| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Several cell lines showed deletions of the TP 53 ( alias p 53 ) , CDKN2A ( alias p 16 ) , and VHL genes . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Recent knowledge about biological role of tumor suppressor genes and their products : RB 1 , p 53 , WT 1 , DCC , APC / FAP , NF 1 , NF 2 , VHL , MCC and MTS 1 is presented . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Examples include the p16INK4a , p15INK4B , p14ARF , Von Hippel Lindau ( VHL ) , the oestrogen and progesterone receptors , E cadherin , death associated protein ( DAP ) kinase and the first tumour suppressor gene described , retinoblastoma ( Rb ) gene . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| To test whether previously characterized tumor suppressor genes are affected by hypermethylation we performed MS PCR for p15INK4B , p16INK4A , VHL , TP 53 and E cadherin . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| RESULTS : While the following sixteen genes remained the unmethylated in all tumor and normal tissues : CDH 1 , APAF 1 , hMLH 1 , BRCA 1 , hTERC , VHL , RARbeta , TIMP 3 , DAPK 1 , SURVIVIN , p14ARF , RB 1 , p15INK4b , APC , RASSF1c and PTEN , varying degrees of tumor specific hypermethylation were associated with the p16INK4a , RASSF1a , CASP 8 and CDH 13 genes . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| In cancer , this idealistic scenario is disrupted by an interesting phenomenon : the hypermethylation of regulatory regions called CpG islands in some tumour suppressor genes eg , BRCA 1 , hMLH 1 , p16INK4a , APC , VHL which causes their inactivation . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| They are `` classical ' ' tumor suppressor genes with associated familial cancers ( BRCA 1 , hMLH 1 , p16INK4a , VHL , etc . ) and putative new tumor suppressor genes which loss may contribute to the transformed phenotype ( MGMT , p14ARF , GSTP 1 , RARB 2 , etc . ) . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Silencing of tumor suppressor genes such as p16INK4a , VHL , and hMLH 1 have established promoter hypermethylation as a common mechanism for tumor suppressor inactivation in human cancer and as a promising target for molecular detection in bodily fluids . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| In this report , we investigated the methylation status of the p16INK4a cell cycle inhibitor gene and other prominent tumor related genes ( PTEN , RASSF 1 A , CDH 1 , MSH 2 , MLH 1 , VHL , and TIMP 3 ) in sporadic and multiple endocrine neoplasia type 2 ( MEN 2 ) pheochromocytomas by methylation specific PCR . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Loss of heterozygosity ( LOH ) at the von Hippel Lindau ( vHL ) gene locus and the putative tumor suppressor genes APC , INK4A ( 9p16 ) , and p 53 was studied . ^^^ LOH of the vHL gene , INK4A ( 9p16 ) , and APC was also studied in 11 sporadic adenomas of the colon . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Hypermethylation of CpG islands was examined in these samples for 10 genes : p 16 ( INK4a ) , p 15 ( INK4b ) , p 14 ( ARF ) , human leukocyte antigen ( HLA ) A , B , C , hMLH 1 , E cadherin ( E cad ) , fragile histidine triad and von Hippel Lindau ( VHL ) . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| To address the aberrant promoter methylation profiles of MSI H gastric carcinomas , promoter methylation of six genes ( hMLH 1 , p 16 ( INK4A ) , E cadherin , Rb , RASSF1A , and VHL ) and CpG island methylator phenotype ( CIMP ) were explored in 36 MSI H gastric carcinomas and the results were compared with those of 43 microsatellite stable ( MSS ) gastric carcinomas . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Silencing of tumor suppressor genes , such as p 16 ( INK4a ) , VHL , and the mismatch repair gene hMLH 1 , has established promoter hypermethylation as a common mechanism for tumor suppressor inactivation in human cancers . ^^^ |
|
| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| The frequency of hypermethylation of the 10 genes in the 100 tumor DNAs was VHL 8 % ( all clear cell ) , p 16 ( INK4a ) 10 % , p 14 ( ARF ) 17 % , APC 14 % , MGMT 7 % , GSTP 1 12 % , RARbeta 2 12 % , RASSF1A 45 % , E cadherin 11 % , and Timp 3 58 % . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Methylation status of 11 tumor associated genes ( ARF , caspase 8 , CDH 1 , CDKN2A , CDKN2B , MGMT , MLH 1 , RASSF1A , THBS 1 , TP 73 and VHL ) was studied in 30 primary undifferentiated NPC and paired peripheral blood of 12 patients . ^^^ The methylation profile of NPC in order of frequency was CDH 1 ( 50 % ) , CDKN2B ( 50 % ) , THBS 1 ( 50 % ) , RASSF1A ( 46 % ) , MLH 1 ( 40 % ) , MGMT ( 28 % ) , CDKN2A ( 23 % ) , TP 73 ( 20 % ) , caspase 8 ( 7 % ) , ARF ( 3 % ) and VHL ( 0 % ) . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Therefore , we analysed methylation of the VHL , CDKN 2 , MYC , and H 19 genes in primary RCC samples . ^^^ None of the 11 RCCs methylated at VHL had evidence of methylation at either CDKN 2 or MYC ( methylation at CDKN 2 was , however , detected in 3 % , or 1 / 33 , of RCCs without VHL methylation ) . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| LOH on 3p , 9p , 13q , 17p and 18q occurred mainly within the loci of the VHL , CDKN 2 , Rb , TP 53 and DCC tumour suppressor genes respectively . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| LOH at the VHL , APC , CDKN 2 and DCC tumour suppressor and MSH 3 mismatch repair gene loci can be detected in histologically normal tissue and in adjacent adenocarcinoma , and are potential markers of early neoplastic progression . . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multiplex fluorescence microsatellite assays were performed on 27 uveal melanomas using markers at 3p25 p 26 , 3p14 . 2 , 9p21 p 23 , 13q14 , 13q12 . 3 q 13 , and 17p13 , close to or within the von Hippel Lindau ( VHL ) , fragile histidine triad ( FHIT ) , p16 / cyclin dependent kinase inhibitor 2 ( CDKN2A ) , retinoblastoma ( RB 1 ) , breast cancer 2 ( BRCA 2 ) , and p 53 tumor suppressor loci , respectively . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| We studied the methylation status of E cadherin , CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , RASSF1A , RARB , and GSTP 1 by use of TGCT tissues and testicular malignant lymphoma tissues ( 25 primary TGCT tissues and three primary testicular lymphoma tissues ) . ^^^ Methylation was not observed in E cadherin , CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , RASSF1A , RARB , and GSTP 1 in any of the TGCT tissues . ^^^ In contrast , all three ( 100 % ) of the testicular lymphoma tissues demonstrated hypermethylation of E cadherin , RASSF1A , and RARB , but not CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , and GSTP 1 . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular mechanisms of tuberous sclerosis ( TSC ) histopathologic lesions , we have tested for loss of heterozygosity the two TSC loci ( TSC 1 and TSC 2 ) and seven tumor suppressor gene containing regions ( TP 53 , NF 1 , NF 2 , BRCA 1 , APC , VHL , and MLM ) in 20 hamartomas from 18 TSC patients . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| Using sensitive methylation specific PCR , we screened matched tumor DNA and sediment DNA from preoperative urine specimens obtained in 50 patients with kidney tumors , representing all major histological types , for hypermethylation status of a panel of six normally unmethylated tumor suppressor genes VHL , p16 / CDKN2a , p14ARF , APC , RASSF1A , and Timp 3 . ^^^ Hypermethylation of VHL was found only in clear cell , whereas hypermethylation of p14ARF , APC , or RASSF1A was more frequent in nonclear cell tumors , which suggested that the panel might facilitate differential diagnosis . ^^^ |
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| Interacting proteins: P42771 and P40337 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Seventeen genes ( ABL , APC , APAF 1 , BRCA 1 , CSPG 2 , DAPK 1 , hMLH 1 , LKB 1 , PTEN , p14ARF , p15INK4b , p27KIP1 , p57KIP2 , RASSF1C , RB 1 , SURVIVIN , and VHL ) displayed a uniformly unmethylated pattern in all the astrocytoma and non astrocytoma tissues examined . ^^^ |
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