| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of cells with wortmannin and LY 294002 , inhibitors of PI3K , or rapamycin , an inhibitor of the mammalian target of rapamycin kinase and p70S6K , diminished the ANG 4 mediated activation of PDK 1 and PKB alpha as well as phosphorylation of p70S6K . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In the hypertrophic muscle of MLC / mlgf 1 mice , we observed increased phosphorylation of phosphoinositide dependent protein kinase 1 ( PDK 1 ; 53 % increase ) , the mammalian target of rapamycin ( mTOR ; 112 % increase ) , and p 70 S6 kinase ( p70S6K ) ( 254 % increase ) but no significant change in Akt phosphorylation ( 4 % decrease ) . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| In our cellular model , troglitazone appeared to enhance 3 ' phosphoinositide dependent protein kinase 1 ( PDK 1 ) nuclear translocation , resulting in a decrease in cytosolic phosphorylated 70 kDa ribosomal protein kinase ( p70S6 ) and phosphorylated mammalian target of rapamycin ( mTor ) . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Moreover , sequential phosphorylation of p70alpha by mTOR and 3 phosphoinositide dependent protein kinase 1 in vitro resulted in a synergistic stimulation of p70alpha activity to levels similar to that attained by serum stimulation in vivo . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| PDK 1 is required for activation of members of the AGC kinase family ; we show that two such kinases , p 70 S6 kinase ( regulated via mTOR ) and p 90 ( RSK 1 ) ( activated by Erk ) , phosphorylate eEF2k at a conserved serine and inhibit its activity . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Sequential phosphorylation of wild type and S383G mutant of p70beta1 with mTOR and 3 phosphoinositide dependent protein kinase 1 ( PDK 1 ) in vitro synergistically activated their kinase activities . ^^^ CONCLUSION : These results indicate that p70beta is regulated by the mTOR and PDK 1 signalling pathways through a synergistic interaction between phosphorylated Thr 241 and Thr 401 , while Ser 383 plays minor role in their activation mechanism . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| PDK 1 , mTOR , and MAPK inhibitors did not block insulin induced reduction of IRS 1 , suggesting that the PI3K serine kinase activity causes IRS 1 serine phosphorylation and its commitment to proteasomal degradation . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| At a molecular level , this dual control of p 70 S6K activity is attributable to phosphorylation of the two p 70 S6K sites : The Ptd Ins 3 , 4 , 5P3 dependent kinasel ( PDK 1 ) phosphorylates p 70 S6K at a Thr on the activation loop , whereas mTOR phosphorylates a Thr located in a hydrophobic motif carboxyterminal to the catalytic domain . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Investigation of proteins in the phosphatidylinositol 3 ' kinase / Akt signaling pathway in PTEN delivered mouse lung revealed that the PTEN protein was highly expressed , whereas the protein levels of PDK 1 , total Akt 1 , phospho ( Thr 308 ) Akt , phospho ( Ser 2448 ) mTOR , p70S6K , and 4E BP 1 were decreased to varying degrees . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| The rictor mTOR complex directly phosphorylated Akt / PKB on Ser 473 in vitro and facilitated Thr 308 phosphorylation by PDK 1 . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| In agreement , insulin rapidly induced the phosphorylation of 3 phosphoinositide dependent protein kinase 1 ( PDK 1 ) , protein kinase B ( Akt ) , and mTOR , effects that were prevented by the AG 1024 and LY 294002 . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Cells lacking PDK 1 show decreased activity of these protein kinases , including protein kinase B ( PKB ) and p70S6K , whereas mTOR activity remains largely unaffected . ^^^ We show that PKB activity is a critical downstream component of PDK 1 in mediating translation of cystatin C , RANKL , and Rab11a , whereas mTOR activity is less important for effective translation of these targets . . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of FAK , mTOR , p70S6K , and PDK 1 were elevated in both breast cancer cell lines , whereas the phosphorylation of AKT , EGFR , ErbB2 / Her2 , PDGFR , Shc , and Stat 3 were elevated in only one breast cancer line compared to normal primary mammary epithelial cells and telomerase immortalised breast epithelial cells . ^^^ Elevated phosphorylation of PDK 1 , AKT , mTOR , p70S6K , S 6 , EGFR , and Stat 3 were highly associated with invasive breast tumours ( P < 0 . 05 ) . ^^^ This is the first report demonstrating phosphorylation of PDK 1 is frequently elevated in breast cancer with concomitantly increased phosphorylation of downstream kinases , including AKT , mTOR , p70S6K , S 6 , and Stat 3 . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Special emphasis is placed on applicability of EGF R tyrosine kinase , COX 2 , PDK 1 , mTOR and farnesyltransferase inhibitors . . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of individual components , such as PI3K , PDK 1 , Akt , and mTOR , are being developed at a rapid pace and have promise for improving the care of cancer patients . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| The activation process of S 6 kinase involves a complex and sequential series of multiple Ser / Thr phosphorylations and is mainly mediated via phosphatidylinositol 3 kinase ( PI3K ) 3 phosphoinositide dependent protein kinase 1 ( PDK 1 ) and mTor dependent pathways . ^^^ |
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| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42345 and O15530 |
Pubmed |
SVM Score :0.0 |
| NA |
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