| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| PGE 2 > PGF 2 alpha > PGD 2 competed for [ 3H ] PGE 2 binding sites as did the EP 3 receptor agonists M & B 28767 = sulprostone > misoprostol but not the EP 1 receptor antagonist SC 19220 . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Natural PGs and analogues that are selective for the FP ( PGF2a ) , DP ( PGD 2 ) , EP 1 ( sulprostone ) , EP 3 ( MB 28767 ) , and EP 4 ( 1 OH PGE 1 ) receptors were inactive or competed poorly with the binding of [ 3H ] PGE 2 ( < 50 % displacement of specific binding at 10 microM ) . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| PGF2alpha stimulated the release at concentrations higher than 1 microM , but PGD 2 ( up to 10 microM ) did not enhance it . 4 . 17 Phenyl omega trinor PGE 2 ( EP 1 > EP 3 ) and sulprostone ( EP 1 < EP 3 ) were as potent as PGE 2 , but PGE 1 was less potent , in stimulating NO release . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| A high degree of homology between the four Gs coupled prostaglandin ( PG ) receptors [ EP 2 , EP 4 , prostacyclin ( IP ) , PGD 2 ( DP ) ] and the four Gq / Gi coupled receptors [ EP 1 , EP 3 , PGF2alpha ( FP ) , thromboxane A 2 ( TP ) ] suggests that prostaglandin receptors evolved functionally from an ancestral EP receptor before the development of distinct binding epitopes . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Administration of nonselective COX inhibitor ibuprofen or COX 2 inhibitor nimesulide every 8 h for 24 h to newborn rats and pigs reduced prostaglandin levels and caused comparable reductions in nNOS mRNA , protein , and activity to levels of adults ; COX inhibitor induced changes were prevented by cotreatment with PGE 2 analog , 16 , 16 dimethyl PGE 2 , and agonist for the EP 3 receptor of PGE 2 , sulprostone , but not by PGI 2 analog carbaprostacyclin , PGD 2 , EP 1 receptor agonist 17 phenyl trinor PGE 2 , and EP 2 agonist butaprost . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| In addition , the rank order of potency for prostaglandins in competition for [ 3H ] PGE 2 specific binding to membranes prepared from EP 1 cDNA transfected COS cells was PGE 2 > PGE 1 > PGF 2 alpha > PGD 2 . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Further studies involving selective agonists and antagonists suggested that EP 1 receptors , IP receptors and PGD 2 sensitive receptors may mediate prostanoid induced conjunctival itching . ^^^ Although the EP 1 receptor antagonist AH 6809 and the DP receptor antagonist BW A868C inhibited PGE 2 and PGD 2 induced itching , respectively , neither antagonist alone significantly affected the itching associated with experimental allergic conjunctivitis . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Since PGD 2 and 17 phenyl omega trinor PGE 2 ( EP 1 agonist ) did not suppress TNF alpha generation , the EP1 / EP2 / DP receptor antagonist , AH 6809 , was employed to assess if EP 2 receptors mediated the inhibitory effect of PGE 2 . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| PGE 2 induced increase on cyclic AMP levels was unaffected by AH 6809 , an antagonist at both PGD 2 ( DP ) and E 2 ( EP 1 ) receptors . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Examination of prostanoid receptors using bath perfusions ( 1 microM PGE 2 and PGD 2 ) , specific agonists ( BW245C , sulprostone , and butaprost ) , and antagonists ( AH 6809 and SC 19220 ) found evidence for both the PGE 2 specific EP 2 and EP 3 receptors , but not for EP 1 or the PGD 2 specific prostanoid ( DP ) receptors . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| All prostanoid receptor agonists , except butaprost , contracted the tissues concentration dependently ; the rank order of potency ( U 46619 > sulprostone > PGE 2 > PGF2alpha > PGD 2 = PGI 2 ) suggests the presence of TP and EP 1 and EP 3 receptors on the circular smooth muscle cells . . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| Prostanoids exert their biological actions through binding to eight specific membrane receptors ; the four subtypes EP 1 to EP 4 for PGE 2 ; DP for PGD 2 ; FP for PGF 2 ; IP for PGI 2 ; and TP for thromboxane A 2 . ^^^ |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34995 and P41222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Natural PGs and analogues that are selective for the FP ( PGF2a ) , DP ( PGD 2 ) , EP 1 ( sulprostone ) , EP 3 ( MB 28767 ) , and EP 4 ( 1 OH PGE 1 ) receptors were inactive or competed poorly with the binding of [ 3H ] PGE 2 ( < 50 % displacement of specific binding at 10 microM ) . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| In addition , the rank order of potency for prostaglandins in competition for [ 3H ] PGE 2 specific binding to membranes prepared from EP 1 cDNA transfected COS cells was PGE 2 > PGE 1 > PGF 2 alpha > PGD 2 . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Further studies involving selective agonists and antagonists suggested that EP 1 receptors , IP receptors and PGD 2 sensitive receptors may mediate prostanoid induced conjunctival itching . ^^^ Although the EP 1 receptor antagonist AH 6809 and the DP receptor antagonist BW A868C inhibited PGE 2 and PGD 2 induced itching , respectively , neither antagonist alone significantly affected the itching associated with experimental allergic conjunctivitis . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Since PGD 2 and 17 phenyl omega trinor PGE 2 ( EP 1 agonist ) did not suppress TNF alpha generation , the EP1 / EP2 / DP receptor antagonist , AH 6809 , was employed to assess if EP 2 receptors mediated the inhibitory effect of PGE 2 . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| PGE 2 induced increase on cyclic AMP levels was unaffected by AH 6809 , an antagonist at both PGD 2 ( DP ) and E 2 ( EP 1 ) receptors . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| PGE 2 > PGF 2 alpha > PGD 2 competed for [ 3H ] PGE 2 binding sites as did the EP 3 receptor agonists M & B 28767 = sulprostone > misoprostol but not the EP 1 receptor antagonist SC 19220 . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| PGF2alpha stimulated the release at concentrations higher than 1 microM , but PGD 2 ( up to 10 microM ) did not enhance it . 4 . 17 Phenyl omega trinor PGE 2 ( EP 1 > EP 3 ) and sulprostone ( EP 1 < EP 3 ) were as potent as PGE 2 , but PGE 1 was less potent , in stimulating NO release . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| A high degree of homology between the four Gs coupled prostaglandin ( PG ) receptors [ EP 2 , EP 4 , prostacyclin ( IP ) , PGD 2 ( DP ) ] and the four Gq / Gi coupled receptors [ EP 1 , EP 3 , PGF2alpha ( FP ) , thromboxane A 2 ( TP ) ] suggests that prostaglandin receptors evolved functionally from an ancestral EP receptor before the development of distinct binding epitopes . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Administration of nonselective COX inhibitor ibuprofen or COX 2 inhibitor nimesulide every 8 h for 24 h to newborn rats and pigs reduced prostaglandin levels and caused comparable reductions in nNOS mRNA , protein , and activity to levels of adults ; COX inhibitor induced changes were prevented by cotreatment with PGE 2 analog , 16 , 16 dimethyl PGE 2 , and agonist for the EP 3 receptor of PGE 2 , sulprostone , but not by PGI 2 analog carbaprostacyclin , PGD 2 , EP 1 receptor agonist 17 phenyl trinor PGE 2 , and EP 2 agonist butaprost . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Examination of prostanoid receptors using bath perfusions ( 1 microM PGE 2 and PGD 2 ) , specific agonists ( BW245C , sulprostone , and butaprost ) , and antagonists ( AH 6809 and SC 19220 ) found evidence for both the PGE 2 specific EP 2 and EP 3 receptors , but not for EP 1 or the PGD 2 specific prostanoid ( DP ) receptors . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| All prostanoid receptor agonists , except butaprost , contracted the tissues concentration dependently ; the rank order of potency ( U 46619 > sulprostone > PGE 2 > PGF2alpha > PGD 2 = PGI 2 ) suggests the presence of TP and EP 1 and EP 3 receptors on the circular smooth muscle cells . . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| Prostanoids exert their biological actions through binding to eight specific membrane receptors ; the four subtypes EP 1 to EP 4 for PGE 2 ; DP for PGD 2 ; FP for PGF 2 ; IP for PGI 2 ; and TP for thromboxane A 2 . ^^^ |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41222 and P34995 |
Pubmed |
SVM Score :0.0 |
| NA |
|