Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.77979936
For all subjects , leptin was independently associated with CRP after adjustment for age , gender , BMI , waist to hip ratio , smoking , and alcohol consumption ( F=12 . 39 , P=0 . 0007 ) . 0.77979936^^^ The association between leptin and CRP was significant even after adjustment for age , BMI , waist to hip ratio , smoking , and alcohol consumption in women ( F=7 . 13 , P=0 . 01 ) and men ( F=5 . 69 , P=0 . 02 ) . 0.52971976^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.52752053
Thus , our results suggest a potential mechanism contributing to leptin resistance , by which circulating CRP binds to leptin and attenuates its physiological functions . . 0.52752053^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In addition , serum leptin levels , C reactive protein ( CRP ) , body composition ( by dual energy 10 ray absorptiometry ) and ob gene expression ( by in situ hybridization histochemistry ) were determined in 15 patients with advanced CRF . ^^^ A negative correlation between serum leptin levels and ob gene expression ( r = 0 . 66 ; P < 0 . 05 ) was found in patients with CRP < 25 mg / liter . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Then we analyzed concentration of leptin receptor ( double sandwich ELISA , standard recombinant human leptin ) , leptin , glucose , insulin , proinsulin , CRP and uric acid in the serum . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Therefore , in the present study , we measured CRP concentration ( and leptin concentration as an index of fat mass ) in nine healthy subjects ( mean age 53+ / 8 . 1 years ; body mass index 27+ / 3 . 2 kg / m ( 2 ) ; mean arterial blood pressure 101+ / 9 . 0 mmHg ) undergoing measurement of basal endothelial nitric oxide ( NO ) synthesis using intra brachial infusions of N ( G ) monomethyl L arginine ( L NMMA ; a substrate inhibitor of endothelial NO synthase ) and noradrenaline ( a non specific control vasoconstrictor ) . ^^^ In univariate analysis , CRP concentration was correlated with ( 1 ) the percentage decrease in forearm blood flow ( FBF ) during L NMMA infusion ( r=0 . 85 , P=0 . 004 ) ; and ( 2 ) the serum leptin concentration ( r=0 . 65 , P=0 . 05 ) . ^^^ In multivariate analysis , the relationship between CRP concentration and the FBF response to L NMMA remained significant when age and leptin ( t=2 . 65 , P=0 . 045 ) , age and BMI ( t=3 . 69 , P=0 . 014 ) , or age and low density lipoprotein cholesterol plus high density lipoprotein cholesterol ( t=3 . 37 , P=0 . 044 ) , were included in regression models . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In this prospective study , serum leptin , C reactive protein ( CRP ) , plasma insulin , and body composition ( dual energy 10 ray absorptiometry ) were measured in 36 patients ( 53 + / 1 yr ) close to start and after about 1 yr of PD . ^^^ Patients that lost lean body mass during PD had higher initial CRP levels and increased their serum leptin levels significantly during PD compared to those patients that gained lean body mass . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The secondary endpoints were effects of treatment on cancer related anorexia / cachexia syndrome ( CACS ) symptoms , on serum levels of proinflammatory cytokines , IL 2 , C reactive protein ( CRP ) and leptin as well as the evaluation of quality of life ( QL ) . rIL 2 was administered at a dose of 1 . 8 MIU subcutaneously three times / week on alternate days for the first two weeks of every month and MPA was given orally at a dose of 500 mg once a day at alternate days without interruption . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum samples were obtained three times weekly for six weeks and then monthly from 29 chronic hemodialysis patients , and the levels of the positive acute phase proteins [ C reactive protein ( CRP ) , alpha 1 acid glycoprotein ( alpha 1 AG ) , serum amyloid A , ceruloplasmin ] and the negative acute phase proteins ( albumin and transferrin ) as well as leptin and interleukin 6 ( IL 6 ) were measured . ^^^ When CRP was elevated , leptin levels were significantly reduced , as were the negative acute phase proteins albumin and transferrin . ^^^ The change in leptin correlated negatively with the change in CRP ( R = 0 . 437 , P = 0 . 018 ) , as did changes in albumin ( R = 0 . 620 , P < 0 . 001 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Study parameters were bacterial growth , markers of systemic inflammation ( C reactive protein ( CRP ) and interleukin 6 ) , and parameters of nutritional status ( estimated dry weight , upper mid arm muscle circumference , serum albumin concentration , insulin like growth factor 1 , leptin , and protein catabolic rate ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In the male cirrhotic and control patients , log ( leptin ) levels correlated with CRP ( C reactive protein ) ( r=0 . 365 , P=0 . 0223 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
MEASUREMENTS : Plasma concentrations of leptin , the inflammatory parameter soluble TNF alpha receptors ( TNFR 55 and TNFR 75 ) , the acute phase proteins lipopolysaccharide binding protein ( LBP ) , serum amyloid A ( SAA ) , alpha acid glycoprotein ( AGP ) , C reactive protein ( CRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the anti inflammatory soluble Interleukin 1 decoy receptor ( sIL 1RII ) were measured . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum leptin levels in septic men correlate well with C reactive protein ( CRP ) and TNF alpha but not with BMI . ^^^ The regression coefficient was the highest for leptin and CRP ( r=0 . 48 , p < 0 . 05 ) , and for leptin and alpha 1 antitrypsin ( r=0 . 46 , p < 0 . 05 ) in the septic group . ^^^ The significant correlation between leptin and CRP and leptin and alpha 1 antitrypsin indicates that leptin can participate in APP synthesis regulation during a systemic inflammatory response . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In an urban clinic in Indonesia , plasma leptin concentrations , indicators of adipocyte mass , appetite , C reactive protein ( CRP ) , tuberculin reactivity , and cytokine response were measured in tuberculosis patients and healthy controls . ^^^ Multivariate regression analysis showed that body fat mass and inflammation were two independent factors determining plasma leptin concentrations ; there was a positive correlation between fat and leptin , whereas , unexpectedly , leptin was inversely associated with CRP and tumor necrosis factor alpha production . ^^^ Concentrations of both CRP and leptin were independently associated with loss of appetite . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
