| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| In the past 5 years , this prediction has been confirmed and different types of mutations ( dominant or recessive , nonfunctional or hypofunctional ) in four genes ( IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 ) have revealed both allelic and nonallelic heterogeneity . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| Mutations in IL12B , encoding the interleukin ( IL ) 12 p 40 subunit , and in IL12RB1 , encoding the beta 1 chain of the IL 12 receptor , result in impaired IFN gamma production . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| Different types of mutations in four genes ( IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 ) have revealed both allelic and nonallelic heterogeneity and result in eight different disorders whose common pathogenic pathway is impaired interferon gamma ( IFNgamma ) mediated immunity . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| Mutations in five genes ( IFNGR 1 , IFNGR 2 , STAT 1 , IL12B and IL12RB1 ) have been shown to be responsible for MSMD and further allelic heterogeneity accounts for the existence of nine distinct inherited disorders . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 ( IL12B ) , interleukin 12 receptor ( IL12RB1 ) and interleukin 23 ( IL23A ) gene polymorphism in systemic lupus erythematosus . ^^^ OBJECTIVE : The aim of this study was to assess the possible association between the interleukin 12B ( IL12B ) and interleukin 12 receptor beta 1 ( IL12RB1 ) gene polymorphisms with systemic lupus erythematosus ( SLE ) . ^^^ Genotyping of the IL12B [ IL12Bpro and IL12B 3 ' untranslated region ( UTR ) ] and IL12RB1 ( 641A > G , 1094T > C and 1132G > C ) polymorphisms was performed with polymerase chain reaction restriction fragment length polymorphism ( PCR RFLP ) and PCR fluorescent methods , whereas IL23A genetic variants were realized with direct sequencing . ^^^ RESULTS : No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles were observed when comparing SLE patients and control subjects . ^^^ CONCLUSIONS : These results suggest that polymorphisms located in IL12B , IL12RB1 and IL23A genes may not play a relevant role in the susceptibility or severity of SLE in the Spanish population . . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 ( IL12B ) and interleukin 12 receptor ( IL12RB1 ) gene polymorphisms in rheumatoid arthritis . ^^^ The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis ( RA ) . ^^^ Genotyping of the IL12B ( IL12Bpro and IL12B 3 ' untranslated region ) and IL12RB1 ( 641A > G , 1094T > C , and 1132G > C ) polymorphisms was performed by polymerase chain reaction restriction fragment length polymorphism and polymerase chain reaction fluorescent methods . ^^^ No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles between patients with RA and control subjects were observed . ^^^ These results suggest that IL12B and IL12RB1 genes may not play a relevant role in the susceptibility or severity of RA in the Spanish population . . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| STATE OF THE ART : In the last nine years , fife genes have been found to be mutated in patients with this syndrome : IFNGR 1 , IFNGR 2 , STAT 1 , IL12B , IL12RB1 . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| To identify a key genetic factor in the pathogenesis of sarcoidosis , we investigated single nucleotide polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA 17 , IFNB , IFNG , IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 , IL12RB2 , ETA 1 , and NRAMP 1 ) in an association based study of 102 Japanese patients with sarcoidosis , 114 with tuberculosis , and 110 control subjects . ^^^ |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29460 and P42701 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| In the past 5 years , this prediction has been confirmed and different types of mutations ( dominant or recessive , nonfunctional or hypofunctional ) in four genes ( IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 ) have revealed both allelic and nonallelic heterogeneity . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| Mutations in IL12B , encoding the interleukin ( IL ) 12 p 40 subunit , and in IL12RB1 , encoding the beta 1 chain of the IL 12 receptor , result in impaired IFN gamma production . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| Different types of mutations in four genes ( IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 ) have revealed both allelic and nonallelic heterogeneity and result in eight different disorders whose common pathogenic pathway is impaired interferon gamma ( IFNgamma ) mediated immunity . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| Mutations in five genes ( IFNGR 1 , IFNGR 2 , STAT 1 , IL12B and IL12RB1 ) have been shown to be responsible for MSMD and further allelic heterogeneity accounts for the existence of nine distinct inherited disorders . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| To identify a key genetic factor in the pathogenesis of sarcoidosis , we investigated single nucleotide polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA 17 , IFNB , IFNG , IFNGR 1 , IFNGR 2 , IL12B , IL12RB1 , IL12RB2 , ETA 1 , and NRAMP 1 ) in an association based study of 102 Japanese patients with sarcoidosis , 114 with tuberculosis , and 110 control subjects . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| STATE OF THE ART : In the last nine years , fife genes have been found to be mutated in patients with this syndrome : IFNGR 1 , IFNGR 2 , STAT 1 , IL12B , IL12RB1 . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 ( IL12B ) , interleukin 12 receptor ( IL12RB1 ) and interleukin 23 ( IL23A ) gene polymorphism in systemic lupus erythematosus . ^^^ OBJECTIVE : The aim of this study was to assess the possible association between the interleukin 12B ( IL12B ) and interleukin 12 receptor beta 1 ( IL12RB1 ) gene polymorphisms with systemic lupus erythematosus ( SLE ) . ^^^ Genotyping of the IL12B [ IL12Bpro and IL12B 3 ' untranslated region ( UTR ) ] and IL12RB1 ( 641A > G , 1094T > C and 1132G > C ) polymorphisms was performed with polymerase chain reaction restriction fragment length polymorphism ( PCR RFLP ) and PCR fluorescent methods , whereas IL23A genetic variants were realized with direct sequencing . ^^^ RESULTS : No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles were observed when comparing SLE patients and control subjects . ^^^ CONCLUSIONS : These results suggest that polymorphisms located in IL12B , IL12RB1 and IL23A genes may not play a relevant role in the susceptibility or severity of SLE in the Spanish population . . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| Interleukin 12 ( IL12B ) and interleukin 12 receptor ( IL12RB1 ) gene polymorphisms in rheumatoid arthritis . ^^^ The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis ( RA ) . ^^^ Genotyping of the IL12B ( IL12Bpro and IL12B 3 ' untranslated region ) and IL12RB1 ( 641A > G , 1094T > C , and 1132G > C ) polymorphisms was performed by polymerase chain reaction restriction fragment length polymorphism and polymerase chain reaction fluorescent methods . ^^^ No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles between patients with RA and control subjects were observed . ^^^ These results suggest that IL12B and IL12RB1 genes may not play a relevant role in the susceptibility or severity of RA in the Spanish population . . ^^^ |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42701 and P29460 |
Pubmed |
SVM Score :0.0 |
| NA |
|