| Interacting proteins: P55089 and P41159 |
Pubmed |
SVM Score :0.0 |
| Relative to food restricted control animals , UCN in the PVN significantly increased plasma leptin and UCP 1 mRNA in brown adipose tissue and decreased UCP 3 mRNA in acromiotrapezius muscle , suggesting a role for PVN UCN in the regulation of energy balance . . ^^^ |
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| Interacting proteins: P55089 and P41159 |
Pubmed |
SVM Score :0.0 |
| UCN 1 barely enters the brain from blood unless its latent saturable influx system is activated by leptin or pretreatment with glucose . ^^^ However , neither leptin nor glucose affected the entry of intact UCN 2 . ^^^ Influx of CRH into brain was slower than UCN 2 but faster than UCN 1 ; it was inhibited by excess CRH but not by excess UCN 1 , 2 , 3 , or leptin . ^^^ |
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| Interacting proteins: P55089 and P41159 |
Pubmed |
SVM Score :0.0 |
| Combined peripheral administration of leptin and urocortin ( UCN ) significantly decreased food intake , whereas neither one showed an effect when given alone in the same doses . ^^^ We further provide a mechanism whereby this novel cooperativity can occur by demonstrating that UCN , which by itself does not cross the BBB , can readily enter the brain by associating with leptin . ^^^ |
|
| Interacting proteins: P55089 and P41159 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P41159 |
Pubmed |
SVM Score :0.0 |
| NA |
|