| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| In follicular carcinomas , 2 of 14 tumors contained mutations ( N ras 61 , Gln to Arg ) , and both of these patients had bone metastases . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| The most common mutation site was Ha ras codon 61 with Gln Arg substitution . ^^^ Two ras mutations at codon 61 ( Gln Lys in N ras and Gln Arg in Ha ras ) were found in a microfollicular adenoma specimen from Eastern Hungary . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Within the cancer group as a whole , there was no significant correlation with pathological grade or clinical stage of tumor but in one subgroup follicular carcinomas a significant association was noted between TGF beta immunostaining and the presence of a specific mutation of the H ras oncogene ( codon 61 , gln arg ) . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| This Arg residue is located in a domain of alpha s not represented in EF Tu or p21ras . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Ras alterations were detected in the H ras gene in 3 tumors , 2 of which harbored a codon 13 ( Gly > Arg ) and one a codon 12 ( Gly > Ser ) point mutation . p 53 mutations were recorded in 12 tumors ( 57 % ) , 6 of which stained positively for p 53 . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| A panel of 21 clones deriving from the metastatic lesion Me665 / 2 , which had a Gln > Arg substitution at codon 61 of N RAS ( N RAS / 61+ ) , were also examined . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Five of these clones and the parental cell line showed a mutation at codon 61 of N RAS that resulted in Gln > Arg substitution ( N RAS / 61+ ) , while in the remaining 14 , only the wild type allele for N RAS was present ( N RAS / 61 ) . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Purified wild type or mutant H Ras proteins ( containing single amino acid substitutions at position 12 converting Gly to Arg or Val ) were used to immunize BALB / c mice intraperitoneally . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Only one of three cell lines ( KOA 2 ) had a N ras mutation [ codon 61 CAA ( Gln ) > CGA ( Arg ) ] and a p 53 gene mutation [ exon 6 codon 192 Caa ( Gln ) > TAG ( stop ) ] . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| The lower catalytic powers of G proteins may be ascribed to the absence of general base catalysis , and additionally in the case of p21ras , to the absence of a catalytic Arg residue , which interacts with the transition state . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Activating point mutations in the N ras gene ( nine CAA ( Gln ) to AAA ( Lys ) transversions and one CAA ( Gln ) to CGA ( Arg ) transition at codon 61 ) were detected at high frequency ( 56 % ) . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| By using an automated DNA sequencer , a K ras mutation ( codon 12 , GGT to CGT , Gly to Arg ) was detected in the pancreatic tumor tissue taken from the patient , whereas no p 53 mutation was detected . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Amino acid number 12 of K Ras ( wild type ; Gly ) was changed to Ser , Arg , Cys , Asp , Ala , or Val , and the mobility shift of the greenish fluorescent bands in the SDS / urea gel was analyzed . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| Only one point mutation could be found in the N ras gene codon 61 ( Gly to Arg ) in a cold adenomatous nodule which was monoclonal . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Activating mutations in NRAS codon 61 , all of which were either CAA ( Gln ) AAA ( Lys ) or CAA ( Gln ) CGA ( Arg ) mutations , were found in 95 % ( 20 / 21 ) of primary hereditary melanomas but in only 10 % ( 1 / 10 ) of sporadic melanomas ( P < . 001 ) . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : The data suggest that constitutively upregulated autocrine / paracrine secretion of EGF receptor ligands , especially ARG from K Ras mutated cells , mediates radioresistance in Rasmt cells through stimulation of EGFR PI3K AKT pathway . . ^^^ |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P01112 |
Pubmed |
SVM Score :0.0 |
| NA |
|