| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| These data suggest that Gbetagamma subunit mediated formation of Shc . c Src complexes and c Src kinase activation are early events in Ras dependent activation of MAP kinase via pertussis toxin sensitive G protein coupled receptors . . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Furthermore AG 1478 , a specific inhibitor of the EGF receptor kinase , blocked Erk 1 and Erk 2 activation . c Src kinase was not involved in the IL 8 mediated phosphorylation of the EGF receptor , but was critical for Shc phosphorylation and downstream Erk1 / 2 kinase activation . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Specific motifs recognized by the SH 2 domains of Csk , 3BP2 , fps / fes , GRB 2 , HCP , SHC , Syk , and Vav . ^^^ We report here the optimal recognition motifs for SH 2 domains from GRB 2 , Drk , Csk , Vav , fps / fes , SHC , Syk ( carboxy terminal SH 2 ) , 3BP2 , and HCP ( amino terminal SH 2 domain , also called PTP1C and SHPTP 1 ) . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Binding of FYN and SHC to the diphosphorylated Tyr568 / 570 site was observed , while binding of Csk to this site was not observed . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| EGF led to an increase in the CSK association of SHC at both states of confluence and was greater at confluence . ^^^ EGFR association with SHC was primarily soluble at subconfluence , while at confluence EGFR association was markedly increased and predominantly in the CSK . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Significantly , repression of endogenous Src family PTK activity by p 50 ( csk ) overexpression inhibited FN stimulated cell spreading , Pyk 2 tyrosine phosphorylation , Grb 2 binding to Shc , and ERK 2 activation in the FAK but not in FAK+ cells . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Expression of Csk , which inactivates Src family kinases , totally inhibited gastrin induced Src like activity detected in anti Src and anti Shc precipitates but diminished by 50 % Shc phosphorylation and ERK 1 activation . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| Using a GST fusion protein carrying the cytoplasmic tail of beta dystroglycan , we identified five SH 2 domain containing proteins that interact with beta dystroglycan in a phosphorylation dependent manner , including c Src , Fyn , Csk , NCK , and SHC . ^^^ |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|