| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| To determine whether the Th 1 response in tuberculosis correlated with IL 12R expression , we measured expression of the IL 12R beta 1 and IL 12R beta 2 subunits , as well as IL 12R beta 2 mRNA expression in tuberculosis patients and healthy tuberculin reactors . ^^^ In tuberculosis patients , IFN gamma production by Mycobacterium tuberculosis stimulated PBMC was reduced , the percentages of T cells expressing IL 12R beta 1 and IL 12R beta 2 were significantly decreased , and IL 12R beta 2 mRNA expression was also markedly reduced . ^^^ In M . tuberculosis stimulated peripheral blood T cells from tuberculosis patients , anti IL 10 and anti TGF beta enhanced IL 12R beta 1 and IL 12R beta 2 expression , and IFN gamma production . ^^^ In M . tuberculosis stimulated peripheral blood T cells from healthy tuberculin reactors , recombinant IL 10 and TGF beta reduced IL 12R beta 1 and IL 12R beta 2 expression , as well as IFN gamma production . ^^^ In combination with prior studies showing increased production of TGF beta by blood monocytes from tuberculosis patients , this suggests that increased TGF beta production is the underlying abnormality that reduces IL 12R beta 1 and IL 12R beta 2 expression in tuberculosis . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Two human IL 12 receptor proteins , designated IL 12R beta 1 and IL 12R beta 2 , have been previously identified . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Interestingly , Ba / F3 cells transfected with IL 12R beta 2 alone proliferated in response to huIL 12 with an ED 50 of about 50 pM , although a role for endogenous mouse IL 12R beta 1 in IL 12 signal transduction in these transfectants can not be ruled out . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Because these two types of IL 12 receptors have the general makeup of beta type cytokine receptor subunits , they are designated as IL 12R beta 1 and IL 12R beta 2 . ^^^ Coexpression of IL 12R beta 1 and IL 12R beta 2 leads to the formation of high affinity IL 12 binding sites and reconstitution of IL 12 dependent signaling . . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IL 12R beta 1 and IL 12R beta 2 in COS 7 cells results in formation of two classes of 125 1 huIL 12 binding sites with Kds of about 50 pM and 5 nM . ^^^ Mouse IL 12 p 40 subunit homodimer ( mo ( p 40 ) 2 ) blocked 125I huIL 12 binding to human IL 12R beta 1 , but did not inhibit binding to human IL 12R beta 2 . ^^^ In contrast , anti huIL 12 monoclonal antibody 20C2 , which does not block 125I huIL 12 binding to human IL 12R beta 1 , completely blocked binding to human IL 12R beta 2 . ^^^ These results demonstrate that two classes of IL 12 inhibitors , one that primarily blocks IL 12 / IL 12R beta 1 interaction ( e . g . , mo ( p 40 ) 2 ) , and one that primarily blocks IL 12 / IL 12R beta 2 interaction ( e . g . , 20C2 ) , can be identified . . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Assignment of IL12RB1 and IL12RB2 , interleukin 12 receptor beta 1 and beta 2 chains , to human chromosome 19 band p13 . 1 and chromosome 1 band p31 . 2 , respectively , by in situ hybridization . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| IL 12 receptor ( IL 12R ) expression and accumulation of IL 12R beta 1 and IL 12R beta 2 mRNAs in CD4+ T cells by costimulation with B 7 2 molecules . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| To identify a key genetic factor in the pathogenesis of sarcoidosis , we investigated single nucleotide polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA 17 , IFNB , IFNG , IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 , IL12RB2 , ETA 1 , and NRAMP 1 ) in an association based study of 102 Japanese patients with sarcoidosis , 114 with tuberculosis , and 110 control subjects . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| The receptor for IL 12 is composed of IL 12R beta 1 and IL 12R beta 2 , whereas IL 23 binds to a receptor composed of IL 12R beta 1 and IL 23R . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Two subunits of the IL 12 receptor ( IL 12R ) , IL 12R beta 1 and IL 12R beta 2 , have been identified and cloned . ^^^ These results demonstrate that although mouse IL 12R beta 1 is the subunit primarily responsible for binding IL 12 , IL 12R beta 2 plays an essential role in mediating the biological functions of IL 12 in mice . . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| IL 23 binds to IL 12R beta 1 but fails to engage IL 12R beta 2 ; nonetheless , IL 23 activates Stat 4 in PHA blast T cells . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Although no common polymorphisms could be identified in the IL 12R beta 2 gene ( IL 12RB2 ) , we confirmed four single nucleotide polymorphisms ( SNPs ; 641A > G , 684C > T , 1094T > C , and 1132G > C ) causing three missense variants ( Q214R , M365T , G378R ) and one synonymous substitution in the extracellular domain of the IL 12R beta 1 gene ( IL12RB1 ) . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 receptor beta 1 ( IL12RB1 ) , interleukin 12 receptor beta 2 ( IL12RB2 ) , and interferon gamma receptor 1 ( IFNGR 1 ) perform important roles in the host defense against intracellular pathogens such as Mycobacteria . ^^^ However , the association between mutations of the IL12RB1 , IL12RB2 , and IFNGR 1 encoding genes and lepromatous leprosy has not been studied . ^^^ This study screened for polymorphisms within IL12RB1 , IL12RB2 , and IFNGR 1 encoding genes in the Korean populations using polymerase chain reaction ( PCR ) / single strand conformation polymorphism ( SSCP ) DNA sequencing assay , and an association study was performed using the missense mutations of 705 A / G ( Q214R ) , 1196 G / C ( G378R ) , 1637 G / A ( A525T ) , and 1664 C / T ( P534S ) of the IL12RB1 , 83 G / A ( V14M ) , and 1443 T / C ( L467P ) for the IFNGR 1 encoding genes . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Examination of resting PBMCs from HIV ( + ) and HIV ( ) donors showed that neither of these populations expressed IL 12R beta 1 or IL 12R beta 2 chains on their cell surface as detected by flow cytometry . ^^^ However , examination of mRNA showed that both IL 12R beta 1 and IL 12R beta 2 mRNAs were markedly reduced in HIV ( + ) PBMCs when compared with HIV ( ) PBMCs . ^^^ In addition , we provide further evidence that IL 12R beta 1 and IL 12R beta 2 regulation in human PBMCs is independent of IFN gamma . . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Nineteen MSs were identified in six Th 1 related genes ( IFNGR 1 , IFNGR 2 , IL12RB1 , IL12RB2 , STAT 1 and STAT 4 ) and then eight were further characterized as useful polymorphic markers . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the role of the IL 12R during VSV pathogenesis , using IL 12R beta 2 and IL 12R beta 1 deficient mice . ^^^ We showed that a deficiency in either IL 12R beta 2 or IL 12R beta 1 had no effect on the outcome of VSV infection of the CNS or on the clearance of VSV from the CNS . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| In contrast , some lineage attributes , such as expression of IL 12R beta 2 ( interleukin 12 receptor beta 2 ) , required ongoing T bet activity in mature T ( H ) 1 cells and their progeny . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| It has been shown that cytokine signaling molecules , including transcription factors T bet and GATA 3 , interleukin 12 receptor beta 2 ( IL 12R beta 2 ) and suppressors of cytokine signaling ( SOCS ) , such as SOCS 1 , are important in differentiation of naive T cells into Th 1 helper T cells . ^^^ |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and Q99665 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Interestingly , Ba / F3 cells transfected with IL 12R beta 2 alone proliferated in response to huIL 12 with an ED 50 of about 50 pM , although a role for endogenous mouse IL 12R beta 1 in IL 12 signal transduction in these transfectants can not be ruled out . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Because these two types of IL 12 receptors have the general makeup of beta type cytokine receptor subunits , they are designated as IL 12R beta 1 and IL 12R beta 2 . ^^^ Coexpression of IL 12R beta 1 and IL 12R beta 2 leads to the formation of high affinity IL 12 binding sites and reconstitution of IL 12 dependent signaling . . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IL 12R beta 1 and IL 12R beta 2 in COS 7 cells results in formation of two classes of 125 1 huIL 12 binding sites with Kds of about 50 pM and 5 nM . ^^^ Mouse IL 12 p 40 subunit homodimer ( mo ( p 40 ) 2 ) blocked 125I huIL 12 binding to human IL 12R beta 1 , but did not inhibit binding to human IL 12R beta 2 . ^^^ In contrast , anti huIL 12 monoclonal antibody 20C2 , which does not block 125I huIL 12 binding to human IL 12R beta 1 , completely blocked binding to human IL 12R beta 2 . ^^^ These results demonstrate that two classes of IL 12 inhibitors , one that primarily blocks IL 12 / IL 12R beta 1 interaction ( e . g . , mo ( p 40 ) 2 ) , and one that primarily blocks IL 12 / IL 12R beta 2 interaction ( e . g . , 20C2 ) , can be identified . . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| IL 12 receptor ( IL 12R ) expression and accumulation of IL 12R beta 1 and IL 12R beta 2 mRNAs in CD4+ T cells by costimulation with B 7 2 molecules . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| To determine whether the Th 1 response in tuberculosis correlated with IL 12R expression , we measured expression of the IL 12R beta 1 and IL 12R beta 2 subunits , as well as IL 12R beta 2 mRNA expression in tuberculosis patients and healthy tuberculin reactors . ^^^ In tuberculosis patients , IFN gamma production by Mycobacterium tuberculosis stimulated PBMC was reduced , the percentages of T cells expressing IL 12R beta 1 and IL 12R beta 2 were significantly decreased , and IL 12R beta 2 mRNA expression was also markedly reduced . ^^^ In M . tuberculosis stimulated peripheral blood T cells from tuberculosis patients , anti IL 10 and anti TGF beta enhanced IL 12R beta 1 and IL 12R beta 2 expression , and IFN gamma production . ^^^ In M . tuberculosis stimulated peripheral blood T cells from healthy tuberculin reactors , recombinant IL 10 and TGF beta reduced IL 12R beta 1 and IL 12R beta 2 expression , as well as IFN gamma production . ^^^ In combination with prior studies showing increased production of TGF beta by blood monocytes from tuberculosis patients , this suggests that increased TGF beta production is the underlying abnormality that reduces IL 12R beta 1 and IL 12R beta 2 expression in tuberculosis . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Two human IL 12 receptor proteins , designated IL 12R beta 1 and IL 12R beta 2 , have been previously identified . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Two subunits of the IL 12 receptor ( IL 12R ) , IL 12R beta 1 and IL 12R beta 2 , have been identified and cloned . ^^^ These results demonstrate that although mouse IL 12R beta 1 is the subunit primarily responsible for binding IL 12 , IL 12R beta 2 plays an essential role in mediating the biological functions of IL 12 in mice . . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| IL 23 binds to IL 12R beta 1 but fails to engage IL 12R beta 2 ; nonetheless , IL 23 activates Stat 4 in PHA blast T cells . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| In contrast , some lineage attributes , such as expression of IL 12R beta 2 ( interleukin 12 receptor beta 2 ) , required ongoing T bet activity in mature T ( H ) 1 cells and their progeny . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Although no common polymorphisms could be identified in the IL 12R beta 2 gene ( IL 12RB2 ) , we confirmed four single nucleotide polymorphisms ( SNPs ; 641A > G , 684C > T , 1094T > C , and 1132G > C ) causing three missense variants ( Q214R , M365T , G378R ) and one synonymous substitution in the extracellular domain of the IL 12R beta 1 gene ( IL12RB1 ) . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Examination of resting PBMCs from HIV ( + ) and HIV ( ) donors showed that neither of these populations expressed IL 12R beta 1 or IL 12R beta 2 chains on their cell surface as detected by flow cytometry . ^^^ However , examination of mRNA showed that both IL 12R beta 1 and IL 12R beta 2 mRNAs were markedly reduced in HIV ( + ) PBMCs when compared with HIV ( ) PBMCs . ^^^ In addition , we provide further evidence that IL 12R beta 1 and IL 12R beta 2 regulation in human PBMCs is independent of IFN gamma . . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| The receptor for IL 12 is composed of IL 12R beta 1 and IL 12R beta 2 , whereas IL 23 binds to a receptor composed of IL 12R beta 1 and IL 23R . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| It has been shown that cytokine signaling molecules , including transcription factors T bet and GATA 3 , interleukin 12 receptor beta 2 ( IL 12R beta 2 ) and suppressors of cytokine signaling ( SOCS ) , such as SOCS 1 , are important in differentiation of naive T cells into Th 1 helper T cells . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the role of the IL 12R during VSV pathogenesis , using IL 12R beta 2 and IL 12R beta 1 deficient mice . ^^^ We showed that a deficiency in either IL 12R beta 2 or IL 12R beta 1 had no effect on the outcome of VSV infection of the CNS or on the clearance of VSV from the CNS . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Assignment of IL12RB1 and IL12RB2 , interleukin 12 receptor beta 1 and beta 2 chains , to human chromosome 19 band p13 . 1 and chromosome 1 band p31 . 2 , respectively , by in situ hybridization . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 receptor beta 1 ( IL12RB1 ) , interleukin 12 receptor beta 2 ( IL12RB2 ) , and interferon gamma receptor 1 ( IFNGR 1 ) perform important roles in the host defense against intracellular pathogens such as Mycobacteria . ^^^ However , the association between mutations of the IL12RB1 , IL12RB2 , and IFNGR 1 encoding genes and lepromatous leprosy has not been studied . ^^^ This study screened for polymorphisms within IL12RB1 , IL12RB2 , and IFNGR 1 encoding genes in the Korean populations using polymerase chain reaction ( PCR ) / single strand conformation polymorphism ( SSCP ) DNA sequencing assay , and an association study was performed using the missense mutations of 705 A / G ( Q214R ) , 1196 G / C ( G378R ) , 1637 G / A ( A525T ) , and 1664 C / T ( P534S ) of the IL12RB1 , 83 G / A ( V14M ) , and 1443 T / C ( L467P ) for the IFNGR 1 encoding genes . ^^^ Interleukin 12 receptor beta 1 ( IL12RB1 ) , interleukin 12 receptor beta 2 ( IL12RB2 ) , and interferon gamma receptor 1 ( IFNGR 1 ) perform important roles in the host defense against intracellular pathogens such as Mycobacteria . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| To identify a key genetic factor in the pathogenesis of sarcoidosis , we investigated single nucleotide polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA 17 , IFNB , IFNG , IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 , IL12RB2 , ETA 1 , and NRAMP 1 ) in an association based study of 102 Japanese patients with sarcoidosis , 114 with tuberculosis , and 110 control subjects . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| Nineteen MSs were identified in six Th 1 related genes ( IFNGR 1 , IFNGR 2 , IL12RB1 , IL12RB2 , STAT 1 and STAT 4 ) and then eight were further characterized as useful polymorphic markers . ^^^ |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99665 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|