Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.67579931
Expression of a dominant negative PKCdelta or depletion of the endogenous PKCdelta by phorbol 12 myristate 3 acetate treatment abrogates the association of Stat 3 with gp 130 . 0.67579931^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Association of transcription factor APRF and protein kinase Jak 1 with the interleukin 6 signal transducer gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Differential activation of acute phase response factor / STAT3 and STAT 1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130 . 1 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Differential activation of acute phase response factor / Stat3 and Stat 1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130 . 2 . ^^^ Chem . 271 , 12991 12998 ) , we demonstrated that two tyrosine motifs within the cytoplasmic part of the interleukin 6 signal transducer gp 130 specifically mediate APRF activation while two others can recruit both APRF and Stat 1 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In HepG 2 hepatoma cells , however , these truncated Stat 3 forms transmit signals from the interleukin 6 signal transducer gp 130 equally well as does full length Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We show that LANA directly associates with an interleukin 6 signal transducer , signal transducer and activator of transcription 3 ( STAT 3 ) and that LANA enhances the transcriptional activity of STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Molecular cloning of APRF , a novel IFN stimulated gene factor 3 p 91 related transcription factor involved in the gp 130 mediated signaling pathway . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
However , gp 130 preferentially activated STAT 1 and STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
STAT 3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification requiring an H 7 sensitive kinase . ^^^ Here we show that all cytokines that utilize gp 130 sequentially induce two distinct forms of STAT 3 in all responding cells examined , with the two forms apparently differing because of a time dependent secondary serine / threonine phosphorylation involving an H 7 sensitive kinase . ^^^ Granulocyte colony stimulating factor , which utilizes a receptor highly related to gp 130 , also induces these two forms of STAT 3 . ^^^ In contrast to a number of other cytokines and growth factors , all cytokines using gp 130 and related signal transducers consistently and preferentially induce the two forms of STAT 3 as compared with STAT 1 ; this characteristic STAT activation pattern is seen regardless of which Jak / Tyk kinases are used in a particular response , consistent with the notion that the receptor components themselves are the primary determinants of which STATs are activated . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Serine phosphorylation of Stat 3 was constitutive and was enhanced by signaling through gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The activation of DNA binding of STAT 3 required the same gp 130 domains as the IL 6RE response . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Selection of particular substrates the transcriptional activator Stat 3 and protein tyrosine phosphatase PTP1D that characterize responses to the ciliary neurotrophic factor interleukin 6 cytokine family depended not on which Jak was activated , but was instead determined by specific tyrosine based motifs in the receptor components gp 130 and LIFR shared by these cytokines . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Here we demonstrate that APRF is activated by all cytokines acting through gp 130 and is detected in a wide variety of cell types , indicating a central role of this transcription factor in gp 130 mediated signaling . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
By using tyrosine to phenylalanine substitution mutants of G CSF R , we further show that tyrosine 704 , present in a YXXQ consensus sequence shown to be essential for STAT 3 binding to gp 130 , is not exclusively involved in the activation of STAT 3 by G CSF R . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp 130 that is essential for Stat 3 activation . ^^^ By using chimeric receptors consisting of the extracellular domain of growth hormone receptor and the transmembrane and cytoplasmic domain of gp 130 with progressive C terminal truncations , we showed that the membrane proximal 133 , but not 108 , amino acids of gp 130 could generate the signals for growth arrest , macrophage differentiation , down regulation of c myc and c myb , induction of junB and IRF 1 and Stat 3 activation . ^^^ The tight correlation between Stat 3 activation and other IL 6 functions was further observed in the context of the full length cytoplasmic region of gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
STAT 3 activation is a critical step in gp 130 mediated terminal differentiation and growth arrest of a myeloid cell line . ^^^ In the case of IL 6 and LIF , which share a signal transducing receptor gp 130 , STAT 3 is specifically tyrosine phosphorylated and activated by stimulation with each cytokine in various cell types . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Lysates from neonatal rat cardiac myocytes were immunoprecipitated with anti gp 130 , anti JAK 1 , or anti STAT 3 antibody and blotted with anti phosphotyrosine antibody . ^^^ Tyrosine phosphorylation of gp 130 , JAK 1 , and STAT 3 was observed after LIF stimulation in cardiac myocytes . ^^^ Furthermore , anti gp 130 antibody significantly inhibited the LIF induced activation of JAK 1 , STAT 3 , and MAPKs . ^^^ To examine whether these signaling pathways were also activated in the adult heart in vivo , LIF was injected intravenously into a 6 week old mouse , and the heart was examined subsequently . gp 130 , STAT 3 , and MAPKs were activated in the heart after LIF treatment . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Two signals are necessary for cell proliferation induced by a cytokine receptor gp 130 : involvement of STAT 3 in anti apoptosis . gp 130 is a common signal transducer for the interleukin 6 related cytokines . ^^^ These data demonstrate that two distinct signals , mitogenesis and anti apoptosis , are required for gp 130 induced cell growth and that STAT 3 is involved in anti apoptosis . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stimulation of either a long form of OB R or gp 130 led to tyrosine phosphorylation of STAT 3 , whereas stimulation of the truncated form of OB R that is predominantly expressed in dbldb mice failed to do so . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In signaling from gp 130 , a common signal transducer for the IL 6 family cytokines , STAT 3 , a transcription factor that contains an SH 2 domain , is recruited by phosphotyrosines on gp 130 and is subsequently phosphorylated by gp 130 associated JAKs . ^^^ Furthermore , we showed that the activation of STAT 5 via gp 130 did not need any phosphotyrosines on gp 130 while that of STAT 3 strictly depended on phosphotyrosines on gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Co immunoprecipitation experiments demonstrated that these mutants were associated with gp 130 at an extent similar to wild type Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Expression of this form of gp 130 in lymphocytes significantly suppressed interleukin 6 induced tyrosine phosphorylation of endogenous gp 130 and a downstream signaling molecule , signal transducer and activator of transcription 3 , indicating that this form has a dominant negative function . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Moreover , EGF treatment induced Stat 3 phosphorylation in cells transfected with the intact chimeric EGF gp 130 receptor along with induction of DNA mobility shift of a classical interferon gamma activated site . ^^^ To define further the relation between Stat 3 activation and enhanced IgM production , we determined the effect of chimeric gp 130 on the transcriptional activation of a genetic element linked to immunoglobulin production , namely the immunoglobulin heavy chain enhancer ( IgH enhancer ) . ^^^ Moreover , the gp 130 induced activity of this reporter gene was abrogated by Stat3EE , a mutant Stat 3 incapable of binding DNA . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Enhancement of gp 130 mediated tyrosine phosphorylation of STAT 3 and its DNA binding activity in dexamethasone treated AIDS associated Kaposi ' s sarcoma cells : selective synergy between dexamethasone and gp 130 related growth factors in Kaposi ' s sarcoma cell proliferation . ^^^ Thus , Dex appears to participate in the gp 130 STAT3 signaling and transcriptional events by enhancing STAT 3 activation , thereby leading to selective synergistic stimulation of KS cell growth with Dex and the gp 130 related growth factors . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Like the wild type STAT 3 , both mutant STAT 3 forms are activated by the signal transducing subunit of the IL 6 receptor , gp 130 , or by co transfected IL 3 receptor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Forced overexpression of SSI 1 complementary DNA interfered with IL 6 and LIF mediated apoptosis and macrophage differentiation of M 1 cells , as well as IL 6 induced tyrosine phosphorylation of a receptor glycoprotein component , gp 130 , and of Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor , along with other neuropoietic cytokines , signals through the shared receptor subunit gp 130 [ 1 3 ] , leading to the tyrosine phosphorylation of a number of substrates [ 4 , 5 ] , including the transcription factors STAT 1 and STAT 3 and the protein tyrosine phosphatase SHP 2 [ 6 , 7 ] [ 8 ] . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
LIF ( 10 ( 3 ) U / mL ) induced rapid tyrosine phosphorylation of gp 130 , JAK 1 , JAK 2 , STAT 1 , and STAT 3 but not Tyk 2 or STAT 2 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
After a short exposure of purified BM MKs to rhIL 11 , enhanced phosphorylation of both its signal transduction subunit , gp 130 , and the transcription factor , STAT 3 was detected , showing a direct activation of receptor signaling by the cytokine . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Early intracellular events stimulated by the sIL 11R including phosphorylation of gp 130 , STAT 3 , and SHP 2 were similar to signaling through the transmembrane IL 11R . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
METHODS : Active transcription of LIF , IL 6 , and OSM , their related receptors ( LIF R , IL 6 R , and gp 130 ) , and the consecutive signal transducing molecules ( STAT 1 , STAT 3 , and STAT 5a ) were analyzed in reverse transcriptase polymerase chain reaction experiments . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Hematopoietic growth control by gp 130 is critically dependent on activation of both STAT 3 and protein tyrosine phosphatase 2 ( SHP 2 ) . ^^^ Both chimeric receptors transmitted a G CSF induced signal characteristic of that triggered by IL 6 through the endogenous gp 130 receptor ; i . e . , both activated the appropriate JAK , induced DNA binding activity by STAT 1 and STAT 3 , and up regulated expression of the target APP genes , those for alpha fibrinogen and haptoglobin . ^^^ Moreover , the tyrosine phosphorylation state of the chimeric receptor , the associated JAK activity , and the induced DNA binding activity of STAT 1 and STAT 3 were maintained at elevated levels and for an extended period of time in G gp 130 ( Y2F ) expressing cells following G CSF treatment compared to that in cells displaying the G gp 130 receptor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We show that the region of the signal transducing subunit , gp 130 , essential for STAT 3 activation , is also required for activation of the Stat 3 gene . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Subsequently , the transcription factors named STATs ( signal transducers and activators of transcription ) STAT 1 alpha and STAT 3 are transiently recruited to the cytoplasmic domain of gp 130 , where they become tyrosine phosphorylated by JAK kinases . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Detailed mutational analyses unexpectedly revealed that the four STAT 3 docking sites in gp 130 are not functionally equivalent . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Western blot analysis revealed an inhibition of LIF stimulated gp 130 and STAT 3 phosphorylation in SOCS 3 overexpressing AtT 20 cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of gp 130 transduces hypertrophic signals via STAT 3 in cardiac myocytes . ^^^ In the present study , we examined whether the JAK / STAT pathway , especially the STAT 3 mediated pathway , plays a critical role in gp 130 dependent myocardial hypertrophy by transfecting wild type and mutated type STAT 3 cDNA to cardiac myocytes . ^^^ CONCLUSIONS : These results suggest that the STAT 3 dependent signaling pathway downstream of gp 130 promotes cardiac myocyte hypertrophy under stimulation with LIF . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
