Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Evidence of insulin stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Finally , the negative regulatory effects of PDGF and Akt were inhibited by rapamycin , an inhibitor of the mammalian target of rapamycin ( mTOR ) , one of the downstream targets of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Role of mammalian target of rapamycin , protein kinase b , and phosphatidylinositol 3 kinase in GLUT 1 mRNA translation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Growth factor induced activation of phosphoinositide 3 kinase and protein kinase B ( PKB ) leads to increased activity of the mammalian target of rapamycin ( mTOR ) . ^^^ Mammalian target of rapamycin is a direct target for protein kinase B : identification of a convergence point for opposing effects of insulin and amino acid deficiency on protein translation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
A direct linkage between the phosphoinositide 3 kinase AKT signaling pathway and the mammalian target of rapamycin in mitogen stimulated and transformed cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Rapamycin abrogated 4E BP 1 phosphorylation in response to insulin , suggesting involvement of mammalian target of rapamycin ( mTOR ) , a kinase downstream of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibition of IRS 1 tyrosine phosphorylation by TNF was blocked by rapamycin , an inhibitor of the mammalian target of rapamycin ( mTOR ) , a downstream target of Akt . mTOR induced the serine phosphorylation of IRS 1 ( Ser 636 / 639 ) , and such phosphorylation was inhibited by rapamycin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
One component involved here is p 70 S6 kinase 1 ( S6K1 ) , which lies downstream of mammalian target of rapamycin , whose regulation is thought to involve phosphatidylinositol 3 kinase and protein kinase B ( PKB ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We report that Akt promotes hypertrophy by activating downstream signalling pathways previously implicated in activating protein synthesis : the pathways downstream of mammalian target of rapamycin ( mTOR ) and the pathway activated by phosphorylating and thereby inhibiting glycogen synthase kinase 3 ( GSK 3 ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Through a requisite interaction with alphaVbeta 3 integrin , tumstatin inhibits activation of focal adhesion kinase ( FAK ) , phosphatidylinositol 3 kinase ( PI 3 kinase ) , protein kinase B ( PKB / Akt ) , and mammalian target of rapamycin ( mTOR ) , and it prevents the dissociation of eukaryotic initiation factor 4E protein ( eIF4E ) from 4E binding protein 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We investigated the roles of Akt and mammalian target of rapamycin ( mTOR ) in skeletal muscle differentiation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin ( mTOR ) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser ( 473 ) , mTOR on Ser ( 2448 ) , ribosomal protein S 6 kinase on Thr ( 389 ) , and eukaryotic initiation factor eIF4E binding protein on Thr ( 37 ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Muscle fiber hypertrophy induced by activated PKB and by a Ras double mutant ( RasV12C40 ) that activates selectively the phosphoinositide 3 kinase PKB pathway is completely blocked by rapamycin , showing that the mammalian target of rapamycin kinase is the major downstream effector of this pathway in the control of muscle fiber size . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Because PTEN deficient myeloma cells may have up regulated activity of the mammalian target of rapamycin ( mTOR ) , downstream of AKT , they may be particularly sensitive to mTOR inhibition . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Ultraviolet induced phosphorylation of p 70 ( S6K ) at Thr ( 389 ) and Thr ( 421 ) / Ser ( 424 ) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C . ^^^ These results demonstrated that H ( 2 ) O ( 2 ) , phosphatidylinositol 3 kinase , and mammalian target of rapamycin were important players for UV induced p 70 ( S6k ) phosphorylation at Thr ( 389 ) and Thr ( 421 ) / Ser ( 424 ) , whereas Akt and atypical protein kinase C were not involved in this activation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
PE and ET 1 do not activate protein kinase B but stimulate Ras and Erk , and their ability to activate protein synthesis was blocked by inhibition of Ras or MEK and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
IGF 1 elicited sequential Akt ( Ser ( 308 ) ) , Akt ( Ser ( 473 ) ) , and mammalian target of rapamycin ( Ser ( 2448 ) ) phosphorylation ; however , transfection of muscle cells with kinase inactive Akt 1 ( K179M ) showed that these events were not required for IGF 1 to activate p70S6 kinase and stimulate proliferation of human intestinal muscle cells . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Upon depletion of IL 6 , both mutated ras containing myeloma lines demonstrated constitutive activation of mitogen activated extracellular kinase 2 ( MEK ) / extracellular signal regulated kinase ( ERK ) , phosphatidylinositol 3 kinase ( PI 3 kinase ) / AKT , mammalian target of rapamycin ( mTOR ) / p70S6 kinase , and nuclear factor kappa B ( NF kappa B ) pathways . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
However , anisomycin had little effect on phosphorylation of either Akt or the mammalian target of rapamycin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
PI3K / protein kinase B derived signals also affect activation of p 70 S6 kinase and the mammalian target of rapamycin , enzymes involved in cell growth control . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Furthermore , other serine kinases including Akt , extracellular regulated kinase , mammalian target of rapamycin , and PKCzeta were also activated by TNF alpha ( as assessed by phospho specific antibodies ) . ^^^ Phosphorylation of Akt and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in response to TNF alpha was inhibited by aspirin treatment . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We also show that Akt activation is significantly correlated with phosphorylation of mammalian target of rapamycin ( mTOR ) , the family of forkhead transcription factors ( FOXO 1 , FOXO3a , and FOXO 4 ) , and S 6 , which are thought to promote its effects . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The description of therapies that target AKT , protein kinase C , phosphodiesterase 4 , mammalian target of rapamycin , histone deacetylase , and methyltransferase offer the opportunity to utilize molecularly targeted therapy for this disease . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin ( mTOR ) , a downstream effector of the phosphatidylinositol 3 kinase ( PI3K ) / Akt ( protein kinase B ) signaling pathway that mediates cell survival and proliferation , is a prime strategic target for anticancer therapeutic development . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In this report , we demonstrate that canstatin inhibits the phosphorylation of Akt , focal adhesion kinase , mammalian target of rapamycin , eukaryotic initiation factor 4E binding protein 1 , and ribosomal S 6 kinase in cultured human umbilical vein endothelial cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Further transfection experiments including expression of constitutively active and dominant negative Akt and rapamycin treatment suggest that suppression of TGF beta signaling / Smad3 activation by IGF 1 occurs downstream of Akt and through mammalian target of rapamycin activation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This effect was completely blocked by the specific inhibitors of phosphatidylinositol 3 kinase ( PI 3 kinase , LY 294002 ) , mammalian target of rapamycin , and extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 , U 0126 ) or by a recombinant adenovirus encoding dominant negative Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here we report that activin A alone activates IkappaB alpha , and stimulates nuclear translocation of NFkappaB and receptor activator of nuclear factor kappaB ( RANK ) expression for osteoclastogenesis , but not Akt / PKB survival signal transduction including BAD and mammalian target of rapamycin ( mTOR ) for survival in osteoclast precursors in vitro . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt and the mammalian target of rapamycin ( mTOR ) are regarded as PI3K downstream effectors . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Pharmacological inhibition of the Akt effector , mammalian target of rapamycin ( mTOR ) , with rapamycin prevents the morphological disruption elicited by Akt activation , including its effect on cell size and number , and the cooperative effect of Akt on oncogene driven proliferation , indicating that mTOR function is required for the multiple biological effects of Akt activation during morphogenesis . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
AKT activity determines sensitivity to mammalian target of rapamycin ( mTOR ) inhibitors by regulating cyclin D 1 and c myc expression . ^^^ Prior work demonstrates that AKT activity regulates sensitivity of cells to G ( 1 ) arrest induced by mammalian target of rapamycin ( mTOR ) inhibitors such as rapamycin and CCI 779 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Consistent with PKB mediating this phosphorylation , inhibitors of PI 3 kinase ( phosphoinositide 3 kinase ; wortmannin and LY 294002 ) but not inhibitors of mammalian target of rapamycin ( rapamycin ) or MEK 1 ( mitogen activated protein kinase kinase 1 ) activation ( PD 184352 ) , inhibited IGF 1 induced phosphorylation of endogenous WNK 1 at Thr 60 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In vivo , increased activation of Akt and mammalian target of rapamycin was observed with increased phenotypic progression . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin ( mTOR ) is an important regulator of cell growth and metabolism and is often upregulated by Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The inhibition of IRS 1 associated PI3K activity by carbachol ( 1 ) was rapid ( < 1 min ) , persistent ( > or =60 min ) and potent ( half maximal concentration approximately 1 microM ) ; ( 2 ) was reproduced by stimuli for several phospholipase C coupled receptors ; ( 3 ) was prevented by the inhibition of protein kinase C , but not by chelation of intracellular Ca2+ ; and ( 4 ) was not blocked or reproduced by inhibitors or stimuli respectively of mitogen activated protein kinase , PI3K , protein kinase B or the mammalian target of rapamycin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mammalian target of rapamycin ( mTOR ) is a PKB substrate , and regulates p 70 S6 kinase ( p 70 S6K ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Follicle stimulating hormone activation of hypoxia inducible factor 1 by the phosphatidylinositol 3 kinase / AKT / Ras homolog enriched in brain ( Rheb ) / mammalian target of rapamycin ( mTOR ) pathway is necessary for induction of select protein markers of follicular differentiation . ^^^ Our results define a signaling pathway in GCs whereby the inactivating phosphorylation of tuberin downstream of phosphatidylinositol ( PI ) 3 kinase / AKT activity leads to Rheb ( Ras homolog enriched in brain ) and subsequent mTOR ( mammalian target of rapamycin ) activation . mTOR then stimulates translation by phosphorylating p 70 S6 kinase and , consequently , the 40 S ribosomal protein S 6 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The results suggest that IGF 1 can up regulate MMP 2 synthesis via PI 3 kinase / Akt / mTOR ( the mammalian target of rapamycin ) signaling while concomitantly transmitting a negative regulatory signal via the Raf / ERK pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our study shows that PI3K transmits a mitogenic signal through AKT and mammalian target of rapamycin ( mTOR ) to p70S6K1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here we show that induction of mitogenic signaling by H2O2 activates sequentially PI3K , Akt , mammalian target of rapamycin ( mTOR ) , and Ran protein . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The phosphatidylinositol 3 kinase ( PI3K ) inhibitors , wortmannin and LY 294002 [ 2 ( 4 morpholinyl ) 9 phenyl 4H 1 benzopyran 4 one ] , dominant negative Akt , or rapamycin , an inhibitor of mTOR ( mammalian target of rapamycin ) and ribosomal p 70 S6 kinase ( p70S6K ) phosphorylation , inhibited the insulin mediated increase in GCLC protein and GSH levels . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Long term activation of the phosphatidylinositol 3 kinase / Akt signaling pathway , but not the mammalian target of rapamycin or mitogen activated protein kinase pathways , is required for IGF 1 to hyperphosphorylate retinoblastoma and to cause accumulation of E2F 1 and cyclin A . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In addition , there was a concentration dependent inhibition of cell migration and p70S6K phosphorylation ( Thr ( 389 ) and Thr ( 421 ) / Ser ( 424 ) ) in the presence of Rapamycin , a specific inhibitor of the mammalian target of rapamycin ( mTOR , a downstream of AKT ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mammalian target of rapamycin ( mTOR ) is a serine threonine kinase member of the cellular phosphatidylinositol 3 kinase ( PI3K ) pathway , which is involved in multiple biologic functions such as transcriptional and translational control . mTOR is a downstream mediator in the PI3K / Akt signaling pathway and plays a critical role in cell survival . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin ( mTOR ) is a downstream effector of the phosphatidylinositol 3 kinase ( PI3K ) / Akt ( protein kinase B ) signaling pathway , which mediates cell survival and proliferation . mTOR regulates essential signal transduction pathways , is involved in the coupling of growth stimuli with cell cycle progression , and initiates mRNA translation in response to favorable nutrient environments . mTOR is involved in regulating many aspects of cell growth , including membrane traffic , protein degradation , protein kinase C signaling , ribosome biogenesis , and transcription . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The role of phosphatidylinositol 3 kinase ( PI3K ) / AKT and mammalian target of rapamycin ( mTOR ) signaling in TGF beta 1 resistance was studied in prostate cancer cell lines . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our results showed that FGFR 4 and ErbB 2 via the MAPK and the phosphatidylinositol 3 kinase / protein kinase B pathways , respectively , both contribute to the maintenance of constitutive activity of the mammalian target of rapamycin translational pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In contrast , rapamycin , an inhibitor of mTOR ( mammalian target of rapamycin ) , altered effects of elevated Akt 1 selectively : it eliminated the increase in stem cells and reduced the proliferative response , but had no effect on survival . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In this report , we show that PMA stimulated activation of PKC eta in U 251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin ( mTOR ) signaling pathways and an increase in cell proliferation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Combined treatment also resulted in pronounced reductions in levels of phospho Akt , glycogen synthase kinase 3 ( GSK 3 ) , p 70 ( S6K ) , mammalian target of rapamycin ( mTOR ) , forkhead transcription factor ( FKHR ) , caspase 9 , and Bad . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of phosphatidylinositol 3 kinase , Akt , and mammalian target of rapamycin is necessary for hypoxia induced pulmonary artery adventitial fibroblast proliferation . ^^^ Previous studies have suggested that ERK1 / 2 , phosphatidylinositol 3 kinase ( PI3K ) , Akt , and mammalian target of rapamycin ( mTOR ) are activated by hypoxia and play a role in a variety of cell responses . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Extracellular ATP induced proliferation of adventitial fibroblasts requires phosphoinositide 3 kinase , Akt , mammalian target of rapamycin , and p 70 S6 kinase signaling pathways . ^^^ By using both pharmacologic and genetic approaches , we found that in addition to ERK1 / 2 , phosphatidylinositol 3 kinase ( PI3K ) , Akt , mammalian target of rapamycin ( mTOR ) , and p 70 S6K dependent signaling pathways are required for ATP induced proliferation of adventitial fibroblasts . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt1 / Akt2 and mammalian target of rapamycin / Bim play critical roles in osteoclast differentiation and survival , respectively , whereas Akt is dispensable for cell survival in isolated osteoclast precursors . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3 L 1 and human adipocytes . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Several studies have demonstrated that rapamycin , which inhibits mammalian target of rapamycin ( mTOR ) , a downstream target of Akt , sensitizes certain resistant cancer cells to chemotherapeutic agents . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Moreover , PI3K and Akt inhibitors , but not mammalian target of rapamycin inhibitor , inhibited the effect of insulin on the coprecipitation of procaspase 9 and XIAP . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt up regulation increases resistance to microtubule directed chemotherapeutic agents through mammalian target of rapamycin . ^^^ Rapamycin inhibits Akt mediated maintenance of glycolysis and therapeutic resistance , indicating that these effects are dependent on mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The role of the IGF system in cancer should be examined in the context of the extra cellular and intra cellular signalling networks , in particular : phosphatidylinositol 3 kinase ( PI3K ) , protein kinase B ( Akt / PKB ) , mammalian target of rapamycin ( mTOR ) , and forkhead transcription factors ( FOXO ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Oncogenic forms of Akt can support growth factor independent nutrient transporter expression through a mechanism that depends upon mTOR ( mammalian target of rapamycin ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Finally , mammalian target of rapamycin signaling is attenuated in the brains of Akt 3 / but not Akt 1 / mice , suggesting that differential regulation of this pathway contributes to an isoform specific regulation of cell growth . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We also show that in different tumor cell backgrounds inhibition of mammalian target of rapamycin , a downstream substrate of Akt , is less effective in inducing caspase 3 activity than inhibition of Akt 1 and Akt 2 . ^^^ This shows that the survival phenotype conferred by Akt can be mediated by signaling pathways independent of mammalian target of rapamycin in some tumor cell backgrounds . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin ( mTOR ) and Akt proteins regulate various steps of muscle development and growth , but the physiological relevance and the downstream effectors are under investigation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
These results show in vivo evidence that ILK plays a prominent role in oncogenic phosphatidylinositol 3 kinase / PKB signaling in vivo with major impact on the mammalian target of rapamycin , signal transducers and activators of transcription 3 , and forkhead in rhadomyosarcoma signaling pathways , suggesting that ILK inhibitors might show activity in pancreatic cancer patients . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
PTEN abnormalities result in inappropriate signaling to downstream molecules including protein kinase B ( PKB / Akt ) , and mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin p 70 ribosomal S 6 kinase but not phosphatidylinositol 3 kinase Akt signaling is responsible for fibroblast growth factor 9 induced cell proliferation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Together , these findings indicate that the mammalian target of rapamycin inhibitor potentiates UCN 01 cytotoxicity in a variety of human leukemia cell types and suggest that inhibition of both Raf 1 / MEK / ERK and Akt cytoprotective signaling pathways as well as JNK activation contribute to this phenomenon . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
A decrease in IGF 1 stimulated proteoglycan synthesis was also observed upon inhibition of mTOR ( mammalian target of rapamycin ) and p70S6 kinase , both of which are downstream of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Signaling via the Akt / mammalian target of rapamycin pathway can also increase muscle growth , and recent findings show that activation of this pathway can occur as a response to mechanical stimulation applied directly to muscle cells , independent of signals derived from other cells . ^^^ In addition , mechanical activation of mammalian target of rapamycin , Akt , and other downstream signals is apparently independent of autocrine factors , which suggests that activation of the mechanical pathway occurs independent of muscle mediated IGF 1 release . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The serine / threonine kinase AKT and its downstream mediator mammalian target of rapamycin ( mTOR ) are activated in lung adenocarcinoma , and clinical trials are under way to test whether inhibition of mTOR is useful in treating lung cancer . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mammalian target of rapamycin ( mTOR ) is a downstream effector of the phosphatidylinositol 3 kinase ( PI3K ) / protein kinase B ( Akt ) signaling pathway and a central modulator of cell proliferation in malignant gliomas . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
IL 2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3 ' kinase / Akt , heat shock protein 90 , and mammalian target of rapamycin in transformed NK cells . ^^^ In addition , radicicol , an inhibitor of heat shock protein 90 ( Hsp 90 ) , and rapamycin , an inhibitor of the mammalian target of rapamycin ( mTOR ) , blocked IL 2 induced hTERT activity and nuclear translocation of hTERT but not hTERT mRNA expression . hTERT was coimmunoprecipitated with Akt , Hsp 90 , mTOR , and p 70 S6 kinase ( S6K ) , suggesting that these molecules form a physical complex . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our results indicate that mammalian target of rapamycin inhibitors may be effective in a subset of tumors that depend on Akt activity for survival but not effective in all tumors that exhibit Akt activation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In conclusion , rapamycin targets 2 pathways that are crucial for cell survival and chemoresistance of malignant lymphoblasts PI3k / Akt through the mammalian target of rapamycin and NF kappaB through FKBP 51 suggesting that the drug could be beneficial in the treatment of childhood ALL . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mammalian target of rapamycin phosphorylation was similar to that of Akt during each trial ; however , change or lack of change was not significant . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Binding of fastatin to alphavbeta 3 integrin inhibits phosphorylation of focal adhesion kinase , Raf , extracellular signal regulated kinase , Akt , and mammalian target of rapamycin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
RESULTS : In the hypertrophic muscle of MLC / mlgf 1 mice , we observed increased phosphorylation of phosphoinositide dependent protein kinase 1 ( PDK 1 ; 53 % increase ) , the mammalian target of rapamycin ( mTOR ; 112 % increase ) , and p 70 S6 kinase ( p70S6K ) ( 254 % increase ) but no significant change in Akt phosphorylation ( 4 % decrease ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mammalian target of rapamycin ( mTOR ) is a downstream target of Akt , and we hypothesized that irradiation activates mTOR signaling in both glioma and endothelial cells ( ECs ) and that radiosensitization results from inhibiting mTOR signaling . mTOR inhibitors , rapamycin and RAD 001 ( everolimus ) were found to radiosensitize vascular ECs , but failed to sensitize glioma cells as determined by clonogenic assay . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibition of Akt phosphorylation was associated with the inhibition of IGF 1 stimulation of the mammalian target of rapamycin phosphorylation ( Ser 2448 and Ser 2481 ) , phosphorylation of p 70 S6 kinase ( Thr 389 ) , and ribosomal protein S 6 ( Ser 235 / 236 ) in Rh 1 , Rh 18 , and Rh 30 cell lines . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity . ^^^ The serine / threonine kinase Akt is an upstream positive regulator of the mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The PTEN and TSC 2 tumor suppressors function to antagonize mTOR ( mammalian target of rapamycin ) activation by Akt ; hence , compound heterozygous inactivation of Pten and Tsc 2 in the mouse may in principle exacerbate the tumor phenotypes observed in the single mutants in a reciprocal manner . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NBS 1 overexpression stimulates phosphatidylinositol ( PI ) 3 kinase activity , leading to increased phosphorylation levels of Akt and its downstream targets such as glycogen synthase kinase 3beta and mammalian target of rapamycin in different cell lines and tumor samples . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of Akt and eIF4E survival pathways by rapamycin mediated mammalian target of rapamycin inhibition . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Wortmannin and LY 294002 , two specific inhibitors of phosphatidylinositol 3 kinase ( PI3K ) , blocked both Akt and S6K1 phosphorylation , whereas rapamycin , a specific inhibitor of Akt downstream effector , mammalian target of rapamycin ( mTOR ) , suppressed only S6K1 phosphorylation induced by 15 ( S ) HETE suggesting that this eicosanoid activates the PI3K Akt mTOR S6K1 signaling in HDMVEC . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt , mitogen activated protein kinase / extracellular signal regulated kinase kinase , insulin growth factor 1 , and serum . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In the present study , we investigated the possible additional participation of a phosphatidylinositol 3 kinase ( PI3K ) / serine threonine protein kinase B ( Akt ) / mammalian target of rapamycin ( mTOR ) / p70 ribosomal S 6 kinase ( S6K1 ) pathway in this growth response . ^^^ Serotonin induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3 kinase / serine threonine protein kinase B / mammalian target of rapamycin / p70 ribosomal S 6 kinase 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Recent studies have revealed that the signaling pathways regulating the mammalian target of rapamycin such as Akt and S6K1 are frequently activated in pancreatic cancer . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Double stranded DNA dependent protein kinase ( DNA PK ) , ataxia telangiectasia mutated ( ATM ) gene product , integrin linked kinase ( ILK ) , protein kinase Calpha ( PKCalpha ) , and mammalian target of rapamycin ( mTOR ) , when complexed to rapamycin insensitive companion of mTOR ( RICTOR ) , have all been identified as playing a critical role in Akt Ser 473 phosphorylation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up regulating the insulin like growth factor receptor / insulin receptor substrate 1 / phosphatidylinositol 3 kinase cascade . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt promotes cell proliferation by its ability to coordinate mitogenic signaling with energy and nutrient sensing pathways that control protein synthesis through the atypical serine / threonine kinase , mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We found that a newly developed small molecule compound ( QLT 0267 ) effectively inhibited signaling through the ILK / Akt cascade in glioma cells by blocking the phosphorylation of Akt and downstream targets , including mammalian target of rapamycin and glycogen synthase kinase 3beta . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Treatment of cells with the phosphatidylinositol 3 kinase ( PI3K ) inhibitors wortmannin and LY 294002 [ 2 ( 4 morpholinyl ) 8 phenyl 4H 1 benzopyran 4 one ] or rapamycin , an inhibitor of mammalian target of rapamycin and ribosomal p 70 S6 kinase ( p70S6K ) phosphorylation , or with an adenovirus containing green fluorescent protein and a dominant negative and kinase dead Akt , effectively inhibited the insulin mediated increase in alpha class GST expression and GST activity toward NBD . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Special emphasis is placed on the following targets : receptor tyrosine kinases , PI3K , Akt , and the mammalian target of rapamycin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Reflecting its critical role in integrating cell growth and division with the cellular nutritional environment , the mammalian target of rapamycin * ( mTOR ) is a highly conserved downstream effector of the phosphatidylinositol 3 kinase ( PI3K ) / Akt ( protein kinase B ) signaling pathway . mTOR activates both the 40S ribosomal protein S 6 kinase ( p70s6k ) and the eukaryotic initiation factor 4E binding protein 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Recent work has shown mammalian target of rapamycin ( mTOR ) to be a major target downstream of Akt that contributes to both transformation and therapeutic resistance . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The alterations in the Ane AA group were accompanied by hyperphosphorylation of protein kinase B and the mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We show that inhibition of ILK activity with a pharmacologic ILK inhibitor , QLT 0267 , results in the inhibition of PKB / Akt Ser 473 phosphorylation , stimulation of apoptosis , and a decrease in mammalian target of rapamycin ( mTOR ) expression in human breast cancer cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NBS 1 expression levels correlated with the transformation activity of FADU clones and also correlated with the phosphorylation levels of Akt and its downstream target mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibition of mammalian target of rapamycin ( mTOR ) , a downstream target of Akt , is able to restore tamoxifen response in tamoxifen resistant breast cancer cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Various studies have implicated phosphatidylinositol 3 kinase , protein kinase B ( Akt ) , phosphorylation of the transcription factors forkhead in rhabdomyosarcoma 1 ( Foxo 1 ) / Foxo3 , and the mammalian target of rapamycin ( mTOR ) in insulin ' s effect . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Protein analyses of key cytoplasmic proteins for three signaling pathways deemed important in influencing protein turnover [ phosphatidylinositol 3 kinase Akt mammalian target of rapamycin , P13K / Akt / glycogen synthase kinase ( GSK ) 3 , and MAPK ERK ] were performed by Western blot . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This was mediated through signaling events involving extracellular signal regulated kinase , phosphatidylinositol 3 kinase / Akt , mammalian target of rapamycin ( mTOR ) , and p70S6K . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The macroautophagy is triggered despite activation of Akt , mammalian target of rapamycin ( mTOR ) , and S 6 kinase , but still requires proteins previously implicated in macroautophagy , such as Beclin 1 and hVps 34 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
PKB also phosphorylates the TSC 1 ( tuberous sclerosis complex 1 ) TSC 2 complex to relieve its inhibitory action on the mTOR ( mammalian target of rapamycin ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of PI3K by K 1 results in activation of Akt kinase and mammalian target of rapamycin and inactivation of the proapoptotic proteins FKHR , glycogen synthase kinase 3 , and Bad , which are events indicative of cell survival . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
These results suggest that : 1 ) AA+Fe+CYP2E1 induced oxidative stress decreases AKT activation ; 2 ) AKT inactivation induces mitochondrial impairment associated with opening of the permeability transition pore but is not dependent on the activation state of bad , glycogen synthase kinase 3beta , mammalian target of rapamycin , or bcl xL ; and 3 ) PI 3 kinase / AKT may serve as a survival pathway against CYP2E1 dependent toxicity . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In addition , we found that inhibition of p 53 by NIC 1 mainly occurs through mammalian target of rapamycin ( mTOR ) using phosphatidylinositol 3 kinase ( PI3K ) Akt / protein kinase B ( PKB ) pathway as the mTOR inhibitor , rapamycin treatment abrogated NIC 1 inhibition of p 53 and reversed the chemoresistance . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of Akt stimulated signaling through the protein kinase mammalian target of rapamycin , as evidenced by increased phosphorylation of two of its effectors , the ribosomal protein S 6 kinase and the eukaryotic initiation factor eIF4E binding protein 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Migrating GBM cells are resistant to apoptosis ( Type 1 programmed cell death ) , and thus to radiotherapy and conventional chemotherapy , because of the constitutive activation of several intracellular signaling pathways , of which the most important identified to date are the pathways controlled by phosphatidylinositol 3 kinase , Akt , and the mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
T 3 treatment rapidly increased PI3K activity by 52 + / 3 % ( p < 0 . 005 ) , which resulted in increased phosphorylation of downstream kinases Akt and mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Targeting the Akt / mammalian target of rapamycin pathway for radiosensitization of breast cancer . ^^^ The mammalian target of rapamycin ( mTOR ) is downstream of Akt , and we investigated the effects of radiation on Akt / mTOR signaling in breast cancer cell models . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Current models suggest that AKT acts directly , or indirectly via the TSC complex , to activate the mammalian target of rapamycin ( mTOR ) as the main downstream mediator of AKT signaling . mTOR activation results in subsequent activation of S6K and STAT 3 , as well as suppression ( i . e . , phosphorylation ) of 4E BP 1 , leading to cell cycle progression and inhibition of apoptosis . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Higher activation of Akt was associated with increased phosphorylation of its downstream targets glycogen synthase kinase 3beta ( GSK3beta ) , FKHR , and mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The non receptor tyrosine kinase Src , phosphatidylinositol 3 kinase , protein kinase B and the mammalian target of rapamycin are mediators of the glutamate effect . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Also in MCF 7 cells , Gemini 23 yne 26 , 27 hexafluoro D 3 caused dephosphorylation of the oncogenic kinase , Akt , resulting in dephosphorylation of the Akt target proteins , Forkhead transcription factor and mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here we show that Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 ( Hes 3 ) and Sonic hedgehog ( Shh ) through rapid activation of cytoplasmic signals , including the serine / threonine kinase Akt , the transcription factor STAT 3 and mammalian target of rapamycin , and thereby promotes the survival of neural stem cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In this study , we hypothesized that the mammalian target of rapamycin ( mTOR ) pathway , which functions downstream of AKT , mediates the oncogenic effects of activated PI3K / AKT in ALK+ ALCL . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Melanoma cells constitutively expressed Akt with variable expression of mammalian target of rapamycin , and Epo dose dependently induced their activity . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt 1 activation can augment hypoxia inducible factor 1alpha expression by increasing protein translation through a mammalian target of rapamycin independent pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We have previously shown that enforced expression of Akt , which is a downstream effector of PI ( 3 ) K , could promote tumorigenesis and drug resistance in the Emu myc mouse lymphoma model , and that these tumors were particularly sensitive to inhibition of mammalian target of rapamycin ( mTOR ) with rapamycin when combined with conventional chemotherapy . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The proteins evaluated included activated Akt , as defined by phosphorylation of Akt at Serine 473 ( pAkt ) and mammalian target of rapamycin ( pmTOR ) , defined by phosphorylation of mTOR at Serine 2448 ( pmTOR ) . ^^^ MATERIALS AND METHODS : Immunochemical staining analysis as well as triple color immunofluorescence in combination with confocal microscopy were used to evaluate the presence of activated Akt and mammalian target of rapamycin ( mTOR ) in KSCs within the bulge niche of hair follicles , as identified by expression of the specific markers of mouse KSCs , CD 34 and cytokeratin 15 ( K 15 ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Moreover , the molecular analysis of these events indicated that iNOS expression was regulated by the phosphatidylinositol 3 kinase ( PI 3 kinase ) / AKT / mammalian target of rapamycin ( mTOR ) signaling pathway and activation of hypoxia inducible factor 1alpha ( HIF 1alpha ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Thus , PI3K appears to represent a bifurcation in the insulin signaling pathway , one branch leading through PKC zeta to general protein synthesis and one , through Akt and the target of rapamycin ( mTOR ) , to growth regulated protein synthesis and cell cycle progression . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Both this peptide , corresponding to residues 65 79 of DQA * 03011 ( DQ 65 79 ) , and rapamycin inhibit p 70 S6 kinase activity , but only DQ 65 79 blocks Akt kinase activity , placing the effects of DQ 65 79 upstream of mTOR , a PI kinase family member . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Pharmacological inactivation of mTOR / RAFT / FRAP reduced neoplastic proliferation , tumor size , and p70 / S6 kinase activity , but did not affect the status of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Amplification of mTOR regulated p70S6 kinase , which is downstream of Akt , may also have conferred CCI 779 sensitivity to MCF 7 cells . ^^^ Taken together , the data suggest that mTOR may be a good target for breast cancer therapy , especially in tumors with Akt activation resulting from either growth factor dependency or loss of PTEN function . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