We further determined the serum levels of proinflammatory cytokines ( IL 6 and TNFalpha ) , IL 2 , leptin and C reactive protein ( CRP ) . ^^^ In conclusion , this is the first study that shows that several `` biological ' ' parameters of cancer patients such as antioxidant enzyme activity , cytokines , leptin and CRP strictly correlate with the most important clinical parameters of disease such as Stage and ECOG PS . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
CONCLUSIONS : These results ( a ) implicate leptin in basal thermoregulation ; ( b ) indicate that progestins have a significant influence on circulating IL 6 concentrations , and ( c ) are consistent with the concept that plasma CRP concentrations depend upon combined influences of progestins and bioavailable IL 6 . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
As secondary endpoints we measured the changes of lymphocyte absolute count , the serum levels of proinflammatory cytokines , IL 2 , C reactive protein ( CRP ) and leptin after treatment . rIL 2 was administered at a dose of 1 . 8 MIU subcutaneously 3 times / week on alternate days for the first two weeks of every month and MPA was given orally at a dose of 500 mg / day at alternate days without interruption . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In this study , we measured serum leptin levels ( s leptin ) by RIA kit in 20 healthy subjects ( 10 males and 10 females ) and 49 RA patients ( 14 males and 35 females ) and the markers for joint inflammation such as ESR and CRP . ^^^ However , there was no correlation between s leptin and the values of ESR or CRP , disease stages in RA patients . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Plasma leptin concentrations were correlated with fibrinogen ( r = 0 . 71 , p = 0 . 0001 ) and CRP ( r = 0 . 43 , p = 0 . 044 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
At baseline , we found a significant positive linear correlation ( p < 0 . 05 ) between TNF alpha and leptin ( r = 0 . 52 ) , TNF alpha and C reactive protein [ ( CRP ) r = 0 . 4 ] , CRP and leptin ( r = 0 . 49 ) , fibrinogen and CRP ( r = 0 . 78 , p < 0 . 01 ) , fibrinogen and leptin ( r = 0 . 37 ) , and leptin and body mass index [ ( BMI ) r = 0 . 67 ] . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
METHODS : We investigated whether higher levels of C reactive protein ( CRP ) and leptin were risk factors for progression of chronic kidney disease in the Modification of Diet in Renal Disease ( MDRD ) Study . ^^^ Frozen samples were assayed for high sensitivity C reactive protein ( CRP ) or leptin in 804 patients . ^^^ CRP and leptin were then evaluated as risk factors for glomerular filtration rate ( GFR ) decline using univariate and multivariable analyses . ^^^ RESULTS : At baseline , the mean ( median ) CRP in Study A ( GFR between 25 and 55 mL / min / 1 . 73 m 2 ) and Study B ( GFR between 13 and 24 mL / min / 1 . 73 m 2 ) were 0 . 48 ( 0 . 25 ) and 0 . 46 ( 0 . 20 ) mg / dL , respectively , while the mean ( median ) leptin in Study A and Study B were 15 . 2 ( 9 . 80 ) and 15 . 1 ( 7 . 80 ) ng / mL , respectively . ^^^ CONCLUSIONS : Higher serum levels of CRP and leptin are not independent risk factors for progression of non diabetic kidney disease . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Plasma levels of leptin , ACTH , cortisol , TNF alpha , IL 6 , C reactive protein ( CRP ) , and alpha 1 antitrypsin ( AAT ) were measured from 7 to +3 day related to surgery or 2nd day after a day when signs of sepsis were occurred . ^^^ Maximal levels of measured parameters were found 12 h after surgery ( for cortisol ) , 24 h after surgery ( for leptin , TNF alpha , IL 6 ) , or 36 h after operation ( for CRP and AAT ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
METHODS : Plasma levels of CRP , IL 10 , RANTES , TNF RI , leptin , ferritin and albumin were measured weekly for 12 weeks after the long inter dialytic interval by ELISA in ten stable HD patients with no clinical signs of infection . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
CaSc correlated with age ( R = 0 . 57 ; P < 0 . 0001 ) , body mass index ( R = 0 . 42 ; P < 0 . 005 ) , and serum leptin ( R = 0 . 3 ; P < 0 . 05 ) and CRP levels ( R = 0 . 38 ; P < 0 . 05 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Plasma leptin , testosterone or estradiol and CRP concentrations and body composition by dual energy 10 ray absorptiometry ( DEXA ) were assessed . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Compared with normal controls , LMNA mutation carriers had significantly higher plasma insulin and more dyslipidemia , higher mean triglycerides and lower HDL cholesterol , significantly higher nonesterified free fatty acids and CRP , and significantly lower leptin and adiponectin than controls . