| Insulin like growth factor binding protein 4 , Miz 1 , leptin , prostaglandin D synthase , and granulin precursor were identified as proteins interacting with the N terminal half of mammalian Type 3 hexokinase ( HKIII ) in the yeast two hybrid method . ^^^ Cotransfection with leptin or Miz 1 resulted in distinctly different localization of the HKIII GFP fusion protein , at intracellular sites coincident with localization of leptin GFP or Miz 1 GFP reporter constructs . . ^^^ |