| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.79208845 |
| In resting cells , WASP exists in a complex with WIP , which inhibits its activation by Cdc 42 . 0.79208845^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :1.0053658 |
| WIP , a protein associated with wiskott aldrich syndrome protein , induces actin polymerization and redistribution in lymphoid cells . 1.0053658^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.73406208 |
| Point mutant analyses in the two hybrid system and in vitro show impairment of WASP WIP interaction with three WASP missense mutants known to cause WAS . 0.73406208^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.72110701 |
| Interaction of N WASP with WIP may in turn lead to mobilization of actin from stress fibers and nucleation of new actin filaments in filopodia . . 0.72110701^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The Wiskott Aldrich syndrome protein interacting protein ( WIP ) binds to the adaptor protein Nck . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The novel adaptor protein , Mti1p , and Vrp1p , a homolog of Wiskott Aldrich syndrome protein interacting protein ( WIP ) , may antagonistically regulate type 1 myosins in Saccharomyces cerevisiae . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Finally , we found increased mRNA expression of five unknown and five known genes , including cytochrome c oxidase subunit 1 ( COI ) , cyclooxygenase 2 ( COX 2 ) , matrix metalloproteinase 13 ( MMP 13 ) , Wiskott Aldrich syndrome protein interacting protein ( WASPIP ) , and hyaluronan synthase 2 ( HAS 2 ) . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Wiskott Aldrich syndrome protein ( WASP ) , the product of the gene mutated in Wiskott Aldrich syndrome , and its partner , the Wiskott Aldrich syndrome protein interacting protein ( WIP ) , play important roles in actin re organization in T lymphocytes . ^^^ Wiskott Aldrich syndrome protein ( WASP ) , the product of the gene mutated in Wiskott Aldrich syndrome , and its partner , the Wiskott Aldrich syndrome protein interacting protein ( WIP ) , play important roles in actin re organization in T lymphocytes . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| A series of genes involved in the regulation of actin dynamics , including coronin , Myr 5 , Wiskott Aldrich syndrome protein interacting protein , cofilin , drebrin and dynamin were down regulated by artemin , suggesting that it plays a previously undefined role in the regulation of actin polymerization and synaptic vesicle movement . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The WASp homologue Las17p functions with the WIP homologue End5p / verprolin and is essential for endocytosis in yeast . ^^^ The amino terminus of Las17p interacts with the carboxyl terminus of End5p in the yeast two hybrid system and similar interactions have been shown between WASp and a mammalian End5p homologue , WASp interacting protein ( WIP ) [ 5 ] . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| In this review , the authors discuss the possible role of WASP / NWASP and of the newly described protein WIP , which interacts with WASP and NWASP , in coupling signals from the T cell receptor to the actin based cytoskeleton . . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The myosin 1 SH 3 domain interacted with both Bee1p and Vrp1p , yeast homologues of human WASP and WIP , adapter proteins that link actin assembly and signaling molecules . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Cutting edge : WIP , a binding partner for Wiskott Aldrich syndrome protein , cooperates with Vav in the regulation of T cell activation . ^^^ Wiskott Aldrich syndrome protein ( WASP ) interacting protein ( WIP ) , specifically binds to a region of WASp that is frequently mutated in Wiskott Aldrich syndrome . ^^^ Our data suggests that the WIP WASp interaction is important for NF AT / AP 1 mediated gene transcription , and that defects seen in the activation of T cells from WAS patients may be due to the inability of these cells to form a functional WIP / WASp signaling complex . . ^^^ Wiskott Aldrich syndrome protein ( WASP ) interacting protein ( WIP ) , specifically binds to a region of WASp that is frequently mutated in Wiskott Aldrich syndrome . ^^^ Due to the similar phenotypes of WASp and Vav deficient T cells , and the putative importance of the WIP / WASp complex in mediating normal signals from the TCR , we investigated the role of WIP in regulating NF AT / AP 1 mediated gene transcription . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| A complex of N WASP and WIP integrates signalling cascades that lead to actin polymerization . ^^^ Recruitment of N WASP to vaccinia is mediated by WASP interacting protein ( WIP ) , whereas in Shigella WIP is recruited by N WASP . ^^^ Our observations show that vaccinia and Shigella activate the Arp2 / 3 complex to achieve actin based motility , by mimicking either the SH2 / SH3 containing adaptor or Cdc 42 signalling pathways to recruit the N WASP WIP complex . ^^^ We propose that the N WASP WIP complex has a pivotal function in integrating signalling cascades that lead to actin polymerization . . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| We found that Vrp1p , the yeast homolog of WIP [ Wiskott Aldrich syndrome protein ( WASP ) interacting protein ] , seems necessary to sustain the Myo5p tail F actin interaction . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Recent results from the yeast system show that the Arp2 / 3p complex , Wiskott Aldrich syndrome protein ( WASP ) , and WASP interacting protein ( WIP ) , proteins involved in the nucleation step of actin filament assembly , play a major role in the formation of endocytic vesicles . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Vrp 1 ( verprolin , End 5 ) is a Saccharomyces cerevisiae actin associated protein and is related to mammalian Wiskott Aldrich syndrome protein ( WASP ) interacting protein ( WIP ) . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence is homologous to the sequences of WASP interacting protein ( WIP ) and CR 16 , both of which associate with WASP and / or N WASP , and thus these three proteins constitute a new protein family . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Wiskott Aldrich syndrome protein ( WASP ) , WASP interacting protein ( WIP ) , and ELMO 1 . ^^^ Two major interacting proteins were the actin binding proteins Wiskott Aldrich syndrome protein ( WASP ) and WASP interacting protein ( WIP ) . ^^^ Wiskott Aldrich syndrome protein ( WASP ) , WASP interacting protein ( WIP ) , and ELMO 1 . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 4 , 5 biphosphate ( PIP 2 ) induced vesicle movement depends on N WASP and involves Nck , WIP , and Grb 2 . ^^^ This process resulting in the motility of intracellular vesicles at the tips of actin comets involved the recruitment of the Src homology 3 ( SH 3 ) SH 2 adaptor proteins Nck and Grb 2 as well as of WASP interacting protein ( WIP ) . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| The activity of the WASP proteins has , in turn , been shown to be governed by a number of associated proteins , including the WASP interacting protein ( WIP ) . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| A complex of N WASP and WASP interacting protein ( WIP ) plays an important role in actin based motility of vaccinia virus and the formation of filopodia . ^^^ However , in contrast to many other N WASP binding proteins , WIP does not stimulate the ability of N WASP to activate the Arp2 / 3 complex . ^^^ Although the WASP homology 1 ( WH 1 ) domain of N WASP interacts directly with WIP , we still lack the exact nature of its binding site . ^^^ We have now identified and characterized the N WASP WH 1 binding motif in WIP in vitro and in vivo using Shigella and vaccinia systems . ^^^ Interaction of the WH 1 domain of N WASP with WIP is dependent on the two highly conserved phenylalanine residues in the motif . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Structure of the N WASP EVH 1 domain WIP complex : insight into the molecular basis of Wiskott Aldrich Syndrome . ^^^ We show here that the N WASP EVH 1 domain does not bind phosphatidyl inositol ( 4 , 5 ) bisphosphate , as previously reported , but does specifically bind a 25 residue motif from the WASP Interacting Protein ( WIP ) . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| X linked thrombocytopenia caused by a mutation in the Wiskott Aldrich syndrome ( WAS ) gene that disrupts interaction with the WAS protein ( WASP ) interacting protein ( WIP ) . ^^^ The ability of WASP to physically associate with the WASP interacting protein , WIP , was tested by yeast and mammalian two hybrid techniques . ^^^ Immunoblotting demonstrated reduced expression of the mutant WAS protein , and we showed that the Arg138Pro mutation significantly , but incompletely , disrupts WASP WIP interaction . ^^^ Furthermore , the mutation significantly but incompletely disrupts WASP WIP interaction , whereas substitution of alanine or glutamic acid residues at the same position does not . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| We have shown that WIP interacts with members of the Wiskott Aldrich syndrome protein family and is essential for filopodium formation regulated by Cdc 42 GTPase . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Because WASP L 101 have not shown direct nuclear Overhauser effect ( NOE ) contact with the WASP interacting protein ( WIP ) in NMR spectroscopy , molecular modeling was performed to evaluate the molecular effect of WASP P 101 to WIP peptide . ^^^ A possible model for the molecular pathogenesis of WAS has been proposed by analyzing the interactions of WASP and WIP using a molecular modeling study . . ^^^ It is presumed that P 101 induced a conformational change in the Q 99 residue of WASP and made the side chain of Q 99 move away from the WIP peptide , resulting in disruption of the hydrogen bond between Q 99 WASP and Y 475 WIP . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| RNA interference and dominant negative mutant expression analyses revealed that neural WASP ( N WASP ) , Arp2 / 3 complex , and their upstream regulators , Nck 1 , Cdc 42 , and WIP , are necessary for invadopodium formation . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| There are three mammalian homologues of Verprolin , WIP , CR 16 , and WICH , and all of them bind actin and Wiskott Aldrich syndrome protein ( WASP ) and / or neural WASP . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| We previously showed the yeast Wiskott Aldrich syndrome protein ( WASP ) interacting protein ( WIP ) ortholog , verprolin / Vrp1 / End5 , interacts with Hof 1 and facilitates Hof 1 recruitment to the bud neck . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| In particular , we have reported the significance of WIP ( WASP interacting protein ) for molecular regulation of WASP . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Caenorhabditis elegans WASP interacting protein homologue WIP 1 is involved in morphogenesis through maintenance of WSP 1 protein levels . ^^^ In the present study , we identified WASP interacting protein homologue ( WIP ) 1 in Caenorhabditis elegans . ^^^ Yeast two hybrid analysis detected a physical interaction between WIP 1 and WSP 1 , the sole homologue of WASP / N WASP in C . elegans . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Wiskott Aldrich syndrome is caused by alterations in the Wiskott Aldrich syndrome protein ( WASP ) and several of these mutations affect WASP ' s interaction with WIP ( WASP interacting protein ) , suggesting that loss of interaction between WASP and WIP is causal to the disease . ^^^ WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP . ^^^ We show that Human WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain , only in the presence of WIP . ^^^ WIP mediates cortical localisation of WASP as well as stabilise WASP in yeast cells . ^^^ Mutations which affected WASP WIP interaction abolished WASP ' s ability to suppress the growth defect of las17Delta strain . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| WIP is widely expressed and interacts with Wiskott Aldrich syndrome protein ( WASP ) ( a hematopoietic specific protein ) and its more widely expressed homologue neural WASP ( N WASP ) , to regulate WASP / N WASP function in Arp2 / 3 mediated actin polymerization . ^^^ Several proteins have been described as regulators of actin polymerization : this review will focus on the role of WASP interacting protein ( WIP ) , an actin binding protein that participates in actin polymerization regulation and signal transduction . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| A multiprotein complex weighing approximately 1 . 3 mD and consisting of WASp interacting protein ( WIP ) , Wiskott Aldrich syndrome protein ( WASp ) , actin , and myosin IIA that formed during NK cell activation was identified . ^^^ Formation of a WIP , WASp , actin , and myosin IIA containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling . ^^^ After induction of an inhibitory signal , the recruitment of actin and myosin IIA to a constitutive WIP WASp complex was greatly decreased . ^^^ Both actin and myosin IIA were recruited to WIP in the absence of WASp . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Recently , the WASP N terminal region was found to bind to the three mammalian verprolin homologs : WASP interacting protein ( WIP ) ; WIP and CR 16 homologous protein ( WICH ) / WIP related protein ( WIRE ) ; and CR 16 . ^^^ We have shown that WASP , WIP , and WICH / WIRE are expressed predominantly in the human monocyte cell line THP 1 and that WIP and WICH / WIRE are involved in monocyte chemotaxis . ^^^ Increased expression of WASP and WIP enhanced monocyte chemotaxis . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| Herein , we demonstrate that RP L 10 interacts with the SH 3 domain of Src and activates the binding of the Nck 1 adaptor protein with skeletal proteins such as the Wiskott Aldrich Syndrome Protein ( WASP ) and WASP interacting protein ( WIP ) in neuroblastoma cell line , SH SY 5y . ^^^ |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43516 and P42768 |
Pubmed |
SVM Score :0.0 |
| NA |
|