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Our objective was to determine serum leptin levels ( at admission and on the 15th day ) in 79 male alcohol misusers , hospitalized by somatic complications , who drink more than 80 g ethanol / day , and to analyse its relationships with nutritional status assessed by anthropometry and dual energy 10 ray absortiometry ( DEXA ) , insulin like growth factor ( IGF 1 ) and its binding protein ( IGF1BP 3 ) ; acute phase reaction assessed by C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) and type 2 soluble receptor of tumour necrosis factor ( TNF ) ( sTNFRII ) ; serum oestradiol and testosterone ; and the amount and duration of ethanol intake , the smoking habit and the presence of liver cirrhosis . ^^^ After 15 days of hospitalization , serum leptin did not increase , in contrast with LDL cholesterol , serum albumin , prealbumin , IGF 1 , IGF1BP 3 and testosterone which increased , whereas oestradiol and acute phase reactants , such as CRP , IL 6 and sTNFRII , were decreased . ^^^ CONCLUSIONS : Serum leptin levels are related to many factors , e . g . fat mass , age , smoking , serum testosterone and oestradiol levels , growth factors such as IGF 1 and CRP , and cytokines , such as IL 6 and sTNFRII . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Albumin , fibrinogen , C reactive protein ( CRP ) , interleukin 6 , sTNFR 1 , sTNFR 2 , and leptin levels were measured in serum and plasma samples . ^^^ TNFalpha and leptin adipose tissue expression were higher in the upper tertile of CRP . ^^^ DISCUSSION : These results are in agreement with the hypothesis that the synthesis of adipose tissue TNFalpha and leptin could induce the production of interleukin 6 , CRP , and other acute phase reactants , thus contributing to the maintenance of chronic low grade inflammation state involved in the progression of obesity and its associated comorbidities . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In the first part of the study , we compared circulating concentrations of free and total leptin , percent fat mass , and the inflammatory markers C reactive protein ( CRP ) and interleukin 6 ( IL 6 ) , together with appetite score , in age and gender matched healthy controls ( n = 11 ) and advanced gastrointestinal cancer patients ( n = 26 ) . ^^^ In cancer patients , circulating leptin concentrations , either free or total , were not correlated with IL 6 or CRP concentrations . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
DESIGN AND METHODS : We measured high sensitivity C reactive protein ( hs CRP ) , as an inflammatory marker , and adiponectin and leptin concentrations in 384 nondiabetic Japanese women ( mean+ / s . e . m . age 53 . 6+ / 0 . 8 Years , body mass index ( BMI ) 23 . 0+ / 0 . 2 kg / m ( 2 ) ) undergoing measurement of markers of metabolic syndrome 10 . ^^^ RESULTS : The women who had a low grade hs CRP elevation ( > 2 . 0 mg / l ) were significantly older and had higher BMI , body fat mass ( BFM ) , total cholesterol ( TC ) , triglyceride ( TG ) , atherogenic index ( AI= ( TC HDLC ) / HDLC ) , where HDLC is high density lipoproten cholesterol ) , fasting blood glucose and leptin concentrations before and after adjustment for BMI or BFM , while lower HDLC and adiponectin concentrations before and after adjustment compared with women with normal CRP levels ( < 0 . 5 mg / l ) . ^^^ BMI , BFM , TG , AI and leptin before and after adjustment were found to be correlated with hs CRP levels , while HDLC and adiponectin before and after adjustment were inversely correlated ( all P < 0 . 0001 ) . hs CRP was independently associated with white blood cell count , blood urea nitrogen and AI and inversely with adiponectin / BFM in the stepwise regression analysis model . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
OBJECTIVE : This study was undertaken to evaluate to what extent C reactive protein ( CRP ) can be reduced by exercise by examining its circulating concentrations in male ultramarathon runners and to determine if low leptin as a robust circulating marker of fat mass could account for low CRP in such men . ^^^ CRP and leptin were measured by ELISA and radioimmunoassay , respectively . ^^^ Furthermore , leptin adjustment only minimally attenuated the case control difference in CRP , suggesting that mechanisms other than fat mass reduction contribute to low concentrations of CRP in marathon runners . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The principal aim of this study was to evaluate serum leptin concentrations and to analyze the interaction between serum leptin levels and C reactive protein ( CRP ) levels , hematological parameters before and after antimicrobial therapy in neonates with bacterial septicemia . ^^^ The mean concentration of serum leptin , CRP levels , and immature / total neutrophil ( IT ) ratio in newborns with septicemia were significantly higher than those of controls at the start . ^^^ Although there were positive correlations between serum leptin levels and serum CRP levels and IT ratio in the septicemic group at the start , there were no correlations between serum leptin levels and other hematological parameters . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Plasma levels were monitored for leptin , proinflammatory cytokines ( interleukin ( IL ) 1 beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) ) , stress related parameters ( adrenocorticotropic hormone ( ACTH ) , cortisol , and C reactive protein ( CRP ) ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The changes in glycolipid metabolism as well as plasma high sensitivity C reactive protein ( CRP ) , leptin , adiponectin , and pulse wave velocity ( PWV ) were monitored to analyze the relationship between the antiatherogenic and antidiabetic effects of pioglitazone . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Although CRP was positively correlated with body mass index ( BMI ) , percent fat mass , and serum leptin , correlations with BMI ( r = 0 . 15 , P = . 05 ) and percent body fat ( r = 0 . 16 , P = . 003 ) were not as strong as the correlation with leptin ( r = 0 . 28 , P = . 0002 ) . ^^^ Multiple regression analysis indicated that serum CRP was positively related to serum leptin ( P = . 003 ) and QTc interval ( P = . 01 ) , and negatively correlated with HDL cholesterol ( P = . 01 , R ( 2 ) = 0 . 