| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| The actin based motilities of L . monocytogenes and S . flexneri are known to require the bacterial proteins ActA and IcsA , respectively , and several mammalian cytoskeleton proteins including the Arp2 / 3 complex and VASP ( vasodilator stimulated phosphoprotein ) for L . monocytogenes and vinculin and N WASP ( the neural Wiskott Aldrich syndrome protein ) for S . flexneri . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| Here we show that the actin polymerizing proteins Arp2 / 3 , vasodilator stimulated phosphoprotein ( VASP ) , and neural Wiskott Aldrich syndrome protein ( N WASP ) are present at this interface and that host cell actin polymerization is necessary for parasite infection . . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| The molecular adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) , also known as Fyn binding protein ( FYB ) or Slp 76 associated protein of 130 kilodaltons ( SLAP 130 ) , interacts with a number of signaling intermediates including Slp 76 , the Src family tyrosine kinase Fyn , vasodilator stimulated phosphoprotein ( VASP ) , and the actin nucleating protein WASP . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| WASP WA and Scar WA ( which incorporate the actin and Arp2 / 3 binding regions of WASP and Scar 1 ) , to compete with endogenous WASP family members ; ( 2 ) . proline rich motifs ( PRM ) from the ActA protein of L . monocytogenes or from vinculin , which bind vasodilator stimulated phosphoprotein ( VASP ) , a regulator of cytoskeleton assembly . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| By using green fluorescent protein ( GFP ) fusion constructs , the recruitment of the Arp2 / 3 complex , vasodilator stimulated phosphoprotein ( VASP ) , Neural Wiskott Aldrich syndrome protein ( N WASP ) , zyxin , vinculin , paxillin and alpha actinin to the surface of B . pseudomallei and into corresponding actin tails was studied . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| EVH1 / WH1 domains of VASP and WASP proteins belong to a large family including Ran binding domains of the RanBP 1 family . ^^^ The two cytoskeletal proteins VASP and WASP and the protein Homer share a conserved domain , currently designated the WHI domain ( WASP homology domain 1 ) or EVH 1 domain ( ENA / VASP homology domain 1 ) , which could play an important role in various cellular events such as transport , folding of proteins , and signal transduction . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| Upon TCR engagement , Fyb / SLAP localizes at the interface between T cells and anti CD 3 coated beads , where Evl , a member of the Ena / VASP family , Wiskott Aldrich syndrome protein ( WASP ) and the Arp2 / 3 complex are also found . ^^^ In activated T cells , Fyb / SLAP associates with Ena / VASP family proteins and is present within biochemical complexes containing WASP , Nck , and SLP 76 . ^^^ Inhibition of binding between Fyb / SLAP and Ena / VASP proteins or WASP and the Arp2 / 3 complex impairs TCR dependent actin rearrangement , suggesting that these interactions play a key role in linking T cell signaling to remodeling of the actin cytoskeleton . . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| A WASp VASP complex regulates actin polymerization at the plasma membrane . ^^^ An in vitro analysis demonstrates that the proline rich domain of WASp binds VASP with an affinity of approximately 10 ( 6 ) M ( 1 ) . ^^^ In addition , WASp and VASP both accumulate in actin rich phagocytic cups . ^^^ Finally , in a reconstituted motility medium , VASP enhances actin based propulsion of WASp coated beads in a fashion reminiscent of its effect on Listeria movement . ^^^ We propose that VASP and WASp cooperation is essential in stimulating actin assembly and membrane protrusion at the leading edge . . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| The N terminus includes an FPPPP motif recognized by the Ena Vasp homology domain 1 domain in Ena / vasodilatator stimulated phosphoprotein ( VASP ) / Wiscott Aldrich syndrome protein ( WASP ) protein family . ^^^ Cytoskeletal proteins with FPPPP motif target Ena / VASP / WASP proteins to sites of actin modulation . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| Upon induction of phagocytosis , a large molecular complex , consisting in part of Ena / VASP proteins , the Fyn binding / SLP 76 associated protein ( Fyb / SLAP ) , Src homology 2 ( SH 2 ) domain containing leukocyte protein of 76 kDa ( SLP 76 ) , Nck , and the Wiskott Aldrich syndrome protein ( WASP ) , was formed . ^^^ Evidence for a molecular complex consisting of Fyb / SLAP , SLP 76 , Nck , VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis . ^^^ Our findings suggest that activation of Fcgamma receptors triggers two signalling events during phagocytosis : one through Fyb / SLAP that leads to recruitment of VASP and profilin ; and another through Nck that promotes the recruitment of WASP . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| EVH 1 ( enabled VASP ( vasodilator stimulated protein ) homology 1 ) / WH1 ( WASP ( Wiskott Aldrich syndrome protein ) homology 1 ) domains , present in Ena VASP and WASP , are protein interaction modules specialised in binding proline rich ligands . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| In addition , the proline rich regions of WASP and Scar 1 and the Ena / VASP homology 1 ( EVH 1 ) domain of WASP independently enhanced motility rates . ^^^ WASP and Scar 1 coated bead motility rates were significantly reduced by depletion of profilin and VASP and could be more efficiently rescued by a combination of VASP and wild type profilin than by VASP and a mutant profilin that can not bind proline rich sequences . ^^^ Moreover , motility of WASP WCA beads was not affected by the depletion or addback of VASP and profilin . ^^^ |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
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