| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Selection of particular substrates the transcriptional activator Stat 3 and protein tyrosine phosphatase PTP1D that characterize responses to the ciliary neurotrophic factor interleukin 6 cytokine family depended not on which Jak was activated , but was instead determined by specific tyrosine based motifs in the receptor components gp 130 and LIFR shared by these cytokines . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The second tyrosine ( from the membrane ) of gp 130 , which was required for the tyrosine phosphorylation of SHP 2 , its association with GRB 2 , and activation of a MAP kinase , was essential for mitogenesis , but not for anti apoptosis . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the long form OB R did not induce tyrosine phosphorylation of a Src homology domain 2 containing protein tyrosine phosphatase , SHP 2 , while stimulation of gp 130 did . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Deletion analysis identified a 24 amino acid region of gp 130 that was necessary for maximal stimulation of MAPK , and contained box 3 ( positions 120 129 ) and a consensus tyrosine binding motif ( Tyr 118 ) for the protein tyrosine phosphatase , SHP 2 . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , along with other neuropoietic cytokines , signals through the shared receptor subunit gp 130 [ 1 3 ] , leading to the tyrosine phosphorylation of a number of substrates [ 4 , 5 ] , including the transcription factors STAT 1 and STAT 3 and the protein tyrosine phosphatase SHP 2 [ 6 , 7 ] [ 8 ] . ^^^ To characterize the role of SHP 2 in the regulation of gp 130 stimulated gene expression , we examined the regulation of the VIP CyRE in two systems that prevented ligand dependent SHP 2 phosphorylation . ^^^ Inhibition of SHP 2 , either by mutating the tyrosine residue in gp 130 that mediates the SHP 2 interaction , or by expression of dominant negative SHP 2 , resulted in dramatic increases in gp 130 dependent gene expression , through the VIP CyRE and more specifically through multimerized STAT binding sites . ^^^ These data suggest that SHP 2 has a negative role in gp 130 signaling by modulating STAT mediated transcriptional activation . . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Early intracellular events stimulated by the sIL 11R including phosphorylation of gp 130 , STAT 3 , and SHP 2 were similar to signaling through the transmembrane IL 11R . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase 2 ( SHP 2 ) moderates signaling by gp 130 but is not required for the induction of acute phase plasma protein genes in hepatic cells . ^^^ Hematopoietic growth control by gp 130 is critically dependent on activation of both STAT 3 and protein tyrosine phosphatase 2 ( SHP 2 ) . ^^^ To investigate whether induction of APP genes has a similar requirement for SHP 2 , we constructed two chimeric receptors , G gp 130 and G gp 130 ( Y2F ) , consisting of the transmembrane and cytoplasmic domains of gp 130 harboring either a wild type or a mutated SHP 2 binding site , respectively , fused to the extracellular domain of the granulocyte colony stimulating factor ( G CSF ) receptor . ^^^ Notwithstanding these similarities in the patterns of signaling responses elicited , mutation of the SHP 2 interaction site in G gp 130 ( Y2F ) abrogated ligand activated receptor recruitment of SHP 2 as expected . ^^^ Overexpression of the enzymatically inactive SHP 2 enhanced the signaling by the wild type but not by the Y2F mutant G gp 130 receptor . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SHP 2 has more recently been shown to be tyrosine phosphorylated and recruited to the gp 130 component of the ciliary neurotrophic factor ( CNTF ) receptor complex upon stimulation with CNTF . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| JAK tyrosine kinase is a key molecule that can initiate multiple signal transduction pathways by inducing the tyrosine phosphorylation of the cytokine receptor , gp 130 in the case of IL 6 , on which several signaling molecules are recruited , including STAT , a signal transducer and activator of transcription , and SHP 2 , which links to the Ras MAP kinase pathway . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Additionally , LIF enhances association of SHP 2 with the gp 130 subunit of the LIF receptor signaling complex . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| A mutation of tyrosine 759 , the SHP 2 binding site of gp 130 , abrogated the interactions of Gab 1 with SHP 2 and PI 3 kinase as well as ERK 2 activation . ^^^ These observations suggest that Gab 1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp 130 and that SHP 2 , PI 3 kinase , and Ras are involved in Gab 1 mediated ERK activation . . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Activation of the protein tyrosine phosphatase SHP 2 via the interleukin 6 signal transducing receptor protein gp 130 requires tyrosine kinase Jak 1 and limits acute phase protein expression . ^^^ Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases ( Jak ) , phosphorylation of the signal transducing subunit gp 130 , followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT 3 and STAT 1 and the src homology domain ( SH 2 ) containing protein tyrosine phosphatase ( SHP 2 ) . ^^^ Here we present data on the dose dependence , kinetics and kinase requirements for SHP 2 phosphorylation after the activation of the signal transducer , gp 130 , of the IL 6 type family receptor complex . ^^^ This phosphorylation depends on Tyr 759 in the cytoplasmatic domain of gp 130 , since a Tyr 759 > Phe exchange abrogates SHP 2 activation and in turn leads to elevated and prolonged STAT 3 and STAT 1 activation as well as enhanced acute phase protein gene induction . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In B 9 cells , IL 6 triggered the following in sequence : gp 130 phosphorylation , gp 130 to protein tyrosine phosphatase 1D ( PTP1D ) binding , PTP1D phosphorylation , PTP1D complex formation with Grb 2 Son of sevenless 1 ( Sos 1 ) , and Sos 1 phosphorylation . gp 130 phosphorylation , gp 130 to PTP1D binding , PTP1D phosphorylation , and PTP1D to Grb 2 binding are also induced by IL 6 in all IL 6 independent MM cell lines studied . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We previously found that the adapter protein Gab 1 ( 110 kD ) is tyrosine phosphorylated and forms a complex with SHP 2 and PI 3 kinase upon stimulation through either the interleukin 3 receptor ( IL 3R ) or gp 130 , the common receptor subunit of IL 6 family cytokines . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Signalling molecules activated downstream of gp 130 in ES cells include STAT 3 , the protein tyrosine phosphatase SHP 2 , and the mitogen activated protein kinases , ERK 1 and ERK 2 . ^^^ A chimaeric receptor in which tyrosine 118 in the gp 130 cytoplasmic domain was mutated did not engage SHP 2 and failed to activate ERKs . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| A receptor carrying tyrosine module Y 759 of gp 130 effectively mediated activation of the phosphatase SHP 2 but did not alter cell growth . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of gp 130 in rat hepatoma cells by using transduced chimeric G CSFR gp 130 receptor constructs demonstrates that SHP 2 , the Src homology 2 ( SH 2 ) domain containing protein tyrosine phosphatase , acts as a negative regulator of the JAK / STAT signaling in part by downregulating JAK activity , thereby indirectly moderating the induction of STAT 3 dependent APP genes . ^^^ This study shows that in hepatoma cells , the recruitment and tyrosine phosphorylation of SHP 2 , but not SHC , is the primary signaling event associated with the activation of MAP kinases ( ERK1 / 2 ) by gp 130 . ^^^ Stimulation of the c fos , c jun , and egr 1 genes is essentially absent in cells expressing gp 130 with a Y759F mutation , which is unable to recruit SHP 2 . ^^^ Moreover , disengagement of SHP 2 from gp 130 signaling not only enhances APP gene induction but also further reduces cell proliferation , in part correlated with the attenuated expression of immediate early response genes . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of the cytoplasmic domain of gp 130 revealed that the tyrosine residue of gp 130 responsible for STAT 3 activation is necessary for self renewal of ES cells , while that required for SHP 2 and MAP kinase activation was dispensable . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The Csk effect is attributed to prevention of Src kinases from phosphorylating gp 130 at the docking site for the signal moderating protein tyrosine phosphatase SHP 2 . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The key components involved are the signal transducing receptor subunit gp 130 , the Janus kinases Jak 1 , Jak 2 and Tyk 2 , STAT 1 and STAT 3 of the family of signal transducers and activators of transcription , the protein tyrosine phosphatase SHP 2 and the suppressors of cytokine signalling SOCS 1 , SOCS 2 and SOCS 3 . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Dissection of signaling cascades through gp 130 in vivo : reciprocal roles for STAT 3 and SHP 2 mediated signals in immune responses . ^^^ We generated a series of knockin mouse lines , in which the cytokine receptor gp 130 dependent STAT 3 and / or SHP 2 signals were disrupted , by replacing the mouse gp 130 gene with human gp 130 mutant cDNAs . ^^^ The gp130F759 / F759 mice showed prolonged gp 130 induced STAT 3 activation , indicating a negative regulatory role for SHP 2 . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| In the present study we demonstrate that in addition to STAT 3 , also tyrosine phosphorylation of STAT 1 , signal transducer gp 130 , and phosphotyrosine phosphatase SHP 2 underlies negative regulation by MAP kinases . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SOCS 3 exerts its inhibitory function on interleukin 6 signal transduction through the SHP 2 recruitment site of gp 130 . ^^^ Furthermore , we show that tyrosine 759 in gp 130 is essential for both SHP 2 and SOCS 3 but not for SOCS 1 to exert their inhibitory activities on interleukin 6 signal transduction . ^^^ Besides SHP 2 , SOCS 3 also interacts with the Tyr ( P ) 759 peptide of gp 130 . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The neurally active cytokine leukemia inhibitory factor ( LIF ) signals through a bipartite receptor complex composed of LIF receptor alpha ( LIFR ) and gp 130 . gp 130 and LIFR contain consensus binding motifs for the protein tyrosine phosphatase SHP 2 surrounding tyrosines 118 and 115 ( Y 118 and Y 115 ) of their cytoplasmic domains , respectively . ^^^ Coexpression of catalytically inactive , but not wild type , SHP 2 reduced LIFR and gp 130 mediated activation of MAPK up to 75 % . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Suppressor of cytokine signaling 3 preferentially binds to the SHP 2 binding site on the shared cytokine receptor subunit gp 130 . ^^^ The only high affinity ligand found corresponded to the region of gp 130 centered around phosphotyrosine 757 ( pY 757 ) , previously shown to be a docking site for the tyrosine phosphatase SHP 2 . ^^^ Taken together , these data suggest that the mechanism by which SOCS 3 inhibits the gp 130 signaling pathway depends on recruitment to the phosphorylated gp 130 receptor , and that some of the negative regulatory roles previously attributed to the phosphatase SHP 2 might in fact be caused by the action of SOCS 3 . . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Prior activation of mitogen activated protein kinases by phorbol 13 myristate 12 acetate ( PMA ) results in an inhibition of interleukin ( IL ) 6 induced activation of the Janus kinase / signal transducer and activator of transcription ( STAT ) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling 3 and requires the specific SHP 2 binding site Y 759 of the IL 6 signal transducer gp 130 . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the IL 6R complex leads to Src homology domain containing tyrosine phosphatase 2 ( SHP 2 ) recruitment to the receptor subunit gp 130 and its subsequent tyrosine phosphorylation . ^^^ Tyrosine 759 of gp 130 , the signal transducing subunit of the IL 6R complex , is essential for the phosphorylation of SHP 2 . ^^^ Here we demonstrate that no further tyrosines in the cytoplasmic part of gp 130 are required for the phosphorylation of SHP 2 . ^^^ We also tested whether the tyrosine 759 motifs in both subunits of the gp 130 dimer are required for SHP 2 association and tyrosine phosphorylation . ^^^ Interestingly , one SHP 2 recruiting phosphotyrosine motif in a single chain of the gp 130 dimer is sufficient to mediate SHP 2 association to the gp 130 receptor subunit and its tyrosine phosphorylation as well as to attenuate IL 6 dependent gene induction . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| On IL 6 stimulation , SHP 2 and Gab 1 were recruited to the gp 130 subunit of the IL 6 receptor and tyrosine phosphorylated , allowing downstream signaling to the MAPK and PI3K pathways . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Immediately after receptor complex activation , signal transducers and activators of transcription ( STATs ) 1 and 3 and the Src homology domain containing protein tyrosine phosphatase 2 ( SHP 2 ) are recruited to gp 130 and subsequently tyrosine phosphorylated . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| To determine whether duration is functionally significant , we transduced EC with a chimeric receptor containing extracellular domains of platelet derived growth factor receptor beta and intracellular regions of gp 130 , the signaling subunit of the OnM receptor , mutated to prevent binding of the tyrosine phosphatase SHP 2 . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| M Ernst and colleagues generated and studied knock in mice ( gp130DeltaSTAT / DeltaSTAT ) , in which all STAT binding sites ( sites binding signal transducers and activators of transcription ) were deleted from their gene encoding gp 130 but binding sites for both Janus kinases ( JAKs ) and for the protein tyrosine phosphatase 2 ( SHP 2 ) were preserved . ^^^ Synovial cells from this mouse exhibited mitogenic hyper responsiveness to cytokines of the LIF / IL 6 family , a phenomenon that was caused by sustained gp 130 mediated SHP 2 / Ras / Erk activation due to a defect in the induction of SOCS 1 ( suppressor of cytokine signaling 1 ; also known as SSI or JAB ) . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Suppressor of cytokine signaling 3 ( SOCS 3 ) and the protein tyrosine phosphatase SHP 2 both regulate signaling by cytokines of the interleukin 6 family , and this is dependent upon recruitment to tyrosine 757 in the shared cytokine receptor subunit gp 130 . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Reciprocal regulation of gastrointestinal homeostasis by SHP 2 and STAT mediated trefoil gene activation in gp 130 mutant mice . ^^^ Here , we evaluated the functions of the two major signaling pathways , the signal transducers and activators of transcription 1 and 3 ( STAT1 / 3 ) and the Src homology tyrosine phosphatase 2 ( SHP 2 ) Ras ERK , emanating from the common signal transducer , gp 130 , in the gastrointestinal tract . ^^^ Gp 130 ( 757F ) mice , with a ' knock in ' mutation abrogating SHP 2 Ras ERK signaling , developed gastric adenomas by three months of age . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SHP 2 and SOCS 3 contribute to Tyr 759 dependent attenuation of interleukin 6 signaling through gp 130 . ^^^ We show that receptor and membrane targeted SHP 2 counteracts IL 6 signaling independent of SOCS 3 binding to gp 130 . ^^^ On the other hand , SOCS 3 inhibits signaling in cells expressing a truncated SHP 2 protein , which is not recruited to gp 130 . ^^^ These data suggest , that there are two , largely distinct modes of negative regulation of gp 130 activity , despite the fact that both SOCS 3 and SHP 2 are recruited to the same site within gp130 . . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Tyrosine 759 of gp 130 is required for the negative regulation of LIF mediated signaling by both the protein tyrosine phosphatase SHP 2 and the suppressor of cytokine signaling 3 ( SOCS 3 ) . ^^^ This indicates that STAT signaling is necessary for LIF and CNTF stimulated VIP and ChAT expression and Y 759 of gp 130 mediates the activities of SHP 2 and SOCS 3 , which act to negatively regulate STAT activity . . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Negative regulation of gp 130 signalling mediated through tyrosine 757 is not dependent on the recruitment of SHP 2 . ^^^ Two signalling regulators , suppressor of cytokine signalling 3 ( SOCS 3 ) and Src homology 2 domain containing tyrosine phosphatase 2 ( SHP 2 ) , are recruited to Y 757 following receptor activation ; however , the relative contribution made by each of these in down regulating gp 130 signalling is not known . ^^^ In the present study , we show the design of a mutant gp 130 receptor that can recruit SHP 2 , but not SOCS 3 . ^^^ Cells transfected with a chimaeric receptor containing the SHP 2 selective gp 130 intracellular domain showed an enhanced response to cytokine stimulation , which was similar to that shown by a chimaeric gp 130 receptor mutant carrying a Y757F point mutation that failed to recruit either SOCS 3 or SHP 2 . ^^^ These results demonstrate that the recruitment of SHP 2 alone is not sufficient for Y 757 dependent negative regulation of gp 130 signalling and that this activity must therefore be dependent on SOCS3 . . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| These data suggest that desensitization of vascular cells to OnM is mediated in trans and involves Tyr residue 759 in gp 130 but is not mediated by either SOCS 3 or SHP 2 , the only two proteins currently known to bind to gp 130 at this site . . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP 2 ) to the signal transducing receptor subunit gp 130 attenuates IL 6 mediated STAT activation , we were interested in whether TNF alpha also induces the association of SHP 2 to the gp 130 receptor subunit . ^^^ In this study we demonstrate that stimulation of macrophages and fibroblast cell lines with TNF alpha causes the recruitment of SHP 2 to the gp 130 signal transducing subunit and leads to tyrosine phosphorylation of SHP 2 and gp 130 . ^^^ In this respect murine fibroblasts lacking exon 3 of SHP 2 are not sensitive to TNF alpha , indicating that functional SHP 2 and its recruitment to gp 130 are key events in inhibition of IL 6 dependent STAT activation by TNF alpha . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Activation of gp 130 transduces hypertrophic signal through interaction of scaffolding / docking protein Gab 1 with tyrosine phosphatase SHP 2 in cardiomyocytes . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Further , results from H 35 cells expressing gp 130 receptor subunits lacking functional SHP 2 binding sites revealed normal cytokine activation of Jak and STAT that was inhibited by phosphatase inhibitors . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Further , H 35 hepatoma cells expressing gp 130 receptor chimeras lacking either the SHP 2 docking site or the Box 3 STAT binding sites failed to enhance the IFN gamma STAT 3 response . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Gastric cancer development in mice lacking the SHP 2 binding site on the IL 6 family co receptor gp 130 . ^^^ METHODS : gp 130 ( 757F / F ) Mice that lack the SHP 2 binding site on the IL 6 family receptor gp 130 and have increased STAT 3 activity and wild type littermates were used . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Gp 130 contains a crucial motif around tyrosine Y 759 , which mediates negative regulation through the feedback inhibitor SOCS 3 and the protein tyrosine phosphatase SHP 2 . ^^^ Whereas SHP 2 and SOCS 3 bind directly to the inhibitory motif of gp 130 , only SHP 2 was found to bind to the corresponding inhibitory sequence of the LIF R . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The absence of SOCS 3 enhanced JAK STAT and extracellular signal related kinase 1 / 2 ( ERK 1 / 2 ) mitogen activated protein kinase ( MAPK ) signal transduction via gp 130 , with higher levels of phosphorylated STAT 1 , STAT 3 , SH 2 domain containing cytoplasmic protein tyrosine phosphatase 2 ( SHP 2 ) , and ERK 1 / 2 in steady state and in response to LIF stimulation . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| By contrast , negative regulation of HO 1 expression appeared to be mediated through the SH 2 domain containing tyrosine phosphatase 2 ( SHP 2 ) / suppressors of cytokine signaling 3 ( SOCS 3 ) binding site within the gp 130 IL 6 receptor subunit . ^^^ |
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| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Attenuation of SOCS 3 induction in either ECs or SOCS 3 null murine embryonic fibroblasts abolished the inhibitory effect of cAMP , whereas inhibition of SHP 2 , another negative regulator of gp 130 , was without effect . ^^^ |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|