15 ) . ^^^ In young , apparently healthy men , serum leptin but not BMI was independently associated with serum CRP , suggesting that amount of body fat may be the most significant predictor of CRP . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The present study was conducted to assess the relationship between obesity and serum levels of C reactive protein ( CRP ) , carotenoids , oxidized LDL ( oxLDL ) , oxidized LDL antibodies ( oLAB ) , and leptin in Japanese residents . ^^^ Serum levels of CRP , oxLDL , oLAB , and leptin were measured by enzyme linked immunosorbent assay ( ELISA ) and serum carotenoid levels were measured by high performance liquid chromatography ( HPLC ) . ^^^ Serum levels of CRP and leptin were significantly higher in the obese group than in their non obese counterparts in both genders . ^^^ BMI was positively correlated with log transformed serum levels of CRP and leptin in both genders ( males : r=0 . 231 , p < 0 . 05 ; females : r=0 . 305 , p < 0 . 001 ) . ^^^ Significantly higher odds ratios ( ORs ) for high serum levels of CRP ( males : OR=2 . 12 ; females : OR=3 . 96 ) and leptin ( males : OR=3 . 83 ; females : OR=9 . 07 ) were observed in obese versus non obese men and women , after adjusting for various confounding factors . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
As secondary endpoints , we measured the changes of lymphocyte count , serum levels of proinflammatory cytokines , IL 2 , C reactive protein ( CRP ) and leptin , blood levels of reactive oxygen species ( ROS ) and antioxidant enzymes ( glutathione peroxidase , GPx and superoxide dismertase , SOD ) . ^^^ As for laboratory parameters , absolute lymphocyte count increased significantly , IL 6 , IL 1 beta , tumor necrosis factor alpha , CRP , and fibrinogen decreased significantly whereas IL 2 and leptin increased significantly after treatment . ^^^ Patients alive at study end showed a significant increase in absolute lymphocyte count , IL 2 , leptin , and GPx and a significant decrease of proinflammatory cytokines , CRP , fibrinogen , and ROS , whereas patients who died before study end exhibited only a significant increase in absolute lymphocyte count , IL 2 , and GPx and a significant decrease of ROS . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The routine methods ( albumin , CRP , cholinesterase , haptoglobin , cholesterol ) , special methods ( SOD , glutathion ) and ELISA methods ( leptin , IL 2r , IL 8 , TNF ) were used for evaluation markers . ^^^ CONCLUSIONS : The serum leptin , albumin , haptoglobin , CRP concentrations demonstrated serious dynamics perioperatively . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
A multiple linear regression analysis , performed to quantify further the relationship between leptin levels and the above mentioned variables as well as the inflammatory marker C reactive protein ( CRP ) and including age , body mass index ( BMI ) , waist hip ratio ( WHR ) and lipid parameters as potential confounders , revealed that only FVIIa and VWF were independently related to leptin levels . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In all persons under this study the following parameters were determined in peripheral venous blood : adiponectin , resistin , leptin , ObRe , cholesterol , HDL cholesterol , triacylglycerols , glucose , HbA1c , creatinine , urea , ALT , AST , CRP , homocysteine , thrombocyte aggregation after CPG induction . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum glucose , insulin , lipid profile , C reactive protein ( CRP ) , resistin , leptin , and adiponectin were measured before and after weight loss on a fasting sample . ^^^ There was a decrease in serum resistin , leptin , and CRP levels , and a rise in serum adiponectin ( P < . 05 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
C reactive protein ( CRP ) , erythrocyte sedimentation rate ( ESR ) , interleukin 6 ( IL 6 ) , insulin like growth factor ( IGF 1 ) , IGF binding protein ( IGFBP 3 ) , and leptin were measured at each visit . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Serum leptin and C reactive protein ( CRP ) were measured in samples from 798 participants of the Modification of Diet in Renal Disease Study . ^^^ Multivariable analysis was used to evaluate the independent effects of kidney function and CRP on leptin levels . ^^^ Female gender , higher percent body fat , higher insulin levels , older age , lower GFR and higher CRP were associated with higher serum leptin levels and explained 51 % of the variability in the logarithm of serum leptin levels . ^^^ CONCLUSIONS : Level of kidney function and CRP are associated with serum leptin in patients with reduced GFR . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
METHODS : Serum leptin , vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( b FGF ) , interleukin 1 beta ( IL 1beta ) , beta 2 microglobulin ( beta2M ) and C reactive protein ( CRP ) were measured in 62 newly diagnosed MM patients , 22 of whom obtaining disease stabilization after treatment . ^^^ VEGF , b FGF , IL 1beta , beta2M , CRP but not leptin increased with advancing stage of disease ( p < 0 . 01 ) . ^^^ Although IL 1beta correlated positively with VEGF , beta2M , b FGF and CRP , leptin did not correlate with any of the measured parameters . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum leptin , albumin , transferrin , and C reactive protein ( CRP ) were measured at KTx , 15 days , 3 , and 6 months later . ^^^ Leptin correlated positively with CRP at KTx , but not after normalization of renal function . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
