| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| We have recently identified S6K2 , a homolog of S6K1 , which phosphorylates S 6 in vitro and is regulated by the phosphatidylinositide 3 kinase ( PI 3 K ) and mammalian target of rapamycin pathways in vivo . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that S6K2 is regulated similarly to S6K1 by the mammalian target of rapamycin pathway and by multiple PI 3 K pathway effectors in vivo . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| Like S6K1 , the activation of S6K2 requires signaling from both the phosphatidylinositol 3 kinase and the mammalian target of rapamycin ( mTOR ) . ^^^ Here we report the investigation of the mechanisms of S6K2 regulation by mTOR . ^^^ We demonstrate that similar to S6K1 the serum activation of S6K2 in cells is dependent on mTOR kinase activity , amino acid sufficiency , and phosphatidic acid . ^^^ As a predominantly nuclear protein , S6K2 activation was facilitated by enhanced mTOR nuclear import with the tagging of an exogenous nuclear localization signal and diminished by enhanced mTOR nuclear export with the tagging of a nuclear export sequence . ^^^ However , further increase of mTOR nuclear import by the tagging of four copies of nuclear localization signal resulted in its decreased ability to activate S6K2 , suggesting that mTOR nuclear export may also be an integral part of the activation process . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| This activity was resistant to the effects of rapamycin or wortmannin , indicating that mammalian target of rapamycin ( mTOR ) and phosphoinositide 3 kinase ( PI3K ) regulate S6K2 activity via Thr 388 . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , the ribosomal protein S 6 kinases , S6K1 and S6K2 , lie downstream of mTOR and PI3K , suggesting that translational control through the phosphorylation of S 6 regulates cell growth . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| To better elucidate how mTOR mediates proliferation signals from IL 3 , we assessed the role of S 6 kinase 2 ( S6K2 ) , one of the downstream targets of mTOR , in IL 3 signaling . ^^^ We show that S6K2 is activated by IL 3 in the IL 3 dependent Ba / F3 cell line and that this is mediated by mTOR and its upstream activator PI 3K but not by the MAPK kinase / extracellular signal regulated kinase pathway . ^^^ In cells expressing T388E , rapamycin still reduces proliferation at all doses of rapamycin , showing that mTOR targets other than S6K2 play an important role in IL 3 dependent proliferation . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| S6K1 dephosphorylation may thus be mTOR independent , and the functional mTOR / S6K2 pathway may maintain S 6 phosphorylation . ^^^ |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBS0 and P42345 |
Pubmed |
SVM Score :0.0 |
| NA |
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