By measuring cellular responses , such as morphological changes upon differentiation , soft agar colony formation , and induction of tyrosine phosphorylation of the signal transducer and activator of transcription , STAT 3 , we show that signaling by IL 6 , but not LIF , is significantly reduced by mutations in the Ig like module of gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases ( Jak ) , phosphorylation of the signal transducing subunit gp 130 , followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT 3 and STAT 1 and the src homology domain ( SH 2 ) containing protein tyrosine phosphatase ( SHP 2 ) . ^^^ This phosphorylation depends on Tyr 759 in the cytoplasmatic domain of gp 130 , since a Tyr 759 > Phe exchange abrogates SHP 2 activation and in turn leads to elevated and prolonged STAT 3 and STAT 1 activation as well as enhanced acute phase protein gene induction . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
This activity , which we name ES cell renewal factor ( ESRF ) , is distinct from members of the IL 6 / LIF family because ( 1 ) it is effective on ES cells lacking LIF R ; ( 2 ) it is not blocked by anti gp 130 neutralizing antibodies ; and ( 3 ) it acts without activation of STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In the present study , we show that STAT 3 plays a key role in the G 1 to S phase cell cycle transition induced by the cytokine receptor subunit gp 130 , through the upregulation of cyclins D 2 , D 3 and A , and cdc25A , and the concomitant downregulation of p 21 and p 27 . ^^^ Furthermore , unexpectedly , we found that gp 130 could induce the expression of p 21 when STAT 3 activation was suppressed . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
STAT 3 is required for the gp 130 mediated full activation of the c myc gene . ^^^ We show that STAT 3 mostly mediates the rapid activation of the c myc gene upon stimulation of the interleukin ( IL ) 6 receptor or gp 130 , a signal transducing subunit of the receptor complexes for the IL 6 cytokine family . ^^^ We show that STAT 3 binds to a region overlapping with the E2F site in the c myc promoter and this site is critical for the c myc gene promoter driven transcriptional activation by IL 6 or gp 130 signals . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In the present study , we investigated potential interactions between gp 130 dependent and AII signaling pathways , by examining AII regulation of LIF induced anti apoptotic effect and STAT 3 activation in cardiac myocytes . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Cotransfection with the gp 80 and / or gp 130 receptor revealed that the effect of H IL 6 on STAT 3 dependent gene transcription is restricted to the gp80 / gp130 receptor ratio . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
By studying the functional epitopes of the cell membrane gp 130 receptors , it was shown that the activating mAb induced gp 130 dimerization and STAT 3 activation , as did IL 6 . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
An antibody to gp 130 blocked the effects of LIF and CNTF , and both cytokines induced phosphorylation and nuclear translocation of stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
To identify the regions within the cytoplasmic domain of LIFR that generate the signals for growth arrest , macrophage differentiation , and STAT 3 activation independently of gp 130 , we constructed chimeric receptors by linking the transmembrane and intracellular regions of mouse LIFR to the extracellular domains of the human granulocyte macrophage colony stimulating factor receptor ( hGM CSFR ) alpha and betac chains . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In contrast , a mutant gp 130 domain lacking the Box 3 motif activates Janus kinases to a normal level but fails to activate signal transducer and activator of transcription 3 and to up regulate a number of APP genes , including thiostatin , fibrinogen , hemopexin , and haptoglobin . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stat 3 signaling and gp 130 gene expression in primary cultures of human lung fibroblasts . ^^^ These results demonstrate , for the first time , that in HLF cells alpha thrombin inhibits IL 6 induced Stat 3 signaling via activation of MAPKK 1 and that this cross talk regulates IL 6 induced gp 130 gene expression . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The resulting IL 6 / CNTF chimera lost the capacity to signal via gp 130 on cells without LIFR , but acquired the ability to signal via the gp130 / LIFR heterodimer and STAT 3 on responsive cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Following gp 130 dimerization , IL 6 activates multiple signaling pathways ( Ras dependent MAPk cascade , STAT 1 STAT3 heterodimer pathway , and STAT 3 homodimer pathway ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Signalling molecules activated downstream of gp 130 in ES cells include STAT 3 , the protein tyrosine phosphatase SHP 2 , and the mitogen activated protein kinases , ERK 1 and ERK 2 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