After adjusting for other risk factors ( age , gender , blood pressure , lipid levels , insulin resistance , leptin , fibrinogen , C reactive protein ( CRP ) , CAD severity on angiography , smoking status , and a history of myocardial infarction or hypertension ) , BMI had a significant independent association with an acute coronary syndrome , with an odds ratio of 1 . 49 ( P=0 . 014 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Studied parameters included AGE ( fluorescence , CML carboxymethyllysine and pentosidine ) , lipids , glucose , albumin , leptin , prealbumin , C reactive protein ( CRP ) and pregnancy associated plasma protein A ( PAPP A ) . ^^^ In alcoholics , AGE correlate significantly negatively with leptin ( r = 0 . 46 , P < 0 . 05 ) and pentosidine with prealbumin ( r = 0 . 43 , P < 0 . 05 ) , otherwise there was no relationship between AGE and other biochemical parameters ( glucose , cholesterol , albumin , CRP , PAPP A ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
RESEARCH DESIGN AND METHODS : Insulin sensitivity ( through a frequently sampled intravenous glucose tolerance test ) and plasma concentrations of ultrasensitive C reactive protein ( CRP ) , adiponectin , plasminogen activator inhibitor ( PAI ) 1 , tumor necrosis factor alpha , leptin , and interleukin 6 were measured in 89 pGDM ( BMI 26 . 9 + / 0 . 5 kg / m ( 2 ) , age 32 + / 0 . 5 years ) and in 19 women with normal glucose tolerance during pregnancy ( NGT ) ( 23 . 7 + / 0 . 9 kg / m ( 2 ) , 31 + / 1 . 3 years ) . ^^^ RESULTS : pGDM showed lower ( P < 0 . 0001 ) plasma adiponectin ( 6 . 7 + / 0 . 2 microg / ml ) than NGT ( 9 . 8 + / 0 . 6 microg / ml ) and a decreased ( P < 0 . 003 ) insulin sensitivity index ( S ( 1 ) ) and disposition index ( P < 0 . 03 ) , but increased plasma leptin ( P < 0 . 003 ) , PAI 1 ( P < 0 . 002 ) , and CRP ( P < 0 . 03 ) . ^^^ After adjustment for body fat mass , plasma adiponectin remained lower in pGDM ( P < 0 . 004 ) and correlated positively with S ( 1 ) ( P < 0 . 003 ) and HDL cholesterol ( P < 0 . 0001 ) but negatively with plasma glucose ( 2 h oral glucose tolerance test [ OGTT ] ) ( P < 0 . 0001 ) , leptin ( P < 0 . 01 ) , CRP ( P < 0 . 007 ) , and PAI 1 ( P < 0 . 0001 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Leptin remained associated with CAC after further controlling for body mass index ( BMI ) [ 1 . 29 ( 1 . 07 1 . 55 ) ; P = 0 . 008 ] , waist circumference [ 1 . 30 ( 1 . 09 1 . 57 ) ; P = 0 . 003 ] , C reactive protein ( CRP ) levels [ 1 . 28 ( 1 . 07 1 . 55 ) ; P = 0 . 008 ] , and subclinical vascular disease [ 1 . 30 ( 1 . 08 1 . 57 ) ; P = 0 . 006 ] . ^^^ Addition of BMI ( P = 0 . 97 ) , waist ( P = 0 . 55 ) , or CRP ( P = 0 . 39 ) to a model with leptin failed to improve the model ' s explanatory power , whereas addition of leptin to a model with BMI ( P = 0 . 029 ) , waist ( P = 0 . 006 ) , or CRP ( P = 0 . 005 ) improved the model significantly . ^^^ Plasma leptin levels were associated with CAC in type 2 diabetes after controlling adiposity and CRP . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum leptin , tumour necrosis factor ( TNF ) alpha interleukin ( IL ) 1 beta , interleukin ( IL ) 6 , growth hormone , insulin , glucose , triglyceride , total protein , albumin , erythrocyte sedimentation rate , and CRP were measured . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Serum high sensitivity C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , leptin and adiponectin levels were determined as well as other metabolic variables . ^^^ Serum leptin levels were directly related to CRP levels while adiponectin levels were inversely related to CRP levels . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Fasting blood was drawn to determine insulin , leptin , adiponectin and C reactive protein ( CRP ) levels . ^^^ Serum leptin was above normal ( 10 . 4+ / 10 . 7 microg / l ) , whereas serum insulin and CRP were within their normal ranges ( 3 . 5+ / 3 . 3 microU / ml and 2 . 6+ / 5 . 0 mg / l , respectively ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In 312 subjects , serum Hp was correlated directly with body mass index ( BMI ) , leptin , C reactive protein ( CRP ) , and age . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Neither leptin nor adiponectin were associated with CRP in a cross sectional analysis , but they were linked in an opposite fashion to CRP in a longitudinal study in 21 patients with acute inflammation secondary to infection . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Leptin , total tumour necrosis factor ( TNF ) alpha , and C reactive protein ( CRP ) were analyzed in induced sputum supernatant by ELISA . ^^^ A significant relationship was found between sputum leptin and CRP ( r = 0 . 943 , P < 0 . 001 ) and total TNF alpha ( r = 0 . 690 , P < 0 . 01 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Patients without progression showed no calcifications at baseline and follow up and were younger , less overweight , and characterized by significantly lower mean TNF alpha , leptin , and CRP levels during 1 year compared with both progressors and regressors . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In all patients we evaluated the Pediatric Risk of Mortality ( PRISM ) , the Glasgow Scale for Meningococcal Sepsis ( GSMS ) , polymorphonuclear ( PMN ) count and prolactin ( PRL ) , leptin ( LPT ) and C reactive protein ( CRP ) levels . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
CONCLUSIONS : In patients with angiographically confirmed coronary atherosclerosis , leptin is a novel predictor of future cardiovascular events independent of other risk factors , including lipid status and CRP . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In multiple regression analysis only SHBG ( P = . 01 ) and triglycerides ( P = . 0036 ) were associated with insulin sensitivity independently of body mass index ( BMI ) , weight gain , HDL ( 2 ) cholesterol , CRP , TNFalpha , and TNFalpha RII , IL 6 , and leptin . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Although mean adiponectin was higher in subjects classified as non obese compared to obese , adiponectin , in sharp contrast to leptin ( previously reported data ) and to CRP , varied markedly when expressed as a function of adiposity . ^^^ The relationship between CRP ( like leptin ) and gender depends on how CRP is expressed relative to adiposity . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