FOP fibroblast growth factor receptor 1 fusion protein of the t ( 6 ; 8 ) translocation induces cell survival mediated by mitogen activated protein kinase and phosphatidylinositol 3 kinase / Akt / mTOR pathways . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Overall , the results suggest that the blunted protein synthetic response observed in 26 vs . 7 day old neonatal pigs is due in part to decreased content and / or activity of signaling components downstream of PI 3 kinase , e . g . , PKB , mTOR , and S6K1 . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We report here that , whereas serum stimulation can induce a slight accumulation of HIF 1 alpha protein in a PI3K / Akt pathway dependent fashion , hypoxia induces much higher levels of HIF 1 alpha protein and HIF 1 DNA binding activity independently of PI3K and mTOR activity . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The regulation of 4E BP 1 phosphorylation by alpha 6 beta 4 derives from the ability of this integrin to activate the PI 3K Akt pathway and , consequently , the rapamycin sensitive kinase mTOR that can phosphorylate 4E BP 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt maintains cell size and survival by increasing mTOR dependent nutrient uptake . ^^^ Activated forms of Akt maintained these transporters on the cell surface in the absence of growth factor through an mTOR dependent mechanism . ^^^ The mTOR inhibitor rapamycin diminished Akt mediated increases in cell size , mitochondrial membrane potential , and cell survival . ^^^ These results suggest that growth factors control cellular growth and survival by regulating cellular access to extracellular nutrients in part by modulating the activity of Akt and mTOR . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
TSC 2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Role of the phosphatidylinositol 3 kinase / Akt and mTOR / P70S6 kinase pathways in the proliferation and apoptosis in multiple myeloma . ^^^ In both cell lines , constitutive activation of the PI 3 K / Akt / FKHRL 1 , mTOR / P70 ( S6K ) and MAPK pathways was detected . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Transfection of PTEN into the PC 3 cells decreased the activation of Akt and the downstream mTOR regulated 70 kDa S 6 ( p 70 ( s6k ) ) kinase and reversed the resistance to doxorubicin in these cells , indicating that changes in PTEN status / Akt activation modulate the cellular response to doxorubicin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In addition , the phosphatidylinositol 3 kinase ( PI3K ) / Akt / mammalian target of rapamycin ( mTOR ) pathway was found to be specifically involved in this IGF 1 effect . ^^^ Taken together , our data indicate that IGF 1 inhibits PR expression in breast cancer cells via the PI3K / Akt / mTOR pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In summary , ( 1 ) PI3K mediates insulin induced reduction of IRS 1 by phosphorylating it while a PI3K / mTOR pathway controls insulin induced reduction of IRS 2 , ( 2 ) in L 6 cells , IRS 2 is the major adapter molecule linking the insulin receptor to activation of PKB and MAPK , ( 3 ) the mechanism of IRS 1 / 2 down regulation is different in L 6 cells compared with 3T3 L 1 adipocytes . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Increased clearance of mutant huntingtin by raised glucose ( 8 g / l ) and 2DOG correlated with increased autophagy and reduced phosphorylation of mTOR , S6K1 and Akt . ^^^ Thus , raised intracellular glucose / glucose 6 phosphate levels reduce mutant huntingtin toxicity by increasing autophagy via mTOR and possibly Akt . ^^^ As mTOR and Akt regulate a diversity of crucial cellular processes , our data also suggest a major new set of targets for intracellular glucose signalling . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This inhibition was not accounted for by changes in the upstream stimulatory pathway , because caerulein activated Akt as well as phosphorylating the downstream effectors of mTOR , 4E BP 1 , and ribosomal protein S 6 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In contrast , inhibition of neither Rac , mTOR nor GSK 3 , other effectors of PI3K , promoted branch formation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Rapamycin , a specific inhibitor of mTOR function , was found to inhibit the Akt induced increase in cell size by 70 % , presumably via inhibition of the Akt induced increase in protein synthesis . ^^^ These results indicate that Akt increases cell size through both mTOR dependent and independent pathways and that the latter involves inhibition of protein degradation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Interestingly , although this pathway is stimulated by upstream signaling via AKT and mTOR and requires new transcription , IL 1 mediated HIF 1alpha induction also utilizes a post transcriptional mechanism that involves antagonism of VHL dependent HIF 1alpha degradation , which results in increased HIF 1alpha protein stability . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Phosphorylation of protein kinase B ( PKB ) on Ser 473 peaked at 10 min of recovery ( 282 % of control , P < 0 . 05 ) with no significant changes noted for mTOR phosphorylation on Ser 2448 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The cytokine signaling intermediates for mTOR / ribosomal protein S 6 kinase ( S6K ) activation include phosphatidylinositol 3 kinase , Akt , Erks and geranylgeranylated proteins . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The molecular target of rapamycin ( mTOR ) , which is a member of the phosphoinositide 3 kinase related kinase ( PIKK ) family and a central modulator of cell growth , is a prime strategic target for anti cancer therapeutic development . mTOR plays a critical role in transducing proliferative signals mediated through the phosphatidylinositol 3 kinase ( PI3K ) / protein kinase B ( Akt ) signaling pathway , principally by activating downstream protein kinases that are required for both ribosomal biosynthesis and translation of key mRNAs of proteins required for G ( 1 ) to S phase traverse . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Role of PI3K / AKT / mTOR signaling in the cell cycle progression of human prostate cancer . ^^^ PI3K regulates cell cycle through AKT , mTOR to p 70 ( S6K ) . ^^^ These results suggest that PI3K mediates G ( 1 ) cell cycle progression and cyclin expression through the activation of AKT / mTOR / p70 ( S6K ) signaling pathway in the prostate cancer cells . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The phosphorylation of mTOR , itself , is stimulated by insulin in Ser 2448 , a site that is also phosphorylated by protein kinase B ( PKB ) in vitro and in response to activation of PKB activity in vivo . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This site appears not to be an autophosphorylation site but a site potentially phosphorylated by protein kinase B ( PKB ) . mTOR immunopurified from culture cells or tissues phosphorylates in vitro p 70 S6 kinase ( p 70 ) alpha and p70beta , mainly on Thr 412 or Thr 401 , respectively , located in a Phe Thr Tyr motif . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Loss of Tsc1 / Tsc2 activates mTOR and disrupts PI3K Akt signaling through downregulation of PDGFR . ^^^ This activation of mTOR along with downregulation of PDGFR PI3K Akt signaling in cells lacking Tsc 1 or Tsc 2 may explain why these genes are rarely involved in human cancer . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This activation was independent of Akt , a known upstream regulator of mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Studies initiated in Drosophila have identified a role for the Tsc 1 and Tsc 2 genes in the regulation of cell and organ size , and genetic interaction studies have placed them in the PI3K Akt mTOR S6K pathway . ^^^ Biochemical studies have shown that activated Akt phosphorylates TSC 2 in the TSC1 / TSC2 protein complex , inactivating it ; while TSC1 / TSC2 has GAP activity for the Rheb GTPase ( a member of the ras family ) , and activated Rheb GTP activates mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Forced activation of mTOR through upstream regulator Akt also increased ABI in colon cancer cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
P70 / p85 S 6 kinase is probably involved downstream from mTOR and PKB in regulating translation of MMP 2 , which has pyrimidine tracts in its 5 ' UTR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Insulin treatment induced p70S6K , mTOR , and Akt phosphorylation , effects that were completely prevented by the PI3K inhibitor , LY 294002 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The activity of mTOR is controlled not only by amino acids , but also by hormones and growth factors that activate the protein kinase Akt . ^^^ The signaling pathway downstream of Akt leading to mTOR involves the protein products of the genes mutated in tuberous sclerosis , TSC 1 and TSC 2 , and the small guanosine triphosphatase , Rheb . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
These studies identified glycolytic activity , amino acid transporter trafficking , and Akt kinase activity as novel , mTOR modulated functions in mammalian cells . ^^^ Whereas kinase inactive mTOR did not enhance the decreases in cell size and glycolysis induced by rapamycin , expression of this mTOR mutant significantly enhanced the inhibitory effects of rapamycin on cell proliferation , 4EBP1 phosphorylation , and Akt activity . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The dose of Pten affects key downstream targets such as Akt , p 27 ( Kip 1 ) , mTOR , and FOXO 3 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
These results support the hypothesis that LPA activates protein translation through the action of PLD 1 generated PA on mTOR and the PI3K / Akt pathway whereas PDGF acts through P13K / Akt independent of PLD1 . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Previous studies have identified Ser 2448 as a nutrient regulated phosphorylation site located in the mTOR catalytic domain , insulin stimulates Ser 2448 phosphorylation via protein kinase B ( PKB ) , while Ser 2448 phosphorylation is attenuated with amino acid starvation . ^^^ In vitro kinase assays using peptides based on the sequence in amino acids 2440 2551 of mTOR found that PKB and AMPK are capable of phosphorylating sites in this region . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Unique , highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt , mTOR , and p70S6K signaling and is actively repressed by PTEN . ^^^ Western blot analysis demonstrated that cultured embryonic and neointimal SMCs that exhibited serum independent growth capabilities expressed high levels of S6RP and constitutively active Akt , mTOR , and p70S6K . ^^^ Growth of SMCs that exhibit this phenotype is dependent on constitutive Akt and mTOR / p70S6K signaling and is actively inhibited through the timed acquisition of the endogenously produced growth suppressor PTEN . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The data support the hypothesis that Akt may act downstream to PI 3K and upstream to mTOR in an IL 2 mediated signal transduction pathway that controls phosphorylation of the regulatory protein S 6 in CTLL 2 cells . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Amino acid stimulation activated mTOR and resulted in IRS 1 serine 307 phosphorylation without activating PKB or JNK . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Using a murine lymphoma model , we show that Akt promotes tumorigenesis and drug resistance by disrupting apoptosis , and that disruption of Akt signalling using the mTOR inhibitor rapamycin reverses chemoresistance in lymphomas expressing Akt , but not in those with other apoptotic defects . eIF4E , a translational regulator that acts downstream of Akt and mTOR , recapitulates Akt ' s action in tumorigenesis and drug resistance , but is unable to confer sensitivity to rapamycin and chemotherapy . ^^^ These results establish Akt signalling through mTOR and eIF4E as an important mechanism of oncogenesis and drug resistance in vivo , and reveal how targeting apoptotic programmes can restore drug sensitivity in a genotype dependent manner . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Although the mechanisms involved for mechanically induced activation of mTOR are not known , it has been suggested that activation of PI3K ( phosphoinositide 3 kinase ) and protein kinase B ( Akt ) , via the release of locally acting growth factors , underlies this process . ^^^ Consistent with these results , mechanically induced signalling through mTOR was not disrupted in muscles from Akt 1 / mice . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Effects of aerobic exercise training on the protein kinase B ( PKB ) / mammalian target of rapamycin ( mTOR ) signaling pathway in aged skeletal muscle . ^^^ The protein kinase B ( PKB ) / mammalian target of rapamycin ( mTOR ) signaling pathway is thought to play a critical role in the regulation of protein synthesis and skeletal muscle mass . ^^^ The purpose of the present study was to determine the effects of voluntary wheel running on the PKB / mTOR signaling pathway in muscles from aged mice ( 20 22 months ) . ^^^ The total levels of mTOR were 65 % higher in gastrocnemius muscles from aged mice subjected to wheel running compared to aged sedentary mice ( p 0 . 002 ) PKB phosphorlation on Ser 473 was 45 % higher in gastrocnemius muscles from aged mice subjected to wheel running compared to aged sedentary mice ( p=0 . 01 ) The total abundance of PKB was 50 % higher in gastrocnemius muscles from wheel running mice compared to aged controls ( p=0 . 005 ) . ^^^ Protein synthesis , as assessed by [ ( 14 ) C ] phenylalanine incorporation into protein was significantly higher in soleus muscles from aged mice subjected to wheel running compared to aged sedentary mice ( p 0 . 001 ) These findings indicate the aerobic exercise training may attenuate the age related decline in protein synthesis , a process that appears to be due , in part , to increases in mTOR and PKB . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The activation of mTOR was likely due to the rapid activation of Akt following radiation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
