| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| Recently , the WASP N terminal region was found to bind to the three mammalian verprolin homologs : WASP interacting protein ( WIP ) ; WIP and CR 16 homologous protein ( WICH ) / WIP related protein ( WIRE ) ; and CR 16 . ^^^ |
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| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| WICH , a novel verprolin homology domain containing protein that functions cooperatively with N WASP in actin microspike formation . ^^^ WICH associates strongly with N WASP but only weakly with WASP via its C terminal WASP interacting ( W ) region . ^^^ Ectopic expression of WICH induces actin microspike formation through cooperation with N WASP . ^^^ In addition , expression of the W fragment of WICH suppresses microspike formation induced by N WASP , indicating an essential role for WICH in N WASP induced microspike formation . . ^^^ |
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| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| There are three mammalian homologues of Verprolin , WIP , CR 16 , and WICH , and all of them bind actin and Wiskott Aldrich syndrome protein ( WASP ) and / or neural WASP . ^^^ WICH , a member of WASP interacting protein family , cross links actin filaments . ^^^ Importantly , the actin cross linking activity of WICH was modified through a direct association with N WASP . ^^^ Taken together , these data suggest that WICH induces a bundled form of actin filament with actin cross linking activity and the association with N WASP suppresses that activity . ^^^ |
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| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| Loss of the righting response was not associated with any gross reduction in skeletal muscle tone ( inclined screen and wire grip tests ) and it was proposed that the animals were not anaesthetized but instead could be placed on their backs because flurazepam had enhanced the cataleptic effect of THC . ^^^ |
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| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| The WASP binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet derived growth factor receptor . ^^^ WIRE was shown to bind to the WH 1 domain of WASP and N WASP . ^^^ WIRE was localized to actin filaments in transiently transfected PAE / PDGFRbeta cells , and in cells simultaneously expressing WIRE and WASP , WIRE relocalized WASP to actin filaments , a relocalization that required direct interaction between the two proteins . ^^^ In cells expressing both WIRE and WASP , PDGF treatment induced a translocation of WASP to the cell margin , an effect that required the presence of WIRE . ^^^ Taken together , the data presented indicate that WIRE has a role in the WASP mediated organization of the actin cytoskeleton and that WIRE is a potential link between the activated PDGF receptor and the actin polymerization machinery . . ^^^ |
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| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8TF74 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
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