AIMS : The aim of this study was to evaluate the relationship of obesity , leptin , insulin resistance and C reactive protein ( CRP ) with coronary heart disease ( CHD ) risk factors in patients with Type 2 diabetes mellitus ( DM ) with CHD compared with those with Type 2 DM without CHD . ^^^ METHODS : Leptin , CRP ( high sensitivity assay ) , fasting plasma insulin , glucose , HbA ( 1c ) and full lipid profile were determined in 58 Type 2 diabetic patients with CHD and 87 Type 2 DM patients without CHD . ^^^ RESULTS : Leptin showed significant correlations with BMI ( r = 0 . 59 ; P < or = 0 . 0001 ) , waist circumference ( r = 0 . 45 ; P < 0 . 0001 ) , CRP ( r = 0 . 36 ; P < 0 . 0001 ) , and fasting insulin ( r = 0 . 53 ; P < 0 . 0001 ) as well as with systolic ( r = 0 . 23 ; P = 0 . 007 ) and diastolic ( r = 0 . 23 ; P = 0 . 007 ) blood pressure . ^^^ Leptin ( P = 0 . 49 ) , CRP ( P = 0 . 19 ) and lipid parameters were not significantly different between the two groups . ^^^ CONCLUSION : Our study confirms a relationship between leptin and CRP with CHD risk factors . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The main outcome measures were markers of the metabolic syndrome , including the adipokines IL 6 and leptin , and C reactive protein ( CRP ) . ^^^ We conclude that women with TS have various physical and biochemical features suggestive of the metabolic / insulin resistance syndrome , but there is a discrepancy among CRP , IL 6 , and leptin , with leptin and fasting insulin concentrations being lower than expected for the degree of obesity . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
METHODS : Leptin , IL 6 and CRP were measured ( at baseline and after 2 weeks of treatment ) in the blood of 31 patients with RA starting either anti TNF treatment or placebo , and in 18 healthy controls . ^^^ RESULTS : In patients with RA , plasma leptin concentrations at baseline correlated inversely with the degree of inflammation as assessed by C reactive protein ( CRP ; r ( s ) ( 2 ) = 0 . 21 , p < 0 . 01 ) or interleukin ( IL ) 6 concentrations ( r ( s ) ( 2 ) = 0 . 22 , p < 0 . 008 ) . ^^^ Short course anti TNF treatment for 2 weeks did not modify leptin concentrations , despite significant reduction of CRP and IL 6 . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In 91 patients with epithelial ovarian cancer and 95 healthy women matched for age , weight , and height , levels of Hb , C reactive protein ( CRP ) , fibrinogen ( Fbg ) , proinflammatory cytokines , leptin , reactive oxygen species ( ROS ) , and antioxidant enzymes were assessed at diagnosis before treatment . ^^^ Hb negatively correlated with CRP , Fbg , interleukin 1beta ( IL 1beta ) , IL 6 , tumor necrosis factor alpha ( TNFalpha ) , and ROS , and positively correlated with leptin and glutathione peroxidase ( GPx ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the concentration levels of C reactive protein ( CRP ) , leptin and adiponectin in obese pre pubertal children , and their possible relation with metabolic syndrome , fibrinogen and plasminogen activator inhibitor 1 . ^^^ Serum CRP , leptin , adiponectin , glucose , insulin , lipid profile , plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen were all measured . ^^^ RESULTS : The levels of CRP serum ( 1 . 67+ / 0 . 222 vs 0 . 92+ / 0 . 16 mg / l ) and leptin ( 15 . 56+ / 1 . 27 vs 4 . 68+ / 0 . 62 ng / ml ) were significantly higher in obese children . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Fasting blood ( 50 ml ) was obtained , and the following parameters were assayed : high sensitivity CRP , fibrinogen , lipid profile , insulin , whole blood cytokines after stimulation with lipopolysaccharide ( LPS ; 100 ng / ml for 24 h ) , soluble cell adhesion molecules , plasminogen activator inhibitor 1 , CD 40 , CD 40 ligand , leptin , adiponectin , monocyte chemoattractant protein 1 , IL 8 , matrix metalloproteinase 3 ( MMP 3 ) , and MMP 9 . ^^^ High CRP subjects were older and had significantly higher body mass indexes , triglycerides , insulin , homeostasis model assessment , and leptin levels compared with low CRP subjects . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Leptin is associated with arterial wall thickness , decreased vessel distensibility , and elevated C reactive protein ( CRP ) levels . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
We measured plasma insulin , adipokines ( leptin , adiponectin , resistin , tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 6 ) , soluble leptin receptor ( sOb R ) , the main leptin binding protein , and C reactive protein ( CRP ) . ^^^ RESULTS : The cases showed a 48 % increase in insulin concentrations and a 27 % increase in TNF alpha concentrations compared to the controls ( both P < . 0001 ) , but leptin , sOb R , IL 6 , and adiponectin , as well as CRP , concentrations were comparable between cases and controls . ^^^ In the whole group ( n = 219 ) , BMI was correlated with insulin , leptin , IL 6 , and CRP , and inversely with sOb R and adiponectin concentrations ( all P < . 0003 ) . ^^^ CONCLUSIONS : Plasma leptin , sOb R , IL 6 , and adiponectin , as well as CRP , are strongly related to BMI in gravidas at 24 29 weeks gestational age but not to the glucose loading response . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Both associations between the inflammatory mediators as CRP , fibrinogen , alpha 1 glycoproteins , leptin , TNFalpha , PAI 1 and the metabolic syndrome variables , chiefly obesity , seem to suggest that both atherosclerosis and insulin resistance are the results of chronic activation of the nonspecific ( innate ) immune system . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The placental protein accumulation capacity of hCG , hPL , leptin and CRP was compared with the dual in vitro perfusion method of an isolated cotyledon of human term placentae and quantified by ELISA . ^^^ In vitro , the total accumulation rates ( mean+ / SD ) were 31+ / 13 ( mU / g / min , hCG ) , 1 . 16+ / 0 . 19 ( microg / g / min , hPL ) , 4 . 71+ / 1 . 91 ( ng / g / min , CRP ) , and 259+ / 118 ( pg / g / min , leptin ) . mRNA for hCG , hPL and leptin was detectable using conventional RT PCR , while CRP mRNA could only be demonstrated by applying real time RT PCR . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
