| Interacting proteins: P42684 and P46108 |
Pubmed |
SVM Score :1.0838858 |
| In this report we demonstrate that Arg associates with c Crk , an adaptor protein composed of an SH 2 domain and two SH 3 domains , and examine the molecular mechanism of the interaction . 1.0838858^^^ Proline rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk . 0.53235266^^^ The interaction of Arg with c Crk in living cells was confirmed by the detection of coimmunoprecipitation in coinfected Sf 9 cells . 0.5141411^^^ |
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| Interacting proteins: P42684 and P46108 |
Pubmed |
SVM Score :0.0 |
| The ABL binding domain of RIN 1 ( RIN 1 ABD ) increased the activity of ABL 2 immune complexes and purified RIN 1 ABD stimulated ABL 2 kinase activity toward CRK . ^^^ |
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| Interacting proteins: P42684 and P46108 |
Pubmed |
SVM Score :0.0 |
| Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk CAS complexes . c Abl and the Abl related gene product ( Arg ) are nonreceptor tyrosine kinases that regulate the actin cytoskeleton of cells by direct association with F actin and localization to focal contacts . ^^^ Moreover , embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg ( abl / arg / ) demonstrate increased Crk CAS coupling and motility . ^^^ Conversely , expression of a kinase active form of Abl or reconstitution of abl / arg / cells with wild type Abl prevents Crk CAS coupling and inhibits cell migration . ^^^ Thus , Abl and Arg kinases play a critical role in preventing cell migration through regulation of Crk and CAS adaptor protein complexes , which are necessary for cell movement . . ^^^ |
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| Interacting proteins: P42684 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
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