| Interacting proteins: Q66K89 and P42771 |
Pubmed |
SVM Score :0.0 |
| We now report that p 14 ( ARF ) forms a complex with the E1A regulated transcriptional repressor , p 120 ( E4F ) . p 120 ( E4F ) contacts p 14 ( ARF ) and p 53 to form a ternary complex in vivo and enhances p 14 ( ARF ) induced G ( 2 ) cell cycle arrest in a p 53 dependent manner . ^^^ We suggest that the interaction of p 14 ( ARF ) and p 120 ( E4F ) forms an important link between the p 14 ( ARF ) and p 53 tumor suppressor proteins , both of which exhibit enhanced cell cycle inhibitory activity in the presence of this transcriptional repressor . . ^^^ |
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| Interacting proteins: Q66K89 and P42771 |
Pubmed |
SVM Score :0.0 |
| As p 120 ( E4F ) has been reported previously to interact with p14ARF , retinoblastoma , and p 53 , these findings provide an important link between the function of RASSF1A and other major human tumor suppressor genes . . ^^^ |
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| Interacting proteins: Q66K89 and P42771 |
Pubmed |
SVM Score :0.0 |
| Using cell lines and MEF , we also demonstrate that INK4A / ARF and p 53 are not essential for functional interaction between Bmi 1 and E4f1 . ^^^ |
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