| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| Here we studied the effect of the metabotropic glutamate receptor ( mGluR ) interacting proteins , Homer1a , b , and c , in the targeting of mGluR 5 in neurons . ^^^ In contrast , mGluR 5 was found also in dendrites when coexpressed with Homer1b or Homer1c , and in both dendrites and axons when cotransfected with Homer1a . ^^^ Depolarization of the neurons with a mixture of ionotropic glutamate receptor agonists , NMDA and kainate , or potassium channel blockers , tetraethylammonium and 4 aminopyridine , induced transient expression of endogenous Homer1a and persistent neuritic localization of transfected mGluR 5 even long after degradation of Homer1a . ^^^ These results suggest that Homer1a / b / c proteins are involved in the targeting of mGluR 5 to dendritic synaptic sites and / or axons and that this effect can be regulated by neuronal activity . ^^^ Because the activity dependent effect of endogenous Homer1a was also long lasting , the axonal targeting of mGluR 5 by this protein is likely to play an important role in synaptic plasticity . . ^^^ |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| Disruption of this interaction by mutagenesis or antisense strategies , or expression of endogenous Homer1a ( H1a ) , induces constitutive activity in mGluR1a or mGluR 5 . ^^^ |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| These results indicate that Homer 1 proteins regulate synaptic cycling and Ca2+ signaling of mGlu 5 receptors , in response to neuronal activity . . ^^^ Recombinant Homer1a alone did not affect cell surface expression of the receptor , but in neurons transfected with Homer1b , excitation induced expression of native Homer1a reversed the intracellular retention of mGlu 5 receptors , resulting in the receptor trafficking to synaptic membranes . ^^^ Transfected Homer1a also increased the latency and amplitude of the mGlu 5 receptor Ca2+ response . ^^^ |
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| Interacting proteins: P41594 and Q86YM7 |
Pubmed |
SVM Score :0.0 |
| To clarify the function of its N terminus , we expressed Homer1b and 1d in the presence and absence of mGluR5b in HEK293T cells . ^^^ When co expressed , Homer1d and mGluR5b were co localized on the PM , while Homer1b and mGluR5b were retained in the endoplasmic reticulum ( ER ) . ^^^ |
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