| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| The elevated expression of CSK in human colorectal cancer cell lines appeared to correspond to the elevated p60c src ( c Src ) and p62c yes ( c Yes ) protein tyrosine kinase activities found in other studies . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| PP 1 at this concentration is known to inhibit c Fyn kinase , but not c Src kinase , and none of the three known Src family kinases ( c Src , c Fyn , and c Yes ) expressed in fibroblasts is activated by 5 Ha Ras . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| When cells are treated with Ca ( 2+ ) and Ca ( 2+ ) ionophore , c Src kinase activity increases , whereas c Yes kinase activity decreases . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that the enzyme is inactivated by incubation with protein tyrosine kinase Csk in an ATP Mg dependent manner , indicating that cellular Yes can be regulated by Csk phosphorylation . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation . ^^^ Finally , Yes , another member of the Src family , was also only partially inactivated when a sub stoichiometric amount of Csk was used . ^^^ Mutation of the tyrosine autophosphorylation site of Yes to a phenylalanine resulted in a mutant Yes enzyme that can be fully inactivated by a sub stoichiometric amount of Csk in a time dependent manner . ^^^ These results demonstrate that Csk phosphorylation inactivates Src and Yes only when they are not previously autophosphorylated and Src autophosphorylation can block the inactivation by Csk phosphorylation . ^^^ |
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| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| CSK overexpression caused a profound inhibition of NGF induced activation of FYN , YES , RAS , and ERK and inhibited neurite outgrowth , NGF stimulated integrin directed migration and blocked the NGF induced conversion of GDP RAC to its GTP bound active state . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| A similar mechanism was confirmed for Csk recognition of another Src family kinase , Yes . ^^^ |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07947 and P41240 |
Pubmed |
SVM Score :0.0 |
| NA |
|