STUDY DESIGN : In 50 obese children ( age 7 to 14 years ) with ( n = 20 , group 1 ) or without ( n = 30 , group 2 ) hypertransaminasemia and ultrasonographic liver brightness , we studied insulin resistance ( fasting glucose / insulin ratio [ FGIR ] ) and serum levels of leptin , iron , transferrin , ferritin , C reactive protein ( CRP ) , white blood cell ( WBC ) count , tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 6 , C282Y and H63D mutations , and erythrocytic glutathione peroxidase ( GPX ) activity . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Leptin administration increased CRP ( 6 . 3 + / 2 . 4 vs . 0 . 7 + / 0 . 3 mg / liter ; P = 0 . 04 ) , circulating P selectin ( 11 . 6 + / 10 . 2 vs . 28 . 9 + / 15 . 6 ng / ml ; P = 0 . 04 ) , and induction of platelet aggregation ( 5 . 8 + / 2 . 6 vs . 2 . 7 + / 2 . 9 % , P = 0 . 04 , percent maximum platelet aggregation ) relative to placebo administration ( change in leptin vs . change in placebo , respectively , for each variable ) . ^^^ Leptin tended to increase serum amyloid A [ 0 . 1 + / 0 . 2 vs . 0 . 3 + / 0 . 1 log 10 ( ng / ml ) ; P = 0 . 07 ] , and the changes in serum amyloid A and CRP were highly correlated ( r = 0 . 83 ; P < 0 . 0001 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Do adiponectin , TNFalpha , leptin and CRP relate to insulin resistance in pregnancy . ^^^ Adiponectin , TNFalpha , leptin and high sensitivity CRP ( hsCRP ) were measured in fasted blood . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
It has been hypothesized that the hormone leptin , released by fat cells , may stimulate CRP production independent of cytokines . ^^^ This study measured circulating leptin , CRP , interleukin 6 , tumor necrosis factor alpha , interleukin 1beta , and interleukin 8 in 946 community dwelling older subjects ( 398 men , 548 women ; age range 65 to 102 years ) enrolled in a large population based study . ^^^ A direct association was found between leptin and CRP ( p = 0 . 004 ) , independent of cytokines and other possible confounders . ^^^ In conclusion , these findings suggest that leptin may directly stimulate the production of CRP independent of fat cell produced cytokines in older adults . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In this study , we aimed to investigate the diagnostic and prognostic roles and the effects of chemotherapy of serum proinflammatory cytokines consisting of IL 6 , TNF alpha , CRP , and leptin levels in patients with advanced stage non small cell lung cancer . ^^^ Higher serum TNF alpha ( p < 0 . 001 ) and CRP ( p < 0 . 001 ) , and lower leptin ( p = 0 . 021 ) levels in patients than in controls . ^^^ Likewise , serum levels of leptin , IL 6 , TNF alpha , and CRP were all similar in lung cancer patients independently from severity of weight loss ( p > 0 . 05 ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
RESULTS : Insulin resistance ( expressed in the homeostasis model assessment ) , leptin , and CRP were inversely correlated with leukocyte TRFL in premenopausal but not postmenopausal women . ^^^ Insulin resistance , CRP , but not leptin independently accounted for variation in white blood cell TRFL in premenopausal women . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Body height and weight , blood pressure , fasting serum total cholesterol ( TC ) , triacyl glycerol ( TG ) , HDL cholesterol ( HDLc ) , fasting blood sugar ( FBS ) , total fatty acid composition , leptin , and high sensitivity C reactive protein ( CRP ) were measured in 31 men ( age , 41 78 years ) and 11 women ( age , 54 77 years ) . ^^^ The relationships between serum USFA , and body mass index ( BMI ) , leptin , systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP ) , TC , TG , HDLc , FBS , and CRP were analyzed using multiple regression analysis . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Circulating resistin , CRP , adiponectin and leptin levels were determined to assess inflammation . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Plasma levels of ghrelin ( RIA ) , leptin , TNF alpha , IL 1beta , sIL 2R , IL 6 ( ELISA analysis ) , CRP and alpha 1 antitrypsin ( nephelometric analysis ) were analyzed . ^^^ In regard to leptin , the regression coefficient was the highest for IL 6 and leptin ( r=0 . 53 , p < 0 . 05 ) and for leptin and CRP ( r=0 . 51 , p < 0 . 05 ) . ^^^ CONCLUSIONS : During postoperative intra abdominal sepsis , both ghrelin and leptin plasma levels are elevated and positively correlate with both inflammatory cytokines ( TNF alpha , IL 6 ) and main APP member ( CRP ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The aim of the present study was to explore the relationship between tissue levels of leptin , soluble interleukin 6 receptor ( sIL 6R ) , high sensitive C reactive protein ( hs CRP ) and soluble vascular cell adhesion molecule 1 ( sVCAM 1 ) in atherosclerotic plaques , and traditional risk factors . ^^^ The mean tissue levels of leptin , hs CRP and sIL 6R were significantly higher in patients with diabetes mellitus than without diabetes mellitus . ^^^ When patients were classified according to the smoking status , the mean tissue levels of leptin , hs CRP and sIL 6R were significantly higher in current smokers than both former smokers and non smokers . ^^^ There was a positive association between leptin and hs CRP , sIL 6R and plasma glucose in all patients . ^^^ Tissue levels of sIL 6R were associated significantly in a positive manner with leptin , hs CRP and plasma glucose , while tissue levels of hs CRP were associated with both leptin and sIL 6R . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The inflammatory factors such as CRP and leptin may be involved in the pathogenesis of obesity . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