By contrast , the major translational control pathway involving Akt , mTOR , and S6K was strongly regulated by fasting and refeeding . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The integration of these intracellular signals at the level of Akt and its kinase activity , regulates the phosphorylation of its several downstream effectors , such as NF kappa B , mTOR , Forkhead , Bad , GSK 3 and MDM 2 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
RESULTS : Evidence is presented that misregulation of the PI 3 kinase pathway is a feature of many common cancers , either by loss of the suppressor protein PTEN , or by constitutive activation of PI 3 kinase isoforms or downstream elements such as AKT and mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here , we report that mTOR inhibition induced apoptosis of epithelial cells and the complete reversal of a neoplastic phenotype in the prostate of mice expressing human AKT 1 in the ventral prostate . ^^^ Thus , there is an mTOR dependent survival signal required downstream of Akt . ^^^ Expression profiling showed that Hif 1 alpha targets , including genes encoding most glycolytic enzymes , constituted the dominant transcriptional response to AKT activation and mTOR inhibition . ^^^ These data suggest that the expansion of AKT driven prostate epithelial cells requires mTOR dependent survival signaling and activation of HIF 1 alpha , and that clinical resistance to mTOR inhibitors may emerge through BCL 2 expression and / or upregulation of HIF 1 alpha activity . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Interestingly , lymphomas expressing Akt , but not those expressing Bcl 2 are sensitized to chemotherapy induced apoptosis by the mTOR inhibitor rapamycin , an effect that is countered by eIF4E . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In response to IGF 1 , Akt activates downstream effectors , mTOR and p70S6K to stimulate protein synthesis thereby increasing the cytoplasmic compartment in muscle fibers . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Bcl 2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt . ^^^ The serine / threonine kinase mTOR , the major sensor of cell growth along the PI3K / Akt pathway , can be activated by agents acting on microtubules . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth . ^^^ Phospho AKT staining was associated with that of phospho ( active ) mTOR in 27 of 31 ( 87 % ) ovarian tumors , with 17 ( 55 % ) tumors showing elevated phospho mTOR positivity . ^^^ We tested the effects of AKT / mTOR activation on the therapeutic sensitivity of ovarian cancer cells . ^^^ Collectively , these findings indicate that active AKT and downstream mTOR represent potentially important therapeutic and / or chemopreventive targets in ovarian cancer . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
ERK1 / 2 phosphorylation was reduced not only by MAPK pathway inhibitors but also by PI3K and mTOR inhibitors ; when PI3K was inhibited , ERK phosphorylation could be induced by microinjected activated Akt , indicating important cross talk between the PI3K and ERK1 / 2 pathways . ^^^ In conclusion , glucose sensitizes VSMC to serum , inducing chemotaxis via pathways involving p110beta PI3K , Akt , mTOR , and ERK1 / 2 MAPK . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We show that insulin increases mTOR phosphorylation on Ser 2448 , a consensus phosphorylation site for protein kinase B ( PKB ) . ^^^ Surprisingly , glucagon and 8 ( 4 chlorophenylthio ) adenosine cAMP , which do not activate PKB , stimulate the phosphorylation on Ser 2448 of mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Because earlier work suggested heightened AKT activity in OPM 2 tumors might induce hypersensitivity to mTOR inhibition , we directly tested this by stably transfecting a constitutively active AKT allele into U 266 cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Incorporation of L [ 1 13C ] leucine in muscle proteins ( fractional synthesis rate , FSR ) was measured in vastus lateralis , before and during a euglycemic hyperinsulinemic hyperaminoacidemic clamp , together with Western blot analysis of protein kinase B ( PKB ) , mTOR , 4E BP 1 , and S6K1 phosphorylation . ^^^ Phosphorylation of PKB , mTOR , and 4E BP 1 were similarly increased by insulin and amino acid in both groups , except for S6K1 phosphorylation , which was not stimulated in elderly subjects . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Furthermore , it was shown that mTOR was not required for Akt mediated survival . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Phosphatidylinositol 3 kinase ( PI3K ) inactivates the tumor suppressor complex and enhances mTOR signaling by means of phosphorylation of tuberin by Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We hypothesize that overexpressed eIF4E is functionally active in tumor margins through activation of the Akt / mammalian target of rapamycin ( mTOR ) pathway EXPERIMENTAL DESIGN : Western blots and / or immunohistochemistry were performed to determine whether phosphorylation of mTOR and activation of its downstream molecules eIF4E binding protein 1 ( 4E BP 1 ) and p 70 S6 kinase and the upstream modulator of mTOR , Akt , were expressed in margins overexpressing eIF4E . ^^^ CONCLUSIONS : Overexpression of eIF4E is functionally active in tumor margins through activation of the Akt / mTOR signaling pathway . ^^^ The greater degree of expression of downstream targets and upstream regulators of mTOR in margins compared with the tumors indicates preferential activation of the Akt / mTOR signaling pathway in margins overexpressing eIF4E . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
EGF receptor transactivation mediates ANG 2 stimulated mitogenesis in intestinal epithelial cells through the PI 3 kinase / Akt / mTOR / p70S6K1 signaling pathway . ^^^ To elucidate the downstream targets of EGFR , we demonstrated that ANG 2 stimulated phosphorylation of Akt at Ser 473 , mTOR at Ser 2448 , p70S6K1 at Thr 389 , and S 6 ribosomal protein at Ser ( 235 / 236 ) . ^^^ Taken together , our results demonstrate that EGFR transactivation mediates ANG 2 stimulated mitogenesis through the PI 3 kinase / Akt / mTOR / p70S6K1 signaling pathway in IEC 18 cells . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Reduced mTOR phosphorylation did not result from decreased phosphorylation of PKB . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This mTOR activation is mediated through phosphatidylinositol 3 kinase ( PI3K ) Akt / protein kinase B ( PKB ) signaling cascade because T 3 induced Akt / PKB phosphorylation more rapidly than that of mTOR , and these T 3 dependent phosphorylations were blocked by both PI3K inhibitors and by expression of a dominant negative PI3K ( Deltap85alpha ) . ^^^ The liganded TR induces the activation of PI3K and Akt / PKB , leading to the nuclear translocation of the latter , which subsequently phosphorylates nuclear mTOR . ^^^ The rapid activation of PI3K Akt / PKB mTOR p 70 ( S6K ) cascade by T 3 provides a new molecular mechanism for thyroid hormone action . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Amino acids and leucine allow insulin activation of the PKB / mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db / db mice . ^^^ We show that in freshly isolated rat adipocytes , insulin stimulates the phosphorylation of mTOR on serine 2448 , a protein kinase B ( PKB ) consensus phosphorylation site . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The PI3K pathway involves the Akt kinase , an upstream regulator of mTOR . ^^^ We also found that the level of activity of Akt can regulate Bcl 2 phosphorylation , through the mTOR kinase . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The Akt / mammalian target of rapamycin ( mTOR ) / 4E BP 1 pathway is considered to be a central regulator of protein synthesis , involving the regulation of cell proliferation , differentiation , and survival . ^^^ However , the activation status of the Akt / mTOR / 4E BP 1 pathway and its potential roles in breast cancers remain unknown . ^^^ Thus , we examined 165 invasive breast cancers with specific antibodies for the phosphorylation of Akt , mTOR , and 4E BP 1 by immunohistochemistry and compared them with normal breast epithelium , fibroadenoma , intraductal hyperplasia , and ductal carcinoma in situ . ^^^ We discovered that the phosphorylation of Akt , mTOR , and 4E BP 1 increased progressively from normal breast epithelium to hyperplasia and abnormal hyperplasia to tumor invasion . ^^^ Phosphorylated Akt , mTOR , and 4E BP 1 were positively associated with ErbB 2 overexpression . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Investigation of proteins in the phosphatidylinositol 3 ' kinase / Akt signaling pathway in PTEN delivered mouse lung revealed that the PTEN protein was highly expressed , whereas the protein levels of PDK 1 , total Akt 1 , phospho ( Thr 308 ) Akt , phospho ( Ser 2448 ) mTOR , p70S6K , and 4E BP 1 were decreased to varying degrees . ^^^ Additionally , the kinase activities of both Akt and mTOR were suppressed . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Finally , we found that chronic activation of mTOR leading to decreased levels of IRS 2 in INS 1 cells led to a significant decrease in PKB activation and consequently increased beta cell apoptosis . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Tuberin , serving as a substrate of AKT and AMPK , mediates mTOR activity by coordinating inputs from growth factors and energy availability in the control of cell growth , proliferation , and survival . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Time course studies also revealed that mTOR and S6K1 activation by insulin was accelerated in tissues of obese rats , in association with increased inhibitory phosphorylation of insulin receptor substrate 1 ( IRS 1 ) on Ser636 / Ser639 and impaired Akt activation . ^^^ The relationship between mTOR / S6K1 overactivation and impaired insulin signaling to Akt was also examined in hepatic cells in vitro . ^^^ Inhibition of mTOR / S6K1 by rapamycin blunted insulin induced Ser636 / Ser639 phosphorylation of IRS 1 , leading to a rapid ( approximately 5 min ) and persistent increase in IRS 1 associated phosphatidylinositol 3 kinase activity and Akt phosphorylation . ^^^ In vitro studies with rapamycin suggest that mTOR / S6K1 overactivation contributes to elevated serine phosphorylation of IRS 1 , leading to impaired insulin signaling to Akt in liver and muscle of this dietary model of obesity . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our data support that RTP 801 and RTP801L work downstream of AKT and upstream of TSC 2 to inhibit mTOR functions . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Hypersensitivity to mTOR inhibitors has been demonstrated in cells having elevated levels of AKT kinase activity , whereas cells containing quiescent AKT activity are relatively resistant . ^^^ Thus , continued IRES mediated translation initiation may permit cell cycle progression upon mTOR inactivation in cells in which AKT kinase activity is relatively low . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In addition , we demonstrated an impairment of the insulin induced IR / IRSs / PI3K / Akt pathway in liver and muscle of chronic hyperinsulinaemic rats that parallels increases in IRS1 / 2 serine phosphorylation , IR / PTP1B association and mTOR activity . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR dependent translation . ^^^ In Akt transformed leukemic cells , tumor growth can be inhibited by the mTOR inhibitor rapamycin , and clinical trials of rapamycin analogs for the treatment of leukemia are under way . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Constitutive activation of phosphatidyl inositide 3 kinase contributes to the survival of Hodgkin ' s lymphoma cells through a mechanism involving Akt kinase and mTOR . ^^^ Several downstream effectors of Akt signalling , including glycogen synthase kinase 3 ( GSK 3 ) alpha and beta and mTOR substrates 4E BP 1 and p 70 S6 kinase , were also phosphorylated in HL cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Selective activation of AMPK PGC 1alpha or PKB TSC 2 mTOR signaling can explain specific adaptive responses to endurance or resistance training like electrical muscle stimulation . ^^^ In contrast , HFS acutely increased phosphorylation of PKB at Ser 473 5 . 3 fold and the phosphorylation of TSC 2 , mTOR , GSK 3beta at PKB sensitive sites . ^^^ HFS selectively activates the PKB TSC 2 mTOR cascade causing a prolonged activation of translational regulators , which is consistent with increased protein synthesis and muscle growth . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Phosphorylation and regulation of Akt / PKB by the rictor mTOR complex . ^^^ We show that in Drosophila and human cells the target of rapamycin ( TOR ) kinase and its associated protein rictor are necessary for Ser 473 phosphorylation and that a reduction in rictor or mammalian TOR ( mTOR ) expression inhibited an Akt / PKB effector . ^^^ The rictor mTOR complex directly phosphorylated Akt / PKB on Ser 473 in vitro and facilitated Thr 308 phosphorylation by PDK 1 . ^^^ Rictor mTOR may serve as a drug target in tumors that have lost the expression of PTEN , a tumor suppressor that opposes Akt / PKB activation . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In agreement , insulin rapidly induced the phosphorylation of 3 phosphoinositide dependent protein kinase 1 ( PDK 1 ) , protein kinase B ( Akt ) , and mTOR , effects that were prevented by the AG 1024 and LY 294002 . ^^^ Taken together , these findings suggest that activation of the PI3K Akt mTOR signaling pathway is essential for the insulin induced up regulation of local PSD 95 protein synthesis in neuronal dendrites and indicate a new molecular mechanism that may contribute to the modulation of synaptic function by insulin in hippocampal area CA1 . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In concordance , significant increases in the levels of phosphorylation of total Akt substrates , including : GSK3beta ( Ser 9 ) , tau ( Ser 214 ) , mTOR ( Ser 2448 ) , and decreased levels of the Akt target , p 27 ( kip 1 ) , were found in AD temporal cortex compared with controls . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Nicotinic activation of Akt increased phosphorylation of multiple downstream substrates of Akt in a time dependent manner , including GSK 3 , FKHR , tuberin , mTOR and S6K1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Intracellular signaling pathways involved in the acquisition of resistance to apoptosis by migrating glioma cells concern PI3K , Akt , mTOR , NF kappaB , and autophagy ( programmed cell death type 2 ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In addition to giving an overview of the TGF beta field as related to its function in prostate cancer , this Review focuses on novel findings that support the tumour suppressor function of TGF beta is lost or altered by changes in the activity of the androgen receptor , insulin like growth factor 1 , Akt , and mTOR during malignant progression . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In contrast , the ability of a maximally stimulating dose of insulin to increase the phosphorylation of PKB , 4E BP 1 , S6K1 , or mTOR was not altered 20 min after intravenous injection . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibition of the PI3K / Akt downstream target mTOR by rapamycin also significantly enhanced fludarabine induced apoptosis . ^^^ These results also strongly suggest that combining fludarabine with an inhibitor of the PI3K / Akt / mTOR pathway may represent a novel therapeutic strategy for hematological malignancies . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
T 4 treatment caused phosphorylation of Akt and downstream signaling components such as GSK 3beta , mTOR , and S 6 kinase . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The phosphatidylinositol 3 kinase AKT pathway is centrally involved in the transmission of mitogenic signals to mTOR . ^^^ Previous studies have shown that mTOR is a direct substrate for the AKT kinase and identified Ser 2448 as the AKT target site in mTOR . ^^^ In this study , we demonstrate that rapamycin , a specific inhibitor of mTOR function , blocks serum stimulated Ser 2448 phosphorylation and that this drug effect is not explained by the inhibition of AKT . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In contrast , increased phosphorylation of the molecular target of rapamycin ( mTOR ) and its downstream target p 70 S6 kinase and increased levels of Akt 1 and Akt 2 were demonstrated in HCT 116R cells . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We show that S 6 kinase 1 ( S6K1 ) , but not Akt , directly phosphorylates mTOR in cell free in vitro system and in cells . ^^^ Expression of a constitutively active , rapamycin and wortmannin resistant S6K1 leads to constitutive phosphorylation of mTOR , whereas knock down of S6K1 using small inhibitory RNA greatly reduces mTOR phosphorylation despite elevated Akt activity . ^^^ Many models for Akt signaling to mTOR have been presented , suggesting direct phosphorylation by Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In human lung epithelial adenocarcinoma ( A 549 ) cells , LY 303511 , like rapamycin , inhibited mTOR dependent phosphorylation of S6K , but not PI3K dependent phosphorylation of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Insulin like growth factor 1 inhibits dexamethasone induced proteolysis in cultured L 6 myotubes through PI3K / Akt / GSK 3beta and PI3K / Akt / mTOR dependent mechanisms . ^^^ Here we tested the hypothesis that PI3K / Akt mediated inactivation of GSK 3beta and activation of mTOR contribute to the anabolic effects of IGF 1 in dexamethasone treated myotubes . ^^^ These effects of IGF 1 were associated with increased phosphorylation of Akt , GSK 3beta , and the mTOR downstream targets p 70 ( S6K ) and 4E BP 1 . ^^^ Our results suggest that PI3K / Akt mediated inactivation of GSK 3beta and activation of mTOR contribute to the anabolic effects of IGF 1 in dexamethasone treated myotubes . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Primary RCCs vs cell lines contained similar amounts of phospho ERK1 / 2 , much higher levels of ErbB 3 , less phospho AKT , and no evidence of phospho RPS 6 , suggesting that mTOR activity was reduced . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We observed only minimal inhibition of Akt , an effector upstream of mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mechanistic justification for the therapeutic blockade of targets downstream of AKT , such as mTOR , in these cancers requires demonstration that the oncogenic effect of PTEN loss is through elevated AKT activity . ^^^ We further delineate the role of mTOR activity downstream of AKT in the maintenance of AKT+KRas induced GBMs . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of the N Ras PI3K Akt mTOR pathway by hepatitis C virus : control of cell survival and viral replication . ^^^ We found that the activities of PI3K and Akt , as well as the activity of their downstream target , mTOR , in the HCV replicating cells were increased . ^^^ Both PI3K Akt and mTOR dependent pathways have been shown to promote cell survival . ^^^ Taken together , these data suggest that increased N Ras levels in subcellular sites of HCV replication and stimulation of the prosurvival PI3K Akt pathway and mTOR by HCV not only protect cells against apoptosis but also contribute to the maintenance of steady state levels of HCV replication . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Gefitinib resistant NSCLC cell lines , showing EGFR independent activity of the PI3K / Akt or Ras / Erk pathways , were treated with gefitinib in combination with specific inhibitors of mTOR , P13K , Ras , and MEK . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Activation of the potential upstream regulators of 4E BP 1 and S6K1 phosphorylation via PKB and mTOR was also observed . ^^^ Furthermore , the results are consistent with a role for assembly of active eIF4G . eIF4E complex and activation of S6K1 in mediating the stimulation of mRNA translation initiation by IGF 1 through a PKB / mTOR signaling pathway . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The mTOR signaling network contains a number of tumor suppressor genes including PTEN , LKB 1 , TSC 1 , and TSC 2 , and a number of proto oncogenes including PI3K , Akt , and eIF4E , and mTOR signaling is constitutively activated in many tumor types . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Mechanistic studies to determine the potential of deguelin to block a number of established UVB induced molecular events yielded negative results [ including UVB induced AP 1 DNA binding , c fos and TNFalpha mRNA induction , arachidonic acid release and UVB induced phosphorylation of mTOR ( Ser 2448 ) , akt ( Ser 473 ) and erk ( Thr202 / Tyr204 ) ] . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Hepatectomy induced immediate but transient phosphorylation of Akt , p70S6K , mTOR and GSK 3beta in LS 3 KO mice much more than in control mice . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Compared with control cells , HUVEC overexpressing T cad ( T cad+ HUVEC ) had higher phosphorylation levels for phosphatidylinositol 3 kinase ( PI3K ) target Akt and mTOR target p 70 ( S6K ) ( survival pathway regulators ) , but lower levels for p38MAPK ( death pathway regulator ) . ^^^ We conclude that T cad overexpression in HUVEC protects against stress induced apoptosis through activation of the PI3K / Akt / mTOR survival signal pathway and concomitant suppression of the p 38 MAPK proapoptotic pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibition of PI 3 kinase / Akt / mTOR , but not calcineurin signaling , reverses insulin like growth factor 1 induced protection against glucose toxicity in cardiomyocyte contractile function . ^^^ This study examined the role of PI 3 kinase / Akt / mammalian target of rapamycin ( mTOR ) and calcineurin pathways in cardiac effects of IGF 1 against glucose toxicity . ^^^ Adult rat ventricular myocytes were cultured for 8 h with either normal ( NG , 5 . 5 mM ) or high ( HG , 25 . 5 mM ) glucose , in the presence or absence of IGF 1 ( 10 500 nM ) , the PI 3 kinase / Akt inhibitor LY 294002 ( 10 microM ) , the mTOR inhibitor rapamycin ( 20 microM ) or the calcineurin inhibitors cyclosporin A ( 5 microM ) or FK 506 ( 10 mg / l ) . ^^^ Western blot analysis indicated that HG and IGF 1 stimulated phosphorylation of Akt and mTOR . ^^^ However , the HG induced alterations in phosphorylation of Akt , mTOR , p70s6k and GSK 3beta were significantly reversed by IGF 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Compensatory PI 3 kinase / Akt / mTor activation regulates imatinib resistance development . ^^^ Here , we demonstrate that IM treatment activated the phosphatidylinositol 3 kinase ( PI3K ) / Akt / mammalian target of rapamycin ( mTor ) pathway in BCR / ABL positive LAMA cells and primary leukemia cells in vitro , as well as in a chronic phase CML patient in vivo . ^^^ Accordingly , inhibition of IM induced Akt activation using mTor inhibitors and Akt specific siRNA effectively antagonized development of incipient IM resistance in vitro . ^^^ In contrast , IM resistant chronic myeloid leukemia ( CML ) patients with BCR / ABL kinase mutations ( n=15 ) , and IM refractory BCR / ABL positive acute lymphatic leukemia patients ( n=2 ) displayed inconsistent and kinase mutation independent autonomous patterns of Akt pathway activation , and mTor inhibition overcame IM resistance only if Akt was strongly activated . ^^^ Together , an IM induced compensatory Akt / mTor activation may represent a novel mechanism for the persistence of BCR / ABL positive cells in IM treated patients . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Novel indole alpha methylene gamma lactones as potent inhibitors for AKT mTOR signaling pathway kinases . ^^^ In an effort to generate novel anticancer agents , a series of hybrids of alpha methylene gamma lactones and 2 phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT , mTOR , p70S6 kinase , and 4E BP 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
To understand the mechanisms by which thrombin induces vascular smooth muscle cell ( VSMC ) DNA synthesis and motility , we have studied the role of phosphatidylinositol 3 kinase ( PI3K ) Akt mammalian target of rapamycin ( mTOR ) S6K1 signaling . ^^^ Blockade of PI3K Akt mTOR S6K1 signaling by LY 294002 , and rapamycin suppressed both thrombin induced VSMC DNA synthesis and migration . ^^^ Furthermore , thrombin induced the expression of Fra 1 in a sustained PI3K Akt dependent and mTOR independent manner in VSMC . ^^^ Thrombin also induced the expression of FGF 2 in a PI3K Akt Fra 1 dependent and mTOR independent manner , and neutralizing anti FGF 2 antibodies inhibited thrombin stimulated VSMC DNA synthesis and motility . ^^^ Together these observations suggest that thrombin induces both VSMC DNA synthesis and motility via EGFR dependent stimulation of PI3K / Akt signaling targeting in parallel the Fra 1 mediated FGF 2 expression and mTOR S6K1 activation . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