STAT 3 activation in stromal / osteoblastic cells is required for induction of the receptor activator of NF kappaB ligand and stimulation of osteoclastogenesis by gp 130 utilizing cytokines or interleukin 1 but not 1 , 25 dihydroxyvitamin D 3 or parathyroid hormone . ^^^ To determine whether STAT 3 is a downstream effector of gp 130 in the osteoclast support function of stromal / osteoblastic cells and whether the gp130 / STAT3 pathway is utilized by other osteoclastogenic agents , we conditionally expressed dominant negative ( dn ) STAT 3 or dn gp 130 in a stromal / osteoblastic cell line ( UAMS 32 ) that supports osteoclast formation . ^^^ These results establish that STAT 3 is essential for gp 130 mediated osteoclast formation and that the target of STAT 3 during this process is induction of RANKL . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Signaling by the IL 6 receptor is mediated through the signal transducing subunit gp 130 and involves the activation of Janus associated kinases ( JAKs ) , signal transducer and activator of transcription 3 ( STAT 3 ) , and mitogen activated protein ( MAP ) kinase . ^^^ Functional analysis of gp 130 in rat hepatoma cells by using transduced chimeric G CSFR gp 130 receptor constructs demonstrates that SHP 2 , the Src homology 2 ( SH 2 ) domain containing protein tyrosine phosphatase , acts as a negative regulator of the JAK / STAT signaling in part by downregulating JAK activity , thereby indirectly moderating the induction of STAT 3 dependent APP genes . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Mutational analysis of the cytoplasmic domain of gp 130 revealed that the tyrosine residue of gp 130 responsible for STAT 3 activation is necessary for self renewal of ES cells , while that required for SHP 2 and MAP kinase activation was dispensable . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The activation was completely blocked by expression of a dominant negative form of STAT 3 , a transcription factor activated downstream of gp 130 , or by introduction of a mutation in the STAT 3 binding motif in the promoter . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
As the gp 130 mutant defective for activating the STAT 3 pathway showed the reduced induction of OIG 37 by cytokine stimulation and expression of dominant negative STAT 3 inhibited the induction of OIG 37 by OSM , STAT 3 is involved in OIG 37 induction by IL 6 family cytokines . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The key components involved are the signal transducing receptor subunit gp 130 , the Janus kinases Jak 1 , Jak 2 and Tyk 2 , STAT 1 and STAT 3 of the family of signal transducers and activators of transcription , the protein tyrosine phosphatase SHP 2 and the suppressors of cytokine signalling SOCS 1 , SOCS 2 and SOCS 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NNT 1 / BSF 3 induces tyrosine phosphorylation of glycoprotein 130 ( gp 130 ) , leukemia inhibitory factor receptor beta , and signal transducer and activator of transcription 3 in the SK N MC human neuroblastoma cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Conditioned medium from cultured cardiac myocytes presented the ability to tyrosine phosphorylate STAT 3 through gp 130 and that was further augmented with hypoxic conditioned medium . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
To investigate the role of CNTF / LIF signaling in regenerative responses of motoneurons , we studied the expression of the three receptor components , CNTF receptor alpha ( CNTFRalpha ) , LIF receptor beta ( LIFRbeta ) , and gp 130 , and the activation of the STAT 3 signal transduction pathway in the rat facial nucleus following peripheral nerve transection . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
SS was found effective in the blockade of the signaling cascade of IL 6 : phosphorylation of both gp 130 and Stat 3 was eliminated by SS treatment and the production of IL 6 stimulated haptoglobin by the cells was abolished . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The activation of STAT 3 by the cytokine receptor gp 130 is required for both the G 1 to S cell cycle transition and antiapoptosis . ^^^ We found that Pim 1 and Pim 2 are targets for the gp 130 mediated STAT 3 signal . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of Stat 3 by cytokine receptor gp 130 ventralizes Xenopus embryos independent of BMP 4 . ^^^ Stat 3 is one of the main signaling components of cytokine receptors , including gp 130 . ^^^ Here we show that activation of cytokine receptor gp 130 resulted in a dramatic ventralization of Xenopus embryos and that the ventralization correlated well with Stat 3 activation potential of the receptor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Dissection of signaling cascades through gp 130 in vivo : reciprocal roles for STAT 3 and SHP 2 mediated signals in immune responses . ^^^ We generated a series of knockin mouse lines , in which the cytokine receptor gp 130 dependent STAT 3 and / or SHP 2 signals were disrupted , by replacing the mouse gp 130 gene with human gp 130 mutant cDNAs . ^^^ In contrast , the STAT 3 signal deficient mice ( gp130FXQ / FXXQ ) died perinatally , like the gp 130 deficient mice ( gp130D / D ) . ^^^ The gp130F759 / F759 mice showed prolonged gp 130 induced STAT 3 activation , indicating a negative regulatory role for SHP 2 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of stat 3 and stat 1 DNA binding and transcriptional activity in human brain tumour cell lines by gp 130 cytokines . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
AngII induced phosphorylation of gp 130 in the late stage , which was temporally in parallel with the delayed phosphorylation of STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In conclusion , these data indicate that IL 6 induced STAT 3 transactivation and Ser ( 727 ) phosphorylation is independent of ERK 1 or JNK 1 activity , but involves a gp 130 receptor signalling cascade that includes Vav , Rac 1 , MEKK and SEK 1 / MKK 4 as signal transduction components . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
This differentiation process is totally dependent on the gp 130 mediated signal transduction pathway involving activation of a latent cytoplasmic transcription factor , STAT 3 ( for signal transducer and activator of transcription 3 ) , because ( a ) IL 11 induced astrocyte differentiation is not observed when neuroepithelial cells prepared from gp 130 deficient mice were used , ( b ) stimulation of neuroepithelial cells by IL 11 rapidly induces tyrosine phosphorylation of STAT 3 , and ( c ) transfection of neuroepithelial cells with a dominant negative form of STAT 3 inhibits IL 11 induced activation of the GFAP gene promoter . ^^^ Astrocyte differentiation of fetal neuroepithelial cells by interleukin 11 via activation of a common cytokine signal transducer , gp 130 , and a transcription factor , STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In the present study we demonstrate that in addition to STAT 3 , also tyrosine phosphorylation of STAT 1 , signal transducer gp 130 , and phosphotyrosine phosphatase SHP 2 underlies negative regulation by MAP kinases . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These phenotypic changes in the IL 6 ( / ) mice are associated with decreased expression and phosphorylation of gp 130 and the transcription factor STAT 3 , compared to IL 6 ( + / + ) mice . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
