| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| We describe the molecular cloning of a cDNA for the alpha chain of the human IL 11 receptor ( IL 11R alpha ) and demonstrate the requirement of either the human or mouse gp 130 molecule for signalling . cDNA clones encoding IL 11R alpha were isolated from a bone marrow cDNA library using a fragment from the murine IL 11R alpha as a probe . ^^^ Interaction of the human IL 11R alpha with murine gp 130 was demonstrated : expression of the human IL 11R alpha in murine M 1 cells which constitutively express murine gp 130 ( and murine LIF receptor ) , resulted in the generation of specific high affinity binding sites for IL 11 ( Kd = 250 pM ) . ^^^ These results suggested that the human IL 11R alpha chain was able to form a functional receptor complex in association with murine gp 130 . ^^^ The requirement of gp 130 for signalling was confirmed by expression of the human IL 11R alpha in Ba / F3 cells . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| Primary osteoblasts constitutively expressed mRNAs for both IL 11 receptor ( IL 11R alpha ) and gp 130 . ^^^ Osteotropic factors did not modulate IL 11R alpha mRNA at 24 h , but steady state gp 130 mRNA expression in osteoblasts was upregulated by 1 alpha , 25 ( OH ) 2D3 , PTH , or IL 1 . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| The receptor for IL 11 is a heterodimer of the signal transduction unit gp 130 and a specific receptor component , the alpha chain ( IL 11R alpha ) . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 11 acts via a heterodimeric receptor composed of a ligand specific receptor alpha chain ( IL 11R alpha ) and the signalling moiety gp 130 . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| The binding of ( 32 ) P labeled FP Delta IL 11 to Ba / F3 cells stably transfected with plasmids encoding human IL 11 receptors alpha and beta chains ( IL 11R alpha and gp 130 ) was specific and saturable with a high affinity as determined from Scatchard plot analysis . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 11 receptor alpha chain , a member of the hematopoietin receptor superfamily , forms , together with gp 130 , a functional high affinity receptor complex for interleukin 11 . ^^^ |
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| Interacting proteins: Q14626 and P40189 |
Pubmed |
SVM Score :0.0 |
| AIM : To explore the effect of recombinant human interleukin 11 ( rhIL 11 ) on the expressions of interleukin 11 receptor alpha chain ( IL 11Ralpha ) and an additional signal transducer glycoprotein 130 ( gp 130 ) in intestinal epithelium cell line 6 ( IEC 6 ) after neutron irradiation . ^^^ |
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