| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| DESIGN : A nationwide mail survey of IM and FP program directors ( PDs ) . ^^^ IM PDs gave more clinical importance to auscultation and expressed a greater desire for expanded teaching than did their counterparts in FP programs . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| The generation of inositol phosphates was stimulated by PGs ( PGF 2 alpha greater than PGD 2 much greater than PGE 2 = DM PGE 2 much greater than iloprost greater than sulprostone = misoprostol = 0 ) , reflecting a PGF 2 alpha receptor mediated process , which was insensitive to pertussis toxin ( PTX ) . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Natural PGs and analogues that are selective for the FP ( PGF2a ) , DP ( PGD 2 ) , EP 1 ( sulprostone ) , EP 3 ( MB 28767 ) , and EP 4 ( 1 OH PGE 1 ) receptors were inactive or competed poorly with the binding of [ 3H ] PGE 2 ( < 50 % displacement of specific binding at 10 microM ) . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with a maximally effective concentration of PGF 2 alpha , PGD 2 , or PGE 2 rendered the cells refractory to the FP receptor selective agonist fluprostenol , which further supports the hypothesis that Ca2+ transient signals in response to prostanoids in Swiss 3T3 cells are mediated by the FP receptor . ^^^ These results support the contention that the FP receptor has particular sensitivity to PGF 2 alpha but will also recognize PGD 2 and PGE2 . . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Radioreceptor binding studies using membranes prepared from mammalian COS cells transfected with the FP receptor cDNA showed that the rank order of potency for prostaglandins and prostaglandin analogs in competition for [ 3H ] PGF 2 alpha specific binding sites was as predicted for the FP receptor , with PGF 2 alpha approximately fluprostenol > PGD 2 > PGE 2 > U 46619 > iloprost . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Functional studies suggest that the FP receptor has particular sensitivity to PGF 2 alpha and certain PGF 2 alpha analogs but is also stimulated by PGD 2 and PGE 2 . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Other classes of PGs evaluated ( PGD 2 , enprostil , 17 phenyl PGE 2 , PGE 2 , sulprostone and U 46619 ) were less potent and less efficacious than the FP receptor agonists , or were inactive . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| A high degree of homology between the four Gs coupled prostaglandin ( PG ) receptors [ EP 2 , EP 4 , prostacyclin ( IP ) , PGD 2 ( DP ) ] and the four Gq / Gi coupled receptors [ EP 1 , EP 3 , PGF2alpha ( FP ) , thromboxane A 2 ( TP ) ] suggests that prostaglandin receptors evolved functionally from an ancestral EP receptor before the development of distinct binding epitopes . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| The effects of PGE 2 were mimicked by PGF2alpha or the FP agonist , fluprostenol , whereas PGD 2 or the selective EP , IP or TP agonist was less effective or had no effect . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Specific [ 3H ] AL 5848 binding was potently inhibited by the FP receptor ligands 16 phenoxyPGF2alpha ( inhibition constant Ki = 17 . 3 nM ) ; cloprostenol ( Ki = 56 . 8 nM ) ; 17 phenyl PGF2alpha ( Ki = 87 . 0 nM ) ; AL 5848 ( Ki = 52 . 1 nM ) ; PGF2alpha ( Ki = 195 nM ) ; PHXA 85 ( Ki = 223 nM ) ; ( n = 3 11 ) but very weakly by PGD 2 , ZK 118182 , BW245C , PGE 2 , PGI 2 and U 46619 . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| The luteal FP receptor binds PGF 2 alpha ' PGD 2 ( high affinity ) , and PGE 2 ( moderate affinity ) but not PGE 1 due to affinity determination by the C 9 and C5 / C6 moieties , but not the C 11 moiety . . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| They include the DP , EP , FP , IP , and TP receptors for PGD 2 , PGE 2 , PGF2alpha , PGI 2 , and TXA 2 , respectively . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| To clarify the uterine region dependent distribution of prostanoid receptors , we compared the mechanical responses to selective prostanoid receptor agonists ( FP , EP 3 , DP , EP 2 ) and naturally occurring prostaglandins ( PGF2alpha PGE 2 , PGD 2 ) in longitudinal and circular muscles isolated from three different regions ( cornu , corpus and cervix ) of the non pregnant porcine uterus . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| The DP agonist PGD 2 , the FP agonist PGF ( 2alpha ) , the IP agonist iloprost and the TP agonist U 46619 were ineffective inhibitors of IgE mediated histamine release from mast cells . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| Prostanoids exert their biological actions through binding to eight specific membrane receptors ; the four subtypes EP 1 to EP 4 for PGE 2 ; DP for PGD 2 ; FP for PGF 2 ; IP for PGI 2 ; and TP for thromboxane A 2 . ^^^ |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P43088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| The generation of inositol phosphates was stimulated by PGs ( PGF 2 alpha greater than PGD 2 much greater than PGE 2 = DM PGE 2 much greater than iloprost greater than sulprostone = misoprostol = 0 ) , reflecting a PGF 2 alpha receptor mediated process , which was insensitive to pertussis toxin ( PTX ) . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Natural PGs and analogues that are selective for the FP ( PGF2a ) , DP ( PGD 2 ) , EP 1 ( sulprostone ) , EP 3 ( MB 28767 ) , and EP 4 ( 1 OH PGE 1 ) receptors were inactive or competed poorly with the binding of [ 3H ] PGE 2 ( < 50 % displacement of specific binding at 10 microM ) . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with a maximally effective concentration of PGF 2 alpha , PGD 2 , or PGE 2 rendered the cells refractory to the FP receptor selective agonist fluprostenol , which further supports the hypothesis that Ca2+ transient signals in response to prostanoids in Swiss 3T3 cells are mediated by the FP receptor . ^^^ These results support the contention that the FP receptor has particular sensitivity to PGF 2 alpha but will also recognize PGD 2 and PGE2 . . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Radioreceptor binding studies using membranes prepared from mammalian COS cells transfected with the FP receptor cDNA showed that the rank order of potency for prostaglandins and prostaglandin analogs in competition for [ 3H ] PGF 2 alpha specific binding sites was as predicted for the FP receptor , with PGF 2 alpha approximately fluprostenol > PGD 2 > PGE 2 > U 46619 > iloprost . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Functional studies suggest that the FP receptor has particular sensitivity to PGF 2 alpha and certain PGF 2 alpha analogs but is also stimulated by PGD 2 and PGE 2 . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Other classes of PGs evaluated ( PGD 2 , enprostil , 17 phenyl PGE 2 , PGE 2 , sulprostone and U 46619 ) were less potent and less efficacious than the FP receptor agonists , or were inactive . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| A high degree of homology between the four Gs coupled prostaglandin ( PG ) receptors [ EP 2 , EP 4 , prostacyclin ( IP ) , PGD 2 ( DP ) ] and the four Gq / Gi coupled receptors [ EP 1 , EP 3 , PGF2alpha ( FP ) , thromboxane A 2 ( TP ) ] suggests that prostaglandin receptors evolved functionally from an ancestral EP receptor before the development of distinct binding epitopes . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| The effects of PGE 2 were mimicked by PGF2alpha or the FP agonist , fluprostenol , whereas PGD 2 or the selective EP , IP or TP agonist was less effective or had no effect . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Specific [ 3H ] AL 5848 binding was potently inhibited by the FP receptor ligands 16 phenoxyPGF2alpha ( inhibition constant Ki = 17 . 3 nM ) ; cloprostenol ( Ki = 56 . 8 nM ) ; 17 phenyl PGF2alpha ( Ki = 87 . 0 nM ) ; AL 5848 ( Ki = 52 . 1 nM ) ; PGF2alpha ( Ki = 195 nM ) ; PHXA 85 ( Ki = 223 nM ) ; ( n = 3 11 ) but very weakly by PGD 2 , ZK 118182 , BW245C , PGE 2 , PGI 2 and U 46619 . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| The luteal FP receptor binds PGF 2 alpha ' PGD 2 ( high affinity ) , and PGE 2 ( moderate affinity ) but not PGE 1 due to affinity determination by the C 9 and C5 / C6 moieties , but not the C 11 moiety . . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| DESIGN : A nationwide mail survey of IM and FP program directors ( PDs ) . ^^^ IM PDs gave more clinical importance to auscultation and expressed a greater desire for expanded teaching than did their counterparts in FP programs . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| They include the DP , EP , FP , IP , and TP receptors for PGD 2 , PGE 2 , PGF2alpha , PGI 2 , and TXA 2 , respectively . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| To clarify the uterine region dependent distribution of prostanoid receptors , we compared the mechanical responses to selective prostanoid receptor agonists ( FP , EP 3 , DP , EP 2 ) and naturally occurring prostaglandins ( PGF2alpha PGE 2 , PGD 2 ) in longitudinal and circular muscles isolated from three different regions ( cornu , corpus and cervix ) of the non pregnant porcine uterus . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| The DP agonist PGD 2 , the FP agonist PGF ( 2alpha ) , the IP agonist iloprost and the TP agonist U 46619 were ineffective inhibitors of IgE mediated histamine release from mast cells . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| Prostanoids exert their biological actions through binding to eight specific membrane receptors ; the four subtypes EP 1 to EP 4 for PGE 2 ; DP for PGD 2 ; FP for PGF 2 ; IP for PGI 2 ; and TP for thromboxane A 2 . ^^^ |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43088 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|