| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Several members of this family that are known to signal through the transmembrane protein gp 130 stimulate cardiac myocyte hypertrophy , like cardiotrophin 1 , suggesting that the gp 130 signaling pathway may play a role in cardiac hypertrophy . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitor factor ( LIF ) , oncostatin M ( OSM ) and probably the recently cloned cytokine cardiotrophin 1 , signal , in combination with their specific receptors , through the common signal transducer gp 130 . ^^^ |
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| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Mouse cardiotrophin 1 ( CT 1 ) is a hypertrophy inducing factor for cardiac myocytes and interacts with cell surface receptors that incorporate the signaling molecule gp 130 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 : a multifunctional cytokine that signals via LIF receptor gp 130 dependent pathways . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a cytokine whose structural and functional features are similar to other members of the interleukin ( IL ) 6 family of cytokines ( IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , granulocyte colonystimulating factor , ciliary neurotrophic factor , and cardiotrophin 1 ) , many of which utilize gp 130 as a common receptor subunit . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| A family of cytokines [ IL 6 , IL 11 , oncostatin M ( OM ) , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ] involved in various inflammatory or tumoral diseases share the same gp 130 signal transducer chain . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 and the role of gp 130 dependent signaling pathways in cardiac growth and development . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Overexpression of cardiotrophin 1 and gp 130 during experimental acute Chagasic cardiomyopathy . ^^^ Cardiotrophin 1 ( CT 1 ) , a cytokine with structural similarities to interleukin 6 , has been shown to signal through gp 130 dependent pathways . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 family of cytokines : signaling mechanisms and thrombopoietic activities . gp 130 is a common signal transducing component of the functional receptor complexes for the interleukin ( IL ) 6 family of cytokines , ie , IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The family of cytokines signalling through the common receptor subunit gp 130 comprises interleukin ( IL ) 6 , IL 11 , leukaemia inhibitory factor , oncostatin M , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The pleiotrophic but overlapping functions of the cytokine family that includes interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are mediated by the cytokine receptor subunit gp 130 as the common signal transducer . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Glycoprotein 130 ( gp 130 ) belongs to the family of class 1 cytokine receptors and is the common signal transducing receptor subunit shared by the so called IL 6 type cytokines ( IL 6 , IL 11 , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and cardiotrophin 1 ) . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a recently discovered member of the gp 130 cytokine family , which includes IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , and oncostatin M . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The present study also suggests that cardiotrophin 1 , but not LIF , is a possible candidate for natural ligand of a gp 130 signaling pathway in the heart . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) , a novel cytokine that belongs to the interleukin 6 cytokine family , activates gp 130 dependent signaling pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| These results indicated that angiotensin 2 induced IL 6 , LIF , and cardiotrophin 1 in cardiac fibroblasts , and that these cytokines , particularly LIF and cardiotrophin 1 , activated gp 130 linked signaling and contributed to angiotensin 2 induced cardiomyocyte hypertrophy . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a novel cytokine capable of inducing hypertrophy in cardiac myocytes and belongs to the interleukin 6 family that exert their biological effects through gp 130 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Augmented expression of cardiotrophin 1 and its receptor component , gp 130 , in both left and right ventricles after myocardial infarction in the rat . ^^^ Cardiotrophin 1 ( CT 1 ) is a potent cytokine that stimulates the assembly of sarcomeric units in series in cardiomyocytes through gp 130 signaling , resulting in myocardial cell hypertrophy . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Cardiotrophin 1 ( CT 1 ) , a member of the interleukin 6 related cytokine family that act via the gp 130 signalling pathway , has been shown to stimulate the assembly of sarcomeric units in series in cardiomyocytes resulting in eccentric hypertrophy , ventricular dilatation and finally loss of function . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a new member of the interleukin ( IL ) 6 family of cytokines and one of the endogenous ligands for gp 130 signaling pathways in the heart , which has potent hypertrophic and survival effects on cardiac myocytes . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Cardiotrophin 1 is a newly identified member of the interleukin 6 ( IL 6 ) family of cytokines and one of the endogenous ligands for gp 130 signaling pathways in the heart , and it has potent hypertrophic and survival effects on cardiac myocytes . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) , a cytokine acting via the gp 130 pathway , is involved in the process of ventricular remodelling following acute myocardial infarction ( AMI ) in animals . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 stimulates endothelin 1 via gp 130 in vascular endothelial cells . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Upon binding LIF or cardiotrophin 1 , the LIF receptor alpha subunit ( LIFRalpha ) dimerizes with gp 130 , leading to activation of constitutively associated Jak 1 proteins and LIFRalpha gp 130 tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) , a potent novel hypertrophic cytokine , depends on gp 130 to induce signaling and depends on STAT 3 to exert hypertrophic effect . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Hypertrophic responses to cardiotrophin 1 are not mediated by STAT 3 , but via a MEK 5 ERK5 pathway in cultured cardiomyocytes . gp 130 dependent signaling is known to play a critical role in the onset of heart failure . ^^^ In that regard , cardiotrophin 1 ( CT 1 ) activates several signaling pathways via gp 130 , and induces hypertrophy in neonatal rat cardiomyocytes . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition also the other gp 130 ligands tested , cardiotrophin 1 ( CT 1 ) , interleukin 6 ( IL 6 ) and leukemia inhibitory factor ( LIF ) had no effect on the expression of TIMPs and MMPs studied . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using cortical precursor cultures , which temporally mimic this in vivo differentiation pattern , we demonstrate that cortical neurons synthesize and secrete the neurotrophic cytokine cardiotrophin 1 , which activates the gp 130 JAK STAT pathway and is essential for the timed genesis of astrocytes in vitro . