| Interacting proteins: P41567 and Q99613 |
Pubmed |
SVM Score :0.0 |
| Here we show that the entire HEAT domain and flanking residues of Saccharomyces cerevisiae eIF4G2 are required for the optimal interaction with the AUG recognition factors eIF 5 and eIF 1 . eIF 1 binds simultaneously to eIF4G and eIF3c in vitro , as shown previously for the C terminal domain of eIF 5 . ^^^ |
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| Interacting proteins: P41567 and Q99613 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminal domain ( CTD ) of eukaryotic initiation factor ( eIF ) 5 interacts with eIF 1 , eIF2beta , and eIF3c , thereby mediating formation of the multifactor complex ( MFC ) , an important intermediate for the 43 S preinitiation complex assembly . ^^^ Here we demonstrate in vitro formation of a nearly stoichiometric quaternary complex containing eIF 1 and the minimal segments of eIF2beta , eIF3c , and eIF 5 . ^^^ |
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| Interacting proteins: P41567 and Q99613 |
Pubmed |
SVM Score :0.0 |
| We show that the binding site for eIF2beta is located in a surface area containing aromatic and acidic residues ( aromatic / acidic boxes ) , that the binding sites for eIF 1 and eIF3c are located in a conserved surface region of basic residues , and that eIF4G binds eIF 5 CTD at an interface overlapping with the acidic area . ^^^ |
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| Interacting proteins: P41567 and Q99613 |
Pubmed |
SVM Score :0.0 |
| The IF 5 CTD interacts directly with the translation initiation factors eIF 1 , eIF 2 beta , and eIF3c , thus forming together with eIF 2 bound Met tRNA ( 1 ) ( Met ) the MFC . ^^^ |
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