . ^^^ |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| Syk colocalized with CD 18 during cell spreading and initiated downstream signaling events leading to actin polymerization . ^^^ |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Syk is associated with CD 18 , the beta subunit of the leukocyte adhesion molecules of the beta ( 2 ) integrin family ( CD11 / CD18 ) , and becomes activated upon beta ( 2 ) integrin mediated adhesion . ^^^ This effect was abolished by function blocking anti CD 18 antibody or by treatment of the cells with the Syk inhibitor piceatannol ( 30 microM ) suggesting that the redistribution of Syk required both , beta ( 2 ) integrin mediated adhesion and Syk activation . ^^^ |
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| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| Here , in a model of thrombohemorrhagic vasculitis , the CD 18 integrin Mac 1 on neutrophils recognized complement C 3 deposited within vessel walls and triggered a signaling pathway involving the Src family kinase Hck and the Syk tyrosine kinase . ^^^ Mac 1 signaling via Src family and Syk kinases results in elastase dependent thrombohemorrhagic vasculopathy . ^^^ Mice genetically deficient in any of these components ( C 3 , Mac 1 , Hck , Syk , or elastase ) were resistant to disease despite normal tissue neutrophil accumulation . ^^^ |
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| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05107 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|