| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Site directed mutagenesis of the c src gene was used to generate c src variants encoding pp60c src proteins with the following amino acid alterations : tyr 90 to phe ( pm90F ) ; tyr 92 to phe ( pm92F ) ; arg 95 to either trp , lys , glu or gln ( pm95W , 95K , 95E and 95Q , respectively ) , and deletion of residues 92 95 ( dl 92 ) . ^^^ C src variants encoding proteins with the alteration of arg 95 to trp , glu , or lys , or containing the deletion of residues 92 95 , induced alterations in cell morphology and promoted growth in soft agar as well as changes in glucose transport and in vivo tyrosine phosphorylation of cellular proteins ( including calpactin 1 heavy chain , p 36 ) . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , okadaic acid treatment induces a small decrease in Tyr 527 phosphorylation of wild type pp60c src and a large decrease in Tyr 527 phosphorylation of kinase defective pp60c src ( Lys 295 > Arg ) . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Structural analysis of the Src SH 3 domain ( Src SH 3 ) complexed with proline rich peptide ligands revealed three binding sites involved in this interaction : two hydrophobic interactions ( between aliphatic proline dipeptides in the SH 3 ligand and highly conserved aromatic residues on the surface of the SH 3 domain ) , and one salt bridge ( between Asp 99 of Src and an Arg three residues upstream of the conserved Pro 10 10 Pro motif in the ligand ) . ^^^ We found that the D99N mutation diminished binding to most Src SH 3 binding proteins in whole cell extracts ; however , there was only a moderate reduction in binding to a small subset of Src SH 3 binding proteins ( including the Src substrate p 68 ) . p 68 was shown to contain two Arg containing Asp 99 dependent binding sites and one Asp 99 independent binding site which lacks an Arg . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| In tyrosine kinases , the analogous sequence is Ala Ala Arg in the receptor tyrosine kinase subfamily and Arg Ala Ala in the Src tyrosine kinase subfamily . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| ArgBP 2 , a multiple Src homology 3 domain containing , Arg / Abl interacting protein , is phosphorylated in 5 Abl transformed cells and localized in stress fibers and cardiocyte Z disks . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , the role of this Arg ( Arg 318 ) in the protein tyrosine kinase C terminal Src kinase ( Csk ) was investigated . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C terminal region of c Abl . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also find that the Src family kinase Hck phosphorylates the Abl and Arg activation loops , leading to an additional twofold stimulation of kinase activity . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mutations were made to an Arg residue in a conserved SRC motif in the delta ' and gamma subunits that interacts with the ATP site of the neighboring gamma subunit . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| ICAM 1 promoter activities induced by the overexpression of wild type JAK 1 and PLC gamma 2 were blocked by the PLCgamma 2 mutant or the dominant negative PKCalpha ( Lys > Arg ) , c Src ( Lys > Met ) , or STAT 1 ( Y701M ) mutants , but not by dominant negative STAT 3 ( DN ) mutants . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma 1 ( PLC gamma 1 ) mediated phosphatidylinositol 4 , 5 bisphosphate ( PIP 2 ) hydrolysis , as we showed previously for c Abl . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we utilized `` homology scanning ' ' mutagenesis to identify beta tail mutants selectively defective in c Src binding and found that amino acid exchanges affecting a combination of an Arg and Thr residue in the integrin beta 3 tail control the binding specificity for SFKs but have no effect on talin binding . ^^^ |
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| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| Most classical phosphotyrosyl phosphatases ( PTPs ) , including the Src homology phosphotyrosyl phosphatase 2 ( SHP 2 ) possess a Thr or a Ser residue immediately C terminal to the invariant Arg in the active site consensus motif ( H / V C X 5 R S / T ) , also known as the `` signature motif ' ' . ^^^ |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|