| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| These results indicate AngII influences AT 2 receptor expression through the AT 1 receptor via a signaling pathway that includes PI3K . . ^^^ |
|
| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| In the present study , we identified novel negative cross talk between the angiotensin 2 subtype 2 ( AT 2 ) receptor and insulin receptor signaling in the regulation of phosphoinositide 3 kinase ( PI3K ) , Akt , and apoptosis in rat pheochromocytoma cell line , PC12W cells , which exclusively express AT 2 receptor . ^^^ We demonstrated that insulin mediated insulin receptor substrate ( IRS ) 2 associated PI3K activity was inhibited by AT 2 receptor stimulation , whereas IRS 1 associated PI3K activity was not significantly influenced . ^^^ AT 2 receptor stimulation did not change insulin induced tyrosine phosphorylation of IRS 2 or its association with the p85alpha subunit of PI3K , but led to a significant reduction of insulin induced p85alpha phosphorylation . ^^^ Overexpression of a catalytically inactive dominant negative SHP 1 markedly attenuated the AT 2 receptor mediated inhibition of IRS 2 associated PI3K activity , Akt phosphorylation , and antiapoptotic effect induced by insulin . ^^^ Taken together , these results indicate that AT 2 receptor mediated activation of SHP 1 and the consequent inhibition IRS 2 associated PI3K activity contributed at least partly to the inhibition of Akt phosphorylation , thereby inducing apoptosis . . ^^^ |
|
| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| In the present study , we used skin fibroblasts of human hypertrophic scar , which expressed both AT 1 and AT 2 receptors , and observed that Ang 2 increased Akt phosphorylation and phosphoinositide 3 kinase ( PI 3 K ) activity . ^^^ |
|
| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42338 and P50052 |
Pubmed |
SVM Score :0.0 |
| NA |
|