| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| TPA induced activation of the SRE was also partially inhibited by a dominant negative MEKK 1 . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Nerve growth factor ( NGF ) and 12 O tetradecanoylphorbol 13 acetate ( TPA ) also activated MEKK , although to a lesser degree than did EGF . ^^^ Stimulation of synthesis of cyclic adenosine 3 ' , 5 ' monophosphate abolished activation of MEKK and B Raf by EGF , NGF , and TPA . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Coexpression of dominant negative and constitutively active forms of CDC 42 , Rac 1 , Ras , MEKK 1 , and MEK 1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC 42 and MEKK 1 . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Co transfection of the hINV promoter with dominant negative forms of Ras , MEKK 1 , MEK 1 , MEK 7 , MEK 3 , p38 / RK , and c Jun inhibit the TPA dependent increase . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| We showed that TPA induced the association of PKCbeta with MEK kinase 1 ( MEKK 1 ) , an upstream effector of the SAPK / ERK kinase 1 ( SEK 1 ) > SAPK cascade . ^^^ The functional role of MEKK 1 in TPA induced SAPK activity was further supported by the demonstration that the expression of a dominant negative MEKK 1 mutant abrogated this response . ^^^ These findings indicate that PKCbeta activation is necessary for activation of the MEKK 1 > SEK 1 > SAPK cascade in the TPA response of myeloid leukemia cells . . ^^^ |
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| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| The results also demonstrate that TPA induced ROS production is required for activation of the MEK kinase 1 ( MEKK 1 ) > SAPK pathway . ^^^ These findings indicate that PKCbetaII is required for TPA induced ROS production and that the MEKK 1 > SAPK pathway is activated by a ROS mediated mechanism . . ^^^ |
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| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Prx 1 gene induction by TPA was decreased by protein kinase C inhibitors and overexpressed dominant negative forms of Ras and MEKK 1 , but not Raf 1 . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| Ser 129 phosphorylation augments JNK phosphorylation by MKK 4 and / or MKK 7 and is required for JNK activation by TPA , TNFalpha , UV irradiation , and PKC , but not by anisomycin or MEKK 1 . ^^^ |
|
| Interacting proteins: P40939 and Q13233 |
Pubmed |
SVM Score :0.0 |
| In addition , several JNK upstream activators , including the phorbol ester TPA , anisomycin and MAPK kinase kinase 1 ( MEKK 1 ) , phosphorylated Nur 77 and induced its nuclear export . ^^^ |
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