Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
Phosphorylated DAP 12 peptides bind ZAP 70 and Syk protein tyrosine kinases , suggesting that the activation pathway is similar to that of the T and B cell antigen receptors . . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
Moreover , we demonstrate that although human DAP 12 reportedly binds the SH 2 domains of both Syk and Zap 70 , ligation of Ly49D leads to activation of Syk but not Zap 70 . ^^^ These data demonstrate the dependence of DAP 12 coupled receptors on Syk and suggest that the outcome of Ly49D / DAP12 engagement will be regulated by Cbl and culminate in the activation of transcription factors . . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
By contrast , triggering receptors assemble with homodimers of immune tyrosine based activation motif ( ITAM ) bearing adaptor molecules ( i . e . , DAP 12 , CD 3 11 ) that engage tyrosine kinases ( ZAP 70 and syk ) . . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
DAP 12 , an ITAM bearing transmembrane adaptor protein , associates non covalently with receptors in natural killer ( NK ) and myeloid cells , and provides signaling function via the Syk and ZAP 70 tyrosine kinase activation pathways . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
Engagement of a DAP 12 coupled KIR or Ly 49 results in phosphorylation of DAP 12 , and other key substrates , including the Syk tryosine kinase , phospholipase C , and c Cbl . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
In NK 92 cells , which express DAP 12 but little DAP10 / NKG2D , we now show that Syk acts upstream of PI3K , subsequently leading to the specific signaling of the PI3K > Rac 1 > PAK 1 > mitogen activated protein / extracellular signal regulated kinase ( ERK ) kinase > ERK cascade that we earlier described . ^^^ Tumor cell ligation stimulated DAP 12 tyrosine phosphorylation and its association with Syk in NK 92 cells ; Syk tyrosine phosphorylation and activation were also observed . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
On the other hand , when plated on osteopontin , Dap 12 / pre osteoclasts do not activate the tyrosine kinase , Syk , which normally binds to the adaptor protein and transmits downstream signals . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
The immunomodulatory adapter proteins DAP 12 and Fc receptor gamma chain ( FcRgamma ) regulate development of functional osteoclasts through the Syk tyrosine kinase . ^^^ DAP 12 ( / ) FcRgamma ( / ) bone marrow cells fail to differentiate into multinucleated osteoclasts or resorb bone in vitro and show impaired phosphorylation of the Syk tyrosine kinase . syk ( / ) progenitors are similarly defective in osteoclast development and bone resorption . ^^^ Intact SH 2 domains of Syk , introduced by retroviral transduction , are required for functional reconstitution of syk ( / ) osteoclasts , whereas intact ITAM domains on DAP 12 are required for reconstitution of DAP 12 ( / ) FcRgamma ( / ) cells . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
It also elicited tyrosine phosphorylation of DAP 12 , Syk , and SLP 76 , and a Syk inhibitor blocked the promotion of phagocytosis and activation of MAPK by SIRPbeta . ^^^ Our results suggest that engagement of SIRPbeta promotes phagocytosis in macrophages by inducing the tyrosine phosphorylation of DAP 12 , Syk , and SLP 76 and the subsequent activation of a MEK MAPK myosin light chain kinase cascade . . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
Additionally , macrophages deficient in spleen tyrosine kinase ( Syk ) , which signals downstream of DAP 12 , showed a phenotype identical to that of DAP 12 deficient macrophages . ^^^
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43914 and P43405	Pubmed	SVM Score :0.0
NA