| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.63454287 |
| We found WASP complexed to activated src after SDF 1 stimulation , suggesting a possible interacting role for src kinase and WASP in mediating SDF 1 action . 0.63454287^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| By examining the ability of different SH 3 domains to interact with deletion variants of Sam 68 and WASP , we demonstrated that the Itk SH 3 domain and the SH 3 domains of Src family kinases bind to overlapping but distinct sets of proline rich regions in Sam 68 and WASP . . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Wiskott Aldrich syndrome protein physically associates with Nck through Src homology 3 domains . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Wiskott Aldrich syndrome protein ( WASp ) is a binding partner for c Src family protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Wiskott Aldrich syndrome protein was identified as a protein that associated selectively with the SH 3 domains derived from c Src , p85alpha , phospholipase Cgamma 1 , and c Fgr . ^^^ Three peptides corresponding to potential Wiskott Aldrich syndrome protein SH 3 domain binding motifs were found to inhibit its association with c Src , Fgr , and phospholipase Cgamma 1 SH3 domains , but not the p85alpha SH 3 domain . ^^^ Identification of regions of the Wiskott Aldrich syndrome protein responsible for association with selected Src homology 3 domains . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Wiskott Aldrich syndrome protein ( WASP ) , which has no homology with any other known protein families , is rich in proline motifs known to contribute to Src homology 3 binding sites . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Essential role of neural Wiskott Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src transformed fibroblasts . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott Aldrich syndrome protein . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , the density and size of spines are decreased by a dominant negative IRSp 53 with a point mutation in the Src homology 3 ( SH 3 ) domain and a dominant negative proline rich region of WAVE 2 ( Wiskott Aldrich syndrome protein family Verprolin homologous protein ) , a downstream effector of IRSp 53 that binds to the SH 3 domain of IRSp 53 . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Herein , we demonstrate that RP L 10 interacts with the SH 3 domain of Src and activates the binding of the Nck 1 adaptor protein with skeletal proteins such as the Wiskott Aldrich Syndrome Protein ( WASP ) and WASP interacting protein ( WIP ) in neuroblastoma cell line , SH SY 5y . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using affinity precipitation , WASP was found to bind to Src SH 3 containing proteins Fyn , Lck , PLC gamma , and Grb 2 , and mutated WASP , if expressed , was able to bind to Fyn glutathione S transferase ( GST ) fusion protein . ^^^ |
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| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of WASp was blocked by Src family kinase inhibitors and reduced by treatment with wortmannin and in patients with 10 linked agammaglobulinemia ( XLA ) , a condition caused by a lack of functional expression of Btk . ^^^ This indicates that Src kinases , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and Btk all contribute to the regulation of tyrosine phosphorylation of WASp . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found that the WASP CIP 4 interaction is mediated by the binding of the Src homology 3 domain of CIP 4 to the proline rich segment of WASP . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| We identified a novel adaptor protein that contains a Src homology ( SH ) 3 domain , SH 3 binding proline rich sequences , and a leucine zipper like motif and termed this protein WASP interacting SH 3 protein ( WISH ) . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our observations indicate that invasin mediated phagocytosis occurs via a Src and WASP family dependent mechanism ( s ) , involving the Arp2 / 3 complex and Rac , but does not require Cdc42 . . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| The molecular adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) , also known as Fyn binding protein ( FYB ) or Slp 76 associated protein of 130 kilodaltons ( SLAP 130 ) , interacts with a number of signaling intermediates including Slp 76 , the Src family tyrosine kinase Fyn , vasodilator stimulated phosphoprotein ( VASP ) , and the actin nucleating protein WASP . ^^^ |
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| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Seven well characterized examples ( e . g . , sigma ( 70 ) , Ets 1 , ERM , SNARE and WASP proteins , SREBP , Src ) are covered in detail . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| This process resulting in the motility of intracellular vesicles at the tips of actin comets involved the recruitment of the Src homology 3 ( SH 3 ) SH 2 adaptor proteins Nck and Grb 2 as well as of WASP interacting protein ( WIP ) . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that the Src family kinase Hck induces phosphorylation of WASp Tyr ( 291 ) independently of Cdc 42 and that this causes a shift in the mobility of WASp upon SDS PAGE . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Internalisation of the human pathogen Yersinia pseudotuberculosis via interaction of bacterial invasin with host beta 1 integrins depends on the actin cytoskeleton and involves Src family kinases , focal adhesion kinase , p130Crk associated substrate , proline rich tyrosine kinase 2 , Rac , Arp 2 / 3 complex and WASP family members . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we show that WASP recruitment occurs through binding to the C terminal Src homology 3 domain of Nck . ^^^ The recruitment and activation of WASP are coordinated by tyrosine phosphorylated Src homology 2 domain containing leukocyte protein of 76 kDa , which functions as a scaffold , bringing Nck and WASP into proximity with Vav 1 and Cdc 42 GTP . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Erk / Src phosphorylation of cortactin acts as a switch on switch off mechanism that controls its ability to activate N WASP . ^^^ In contrast , Src phosphorylation inhibited the ability of cortactin previously phosphorylated by Erk , and that of S 405 , 418D double mutant cortactin , to bind and activate N WASP . ^^^ Furthermore , Y > D mutation of three tyrosine residues targeted by Src ( Y 421 , Y 466 , and Y 482 ) inhibited the ability of S 405 , 418D cortactin to activate N WASP . ^^^ We propose that Erk phosphorylation liberates the SH 3 domain of cortactin from intramolecular interactions with proline rich regions , causing it to synergize with WASP and N WASP in activating the Arp2 / 3 complex , and that Src phosphorylation terminates cortactin activation of N WASP and WASP . . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Kit modulated phosphorylation dependent interactions with pathways controlling focal adhesion ( paxillin , leupaxin , p130CAS , FAK 1 , the Src family kinase Lyn , Wasp , Fhl 3 , G25K , Ack 1 , Nap 1 , SH3P12 / ponsin ) and septin actin complexes ( NEDD 5 , cdc 11 , actin ) . ^^^ |
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| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| WASP and N WASP are also regulated by a large number of other activators , including protein tyrosine kinases , phosphoinositides , and Src homology 3 containing adaptor proteins , and can therefore serve as signal integrators inside cells . ^^^ Here we show that Cdc 42 and the Src family kinase Lck cooperate at two levels to enhance WASP activation . ^^^ Second , Cdc 42 and the Src homology 3 Src homology 2 module of Lck cooperatively stimulate the activity of phosphorylated WASP , with coupling energy of approximately 2 . 4 kcal / mol between the two activators . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| PP 1 , the Src family tyrosine kinase inhibitor , and KT 5720 , the PKA inhibitor , reversed THC induced tolerance . ^^^ These data support a role for PKA and Src tyrosine kinase in phosphorylation events in delta ( 9 ) THC tolerant mice . . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| Kinase inhibitors that specifically inhibit cyclic AMP dependent protein kinase ( PKA ) , cyclic GMP dependent protein kinase ( PKG ) , calmodulin dependent protein kinase ( PKC ) and src tyrosine kinase were tested for reversal of tolerance to THC ' s effects . ^^^ Src tyrosine kinase inhibition reversed tolerance to only the hypoactive effects of THC . ^^^ |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42768 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|