It phosphorylated gp 130 and STAT 3 in cardiomyocytes , which was reduced with RX 435 ( anti gp 130 blocking antibody ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The binding of ligand to gp 130 activates the JAK / STAT signal transduction pathway , where STAT 3 plays a central role in transmitting the signals from the membrane to the nucleus . ^^^ STAT 3 is essential for gp 130 mediated cell survival and G 1 to S cell cycle transition signals . ^^^ STAT 3 is also required for gp 130 mediated maintenance of the pluripotential state of proliferating embryonic stem cells and for the gp 130 induced macrophage differentiation of M 1 cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We generated an erythropoietin receptor ( EpoR ) isoform ( ER343 / 401 S 3 ) that activates Stat 3 rather than Stat 5 by substituting the Stat 3 binding / activation sequence motif from gp 130 for the sequences surrounding tyrosines 343 and 401 in the receptor cytoplasmic region . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
PTPepsilonC expression resulted in lower levels of IL 6 induced tyrosine phosphorylation of Jak 1 , Tyk 2 , gp 130 , and Stat 3 compared with parent cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Furthermore , almost no phosphorylated STAT 3 ( signal transducer and activator of transcription 3 ) , downstream of the LIF receptor and the gp 130 signaling subunit , was observed in the ventricles of JVS and control mice . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The signal transduction of gp 130 involves the Janus tyrosine kinases ( JAK ) JAK 1 , JAK 2 and Tyk 2 and then the downstream effectors comprising the signal transducer and activator of transcription 3 ( STAT 3 ) and mitogen activated protein kinase ( MAPK ) pathways . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The CLF / CLC complex activated gp 130 , LIFR and signal transducer and activator of transcription 3 ( STAT 3 ) and supported motor neuron survival . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) type cytokines stimulate osteoclast formation by activating the glycoprotein 130 ( gp 130 ) receptor subunit on stromal / osteoblastic cells , which in turn leads to signal transducer and activator of transcription 3 ( STAT 3 ) mediated expression of receptor activator of NF kappaB ligand ( RANKL ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of signal transducer and activator of transcription 3 ( STAT 3 ) only occurred via basolaterally located gp 80 , suggesting that endogenous gp 130 is also constrained to the basolateral plasma membrane . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The tyrosine phosphorylation of gp 130 was enhanced , the phosphorylation of STAT 3 and ERK ( extracellular signal regulated kinase ) 1 / 2 was increased and induction of the beta myosin heavy chain ( MHC ) gene was observed in TG hearts without significant phenotypic changes . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Experiments using Stat 3 mutated at serine 727 and using truncated IL 6Rs suggested that the target of inhibition is contained within the membrane proximal region of the cytoplasmic domain of the gp 130 subunit of the IL 6 receptor and is different from the SH 2 domain containing protein tyrosine phosphatase / suppressor of cytokine synthesis 3 docking site . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These findings provide evidence that the constitutive activation of STAT 3 , either in the absence of detectable receptor proximal events or associated with the concomitant activation of gp 130 , can contribute to the process of IL 6 independence . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
A role for GH in regulating cytokine and growth factor signalling is suggested by upregulation of mRNAs encoding three signal transducers : a subunit of the receptor for IL 6 type cytokines ( gp 130 ) , STAT 3 ( signal transducer and activator of transcription ) and p38MAPK ( mitogen activated protein kinase ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
However , luciferase reporter gene assays showed that STAT 3 activation through the gp 130 signal transducer molecule is involved in mediating IL 6 dependent LAP / C / EBPbeta transcription . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In the DU 145 prostate carcinoma cell line , rhIL 11 stimulates a transient and dose dependent increase in the tyrosine 705 phosphorylated , active form of STAT 3 ( STAT 3 P Tyr 705 ) , involved in the downstream signaling of IL 11R and other members of the gp 130 dependent receptors . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Thus , we substituted the major Stat 5 binding sites ( residues 343 and 401 ) in the EpoR cytoplasmic region with the Stat 3 binding / activation motif from gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These results suggest that gp 130 plays a critical role in pressure overload induced cardiac hypertrophy possibly through the STAT 3 pathway . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We demonstrate that exposure of CCL 39 cells to TGF beta completely inhibits IL 6 induced Stat 3 tyrosine phosphorylation and gp 130 gene expression . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Correspondingly , CLC CNTFR activates gp 130 , LIFR and STAT 3 signalling components , and enhances motor neuron survival . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The binding of ligands to gp 130 activates the JAK / STAT signal transduction pathway , where STAT 3 plays a central role in transmitting signals from the membrane to the nucleus . ^^^ STAT 3 is essential for gp 130 mediated cardiac myocyte hypertrophy . ^^^ Thus , the inactivation of STAT 3 resulting from the loss of gp 130 may be a key event in the transition from cardiac hypertrophy to heart failure . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The YXXQ motif in gp 130 is crucial for STAT 3 phosphorylation at Ser 727 through an H 7 sensitive kinase pathway . ^^^ The analysis , using a series of chimeric receptors containing the extracellular domain of the G CSF receptor , the truncated form of gp 130 , and additional short peptides at the gp 130 carboxy terminus , showed that the YXXQ motif of gp 130 was sufficient for the H 7 sensitive STAT 3 Ser727 phosphorylation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Cell lysates were immunoprecipitated with agarose conjugated antiphosphotyrosine antibody and blotted with anti gp 130 , anti Jak 1 , or anti STAT 3 antibody . ^^^ Tyrosine phosphorylation of gp 130 , Jak 1 , and STAT 3 was observed after CNTF stimulation in these three cell lines . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Different levels of IL 6R protein were measured in various HD cell lines : L 428 and Dev cells were characterized by very low levels of gp 80 and gp 130 , on KMH 2 cells only gp 130 but no gp 80 was detected , whereas L 540 , L 591 , HDLM 2 , and L 1236 were positive for both gp 80 and gp 130 , suggesting a possible autocrine stimulation of STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Phosphorylation of JAK 2 , STAT 3 , and STAT 5 was observed upon the addition of lysozyme , suggesting the activation of both EpoR and gp 130 derived signals . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The binding of cytokines to the gp 130 receptor activates the STAT 3 , MEK / MAPK , and PI3K / Akt signalling pathways . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The transcriptional induction of gp 130 gene by OSM involves STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The induction of SOCS 3 was closely correlated with STAT 3 phosphorylation , as well as the activation of an embryonic gene program , suggesting that cardiac gp 130 JAK signaling is precisely controlled by this endogenous suppressor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Signal of the cytoplasmic regions of leukemia inhibitory factor receptor ( LIFR ) alpha subunit and gp 130 involves Stat 3 activation in leukemic U 937 cells ] . ^^^ OBJECTIVE : In order to understand the mechanism of proliferation and differentiation of leukemia cells , we investigate the relation between the cytoplasmic regions LIFR alpha subunit and gp 130 and the transcription activator Stat 3 in human leukemic U 937 cells . ^^^ CONCLUSION : The cytoplasmic domains of both LIFR alpha subunit and gp 130 involve the induction of Stat 3 phosphorylation in U 937 cells . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We further demonstrate that PGE ( 2 ) stimulates soluble IL 6 receptor ( sIL 6R ) release , gp 130 dimerization , Stat 3 protein phosphorylation , and DNA binding activity . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These factors act via receptor complexes involving gp 130 and LIFR beta and ligand binding leads to activation of various signaling pathways , including phosphorylation of Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
By Western blotting the plasma membrane raft fractions obtained using either non detergent or detergent based methods contained significant amounts of STAT 1 and STAT 3 ( up to approximately 10 % of the total cytoplasmic amount ) as well as the integral raft proteins caveolin 1 and flotillin 1 , the IL 6 receptor signal transducing chain gp 130 , the interferon gamma receptor alpha chain ( IFN gammaRalpha ) , and the chaperone glucose regulated protein 58 ( GRP58 / ER 60 / ERp57 ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
IL6RIL6 stimulates the interleukin 6 family cytokine receptor gp 130 , leading to the rapid phosphorylation of Stat 3 on tyrosine 705 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
RESULTS : IL 6 induced tyrosine phosphorylation and increased the DNA binding activity of STAT 3 and , to a lesser extent , STAT 1 in all cell lines except for Caki 1 , which did not express the IL 6 receptor subunit gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In contrast , LIF does not activate STAT 3 , ERK , or the gp 130 receptor in human N tera 2 / D1 EC cells , although all receptor components are expressed . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
While searching for the possible cause of inhibited IL 6 / Stat3 signaling , we found that IL 6 receptor ( IL 6R & gp 130 ) was preserved , that nuclear Stat 3 protein content was lowered , and that IL 6 / Stat3 pathway inhibitors ( SOCS 1 , PIAS 3 ) were induced during the pre replicative Go G 1 period . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
RESULTS : In SKO 007 cells , the mutant could enhance the activated APRF , but the effect was not as strong as that of wide type gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The effects of interleukin 6 on key intermediates in early steps of the interleukin 6 signaling pathway , including janus kinase 1 , gp 130 , the interleukin 6 receptor , STAT 1 , and STAT 3 , were examined in both saline and endotoxin treated rats . ^^^ MEASUREMENTS AND MAIN RESULTS : In endotoxin treated rats , there was significant inhibition of interleukin 6 activation of janus kinase 1 , gp 130 , the interleukin 6 receptor , STAT 1 , and STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
To study IL 6 signal transduction in multiple myeloma ( MM ) , we employed chimeric receptors composed of the epidermal growth factor receptor ( EGFR ) extracellular domain , gp 130 transmembrane domain , and full length or truncated gp 130 cytoplasmic domains lacking regions previously shown to be necessary for MAPK , STAT 1 , and STAT 3 activation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The Stat 3 and GRP 58 containing plasma membrane fraction also contained Stat 1 , Stat5b , and gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Hyper CNTF efficiently induced dose dependent STAT 3 phosphorylation and proliferation of BAF 3 cells stably transfected with gp 130 and LIF R cDNAs . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