In conclusion , serum ALT levels were associated with leptin and CRP as well as many components of the insulin resistance syndrome in young healthy men . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
METHODS : Serum samples in 47 patients with histologically verified NAFLD ( 22 with simple steatosis and 25 with nonalcoholic steatohepatitis [ NASH ] ) , and in 30 age , sex and ethnicity matched healthy controls , were assessed for ( 1 ) general markers of inflammation ( C reactive protein [ CRP ] , tumor necrosis factor [ TNF ] alpha , and interleukin [ IL ] 6 ) , ( 2 ) chemokines ( CC chemokine ligand [ CCL ] 2 / monocyte chemoattractant protein [ MCP ] 1 , CCL 19 and CCL 21 ) , ( 3 ) adipocytokines related to insulin resistance and inflammation ( adiponectin and leptin ) and ( 4 ) a marker of oxidative stress ( 8 isoprostane F2alpha ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
OBJECTIVE : To examine lifestyle factors associated with metabolic syndrome ( MetS ) and to explore the relationships between MetS and non traditional cardiovascular disease risk factors [ adiponectin , leptin , C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , and serum amyloid A ( SAA ) ] in an isolated Aboriginal Canadian community . ^^^ Fasting samples were drawn for glucose , insulin , lipids , adiponectin , leptin , CRP , IL 6 , and SAA . ^^^ Subjects with MetS had significantly higher leptin , CRP , IL 6 , and SAA levels and lower adiponectin levels ; however , only adiponectin remained significantly low after adjustment for age and percentage body fat . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Parameters were measured using the following : a ) Plasma glucose by glucose oxidase method b ) CRP by immunoturbidimetric method ( Roche / Hitachi analyser ) c ) insulin by Medgenix INS ELISA immunoenzymetric assay by Biosource ( Belgium ) d ) Leptin , Adiponectin by radioimmunoassay kits by Linco Research ( St . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Adiponectin , leptin , ghrelin , interleukin 6 ( IL 6 ) , C reactive protein ( CRP ) , and Adult Treatment Panel 3 defined metabolic syndrome components were measured in fasting blood samples obtained in 1984 1987 . ^^^ The association between the metabolic syndrome and CHD mortality was not materially changed after adjustment for adiponectin , leptin , and ghrelin ; it was attenuated by 25 % after adjustment for IL 6 and 35 % after adjustment for CRP . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Compared with non obese subjects ( mean + / SD ) , obese patients had higher concentrations of fibrinogen ( 312 + / 78 vs . 342 + / 81 mg / dl , P < 0 . 001 ) , CRP ( 0 . 41 + / 0 . 75 vs . 0 . 75 + / 1 . 04 mg / l , P = 0 . 014 ) , vWF ( 107 + / 29 vs . 123 + / 55 % , P < 0 . 001 ) , and leptin ( 10 . 4 + / 6 . 5 vs . 37 . 5 + / 26 . 1 ng / ml , P < 0 . 0001 ) . ^^^ In conclusion , the obesity associated increase in the circulating concentrations of fibrinogen , CRP , and vWF is highly associated to BF and apparently not determined by leptin . . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
The aim of the study was to investigate the inflammatory markers C reactive protein ( CRP ) and leptin in the serum of healthy , normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis . ^^^ DESIGN : Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle . ^^^ Serum concentrations of leptin and CRP , as well as of follicle stimulating hormone , luteinising hormone , 17beta oestradiol , progesterone , prolactin ( PRL ) and free testosterone were measured every 1 2 days during one full cycle . ^^^ RESULTS : Serum levels of leptin and CRP behaved differently during ovulatory cycles , with higher concentrations for leptin only during certain phases . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Insulin sensitivity ( assessed by homeostasis model assessment 2 modeling ) , androgen , and HDL cholesterol levels were significantly decreased , whereas total fat mass and LDL cholesterol , triglyceride , CRP , leptin , and fructosamine levels were significantly increased in untreated Klinefelter ' s syndrome patients . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Weight , leptin , adiponectin , TNF alpha , CRP , and insulin were measured at 0 , 6 , and 36 months ( 24 months post counseling ) . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of the study was to determine whether dietary fat or antioxidant intakes influence circulating tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) , C reactive protein ( CRP ) , and leptin concentrations in overweight children . ^^^ Fasting blood samples were collected for the measurement of insulin , glucose , HDL cholesterol , triacylglycerol , CRP , IL 6 , TNF alpha , and leptin concentrations . ^^^ RESULTS : CRP , IL 6 , and leptin increased significantly ( P < 0 . 02 ) with increasing adiposity , independent of age ; TNF alpha did not increase . ^^^ Intakes of antioxidant vitamins ( vitamins E and C and beta carotene ) were significant predictors of leptin ( P < 0 . 05 ) but not of CRP , IL 6 , or TNF alpha . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Exclusion criteria were : 1 . laboratory signs of infection ( increasing OB , increasing CRP , increasing alpha 2 globulin ) ; 2 . clinical symptoms of infection in the respiratory tract , the alimentary tract or in the urinary tract . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
Clinical symptoms and inflammatory indicators such as CRP , OB , pulse , and body temperature were taken into consideration by designation of intensity of main disease . ^^^
Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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Interacting proteins: P41159 and P02741	Pubmed	SVM Score :0.0
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