| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| Solution structure of the Eps 15 homology domain of a human POB 1 ( partner of RalBP 1 ) . ^^^ |
|
| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| POB 1 consists of 521 amino acids , shares a homology with Eps 15 , which has been identified as an epidermal growth factor ( EGF ) receptor substrate , and has two proline rich motifs . ^^^ |
|
| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| POB 1 is a binding protein of RalBP 1 and has the Eps 15 homology ( EH ) domain . ^^^ The EH domain of POB 1 bound directly to Epsin and Eps 15 . ^^^ Taken together with the observation that EGF and insulin activate Ral , these results suggest that Ral , RalBP 1 and POB 1 transmit the signal from the receptors to Epsin and Eps 15 , thereby regulating ligand dependent receptor mediated endocytosis . . ^^^ |
|
| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| POB 1 has been identified as a RalBP 1 binding protein and has the Eps 15 homology ( EH ) domain . ^^^ To clarify the function of POB 1 , we purified a protein which binds to the EH domain of POB 1 from bovine brain cytosol and identified it as Epsin , which is known to bind to the EH domain of Eps 15 . ^^^ |
|
| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| RalBP 1 and POB 1 , the downstream molecules of small GTP binding protein Ral , are involved in receptor mediated endocytosis together with Epsin and Eps 15 . ^^^ RalBP 1 , POB 1 , Epsin , and Eps 15 formed a complex with alpha adaptin of AP 2 in Chinese hamster ovary cells , but the formation was reduced in mitotic phase . ^^^ RalBP 1 , POB 1 , Epsin , and Eps 15 were all phosphorylated in mitotic phase . ^^^ |
|
| Interacting proteins: Q8NFH8 and P42566 |
Pubmed |
SVM Score :0.0 |
| However , hEpsinDA interacted with Eps 15 , POB 1 , and AP 2 , which are involved in receptor mediated endocytosis , as efficiently as wild type hEpsin . ^^^ |
|