| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| Activation of Arp2 / 3 complex by Wiskott Aldrich Syndrome protein is linked to enhanced binding of ATP to Arp 2 . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| ARPC1 / Arc40 mediates the interaction of the actin related protein 2 and 3 complex with Wiskott Aldrich syndrome protein family activators . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| By chemical cross linking , ActA , N WASP , and Scar 1 contact the same three subunits of the Arp2 / 3 complex , p 40 , Arp 2 , and Arp 3 . ^^^ We propose that ActA and endogenous WASP family proteins promote Arp2 / 3 dependent nucleation by similar mechanisms and require simultaneous binding of Arp 2 and Arp3 . . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| Activation of Arp2 / 3 complex : addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp 2 . ^^^ The Arp2 / 3 activating ( VCA ) region of WASP family proteins binds both the Arp2 / 3 complex and an actin monomer and the Arp 2 and Arp 3 subunits of the Arp2 / 3 complex bind ATP . ^^^ We conclude that WASP family VCA domains activate the Arp2 / 3 complex by driving its interaction with a single conventional actin monomer to form an Arp 2 Arp3 actin nucleus . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| The activator WASp binds at the cleft between Arp 2 and Arp 3 , and all WASp bound complexes are closed . ^^^ We conclude that WASp stabilizes p 35 dependent closure of the complex , holding Arp 2 and Arp 3 closer together to nucleate an actin filament . . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| The WH 2 central region of WASP family proteins is proposed to function in an analogous way by forming a special class of tandem repeats whose function is to line up actin and Arp 2 during Arp2 / 3 nucleation . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , the actin related protein 2 and 3 ( Arp2 / 3 ) complex initiates actin assembly to form lamellipodial protrusions by binding to Wiskott Aldrich syndrome ( WASP ) / WASP family verproline homologous protein 2 ( WAVE 2 ) . ^^^ |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P61160 |
Pubmed |
SVM Score :0.0 |
| NA |
|