To address whether adhesion to ECM increases resistance through modulation of signaling pathways , a series of SCLC cell lines were plated on various ECM components , and activation of two signaling pathways that promote cellular survival , the phosphatidylinositol 3 kinase ( PI3K ) / Akt / mammalian target of rapamycin ( mTOR ) pathway and the mitogen activated protein kinase kinase / extracellular signal regulated kinase ( MEK / ERK ) pathway , was assessed . ^^^ Inhibitors of the PI3K / Akt / mTOR pathway ( LY 294002 , rapamycin ) but not the MEK / ERK pathway ( U 0126 ) abrogated laminin mediated survival . ^^^ These studies identify laminin mediated activation of the PI3K / Akt / mTOR pathway as a mechanism of cellular survival and therapeutic resistance in SCLC cells and suggest that inhibition of the PI3K / Akt / mTOR pathway is one strategy to overcome SCLC resistance mediated by ECM . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Cells lacking PDK 1 show decreased activity of these protein kinases , including protein kinase B ( PKB ) and p70S6K , whereas mTOR activity remains largely unaffected . ^^^ We show that PKB activity is a critical downstream component of PDK 1 in mediating translation of cystatin C , RANKL , and Rab11a , whereas mTOR activity is less important for effective translation of these targets . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The Akt mTOR tango and its relevance to cancer . ^^^ A critical downstream effector of Akt , which contributes to tumorigenesis , is mTOR . ^^^ In the PI3K / Akt / mTOR pathway , Akt is flanked by two tumor suppressors : PTEN , acting as a brake upstream of Akt , and TSC1 / TSC2 heterodimer , acting as a brake downstream of Akt and upstream of mTOR . ^^^ In the absence of the TSC1 / TSC2 brake , mTOR activity is unleashed to inhibit Akt via an inhibitory feedback mechanism . ^^^ Two recent studies used mouse genetics to assess the roles of PTEN and TSC 2 in cancer , underscoring the importance of Akt mTOR interplay for cancer progression and therapy . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The increase appears to be mediated by activation of PI3K PKB / Akt and / or PI3K mTOR as well as extracellular signal regulated kinase 1 / 2 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Phosphorylation of PKB , an upstream kinase responsible for phosphorylating mTOR , was elevated only after 0 . 5 h of meal feeding for Thr ( 308 ) , whereas phosphorylation Ser ( 473 ) was significantly elevated at only 0 . 5 and 1 h after initiation of feeding . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably common in metastatic prostate cancer and the resulting activation of phosphoinostide 3 kinase , AKT and mTOR provides a major therapeutic opportunity in this disease as mTOR inhibitors , HSP 90 inhibitors and PI3K inhibitors begin to enter clinical development . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The phosphorylation of FAK , mTOR , p70S6K , and PDK 1 were elevated in both breast cancer cell lines , whereas the phosphorylation of AKT , EGFR , ErbB2 / Her2 , PDGFR , Shc , and Stat 3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase immortalised breast epithelial cells . ^^^ Elevated phosphorylation of PDK 1 , AKT , mTOR , p70S6K , S 6 , EGFR , and Stat 3 were highly associated with invasive breast tumours ( P < 0 . 05 ) . ^^^ This is the first report demonstrating phosphorylation of PDK 1 is frequently elevated in breast cancer with concomitantly increased phosphorylation of downstream kinases , including AKT , mTOR , p70S6K , S 6 , and Stat 3 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
To investigate this hypothesis , skeletal muscles ( ex vivo ) were stimulated with nutrients or intermittent mechanical stretch and the phosphorylation of p70S6k [ P p 70 ( 389 ) ] , PKB [ P PKB ] , mTOR [ P mTOR ( 2481 ) ] , and p 38 [ P p 38 ] was assessed . ^^^ In comparison to vehicle treated controls , both nutrient and mechanical stimuli induced P p 70 ( 389 ) , neither stimulus altered P PKB or P mTOR ( 2481 ) , and only mechanical stimuli induced P p 38 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In this study , we investigated the time course of the dependence of late phase long term potentiation of field excitatory post synaptic potential on phosphatidylinositol 3 kinase and its downstream effectors mTOR and AKT . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We found that the Akt , mTOR and p 70 S6 kinase ( S6K1 ) from the PI3K / mTOR signaling pathway were activated in all of the pancreatic cancer cell lines examined . ^^^ When surgically resected tissue specimens of pancreatic ductal adenocarcinoma were examined , phosphorylation of Akt , mTOR and S6K1 was detected in 50 , 55 and 65 % of the specimens , respectively . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Regulation of dendritic morphogenesis by Ras PI3K Akt mTOR and Ras MAPK signaling pathways . ^^^ Here we report that the Ras phosphatidylinositol 3 kinase ( PI3K ) Akt mammalian target of rapamycin ( mTOR ) signaling pathway plays pivotal roles in the regulation of many aspects of dendrite formation . ^^^ Whereas the PI3K Akt mTOR pathway alone controlled soma and dendrite size , a coordinated activation together with the Ras mitogen activated protein kinase signaling pathway was required for increasing dendritic complexity . ^^^ Chronic inhibition of PI3K or mTOR reduced soma and dendrite size and dendritic complexity , as well as density of dendritic filopodia and spines , whereas a short term inhibition promoted the formation of mushroom shaped spines on cells expressing constitutively active mutants of Ras , PI3K , or Akt , or treated with the upstream activator BDNF . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here , we show that the phosphoinositide 3 ' kinase ( PI3K ) Akt mammalian target of rapamycin ( mTOR ) signaling pathway promotes the growth and branching of dendrites in cultured hippocampal neurons . ^^^ Constitutively active mutants of Ras , PI3K , and Akt , or RNA interference ( RNAi ) knockdown of lipid phosphatase PTEN ( phosphatase and tensin homolog deleted on chromosome Ten ) , induced growth and elaboration of dendrites that was blocked by mTOR inhibitor rapamycin and / or by overexpression of eIF 4E binding protein 1 ( 4E BP 1 ) , which inhibits translation of 5 ' capped mRNAs . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Expression levels of PTEN , phosphorylated forms of the constituent proteins ( Akt , FKHR , mTOR , and S 6 ) and cyclin D 1 were evaluated by immunohistochemistry , on consecutive sections from a tissue microarray containing 145 invasive breast cancers and 140 pure ductal carcinomas in situ . ^^^ In all , 33 , 15 , 32 , and 60 % of ductal carcinoma in situ showed overexpression of Akt , FKHR , mTOR , and cyclin D 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Novel roles of Akt and mTOR in suppressing TGF beta / ALK5 mediated Smad 3 activation . ^^^ Using siRNA , rapamycin ( Rap ) , and adenoviral expression for FKBP 12 resistant and constitutively active TGF beta type 1 receptor ( ALK 5 ) , we demonstrate that mammalian target of Rap ( mTOR ) mediates Akt 1 suppression of phospho activation of S 3 . ^^^ We propose a novel model whereby Akt suppresses activation of S 3 in an Akt kinase dependent manner through mTOR , a likely route for loss of tumor suppression by TGF beta in cancers . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
When BCAAs were supplied to subjects during and after one session of quadriceps muscle resistance exercise , an increase in mTOR , p 70 S6 kinase , and S 6 phosphorylation was found in the recovery period after the exercise with no effect of BCAAs on Akt or glycogen synthase kinase 3 ( GSK 3 ) phosphorylation . ^^^ It has previously been shown that leucine infusion increases p 70 S6 kinase phosphorylation in an Akt independent manner in resting subjects ; however , a relation between mTOR and p 70 S6 kinase has not been reported previously . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Thrombopoietin ( TPO ) induces c myc expression through a PI3K and MAPK dependent pathway that is not mediated by Akt , PKCzeta or mTOR in TPO dependent cell lines and primary megakaryocytes . ^^^ Therefore , we conclude that TPO stimulates c myc expression in primary megakaryocytes through a PI3K and MAPK dependent pathway that is not mediated by Akt , PKCzeta or mTOR . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
HGF and drugs also activate the ERK1 / 2 MAPKs , the PI3K / AKT and the AKT substrate mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The Akt / mammalian target of rapamycin ( mTOR ) / ribosomal protein S 6 kinase ( p70S6K ) pathway is considered a central regulator of protein synthesis and of cell proliferation , differentiation , and survival . ^^^ However , the role of the Akt / mTOR / p70S6K pathway in lung carcinoma remains unknown . ^^^ Herein , we explore the role of the Akt / mTOR / p70S6K pathway in fibronectin induced NSCLC cell growth . ^^^ We found that fibronectin stimulated the phosphorylation of Akt , an upstream inducer of mTOR , and induced the phosphorylation of p70S6K1 and eukaryotic initiation factor 4E binding protein 1 ( 4E BP 1 ) , two downstream targets of mTOR in NSCLC cells ( H 1792 and H 1838 ) , whereas it inhibited the phosphatase and tensin homologue deleted on chromosome 10 , a tumor suppressor protein that antagonizes the phosphatidylinositol 3 kinase / Akt signal . ^^^ Taken together , these observations suggest that fibronectin induced stimulation of NSCLC cell proliferation requires activation of the Akt / mTOR / p70S6K pathway and is associated with inhibition of LKB1 / AMPK signaling . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
While TRAIL sensitivity in tumors has been linked to c myc and MEK / Erk induced enhancement of caspase activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt mTOR pathway . ^^^ We showed that instead of enhancing TRAIL sensitivity , Akt expression , acting through mTOR and the mTOR targets S 6 kinase and eIF 4E , selectively enhances translation of the anti apoptotic protein FLIP ( S ) and confers TRAIL resistance . ^^^ In this perspective article we will discuss the linkage of the Akt mTOR pathway to other regulators of TRAIL sensitivity , its importance in controlling a broader range of apoptotic events , its utility in predicting TRAIL responsiveness , and its potential manipulation for therapeutic benefit . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Likewise , activation of molecules associated with hypertrophy ( AKT , mTOR , and p 70 ( S6k ) ) was diminished in mice overexpressing integrin . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The Akt / mammalian target of rapamycin ( mTOR ) signaling pathway is believed to be activated by these various factors , resulting in skeletal muscle growth through the initiation of protein synthesis . ^^^ It was hypothesized that surgical removal of the ovaries ( Ovx ) may alter activation of the Akt / mTOR signaling pathway , a mechanism necessary for muscle regrowth . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Stimulation of the insulin and insulin like growth factor 1 ( IGF 1 ) receptor activates the phosphoinositide 3 kinase / Akt / mTOR pathway causing pleiotropic cellular effects including an mTOR dependent loss in insulin receptor substrate 1 expression leading to feedback down regulation of signaling through the pathway . ^^^ In model systems , tumors exhibiting mutational activation of phosphoinositide 3 kinase / Akt kinase , a common event in cancers , are hypersensitive to mTOR inhibitors , including rapamycin . ^^^ We now show that mTOR inhibition induces insulin receptor substrate 1 expression and abrogates feedback inhibition of the pathway , resulting in Akt activation both in cancer cell lines and in patient tumors treated with the rapamycin derivative , RAD 001 . ^^^ IGF 1 receptor inhibition prevents rapamycin induced Akt activation and sensitizes tumor cells to inhibition of mTOR . ^^^ Reversal of this feedback loop by rapamycin may attenuate its therapeutic effects , whereas combination therapy that ablates mTOR function and prevents Akt activation may have improved antitumor activity . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The phosphoinositide 3 kinase ( PI3K ) / Akt / mammalian target of rapamycin ( mTOR ) pathway controls many cellular processes that are important for the formation and progression of cancer , including apoptosis , transcription , translation , metabolism , angiogenesis , and cell cycle progression . ^^^ Thus , inhibition of the PI3K / Akt / mTOR pathway is an attractive concept for cancer prevention and / or therapy . ^^^ Inhibitors of individual components , such as PI3K , PDK 1 , Akt , and mTOR , are being developed at a rapid pace and have promise for improving the care of cancer patients . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Taken together , these findings show that rosiglitazone , via up regulation of the PTEN / AMPK and down regulation of the Akt / mTOR / p70S6K signal cascades , inhibits NSCLC cell proliferation through PPARgamma dependent and PPARgamma independent signals . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The PI 3 kinase / Akt pathway and ERK , but not the mTOR / p70s6K pathway account for the suppression of GSK 3beta by bradykinin . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Interestingly , in CaSki cells , which were more suggestive of a resistant phenotype , paclitaxel induced the activation of mTOR as a downstream target of Akt . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
