| RIN 1 binds to the ABL SH 3 and SH 2 domains , and these interactions stimulate ABL 2 catalytic activity . ^^^ Deletion of the RAS binding domain ( RBD ) strongly stimulated the ABL 2 activation function of RIN 1 , suggesting that RAS activation results from the relief of RIN 1 autoinhibition . ^^^ The ABL binding domain of RIN 1 ( RIN 1 ABD ) increased the activity of ABL 2 immune complexes and purified RIN 1 ABD stimulated ABL 2 kinase activity toward CRK . ^^^ |