| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| The levels of plasminogen activators ( uPA and tPA ) and their inhibitors ( PNI and PAI 1 ) were determined by fibrin zymography , ELISA , amidolytic activity assay , complex formation , and Western blot analysis . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| The serpins we analyzed were protease nexin 1 ( PNI ) , PA inhibitor 1 ( PAI 1 , and the kallikrein binding protein ( KBP ) . uPA nearly doubled 48 h after injury , while there was no change in amidolytic activity after addition of fibrin monomer as an estimation of tPA activity . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| Protease Nexin 1 ( PN 1 ) also known as Glia Derived Nexin ( GDN ) inhibits the activity of several serine proteases including thrombin , tissue ( tPA ) and urokinase ( uPA ) type plasminogen activators . ^^^ In the embryonic spinal cord , PN 1 expression occurs in cells lining the neural canal that are different from the cells previously shown to express tPA . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| The abundance of mRNA encoding PN 1 , tissue type PA ( tPA ) , urokinase ( uPA ) and PA inhibitor 1 ( PAI 1 ) were initially upregulated by human chorionic gonadotropin ( hCG ) in bovine preovulatory follicular wall homogenates . ^^^ PN 1 , PAI 1 and tPA mRNA expression then decreased near the expected time of ovulation , whereas uPA mRNA levels remained high . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| The tissue type plasminogen activator ( t PA ) is a serine protease that is involved in neuronal plasticity and cell death induced by excitotoxins and ischemia in the brain . t PA activity in the central nervous system is regulated through the activation of serine protease inhibitors ( serpins ) such as the plasminogen activator inhibitor ( PAI 1 ) , the protease nexin 1 ( PN 1 ) , and neuroserpin ( NSP ) . ^^^ To investigate whether serpins may be involved in neuronal cell death after cerebral ischemia , we determined , by using semiquantitative RT PCR and in situ hybridization , that focal cerebral ischemia in mice induced a dramatic overexpression of PAI 1 without any effect on PN 1 , NSP , or t PA . ^^^ Then we showed that although the expression of PAI 1 is restricted to astrocytes , PN 1 , NSP , and t PA are expressed in both neurons and astrocytes . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| Using ( 32 ) P labeled riboprobes and Northern blots the expression of mRNA for u PA , t PA and the inhibitor protease nexin 1 ( PN 1 ) has been studied in innervated and 1 10 days denervated hind limb muscle from mouse . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| We have examined expression of the components of the plasminogen activation system in human astrocytoma U 373 MG cells and found that interleukin 1beta ( IL 1beta ) , tumour necrosis factor alpha TNF alpha ) , interferon gamma ( INF gamma ) and epidermal growth factor ( EGF ) specifically regulate the expression of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and protease nexin 1 ( PN 1 ) . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| We report here that human astrocytoma cell line U 373 MG is able to express genes of the following components of plasminogen activation system : PA 1 1 , PN 1 , u PA and t PA . ^^^ Treatment of these cells with IL 1beta results in accumulation of PA 1 1 , PN 1 and u PA mRNAs , whereas t PA mRNA remains unaffected . ^^^ IFNy preferentially enhances PN 1 and PA 1 1 , EGF enhances PA 1 1 , u PA and t PA expression . ^^^ |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13526 |
Pubmed |
SVM Score :0.0 |
| NA |
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