| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| The protein GST TK 7 was phosphorylated by c src with a KM of 5 10 microM , which indicated a potential interaction between the connecting segment of the EGFR and the c src kinase . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| However , the cell line over expressing the EGF R showed a twofold enhancement of c Src kinase activity after EGF stimulation . ^^^ The activation of c Src kinase by EGF was confirmed in other EGF R expressing cell types . . ^^^ Functional interaction between the epidermal growth factor receptor and c Src kinase activity . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Concomittantly , erbB 2 : EGFr heterodimer formation and c src kinase activity were also elevated in TPA treated epidermis . ^^^ Activation of erbB 2 and c src kinase were also observed in the epidermis of TGF alpha transgenic mice where expression of human TGF alpha was targeted to basal keratinocytes with the human K 14 promoter . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor receptor ( EGFR ) in whole testis was measured , as were the activities of c Src kinase , protein tyrosine kinase ( PTK ) , mitogen activated protein 2 kinase ( MAP2K also termed as Erk 2 ) , protein kinase A ( PKA ) , and protein kinase C ( PKC ) . ^^^ Epidermal growth factor receptor ( EGFR ) in whole testis was measured , as were the activities of c Src kinase , protein tyrosine kinase ( PTK ) , mitogen activated protein 2 kinase ( MAP2K also termed as Erk 2 ) , protein kinase A ( PKA ) , and protein kinase C ( PKC ) . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Integrin induced epidermal growth factor receptor ( EGFR ) phosphorylation also depended on both EGFR and c Src kinase activities . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| The compounds were ATP competitive inhibitors of c Src kinase with IC ( 50 ) values < 10 nM and from 6 to > 100 fold selectivity for c Src tyrosine kinase relative to basic fibroblast growth factor receptor ( bFGFr ) tyrosine kinase , platelet derived growth factor receptor ( PDGFr ) tyrosine kinase , and epidermal growth factor receptor ( EGFr ) tyrosine kinase . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Exposure to Zn ( 2+ ) , but not EGF , induced phosphorylation of the activating site of c Src ( tyrosine 416 ) , and Zn ( 2+ ) induced phosphorylation of EGFR at tyrosines 845 and 1068 was blocked by the c Src kinase activity inhibitor PP 2 . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Nanomolar concentrations of hypericin inhibit the protein tyrosine kinase activities ( PTK ) of the epidermal growth factor receptor and the insulin receptor , while being ineffective towards the cytosolic protein tyrosine kinases Lyn , Fgr , TPK IIB and CSK . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| The photodynamic inhibitory effect of hypericin and a number of hypericin derivatives were investigated in vitro using numerous growth factor regulated protein kinases including receptor bound ( Insulin R , EGF R ) and non receptor ( Lyn , c Fgr , CSK , Syk ) protein tyrosine kinases as well as Ser / Thr ( PK C , protein kinase CK 2 , CK 1 ) protein kinases . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| EGF receptor ( EGFR ) responsiveness to EGF is mediated by the surface expression of high affinity EGFR , which is associated with the cytoskeleton ( CSK ) . ^^^ EGFR signal transduction appears to be mediated by the CSK association of EGFR and related signaling proteins . ^^^ At confluence , EGFR and tyrosine phosphorylated EGFR were predominantly associated with the Triton 10 100 insoluble CSK at confluence , while predominantly Triton 10 100 soluble at subconfluence . ^^^ Confluent but not subconfluent IEC 6 cells demonstrated a cascade of EGF mediated events consisting of a transient CSK association of PLC gamma with EGFR , a brief expression of tyrosine phosphorylated PLC gamma , a brief increase in PLC gamma CSK association , and a prolonged soluble association of PLC gamma with the EGFR . ^^^ EGFR association with SHC was primarily soluble at subconfluence , while at confluence EGFR association was markedly increased and predominantly in the CSK . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| The stimulatory EGFR signal is insensitive to inhibition of JAKs and appears to involve Src kinases and STAT proteins as shown by inhibition through overexpression of C terminal Src kinase ( Csk ) and transdominant negative STAT 3 , respectively . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| This series of compounds contained low nanomolar inhibitors of Src kinases with selectivity over Csk , epidermal growth factor receptor kinase , protein kinase C , and zeta associated 70 kDa protein . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Overexpression of a dominant negative mutant of p130Cas ( CasDeltaSD ) , Crk ( CrkSH2m ) , Pyk 2 ( PKM ) , or C terminal Src kinase ( Csk ) , but not of a deletion mutant of EGFR ( 533delEGFR ) , attenuated ET induced JNK activation . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| Collectively these results demonstrate that Dok R acts as an EGFR recruited scaffolding molecule that processively assembles c Src and Csk to attenuate signaling from the EGFR . . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| In Csk ( / ) fibroblasts , suppression of SFK results in prolonged EGF induced activation of Erk1 / 2 , with concomitant suppression of EGFR degradation . ^^^ |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41240 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|