| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| Regulation of c Fgr protein kinase by c Src kinase ( CSK ) and by polycationic effectors . ^^^ The protein tyrosine kinase expressed by the protooncogene c fgr is phosphorylated and down regulated in vitro by the c Src kinase ( CSK ) . ^^^ CSK catalyzed phosphorylation affects Tyr 511 of c Fgr , homologous to Tyr 527 of c Src and it prevents the autophosphorylation normally occurring at c Fgr Tyr 400 , homologous to c Src Tyr 416 . ^^^ Once phosphorylated at Tyr 511 and down regulated by CSK , c Fgr is no more susceptible to polylysine stimulation . ^^^ Previous autophosphorylation ( at Tyr 400 ) reduces c Fgr susceptibility to down regulation by CSK , although Tyr 511 can be still phosphorylated by it . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| We also show that the HS 1 peptide can be used for the specific monitoring of p72syk since neither the two Src related c Fgr and Lyn kinases ( needing a hydrophobic instead of acidic residue at position 1 ) nor CSK appreciably phosphorylate it . . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| With all protein kinases tested , namely PKA , CK 1 , CK 2 , MAP kinase ( ERK 1 ) , c Fgr , Lyn , CSK and TPK IIB / p38Syk , staurosporine inhibition was competitive with respect to ATP , regardless of its inhibitory power . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| The photodynamic inhibitory effect of hypericin and a number of hypericin derivatives were investigated in vitro using numerous growth factor regulated protein kinases including receptor bound ( Insulin R , EGF R ) and non receptor ( Lyn , c Fgr , CSK , Syk ) protein tyrosine kinases as well as Ser / Thr ( PK C , protein kinase CK 2 , CK 1 ) protein kinases . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| Lyn and c Fgr phosphorylated by C terminal Src kinase ( CSK ) at their down regulatory site are resistant to the action of both PTPases while the [ Phe 6 ] Src ( 514 533 ) phosphopeptide , representing the highly similar site affected by CSK in c Src , is readily dephosphorylated by both PTPases , although to a different extent . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| Sequence specificity of C terminal Src kinase ( CSK ) a comparison with Src related kinases c Fgr and Lyn . ^^^ An eicosapeptide encompassing the C terminal tail of c Src ( Tyr 527 ) which is conserved in most Src related protein kinases , is phosphorylated by C terminal Src kinase ( CSK ) and by the two Src related protein kinases c Fgr and Lyn , with similar kinetic constants . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| Nanomolar concentrations of hypericin inhibit the protein tyrosine kinase activities ( PTK ) of the epidermal growth factor receptor and the insulin receptor , while being ineffective towards the cytosolic protein tyrosine kinases Lyn , Fgr , TPK IIB and CSK . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| CHK / HYL did not affect the activity of Src , Hck , and Fgr in cultured bone marrow cells , although CSK negatively regulates Src family kinases . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| Csk overexpression resulted primarily in a down regulation of Fgr activity , an src PTK expressed in J774A . 1 , and hyperphosphorylation of several cellular proteins of 35 , 57 , 66 , 97 and 120 130 kDa . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| The protein expression levels of a tyrosine kinase , Fgr , were reduced in Csk knockdown cells , suggesting that Csk is a critical regulator of TLR 4 mediated signalling by modifying the levels of Src like kinases . . ^^^ |
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| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|