| In the hippocampus of CR rats , the specific 3 NT levels of malate dehydrogenase ( MDH ) , phosphoglycerate kinase 1 ( PKG 1 ) and 14 3 3 zeta protein were significantly decreased and expression levels of DLP 1 splice variant 1 ( DLP 1 ) , mitochondrial aconitase ( ACO 2 ) , dihydrolipoamide dehydrogenase ( DLDH ) , neuroprotective peptide H 3 ( NPH 3 ) , and eukaryotic translation initiation factor 5A ( eIF 5A ) are increased . ^^^ Moreover , our study shows that the improvement of glutamate dysregulation , mitochondrial dysfunction and protein synthesis by CR is , at least partially , due to the CR mediated alteration of the oxidation or the expression of PKM 2 , ENO 1 , INSP 1 , ATP F1B , PKG 1 , IMPCH , ATP F1A MDH , PKG 1 and 14 3 3 zeta protein , DLP 1 , ACO 2 , DLDH , NPH 3 , eIF 5A and UNP 1 . ^^^ |