| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Cdc 42 , Rac 1 , and the Wiskott Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Phosphoinositide 3 kinase ( PI3K ) , small Rho GTPases , such as Cdc 42 and Rac 1 , and neuronal Wiskott Aldrich syndrome protein ( N WASP ) are key effectors that regulate dynamic changes in the actin cytoskeleton and cell migration . uPA and EGF stimulated chemotaxis , cytoskeletal rearrangements and activation of Cdc 42 , Rac 1 and N WASP were studied in the highly metastatic human breast cancer cell line MDA MB 231 . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Involvement of Wiskott Aldrich syndrome protein family verprolin homologous protein ( WAVE ) and Rac 1 in the phagocytosis of amyloid beta ( 1 42 ) in rat microglia . ^^^ Although neither neural Wiskott Aldrich syndrome protein ( N WASP ) nor WASP interacting SH 3 protein ( WISH ) immunoreactivity was co localized with filamentous actin ( F actin ) distribution , both WASP family verprolin homologous protein ( WAVE ) and Rac 1 immunoreactivity was co localized with F actin in the lamellipodia of phogocytic microglia . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| We show that netrin 1 induced growth cone expansion requires Cdc 42 ( cell division cycle 42 ) , Rac 1 ( Ras related C 3 botulinum toxin substrate 1 ) , Pak 1 ( p 21 activated kinase ) , and N WASP ( neuronal Wiskott Aldrich syndrome protein ) and that the application of netrin 1 rapidly activates Cdc 42 , Rac 1 , and Pak 1 . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| We present examples for quantitative characterization of ( 1 ) Rac 1 10 GDP interaction , ( 2 ) Cdc 42 interaction with the GTPase binding domain of the Wiskott Aldrich syndrome protein ( three alternative approaches ) , ( 3 ) accelerated nucleotide exchange reaction of RhoA by the catalytic domains of p190RhoGEF , and ( 4 ) intrinsic and stimulated GTP hydrolysis reaction by the catalytic domain of p50RhoGAP . . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| RhoG dependent events are not mediated through a direct interaction with Rac 1 and Cdc42Hs targets such as PAK 1 , POR 1 , or WASP proteins but require endogenous Rac 1 and Cdc42Hs activities : coexpression of a dominant negative Rac 1 impairs membrane ruffling and lamellipodia but not filopodia or microvilli formation . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| We report here that a peptide encompassing Rac 1 amino acids 17 32 binds directly to the established Rac 1 interacting molecules PAK , WASP , 3BP 1 and p85beta ( P13K ) , but not to p 67 ( Phox ) . ^^^ Our results show that a CRIB containing peptide from PAK , but not that from N WASP , inhibits growth cone collapse and that the inhibitory activity correlates with binding to Rac 1 and not to Cdc 42 . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Differing from Rac 1 , the switch 1 domain and the surrounding region ( amino acids 29 to 55 ) of Cdc 42 appeared to be sufficient for specific binding to PAK 1 , whereas determinants outside the switch 1 domain , residues 157 191 and 84 120 in particular , were necessary and sufficient to confer specificity to WASP and IQGAP 1 , respectively . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac 1 Arp 2 / 3 pathway that bypasses N WASP function . ^^^ To determine whether signalling from Rac 1 to Arp 2 / 3 occurred via N WASP , uptake was analysed in a cell line lacking expression of WASP and N WASP . ^^^ Uptake was unaffected by the absence of these proteins , indicating that beta 1 integrin signalling from Rac 1 to Arp 2 / 3 can occur in the absence of N WASP function . . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| The acidic regions of WASp and N WASP can synergize with CDC42Hs and Rac 1 to induce filopodia and lamellipodia . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| The protrusion of two distinct actin containing organelles , lamellipodia and filopodia , is thought to be regulated by two parallel pathways : from Rac 1 through Scar / WAVEs to lamellipodia , and from Cdc 42 through N WASP to filopodia . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| Lastly , Rac 1 and Bsk are both required for the proper encapsulation of eggs from the parasitoid wasp Leptipolina boulardi . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| A weaker interaction was also detected with Rac 1 using WAS protein from cell lysates . ^^^ |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|