| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.56989053 |
| Finally , p110beta was found to be co immunoprecipitated with PKCepsilon . 0.56989053^^^ |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| Products of phosphatidylinositol 3 kinases ( PI3K ) stimulate PKCepsilon . ^^^ In IPRL , TLCA ( 10 micromol / liter ) impaired bile flow by 51 % , biliary secretion of horseradish peroxidase , a marker of vesicular exocytosis , by 46 % , and the Mrp 2 substrate , 2 , 4 dinitrophenyl S glutathione , by 95 % and stimulated PI3K dependent protein kinase B , a marker of PI3K activity , by 154 % and PKCepsilon membrane binding by 23 % . ^^^ The selective PI3K inhibitor , wortmannin ( 100 nmol / liter ) , and the anticholestatic bile acid tauroursodeoxycholic acid ( TUDCA , 25 micromol / liter ) independently and additively reversed the effects of TLCA on bile flow , exocytosis , organic anion secretion , PI3K dependent protein kinase B activity , and PKCepsilon membrane binding in IPRL . ^^^ These data strongly suggest that TLCA exerts cholestatic effects by PI3K and PKCepsilon dependent mechanisms that are reversed by tauroursodeoxycholic acid in a PI3K independent way . . ^^^ |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| Our date demonstrate that leptin plays a key role in the regulation of the earliest signaling pathways activated by growth factors , such as LPA , through a signaling pathway involving PKCdelta and PKCepsilon coupled to Box 3 motif of the OB Rb through PI3K . . ^^^ |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| Increases in phospho PKCepsilon are dependent not only on mGluR 5 stimulation but also on phosphatidylinositol 3 kinase ( PI3K ) . ^^^ Our data indicate that mGluR 5 is coupled to PKCepsilon via a PI3K dependent pathway and that PKCepsilon is required for the ability of the mGluR 5 antagonist MPEP to reduce ethanol consumption . . ^^^ |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| PKCalpha but not PKCepsilon phosphorylated the catalytic subunit of the p110alpha / p85alpha PI3K in vitro in a manner inhibited by the PKC inhibitor bisindolylmaleimide 1 ( BIM 1 ) . ^^^ |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and Q02156 |
Pubmed |
SVM Score :0.0 |
| NA |
|