| FBP 11 regulates nuclear localization of N WASP and inhibits N WASP dependent microspike formation . ^^^ In this study , we show that N WASP dependent microspike formation is inhibited by formin binding protein 11 ( FBP 11 ) . ^^^ Endogenous FBP 11 localizes with nuclear speckles , and co localization of N WASP and FBP 11 was observed when they were co expressed . ^^^ However , transient expression of FBP 11 suppressed N WASP dependent actin microspike formation by trapping N WASP in the nucleus . ^^^ These results indicate that FBP 11 regulates localization of N WASP , thus negatively regulating the function of N WASP in the cytoplasm . . ^^^ |