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiomyogenesis in differentiating mouse embryonic stem ( ES ) cells is promoted by cardiotrophin 1 ( CT 1 ) , a member of the IL 6 interleukin superfamily that acts through the tall gp 130 cytokine receptor . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| CT 1 and LIF cross compete for binding to M 1 cells , Kd [ CT 1 ] approximately 0 . 7 nM , and this binding is inhibited by an anti gp 130 monoclonal antibody . ^^^ These data show that CT 1 has a wide range of hematopoietic , neuronal , and developmental activities and that it can act via the LIF receptor and the gp 130 signaling subunit . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Sequence similarity data suggested that CT 1 is a novel member of a family of structurally related cytokines sharing the receptor component gp 130 . ^^^ The present study documents that gp 130 is required for CT 1 signaling in cardiomyocytes , by demonstrating that a monoclonal anti gp 130 antibody completely inhibits c fos induction by CT 1 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| In the present study we show that CT 1 activates its receptor expressed at the surface of a human neural cell line by recruiting gp 130 and gp190 / leukemia inhibitory factor receptor beta , as shown by analyzing their tyrosine phosphorylation level . ^^^ Neutralizing antibody directed against gp 130 and reconstitution experiments performed in the COS 7 cell line demonstrate that gp 130 gp190 heterocomplex formation is essential for CT 1 signaling . ^^^ Cross linking of iodinated CT 1 to the cell surface led to the identification of a third alpha component in addition to gp 130 and gp 190 , with an apparent molecular mass of 80 kDa . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines IL 6 , LIF , CNTF , OSM , IL 11 , and CT 1 have been grouped into the family of IL 6 type cytokines , since they all require gp 130 for signal transduction . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| This observation is consistent with previous in vitro findings showing that the mRNA for CT 1 is expressed in several tissues , and that CT 1 can function through binding to the leukaemia inhibitory factor ( LIF ) receptor and signalling through the gp 130 pathway . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| In the present study we show that CT 1 binds to the KB epidermoid cancer cell surface through a tripartite receptor complex which includes the gp 130 signal transducing protein , LIF receptor beta ( LIFR beta ) and a third component displaying a molecular weight of 80 kDa . ^^^ CT 1 activates gp 130 and LIFR beta transducing components , as attested by analysing their tyrosine phosphorylation level . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Treatment of HepG 2 cells with CT 1 resulted in the induction of tyrosine phosphorylation of both transducing receptor subunits , gp 130 and LIF receptor , and this phosphorylation was completely inhibited by a neutralizing anti gp 130 mAb . ^^^ Moreover , the use of a neutralizing mAb to gp 130 in cultures of HepG 2 cells grown in the presence of CT 1 , inhibited the induction of acute phase protein secretion , indicating an absolute requirement of gp 130 in the formation of a functional CT 1 receptor . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Our functional data confirm that CT 1 is a member of the neuropoietic cytokine family and suggest that the CT 1 receptor complex contains the gp 130 signal transducing component . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Several other cytokines including oncostatin M , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotropin 1 ( CT 1 ) use gp 130 as a common signal transducing molecule and therefore have similar biological activities . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| These results suggested that gp 130 mediated signaling was involved in the pressure overload induced activation of the JAK / STAT pathway , and that IL 6 and CT 1 might be involved in this activation . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of CT 1 , leukemia inhibitory factor ( LIF ) , and gp 130 by competitive RT PCR and Western blotting in Dahl salt sensitive ( DS ) rats with a high salt diet , which showed a distinct transition from left ventricular hypertrophy ( LVH ) to congestive heart failure ( CHF ) . ^^^ The expression levels of CT 1 mRNA and protein were significantly increased at the CHF stage compared with the LVH stage and age matched Dahl salt resistant ( DR ) rats ( n = 6 for each group ) . mRNA expression of LIF was not changed in the left ventricle at any stage by RT PCR . gp 130 mRNA and protein levels of DS rats at 11 and 17 wk were significantly increased compared with age matched DR rats . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| This study was designed to identify the presence and action of CT 1 and its receptor complex , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor ( LIF ) receptor , on cardiac fibroblast growth in cultured adult canine cardiac fibroblasts . ^^^ Blockade of gp 130 or LIF receptor inhibited basal growth as well as CT 1 or ET 1 stimulated cardiac fibroblast growth . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : This study was designed to determine left ventricular expression of CT 1 and its glycoprotein 130 ( gp 130 ) / leukemia inhibitory factor receptor complex in human end stage heart failure due to ischemic and dilated cardiomyopathy . ^^^ CONCLUSIONS : Our data suggest that gp 130 receptor downregulation balances enhanced CT 1 expression in human heart failure and thereby inhibits excessive activation of the gp 130 signaling pathway . . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| By contrast , no variation of mRNAs levels of CT 1 and gp 130 genes was observed between control and transgenic rats . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| HACMs were treated with the gp 130 ligands CT 1 , IL 6 , LIF or OSM and VEGF 1 was determined by a specific ELISA in the conditioned media of these cells . ^^^ CONCLUSION : The gp 130 gp130 ligand system is also involved in VEGF regulation in human cardiac myocytes and OSM is the gp 130 ligand responsible for this effect in the human system whereas LIF and CT 1 which had been shown to regulate VEGF expression in mouse and rat cardiac myocytes had no effect . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Since adipocytes express both gp 130 and LIFR proteins and are responsive to other IL 6 family cytokines , we examined the effects of CT 1 on 3T3 L 1 adipocytes . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| These effects of CT 1 were abolished in the presence of antibodies specific for gp 130 or LIFR and did not require RNA or protein synthesis . ^^^ |
|
| Interacting proteins: Q16619 and P40189 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that a subset of gp 130 cytokines , in particular CT 1 , LIF , and OSM , has the ability to impair subsequent signaling activity initiated by gp 130 cytokines . ^^^ |
|