To assess the spectrum of activity in other cell types and to compare PIAs with other inhibitors of the phosphatidylinositol 3 kinase ( PI3K ) / Akt / mammalian target of rapamycin ( mTOR ) pathway , we compared growth inhibition by PIAs against the PI3K inhibitors LY 294002 and wortmannin and the mTOR inhibitor rapamycin in the NCI 60 cell line panel . ^^^ These studies show that although PIAs are widely active in cancer cells , which correlates with the presence of its intended target , active Akt , PIAs are biologically distinct from other known inhibitors of the PI3K / Akt / mTOR pathway . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our previous results revealed a new pathway in which amino acids permit insulin induced activation of the protein kinase B ( PKB ) / mTOR pathway in freshly isolated adipocytes when phosphatidylinositol 3 kinase ( PI3K ) is inhibited . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We observed increased proliferation , decreased apoptosis and increased phosphorylation of Ser 473 of Akt and Ser 2448 of mTOR throughout IGFIR structures . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
IB MECA induced GSK 3beta inhibition is mediated by the PI 3 kinase / Akt signal pathway but not by the mTOR / p70s6K pathway . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Pretreatment of NHEK with PFE ( 60 100 microg / mL ) for 24 h before exposure to UVA resulted in a dose dependent inhibition of UVA mediated phosphorylation of STAT 3 at Tyr 705 , AKT at Ser 473 and ERK1 / 2 . mTOR , structurally related to PI3K , is involved in the regulation of p70S6K , which in turn phosphorylates the S 6 protein of the 40S ribosomal subunit . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The presence of p Akt was accompanied by the phosphorylation of p 27 ( kip 1 ) , FRKHL 1 , MDM 2 , Bad , mTOR , and p70S6K . ^^^ Inhibition of the PI3K / Akt pathway in the MCL cell lines abrogated or reduced the phosphorylation of Akt , p 27 ( kip 1 ) , FRKHL 1 , MDM 2 , Bad , mTOR , GSK 3beta , IkappaB , and led to cell cycle arrest and apoptosis . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Inhibitions of the mTOR signaling , as well as its upstream activators , phosphatidylinositol 3 kinase and AKT , blocked NMDA receptor dependent dendritic GFP synthesis . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
RTK activation involves an homogeneous transduction pathway whose components ( MAPK , AKT , PI3K , mTOR and RAS ) are possible targets of new molecular treatment . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
We show that CC formation follows a multistep progression of histopathological changes that are associated with significant alterations , including increased levels of phosphorylated AKT , FOXO 1 , GSK 3beta , mTOR , and ERK and increased nuclear levels of cyclin D 1 . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
In human endothelial cells amino acids inhibit insulin induced Akt and ERK1 / 2 phosphorylation by an mTOR dependent mechanism . ^^^ Our data demonstrate that at the level of human endothelial cells , amino acids synergize with insulin in the phosphorylation of the kinase that lies downstream mTor , as p70 / S6 K , whereas they inhibit the upstream kinases Akt and extracellular signal regulated protein kinase 1 / 2 when activated by insulin , by an mTor dependent mechanism . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Emphasis will be put on three serine / threonine kinases , mTOR , Akt and S 6 Kinase ( S6K ) , and their role in the integration of environmental cues and the coordination of muscle growth . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The present study was designed to clarify the expression and prognostic significance of activated Akt and mTOR in cervical cancer and their correlation with response to neoadjuvant chemotherapy ( NAC ) . ^^^ Immunohistochemical analysis for p Akt and p mTOR expression was performed on paraffin embedded biopsy specimens from 25 patients with advanced cervical cancer ( stage Ib 2 IIb ) . ^^^ Activation of Akt was detected in the cytoplasm and nucleus of the cancer cells in 12 patients ( 48 % ) , whereas p mTOR was detected in the cytoplasm and membrane of the cancer cells in 13 patients ( 52 % ) . ^^^ The expression of p mTOR and distant metastasis significantly correlated with the response to NAC ( p = 0 . 0101 and p = 0 . 0107 ) ; however , there was no significant correlation between p Akt and p mTOR expression and any of the clinicopathological characteristics of the patients . ^^^ In the univariate analysis , activated Akt and mTOR were found to be significant prognostic indicators ( p < 0 . 05 ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
AKT independent phosphorylation of TSC 2 and activation of mTOR and ribosomal protein S 6 kinase signaling by prostaglandin F2alpha . ^^^ Treatment with PGF2alpha did not increase AKT phosphorylation but increased the phosphorylation of Erk and the tumor suppressor protein tuberous sclerosis complex 2 ( TSC 2 ) , an upstream regulator of mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here we show that insulin like growth factor 1 ( IGF 1 ) induced hypertrophy of myoblasts notably increases Neu 2 synthesis by activation of the phosphatidylinositol 3 kinase / AKT / mammalian target of rapamycin ( P13K / AKT / mTOR ) pathway , whereas the proliferative effect mediated by activation of the extracellular regulated kinase 1 / 2 ( ERK1 / 2 ) pathway negatively contributed to Neu 2 activity . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Significantly , DHT stimulation of mTOR was not mediated through activation of the PI3K / Akt or mitogen activated protein kinase / p90 ribosomal S 6 kinase pathways and subsequent tuberous sclerosis complex 2 / tuberin inactivation or by suppression of AMP activated protein kinase . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Leucine stimulates procollagen alpha 1 ( 1 ) translation on hepatic stellate cells through ERK and PI3K / Akt / mTOR activation . ^^^ Leucine also induced mTOR , ERK , and Akt phosphorylation in HSC , without affecting p 38 and JNK activation . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
This study showed that PRL stimulated the phosphorylation of mTOR , p70S6K , Akt , and Jak 2 kinases in a dose and time dependent manner in PRL dependent rat Nb 2 lymphoma cells . ^^^ PRL stimulated phosphorylation of mTOR was detected as early as 10 min , closely following the phosphorylation of Akt ( upstream of mTOR ) , but preceding that of the downstream p70S6K . ^^^ PRL activation of mTOR was inhibited by rapamycin ( mTOR inhibitor ) , LY 249002 , and wortmannin ( P13K inhibitors ) , but not by AG 490 ( Jak 2 inhibitor ) , indicating that it was mediated by the P13K / Akt , but not Jak 2 , pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The authors provide evidence that rapamycin inhibition of PI3K / Akt / mTOR signaling in endothelial cells ( ECs ) , by either reducing Akt activity or blocking mTOR , reverses the pathologic effects associated with excess VEGF signaling in the tumor vasculature . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Key components of the pathway are the lipid kinase PI 3 K , the small guanosine triphosphate binding protein Rheb , and the protein kinases Akt and mTOR . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Malignant hematopoietic cells induce an increased expression of VEGFR 1 and VEGFR 3 on bone marrow endothelial cells via AKT and mTOR signalling pathways . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
EGF induced activation of Akt results in mTOR dependent p70S6 kinase phosphorylation and inhibition of HC 11 cell lactogenic differentiation . ^^^ While expression of CA Akt caused a constitutive activation of p70S6 kinase ( p70S6K ) in HC 11 cells , the inhibition of either PI 3 kinase or mTOR abolished the activation of p70S6K by EGF . ^^^ The EGF induced activation of PI 3 kinase Akt mTOR regulates phosphorylation of molecules including ribosomal protein S 6 , eIF4E and 4E BP 1 that influence translational control in HC 11 cells undergoing lactogenic differentiation . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The PI3K inhibitor LY 294002 completely blocks insulin stimulated glycogen synthesis by inhibiting glycogen synthase , PKB ( Akt 1 ) , and FRAP ( RAFT ) autophosphorylation , as well as p 70 S6 kinase activation , whereas insulin receptor substrates tyrosine phosphorylation and MEK activity were not affected . ^^^ In order to study the role of phosphatidylinositol 3 kinase ( PI3K ) , PKB , FRAP , S 6 kinase , and MAP kinase in insulin stimulated glycogen synthesis , we used a specific inhibitor of PI3K , LY 294002 , the immunosuppressant inhibitor of FRAP , rapamycin , and the inhibitor of MAPK kinase ( MEK ) / MAPK , PD 98059 , in rat HTC hepatoma cells overexpressing human insulin receptors . ^^^ However , rapamycin only partially blocks insulin stimulated glycogen synthesis by partial inhibition of glycogen synthase , whereas it completely blocks S 6 kinase activation and FRAP autophosphorylation , but does not affect either PKB autophosphorylation , MEK activity , or insulin receptor tyrosine phosphorylation . ^^^ However , the inhibition of FRAP and S 6 kinase activation is not sufficient to block insulin stimulated glycogen synthesis , suggesting an important role of a branching pathway upstream of S 6 kinase and downstream of PI3K , which is probably mediated by PKB in the signaling of the insulin receptor in hepatoma HTC cells . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Modulation of hypoxia inducible factor 1alpha expression by the epidermal growth factor / phosphatidylinositol 3 kinase / PTEN / AKT / FRAP pathway in human prostate cancer cells : implications for tumor angiogenesis and therapeutics . ^^^ Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3 kinase ( PI3K ) , AKT ( protein kinase B ) , and its effector FKBP rapamycin associated protein ( FRAP ) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers . ^^^ LY 294002 and rapamycin also inhibit growth factor and mitogen induced secretion of vascular endothelial growth factor , the product of a known HIF 1 target gene , thus linking the PI3K / PTEN / AKT / FRAP pathway , HIF 1 , and tumor angiogenesis . ^^^ These data indicate that pharmacological agents that target PI3K , AKT , or FRAP in tumor cells inhibit HIF 1alpha expression and that such inhibition may contribute to therapeutic efficacy . . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Akt phosphorylation was not affected , indicating FRAP specificity of Rapa . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Here we demonstrate that HER 2 signaling induced by overexpression in mouse 3T3 cells or heregulin stimulation of human MCF 7 breast cancer cells results in increased HIF 1alpha protein and VEGF mRNA expression that is dependent upon activity of PI3K , AKT ( also known as protein kinase B ) , and the downstream kinase FRAP ( FKBP rapamycin associated protein ) . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Our results suggest that HIF 1alpha plays an important role in the induction of VEGF in nonischemic and mechanically stressed myocardium , and that this is regulated by stretch activated channels and the PI3K / Akt / FRAP pathway . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
The IRS 1 , PIK3R1 , PIK3R2 , AKT 2 , AKT 3 , FRAP 1 , and RPS6KB1 genes were neither amplified nor overexpressed in any of the tumors . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
Newly disclosed interactions between gephyrin , exchange factors for G proteins of the Rho and Rac families , the translational regulator RAFT 1 , and actin binding proteins like profilin might integrate activity dependent and trophic factor mediated signals at developing postsynaptic sites . ^^^
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA
Interacting proteins: P42345 and P31749	Pubmed	SVM Score :0.0
NA