| Interacting proteins: P17081 and P42768 |
Pubmed |
SVM Score :0.0 |
| TC 10 stimulated Jun N terminal kinase ( JNK ) and p 21 activated kinase ( PAK ) activities and interacted with a set of effectors ( alpha , beta and gammaPAK , MRCKalpha / beta , MLK 2 , N WASP and MSE 55 ) that overlaps with those for Cdc 42 and Rac . ^^^ TC 10 did not interact with MLK 3 or WASP , and interacted only weakly with ACK 1 . ^^^ |
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| Interacting proteins: P17081 and P42768 |
Pubmed |
SVM Score :0.0 |
| Although Cdc 42 , TC 10 , and other members of the Rho family have been implicated in binding to and activating the WAS proteins , the exact nature of such a protein protein recognition process has remained obscure . ^^^ The crystal structure of TC 10 , together with mutational and bioinformatic analyses , proved that the basic region of WASp and two unique glutamates in Cdc 42 generate favorable electrostatic steering forces that control the accelerated WASp Cdc 42 association reaction . ^^^ |
|
| Interacting proteins: P17081 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17081 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|