| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Fully automatous determination of acid base balance and partial pressures of O 2 and CO 2 in the blood with ABL 2 ( author ' s transl ) ] . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Of 12 children in whom BCR ABL mRNA was studied , 10 had Mbcr exon 2 joined to ABL exon 2 , one had Mbcr exon 3 joined to ABL 2 , and one had both Mbcr ABL junctions . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Two T cell lines ( ABL 1 and ABL 2 ) isolated from an LDA , demonstrated this form of specificity , mediating destruction specifically against the allogeneic acute lymphoblastic leukemic cells . ^^^ Both cell lines ABL 1 and ABL 2 were CD3+ , TCR alpha beta + , and CD4+ . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The analytical reliability was studied of the results from the determination of pH , pCO 2 , and pO 2 obtained by automatic analyzers `` Corning 178 ' ' and `` ABL 2 ' ' . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The determinations were performed as follows : pH by micro electrode , pCO 2 by equilibrium and by selective electrode , pO 2 by electrode , Clark type with apparatuses VME 22 , VME 32 and automatic analyser for blood gas analysis ABL 2 ( Radiometer ) . ^^^ Reproducibility of the results as regards time , presented by variation coefficient ( VC ) , followed up for a period of 9 months by the control materials Acidbasol with ABL 2 apparatus proved to be very good in the three ranges tested for pH and pCO 2 . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Mice carrying homozygous mutations in the c abl gene ( abl ( m 1 ) or abl 2 ) exhibit severe , though variable phenotypes , including a high rate of postnatal mortality , runting , morphological abnormalities , a susceptibility to infections , and selected immune system defects . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Previous work on mice homozygous for targeted mutations in the c abl gene ( ablml and abl 2 mutant strains ) has demonstrated multiple defects , including a susceptibility to infections that results in a high mortality rate after weaning . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| MEASUREMENTS AND MAIN RESULTS : PCO 2 was determined with three blood gas analyzers ( ABL 2 [ Radiometer , Copenhagen , Denmark ] , Corning 288 [ Ciba Corning Diagnostics GmbH , Neuss , Germany ] , and StatProfile 9 Plus [ Nova Biomedical , Waltham , MA ] ) . ^^^ Intrainstrumental comparison of the PCO 2 determinations demonstrated an increase of 12 . 3 + / 9 . 9 % for ABL 2 , 3 . 10 + / 12 . 9 % for Ciba Corning 288 , and 101 . 2 + / 31 . 5 % for StatProfile 9 Plus with the phosphate buffered solution . ^^^ ABL 2 ) ; 40 . 7 + / 9 . 9 % ( StatProfile 9 Plus vs . ^^^ ABL 2 ) ; and 30 . 9 + / 9 . 35 % ( StatProfile 9 Plus vs . ^^^ The coefficients of determination between PCO 2 values in saline and phosphate buffered solution were r2= . 85 for ABL 2 , r2= . 81 for Ciba Corning 288 , and r2= . 74 for StatProfile 9 Plus . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| We used polyclonal Abs directed against the peptide sequences corresponding to the extracellular NH 2 terminus [ residues 70 99 ( AbDD ) and 1 160 ( AbEE ) ] and extracellular loops 1 and 2 [ residues 161 178 ( AbL 1 ) and 244 265 ( AbL 2 ) ] of the seven transmembrane thrombin receptor . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| A new ETV6 / TEL partner gene , ARG ( ABL related gene or ABL 2 ) , identified in an AML M 3 cell line with a t ( 1 ; 12 ) ( q 25 ; p 13 ) translocation . ^^^ We identified a novel ETV 6 partner gene , ARG ( ABL related gene or ABL 2 ) , another TK gene in a cell line established from a patient with acute myelogenous leukemia ( AML M 3 ) with a t ( 15 ; 17 ) ( q 22 ; q11 . 2 ) and a t ( 1 ; 12 ) ( q 25 ; p 13 ) , which has the remarkable feature to differentiate to mature eosinophils in culture with all trans retinoic acid and cytokines . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| These include PDGFRB , JAK 2 , NTRK 3 , ABL 2 , and ABL 1 , each of which encodes for proteins with tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Fusions of the ETV6 / TEL gene to receptor or protein tyrosine kinases ( TKs ) , such as PDGFRbeta , JAK 2 , ABL , ABL 2 , TRKC , and Syk , have been reported in various hematological malignancies . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abl 1 ( previously known as Abl ) and the Abl 1 related gene product Abl 2 ( previously known as Arg ) define a family of tyrosine kinases that regulate actin structure and presynaptic axon guidance . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Imatinib mesylate ( Gleevec , STI 571 , or CP57148B ) is a direct inhibitor of ABL ( ABL 1 ) , ARG ( ABL 2 ) , KIT , and PDGFR tyrosine kinases . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| RIN 1 binds to the ABL SH 3 and SH 2 domains , and these interactions stimulate ABL 2 catalytic activity . ^^^ Deletion of the RAS binding domain ( RBD ) strongly stimulated the ABL 2 activation function of RIN 1 , suggesting that RAS activation results from the relief of RIN 1 autoinhibition . ^^^ The ABL binding domain of RIN 1 ( RIN 1 ABD ) increased the activity of ABL 2 immune complexes and purified RIN 1 ABD stimulated ABL 2 kinase activity toward CRK . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Some of the Ph negative myeloproliferative diseases are characterized by other chromosomal translocations involving a variety of tyrosine kinase genes , including ABL 1 , ABL 2 , PDGFRA , PDGFRB , FGFR 1 , and JAK 2 . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Additionally , a secondary locus , ABLL , which cross hybridized with the ABL probe , was mapped to bovine syntenic group U 1 with the HSA 1 loci PGD and ENO 1 . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Binding of tyrosine phosphorylated c ABL 1b by the relatively high affinity ABL and ARG SH 2 domains was quantitatively analyzed , and equilibrium dissociation constants for both interactions were estimated to be in the range of 5 10 10 ( 7 ) M . ^^^ The ARG SH 2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10 fold less strongly than the ABL SH 2 domain . ^^^ The ABL and ARG SH 2 domains differ by only 10 of 91 amino acids , and the substitution of ABL specific amino acids into either the amino or carboxy terminal half of the ARG SH 2 domain was found to increase its affinity for BCR . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Arg encodes a protein highly related to the c abl gene product with regard to overall structural architecture as well as the amino acid sequences of their tyrosine kinase , and src homologous 2 and 3 domains . ^^^ Analysis of arg expression in murine tissues revealed that arg , like c abl , is widely expressed , further extending the similarities between the two genes , and suggesting that arg probably functions in signaling pathways fundamental to many cell types . . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| We have previously described partial genomic sequences of arg , a human gene related to c abl , and shown that it is expressed as a 12 kilobase transcript and is located at chromosome position 1q24 25 . ^^^ Analysis of the predicted amino acid sequence of arg revealed that it is indeed closely related to that of c abl . ^^^ In addition , arg , like c abl , is expressed as two transcripts that result from a process of alternative splicing and encode alternative protein forms that differ only in their amino termini . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Moreover , substitution of Asp for Thr 98 in Abl SH 3 changed the binding specificity of this domain and conferred the ability to recognize Arg containing ligands . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domain of the ARG protein tyrosine kinase , which shares high amino acid sequence homology with the SH 2 domain of ABL , was less effective in activating the oncogenic potential of c ABL . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Two amino acid substitutions , Arg to His at amino acid 457 and Tyr to His at amino acid 469 of c abl , modeled on mutations known to render 5 src temperature sensitive for tyrosine kinase activity , were introduced into p210BCR ABL . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Analysis of chimeric Gag Arg / Abl molecules indicates a distinct negative regulatory role for the Arg C terminal domain . ^^^ Arg and c Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases . ^^^ To examine Arg structure function relationships we analysed a Gag Arg fusion protein , analogous to the oncogenic Gag Abl fusion protein of Abelson Murine Leukaemia Virus and found that in contrast to Gag Abl , it lacked transforming activity . ^^^ Three observations indicated that the difference in the transforming activity was mediated by the distinct Arg and Abl C terminal domains . ( 1 ) The analysis of chimeric Gag Arg / Abl molecules revealed that the Arg C terminal domain completely abrogated Gag Abl transforming activity and that the Abl C terminus conferred transforming activity to Gag Arg . ^^^ These observations indicate that the C terminal domain regulates Arg biological activity in a manner distinct from c Abl and suggest that this effect may be mediated in part by SH 3 domain binding sites . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Arg and c Abl represent the mammalian members of the Abelson family of nonreceptor protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The nonreceptor kinases are lck , yes , abl , arg , JakI , tyk 2 , and etk / bmx . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Arg and c Abl are ubiquitously expressed proteins which represent the mammalian members of the Abelson family of nonreceptor protein tyrosine kinases ( PTKs ) . ^^^ These results indicate that the subcellular localization of Arg is distinct from that of c Abl and thus suggest that the two proteins have different functions in intracellular signaling . ^^^ In addition , Arg , like c Abl , is expressed as myristoylated and nonmyristoylated isoforms , suggesting that it may have dual cytoplasmic subcellular localizations , and possibly participate in diverse signaling pathways . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| ArgBP 2 , a multiple Src homology 3 domain containing , Arg / Abl interacting protein , is phosphorylated in 5 Abl transformed cells and localized in stress fibers and cardiocyte Z disks . ^^^ ArgBP 2 associates with and is a substrate of Arg and 5 Abl , and is phosphorylated on tyrosine in 5 Abl transformed cells . ^^^ Arg and c Abl represent the mammalian members of the Abelson family of protein tyrosine kinases . ^^^ A novel Arg / Abl binding protein , ArgBP 2 , was isolated using a segment of the Arg COOH terminal domain as bait in the yeast two hybrid system . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that the tyrosine kinase encoded by an Abl related gene ( Arg ) also phosphorylates the CTD in vitro and in transfected cells . ^^^ The SH 2 and kinase domain of Arg are 95 % identical to that of c Abl . ^^^ Mapping studies and sequence analysis have led to the identification of the CTD ID that is highly conserved among the divergent C terminal regions of Abl and Arg . ^^^ These results indicate that tyrosine phosphorylation of RNA polymerase 2 CTD could be catalyzed by either c Abl or Arg kinase . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The products of the human Arg gene and human , mouse , Drosophila , and nematode Abl genes characterize the Abelson family of nonreceptor tyrosine protein kinase . ^^^ The Arg gene , expressed as a 12 kb transcript , codes a protein highly related to c abl in the tyrosine kinase , SH 2 , and SH 3 domains , and both proteins have a myristoylated isoform . ^^^ The C terminal domains of Arg and c abl , poorly similar to each other , may account for their different functions . ^^^ Arg is cytoplasmic , c abl also has nuclear localization , and their products have different transforming activity . ^^^ In the HL 60 cells , under the same differentiating conditions , the c abl RNA level did not change significantly , showing that Arg and c abl responded in a different way to the inducers of differentiation used . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Essential roles for the Abl and Arg tyrosine kinases in neurulation . ^^^ The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system . ^^^ Embryos deficient in both Abl and Arg suffer from defects in neurulation and die before 11 days postcoitum ( dpc ) . ^^^ Although they divide normally , abl ( / ) arg ( / ) neuroepithelial cells display gross alterations in their actin cytoskeleton . ^^^ We find that Abl and Arg colocalize with each other and with actin microfilaments at the apical surface of the developing neuroepithelium . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| We identified 30 tyrosine kinases expressed in these tissues : they include 10 non receptor tyrosine kinases ( yes , fyn , lyn , brk , abl , arg , jak 1 , jak 3 , tyk 2 and itk ) , 17 receptor tyrosine kinases ( erbB 2 , PDGF Ralpha , PDGF Rbeta , kit , c fms , met , ron , FGF R 1 , FGF R 2 , FGF R 3 , FGF R 4 , cek 5 , tie 1 , tkt , axl , sky and Ins R ) , 2 dual kinases ( mek and sek ) and one possible novel kinase . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The ARG gene encodes for a nonreceptor tyrosine kinase characterized by high homology with c Abl in the TK , SH 2 , and SH 3 domains . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| In this study , the kinase specificities of the Bcr Abl and Tel Abl proteins were compared to the physiological Abl family kinases c Abl and Arg ( abl related gene ) . ^^^ The results indicate that the leukaemic Abl fusion proteins have catalytic specificities different from the normal kinases c Abl and Arg and that Tel Abl is capable to activate at least some pathways which are also upregulated by Bcr Abl . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| SELH / Bc , Abl / Arg , Mena / Profilin 1 ) . ^^^ The genes mutated in several mouse NTD models involve actin regulation ( Abl / Arg , Macs , Mena / Profilin1 , Mlp , Shrm , Vcl ) , support the postulated key role of actin in neural fold elevation , and may be a good candidate pathway to search for human NTD genes . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Of 39 binding proteins analyzed , only the Abl related kinase Arg and the Cbl proto oncogene product bound preferentially to the first two SH 3 domains in tandem compared with the individual domains , consistent with a role in the developmental phenotype . ^^^ High level overexpression of c Abl or Arg alone induced anterior truncation , as did lower levels of an activated form of Abl ; Cbl alone had no effect . ^^^ In a sensitized system where subthreshold amounts of a ventralizing Nck mutant were expressed , co expression of the combination of Abl or Arg and Cbl at modest levels strongly potentiated anterior truncation , while Arg , Abl , or Cbl alone were without effect . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The Abl family of mammalian nonreceptor tyrosine kinases consists of c Abl and ARG ( Abl related gene ) . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk CAS complexes . c Abl and the Abl related gene product ( Arg ) are nonreceptor tyrosine kinases that regulate the actin cytoskeleton of cells by direct association with F actin and localization to focal contacts . ^^^ Moreover , embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg ( abl / arg / ) demonstrate increased Crk CAS coupling and motility . ^^^ Conversely , expression of a kinase active form of Abl or reconstitution of abl / arg / cells with wild type Abl prevents Crk CAS coupling and inhibits cell migration . ^^^ Thus , Abl and Arg kinases play a critical role in preventing cell migration through regulation of Crk and CAS adaptor protein complexes , which are necessary for cell movement . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| ARG is a widely expressed tyrosine kinase that shares substantial sequence identity with c ABL in the kinase domain and cooperates with ABL to regulate neurulation in the developing mouse embryo . ^^^ The effects of STI 571 on Ba / F3 cells transformed with BCR / ABL , TEL / ABL , TEL / PDGFbetaR , or TEL / ARG were then compared . ^^^ STI 571 inhibited tyrosine phosphorylation and cell growth of Ba / F3 cells expressing BCR / ABL , TEL / ABL , TEL / PDGFbetaR , and TEL / ARG with an IC ( 50 ) of approximately 0 . 5 microM in each case , but it had no effect on untransformed Ba / F3 cells growing in IL 3 or on Ba / F3 cells transformed by TEL / JAK2 . ^^^ Culture of TEL / ARG transfected Ba / F3 cells with IL 3 completely prevented STI 571 induced apoptosis in these cells , similar to what has been observed with BCR / ABL or TEL / ABL transformed cells . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Multiple signaling interactions of Abl and Arg kinases with the EphB 2 receptor . ^^^ Two hybrid screens identified regions of Abl and Arg that bind to the EphB 2 and EphA 4 receptors , suggesting a novel signaling connection involving the two kinase families . ^^^ The association of full length Abl and Arg with EphB 2 was confirmed by co immunoprecipitation and found to involve several distinct protein interactions . ^^^ The SH 2 domains of Abl and Arg bind to tyrosine phosphorylated motifs in the juxtamembrane region of EphB 2 . ^^^ A second , phosphorylation independent interaction with EphB 2 involves non conserved sequences in the C terminal tails of Abl and Arg . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Glivec is an aminopyrimidine derivative that interacts with the ATP binding site within the kinase domain of ABL and several other tyrosine kinases , including c KIT , PDGF beta receptor , and ARG . ^^^ |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The Abl related gene ( Arg ) nonreceptor tyrosine kinase uses two F actin binding domains to bundle F actin . ^^^ We show here that the Abl related kinase Arg binds with positive cooperativity to F actin in vitro with binding saturating at a ratio of one Arg / two actin molecules . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| We showed that the Arg to Leu mutation in the Phe Leu Val Arg Glu Ser ( FLVRES ) sequence of the SH 2 domain , known to interfere with phosphotyrosine sequence binding , did not block the binding of Bcr first exon sequences to the Abl SH 2 domain . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Based upon these results it is concluded that ARG can be activated as an oncogene in human malignancy and that the ETV6 / ARG oncoprotein triggers some of the same signaling pathways associated with activated ABL oncogenes . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The expression of the non receptor tyrosine kinases Arg and c abl is differently modulated in B lymphoid cells at different stages of differentiation . ^^^ The products of the human ARG gene and the human ABL gene characterize the Abelson family of non receptor tyrosine protein kinases . ^^^ Lymphopenia occurs in mice with homozygous disruption of c abl , indicating that in certain tissues Arg is unable to substitute c abl functions . ^^^ In B and T lymphoid cell lines at different stages of differentiation , we studied , by a reverse transcriptase competitive polymerase chain reaction and Western blotting , Arg and c abl in order to evaluate whether the expression pattern of the two genes could give insight as to why they do not exhibit overlapping roles in lymphocytes and whether the product levels of the two genes are related to lymphoid differentiation . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Arg tyrosine kinase is involved in homologous recombinational DNA repair . c Abl plays important roles in cellular response to DNA damage . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Functional interaction between the c Abl and Arg protein tyrosine kinases in the oxidative stress response . ^^^ The Abl family of mammalian nonreceptor tyrosine kinases consists of c Abl and Arg . ^^^ Recent work has shown that c Abl and Arg are activated in the cellular response to oxidative stress . ^^^ The present studies demonstrate that reactive oxygen species ( ROS ) induce the formation of c Abl and Arg heterodimers . ^^^ The results show that the c Abl SH 3 domain binds directly to a proline rich site ( amino acids 567 576 ) in the Arg C terminal region . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The vertebrate Abl family kinases , Abl and Arg , are expressed in the adult mouse brain , where they may regulate actin cytoskeletal dynamics in mature neurons . ^^^ Using immunoelectron microscopy , we have localized Abl and Arg to the pre and postsynaptic compartments of synapses in the mouse hippocampal area CA 1 . ^^^ Paired pulse facilitation ( PPF ) was significantly reduced at the Schaffer collateral CA 1 ( SC CA 1 ) excitatory synapses in hippocampal slices from abl / and arg / mice as compared with wild type mice . ^^^ Basal synaptic transmission , posttetanic potentiation ( PTP ) , long term potentiation ( LTP ) , and long term depression ( LTD ) were similar to wild type controls in abl / and arg / slices and in STI 571 treated wild type slices . ^^^ These results indicate that an important function of Abl and Arg is to modulate synaptic efficacy via a presynaptic mechanism during repetitive activation . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells , but exposure to several different stimuli results in a two to fivefold stimulation of kinase activity . ^^^ We show here that these two pathways mediate phosphorylation at distinct sites in Abl and Arg and have additive effects on Abl and Arg kinase activation . ^^^ Abl and Arg autophosphorylate at several sites outside the activation loop , leading to 5 . 2 and 6 . 2 fold increases in kinase activity , respectively . ^^^ We also find that the Src family kinase Hck phosphorylates the Abl and Arg activation loops , leading to an additional twofold stimulation of kinase activity . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Among the tyrosine kinases , c Abl and its relative Arg are unique in binding directly to F actin . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Catalase activity is regulated by c Abl and Arg in the oxidative stress response . ^^^ The Abl family of mammalian non receptor tyrosine kinases includes c Abl and Arg . ^^^ Recent studies have demonstrated that c Abl and Arg are activated in the response of cells to oxidative stress . ^^^ This work demonstrates that catalase , a major effector of the cellular defense against H2O2 , interacts with c Abl and Arg . ^^^ The results show that H2O2 induced binding of c Abl and Arg to catalase . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Imatinib is a potent inhibitor of ABL , ARG , PDGFRalpha , PDGFRbeta , and KIT and induces durable hematologic responses in HES patients . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| ARG is a tyrosine kinase closely related to ABL , which is oncogenic when fused to the transcriptional repressor ETV 6 ( ETS translocation variant 6 ) . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Glutathione peroxidase 1 is regulated by the c Abl and Arg tyrosine kinases . ^^^ The c Abl and Arg tyrosine kinases are activated in the cellular response to oxidative stress . ^^^ The present studies demonstrate that c Abl and Arg associate with glutathione peroxidase 1 ( GPx 1 ) and that this interaction is regulated by intracellular oxidant levels . ^^^ The c Abl and Arg SH 3 domains bind directly to a proline rich site in GPx 1 at amino acids 132 145 . ^^^ GPx 1 also functions as a substrate for c Abl and Arg mediated phosphorylation on Tyr 96 . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Role of the c Abl and Arg tyrosine kinases . ^^^ Recent studies have shown that catalase activity is stimulated by the c Abl and Arg tyrosine kinases . ^^^ The present work demonstrates that mouse cells deficient in both c Abl and Arg exhibit increased catalase stability . ^^^ Significantly , ubiquitination of catalase is dependent on c Abl and Arg mediated phosphorylation of catalase on both Y 231 and Y 386 . ^^^ These findings indicate that , in addition to stimulating catalase activity , c Abl and Arg promote catalase degradation in the oxidative stress response . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| METHODS : Tissue microarray blocks of 89 melanocytic lesions were evaluated by immunohistochemistry for the expression of selected PTKs : c kit , c abl , abl related gene ( ARG ) , platelet derived growth factor receptors alpha ( PDGFR alpha ) and beta ( PDGFR beta ) . ^^^ There was a trend toward lower expression of abl and ARG from BN to MMM . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Family members Abl and Arg are catalytically activated upon Shigella infection , accumulate at the site of bacterial entry , and are required for efficient bacterial uptake , as internalization is blocked upon targeted deletion of these kinases or treatment with a specific pharmacological inhibitor . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abl family kinases , which include Drosophila ( D ) Abl and the vertebrate Abl and Arg proteins , relay signals from cell surface growth factor and adhesion receptors to promote cytoskeletal rearrangements . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Apart from inhibition of the Abl protein tyrosine kinases , it also shows activity against platelet derived growth factor receptor ( PDGF R ) , c Kit , Abl related gene ( ARG ) , and their fusion proteins while sparing other kinases . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Genetic or pharmacological interference with Abl ( and the related kinase Arg ) resulted in a marked decrease in Rac activation induced by physiological doses of growth factors . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abl family kinases , which include the mammalian Abl and Arg ( Abl related gene ) kinases , regulate neuronal morphogenesis in developing metazoa ( for review , see [ 1 ] ) . ^^^ However , the mechanisms by which increased Abl or Arg kinase activity promote cytoskeletal rearrangements are unclear . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Imatinib is a selective inhibitor of PDGFRs , c Kit , Abl and Arg protein tyrosine kinases , as well as Bcr Abl , the oncogenic tyrosine kinase that causes chronic myeloid leukemia . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| In particular , we show that Abl and Arg , members of the Abl family of tyrosine kinases , localize and are activated in pedestals . ^^^ We also show that pyrido [ 2 , 3 d ] pyrimidine ( PD ) compounds , which inhibit Abl , Arg , and related kinases , block pedestal formation . ^^^ Finally , we show that Abl and Arg are sufficient for pedestal formation in the absence of other tyrosine kinase activity , but they are not necessary . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Imatinib mesylate is a small molecule drug that in vitro inhibits the Abelson ( Abl ) , Arg ( abl related gene ) , stem cell factor receptor ( Kit ) , and platelet derived growth factor receptor A and B ( PDGFRA and PDGFRB ) tyrosine kinases . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| In preclinical studies , treatment with imatinib , which inhibits both alpha and beta platelet derived growth factor receptors , as well as KIT , ABL , ARG , and BCR ABL tyrosine kinases , has been shown to decrease tumor IFP and concomitantly augment uptake of chemotherapeutic drugs , thereby enhancing the efficacy of chemotherapy . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Imatinib also inhibits the c abl , platelet derived growth factor ( PDGF ) receptor , abl related gene ( ARG ) and stem cell factor ( SCF ) receptor tyrosine kinases , and has been used clinically to inhibit the growth of malignant cells in patients with CML and gastrointestinal stromal tumors ( GISTs ) . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| This drug functions by blocking the ATP binding site of the kinase domain of bcr abl , and has also been found to inhibit the c abl , platelet derived growth factor receptor , ARG and stem cell factor receptor tyrosine kinases . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The Arg ( Abl related gene ) protein belongs to the Abl family of non receptor tyrosine kinases that regulate cell motility and morphogenesis . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The c Abl and Arg nonreceptor tyrosine kinases are activated in the response of cells to oxidative stress . ^^^ The results further demonstrate that c Abl mediated phosphorylation of Arg on Y 261 similarly confers Arg stabilization . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Desulfinylation ( reduction to cysteine ) is achieved by a novel enzyme named sulfiredoxin . c Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H ( 2 ) O ( 2 ) by mechanisms involving the SH 3 domains of the kinases and the Pro ( 293 ) PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr ( 231 ) and Tyr ( 386 ) . ^^^ Similarily , GPx 1 is activated by c Abl and Arg mediated phosphorylation . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| We report that the Abelson ( Abl ) and Abl related gene ( Arg ) nonreceptor tyrosine kinases are required for maintenance of cortical dendrites in the mouse brain . arg / cortical dendrites initially develop normally and are indistinguishable from wild type dendrites at postnatal day 21 . ^^^ More severe dendrite loss is observed in abl / arg / neurons . ^^^ These data suggest that integrin signaling through Abl and Arg support cortical dendrite branch maintenance by promoting dendrite branch dynamics in response to adhesive cues . . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of platelet derived growth factor receptor alpha , beta , c kit , c abl , and arg proteins in glioblastoma : possible implications for patient selection for imatinib mesylate therapy . ^^^ The TK inhibitor imatinib mesylate selectively targets PDGFR alpha , beta , c kit , c abl and arg and has proven successful in the treatment of chronic myeloid leukaemia . ^^^ In a cohort of 101 glioblastoma patients , anti PDGFR alpha , beta , c kit , c abl and arg protein immunohistochemistry was performed . ^^^ Focal PDGFR alpha , beta , c kit , c abl and arg immunolabeling was detected in 25 / 101 , 19 / 101 , 4 / 101 , 7 / 101 and 31 / 101 cases , respectively . ^^^ We show here for the first time in a large series of glioblastomas that PDGFR alpha , beta , c kit , c abl and arg expression is immunohistochemically detectable in a fraction of cases . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Tyr 161 shares similarity to the consensus sequence for phosphorylation by the nonreceptor tyrosine kinases Abl and Arg . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Additionally , Abl and Arg are able to phosphorylate A36R in vitro and are recruited to vaccinia induced actin tails . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| METHODS : Tumor biopsies from 13 patients with metastatic melanoma were screened by immunohistochemistry for PTK [ c kit , C abl , Abl related gene ( ARG ) , PDGF receptor alpha ( PDGFR alpha ) and PDGFR beta ] expression before and after being treated with Gleevec @ 400 mg bid for 2 weeks . ^^^ One patient had a durable clinical response , and the follow up biopsy showed negative expression for four of the PTKs , namely c abl , ARG , PDGFR alpha , and beta . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| Interaction between c Abl and Arg tyrosine kinases and proteasome subunit PSMA 7 regulates proteasome degradation . ^^^ The present study demonstrates that c Abl and Arg ( abl related gene ) tyrosine kinases associate with and phosphorylate the proteasome PSMA 7 ( alpha 4 ) subunit at Tyr 153 . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| The Abl family of nonreceptor tyrosine kinases consists of two related proteins , c Abl and Abl related gene ( Arg ) . ^^^ Activated forms of the Abl kinases ( BCR Abl , Tel Abl , and Tel Arg ) induce the development of human leukemia ; it is not known , however , whether Abl kinases are activated in solid tumors or whether they contribute to tumor development or progression . ^^^ Furthermore , activation of Abl kinases promotes breast cancer cell invasion , as treatment of cells with the Abl kinase inhibitor , STI 571 , or silencing c Abl and Arg expression with RNA interference dramatically inhibits Matrigel invasion . ^^^ |
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| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42684 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
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