| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.57964163 |
| Wiskott Aldrich syndrome protein physically associates with Nck through Src homology 3 domains . 0.57964163^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.7769115 |
| In this report , we demonstrate that recombinant Nck precipitates endogenous WIP , a novel proline rich protein that interacts with the Wiskott Aldrich syndrome protein ( WASP ) , from BJAB cell lysates . 0.7769115^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.51637909 |
| Moreover , activated Nck interacted with Cas and WASP as determined by co immunoprecipitation , and FAK also bound to Cas . 0.51637909^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| The SH 3 SH3 SH 3 SH2 adapter protein Nck links receptor tyrosine kinases , such as EGF and PDGF receptors , to downstream signaling pathways , among which p21cdc42 / rac activated kinase cascade , Sos activated Ras signaling and the human Wiskott Aldrich Syndrome protein ( WASp ) mediated actin cytoskeleton changes , have been implicated . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Here we show that tyrosine 474 of Tir directly binds the host cell adaptor protein Nck , and that Nck is required for the recruitment of both neural Wiskott Aldrich syndrome protein ( N WASP ) and the actin related protein ( Arp ) 2 / 3 complex to the EPEC pedestal , directly linking Tir to the cytoskeleton . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Upon induction of phagocytosis , a large molecular complex , consisting in part of Ena / VASP proteins , the Fyn binding / SLP 76 associated protein ( Fyb / SLAP ) , Src homology 2 ( SH 2 ) domain containing leukocyte protein of 76 kDa ( SLP 76 ) , Nck , and the Wiskott Aldrich syndrome protein ( WASP ) , was formed . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| SLP 76 coordinates Nck dependent Wiskott Aldrich syndrome protein recruitment with Vav 1 / Cdc42 dependent Wiskott Aldrich syndrome protein activation at the T cell APC contact site . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| While both converge on neural Wiskott Aldrich syndrome protein ( N WASP ) , Tir mediated actin accretion by EPEC and EHEC differ in that Tir ( EPEC ) requires both tyrosine phosphorylation and the host adaptor protein Nck , whereas Tir ( EHEC ) is not phosphorylated and utilizes an unidentified linker . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Two such adaptor proteins , Nck and the Wiskott Aldrich syndrome protein ( WASp ) , were recruited to the TCR during initial T cell activation , where they colocalized with the tyrosine kinase Zap 70 . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| With respect to actin polymerization , our results indicate that the actin nucleation promoting factors ( NPF ) neural Wiskott Aldrich syndrome protein ( N WASP ) binds the SH 2 plus SH 3 domain containing adaptor protein Nck in both control and VEGF treated cells . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Tir ( EPEC ) then becomes tyrosine phosphorylated facilitating the recruitment and site specific binding of the eukaryotic adaptor Nck , which in turn binds and activates the Wiskott Aldrich syndrome protein ( N WASP ) , leading to actin related protein 2 / 3 ( Arp2 / 3 ) complex mediated actin polymerization . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Herein , we demonstrate that RP L 10 interacts with the SH 3 domain of Src and activates the binding of the Nck 1 adaptor protein with skeletal proteins such as the Wiskott Aldrich Syndrome Protein ( WASP ) and WASP interacting protein ( WIP ) in neuroblastoma cell line , SH SY 5y . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| WASP has recently been found to bind to the Src homology 3 ( SH 3 ) domain of the adapter protein Nck . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Unlike WASP , which bound the SH 3 domains of several signaling proteins , PRK 2 specifically bound to the middle SH 3 domain of NCK and ( weakly ) that of phospholipase Cgamma . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Both phosphorylation of WASp and its interaction with Grb 2 , as well as with another adapter protein Nck , remain constitutive in serum starved or epidermal growth factor stimulated cells . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| In activated T cells , Fyb / SLAP associates with Ena / VASP family proteins and is present within biochemical complexes containing WASP , Nck , and SLP 76 . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 4 , 5 biphosphate ( PIP 2 ) induced vesicle movement depends on N WASP and involves Nck , WIP , and Grb 2 . ^^^ This process resulting in the motility of intracellular vesicles at the tips of actin comets involved the recruitment of the Src homology 3 ( SH 3 ) SH 2 adaptor proteins Nck and Grb 2 as well as of WASP interacting protein ( WIP ) . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| We used in vitro binding assays and yeast two hybrid screening analysis to identify Nck , betaPIX , Wiscott Aldrich syndrome protein ( WASP ) , and ERK 1 as SPIN 90 binding proteins . ^^^ It appears that betaPIX , WASP , and SPIN 90 form a complex that interacts with Nck in a manner dependent upon cell adhesion to extracellular matrix . ^^^ WASP complex was stable , even in suspended cells , suggesting SPIN 90 serves as an adaptor molecule to recruit other proteins to Nck at focal adhesions . ^^^ WASP complex and Nck . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| RNA interference and dominant negative mutant expression analyses revealed that neural WASP ( N WASP ) , Arp2 / 3 complex , and their upstream regulators , Nck 1 , Cdc 42 , and WIP , are necessary for invadopodium formation . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| Inhibition or genetic deletion of tyrosine phosphorylation , Nck , WASP interacting protein , and Cdc 42 does not affect M . marinum actin tail formation , excluding the participation of these molecules as upstream activators of N WASP in the initiation of actin based motility . ^^^ |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|