| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| We investigated the contributions of LIFR and OSMR to signal transduction in the context of heterodimers with gp 130 . ^^^ Our studies demonstrate that upon heterodimerization with the gp 130 cytoplasmic region , the cytoplasmic parts of both LIFR and OSMR were critical for activation of an acute phase protein promoter in HepG 2 hepatoma cells . ^^^ Membrane distal regions of LIFR and OSMR contributed to STAT activation even in the absence of gp 130 STAT recruitment sites . ^^^ We further show that the Janus kinases Jak 1 and Jak 2 constitutively associated with receptor constructs containing the cytoplasmic part of LIFR , OSMR , or gp 130 , respectively . ^^^ Thus , in spite of extensive functional similarities , differential signaling abilities of gp 130 , LIFR , and OSMR may become evident in a cell type specific manner . . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Its mechanism of action is via specific binding to gp 130 and either the leukaemia inhibitory factor receptor ( LIFR ) or oncostatin M receptor ( OSMR ) systems at the cell surface to form an active signalling complex . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Shc is recruited to the OSM receptor ( OSMR ) , but not to gp 130 . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^ A parallel FACS analysis revealed surface expression of gp 130 and OSMR beta , but not of LIFR on these cells . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^ By immunohistochemistry , 25 of 25 ovarian carcinomas examined expressed the LIFR beta subunit in the malignant epithelial cells ( all samples express gp 130 ) , and two thirds the ovarian carcinomas studied expressed OSMR beta mRNA as determined by RT PCR . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 and IL 11 induce gp 130 homodimerization whereas the others lead to the formation of heterodimers with LIFR or OSMR . ^^^ Thus , epitopes involved in gp 130 homodimerization are distinct from those leading to the formation of gp130 / LIFR or gp130 / OSMR heterodimers . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using a dominant negative LIF mutant ( hLIF 05 ) , we showed that in RC cell cultures mouse OSM ( mOSM ) activates exclusively glycoprotein 130 ( gp 130 ) / OSMR . ^^^ |
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| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| This mutant still binds to the receptor subunits gp 130 and OSMR . ^^^ |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| In the present study , we analyzed the effect of SOCS 3 on signal transduction by the proinflammatory cytokine oncostatin M ( OSM ) , which signals through a receptor complex of gp 130 and the OSM receptor ( OSMR ) . ^^^ We can show that the OSMR mediated signaling is inhibited by SOCS 3 to a similar extent as previously described for gp 130 . ^^^ |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99650 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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