STAT 3 is a key downstream signaling intermediate of gp 130 , a receptor previously shown to activate hematopoietic stem cell ( HSC ) self renewal divisions . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stimulation of gp 130 on hippocampal neurons resulted in tyrosine phosphorylation of STAT 3 and activation of p 42 and p 44 MAP kinases . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These effects involve a transcriptional induction of the cytokine receptor subunits LIFRalpha , OSMRbeta , gp 130 , or the transcription factor STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In addition , we investigated the activation state of signal transducer and activator of transcription 3 ( STAT 3 ) , the downstream effector of gp 130 signaling . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
CYP3A4 down regulation by IL 6 requires activation of the glycoprotein receptor gp 130 ; however , it does not proceed through the JAK / STAT pathway , as demonstrated by the overexpression of a dominant negative STAT 3 factor by means of an adenoviral vector . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The inhibitory effect of IL 6 on Fas ligand expression during activation induced cell death ( AICD ) was augmented in gp 130 ( F759 / F759 ) T cells in a manner dependent on the tyrosine residues of gp 130 required for signal transducer and activator of transcription 3 activation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The effect of sIL 6R or sIL 6R / IL 6 proved to be dependent on gp 130 availability , which is expressed by MSCs , and involves stat 3 phosphorylation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The analysis of intracellular pathways revealed that Sant 7 and anti gp 130 mAb were effectively inhibiting the phosphorylation of gp 130 and STAT 3 in the absence and presence of BMSCs , whereas ERK 1 and ERK 2 ( ERK 1 , 2 ) phosphorylation was only slightly affected . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stimulation of human peritoneal mesothelial cells with OSM induced phosphorylation of gp 130 and OSM receptor beta , which was accompanied by activation of STAT 3 and secretion of CC chemokine ligand 2 / monocyte chemoattractant protein 1 and IL 6 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
To assess the biologic significance of these findings , we introduced PML and PML / RAR alpha into interleukin 3 ( IL 3 ) dependent Ba / F3 cells expressing the chimeric receptor composed of extracellular domain of G CSF R and cytoplasmic domain of gp 130 , in which gp 130 mediated growth is essentially dependent on STAT 3 activity . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We show that gp 130 dependent pathways control Stat 3 activation after PH . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Upregulation of gp 130 and STAT 3 activation in the rat hippocampus following transient forebrain ischemia . ^^^ To determine whether the pathophysiological processes after transient forebrain ischemia are mediated via a signal pathway involving gp 130 ( a signal transducer for the interleukin 6 family ) , we analyzed changes in the expression of gp 130 and its downstream transcription factor , signal transducer and activator of transcription factor 3 ( STAT 3 ) , in the rat hippocampus of a four vessel occlusive ischemia model . ^^^ Increase in gp 130 expression was accompanied by the activation of STAT 3 following ischemic injury . ^^^ These results show a coordinated and long lasting upregulation of gp 130 mRNA and STAT 3 activation in reactive astrocytes of the postischemic hippocampus , indicating that they may be involved in the astrocytic response to an ischemic insult . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Although gp 130 AS clones , which have low gp 130 levels and impaired signal transducer and activator of transcription 3 activity and suppressor of cytokine signaling 3 expression , showed reduced proliferation and hormone secretion ( GH and prolactin ) in response to gp 130 cytokines , they had a normal response to gp 130 independent stimuli . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The binding of ligands to gp 130 activates the JAK / STAT pathway , where STAT 3 plays a central role in transmitting signals from the membrane to the nucleus . ^^^ Thus , the inactivation of STAT 3 resulting from the loss of gp 130 may be a key event in the transition from cardiac hypertrophy to heart failure . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
One good illustration is derived from the in vitro observations that IL 6 promotes the growth arrest and differentiation of M 1 cells through gp 130 mediated STAT 3 activation , whereas the Y759 / SHP 2 mediated cascade by gp 130 stimulation has growth enhancing effects . ^^^ Intriguingly , recent in vivo studies indicated that the SHP 2 binding site and YXXQ mediated pathways through gp 130 are not mutually exclusive but affect each other : a mutation at the SHP 2 binding site prolongs STAT 3 activation , and a loss of STAT activation by gp 130 truncation leads to sustained SHP 2 / ERK MAPK phosphorylation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
To further analyze gp 130 downstream signaling , a dominant negative mutant of STAT 3 was also introduced . ^^^ Such failure was rescued by introduction of a wild type gp 130 expression construct but not its mutant constructs having no ability to activate STAT 3 . ^^^ In particular , the activation of STAT 3 by gp 130 is found to be important in this process . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Genetic profiling of alpha 1 adrenergic receptor subtypes by oligonucleotide microarrays : coupling to interleukin 6 secretion but differences in STAT 3 phosphorylation and gp 130 . ^^^ In addition , all three alpha ( 1 ) AR subtypes robustly stimulated the transcription of the prohypertrophic cytokine interleukin ( IL ) 6 , but differentially altered members of the IL 6 signaling pathway ( gp 130 and STAT 3 ) . ^^^ This was confirmed by measurement of secreted IL 6 , activated STAT 3 , and gp 130 levels . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In contrast , blocking the cytokine gp 130 coreceptor abolished STAT 3 tyrosine phosphorylation in HNSCC cells and that induced by the conditioned medium . ^^^ Thus , constitutive activation of STAT 3 in HNSCC may use an autocrine / paracrine activating loop mediated by IL 6 and other cytokines acting through the gp 130 receptor family , which may confer both proliferative and survival potential in this malignancy . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In this context the cytoplasmic SHP2 / SOCS3 recruitment site of gp 130 tyrosine 759 is shown to be important for the inhibitory effects of TNF alpha , since mutation of this residue completely restores IL 6 stimulated activation of STAT 3 and , consequently , of a STAT 3 dependent promoter . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The adult liver of these mice showed no abnormalities ; however , after IL 6 and OSM stimulation , gp 130 dependent pathways ( STAT 3 , APR gene expression ) were completely blocked in the liver of these animals . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Induction of an interferon gamma Stat 3 response in nerve cells by pre treatment with gp 130 cytokines . ^^^ Further , H 35 hepatoma cells expressing gp 130 receptor chimeras lacking either the SHP 2 docking site or the Box 3 STAT binding sites failed to enhance the IFN gamma STAT 3 response . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stat 3 is a vital transcription factor that is activated downstream of the gp 130 receptor , primarily via IL 6 signaling in adult liver . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
IL 6 activates at least two intracellular pathways including signal transducer and activator of transcription 3 ( STAT 3 ) and extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) following the activation of Janus kinases ( JAKs ) via its receptor complexes composed of the IL 6 receptor alpha chain and gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Signal transducer and activator of transcription 3 ( STAT 3 ) is a major signaling protein that is activated through gp 130 . ^^^ Signal transducer and activator of transcription 3 ( STAT 3 ) is a major signaling protein that is activated through gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
IL 6 stimulation induced a rapid phosphorylation of gp 130 and STAT 3 , and a dominant negative STAT 3 completely abolished the antiapoptotic effect . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
A rapid and sustained seizure induced activation of STAT 3 and STAT 1 , revealed by nuclear STAT 3 and STAT 1 immunoreactivities , was observed exclusively in reactive astrocytes in the hippocampus , nearly coinciding with the time course of gp 130 expression ; however , STAT 3 activation was greater . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Tu11 cells , a subline of the IL 6 dependent human plasma cell line INA 6 expressing gp 130 and the receptor for leukaemia inhibitory factor ( LIF ) , stimulation with BSF 3 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 ( STAT 3 ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
METHODS : The expression profiles of various cytokine signal transduction components , including receptor subunits CNTF receptor alpha ( CNTFRa ) and gp 130 , intracellular protein kinases , Jak 2 and Tyk 2 , as well as latent transcription factors , STAT 1 and STAT 3 , were determined by immunohistochemical staining of mouse retinal sections derived from different postnatal stages . ^^^ RESULTS : In the neonatal retina , intense staining signals for gp 130 , CNTFRalpha , Jak 2 , Tyk 2 , STAT 1 , and STAT 3 were present in the differentiated ganglion cell layer and the developing inner plexiform layer of the mouse retina . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
METHODS : gp 130 ( 757F / F ) Mice that lack the SHP 2 binding site on the IL 6 family receptor gp 130 and have increased STAT 3 activity and wild type littermates were used . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
This global suppression of acute phase gene transcription may be explained by two PPARalpha dependent in vivo effects : 1 ) PPARalpha activation results in the down regulation of the IL 6 receptor components gp 80 and gp 130 in the liver , thereby reducing the phosphorylation and activation of the downstream transcription factors STAT 3 and c Jun that transduce the IL 6 signal ; and 2 ) PPARalpha reduces the basal expression of the transcription factors CCAAT enhancer binding protein alpha , beta , delta , which are responsible for immediate and maintained transcription of APR genes . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
However , other components of the IL 6 pathway are intact , as demonstrated by rescue of STAT 3 activation and APP gene induction with recombinant soluble IL 6R linked to IL 6 cytokine ( Hyper IL 6 ) or with another gp 130 signaling cytokine , Oncostatin M . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In CD45+ U 266 cells , IL 6 increased tyrosine phosphorylation of gp 130 and STAT 3 and stimulated the level of Mcl 1 protein expression . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of a truncated form of the IL 6 receptor subunit , gp 130 , that had only one YXXQ motif , induced both c Fos and JunB in NIH3T3 cells through STAT 3 without an apparent increase in the AP 1 ( activator protein 1 ) activity . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
These effects occurred through activating the signal transducer gp 130 and were associated with stimulation of transcription factors STAT 1 and STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
It acts through a membrane receptor complex comprising CNTF receptor alpha component ( CNTFRalpha ) , gp 130 , and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The basis of this assay is the binding of a fluorescein labeled phosphotyrosine peptide derived from the interleukin 6 receptor subunit gp 130 to unphosphorylated STAT 3 with a K ( d ) of 150 nM . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Viral interleukin 6 ( vIL 6 ) is a homolog of cellular IL 6 that is encoded by the Kaposi ' s sarcoma associated herpesvirus ( KSHV ) genome . vIL 6 binds to the IL 6 signal transducer gp 130 without the cooperation of the IL 6 high affinity receptor to induce STAT 3 DNA binding and cell proliferation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Stimulation of human and mouse ES cells with gp 130 cytokines resulted in a robust phosphorylation of downstream ERK 1 , ERK 2 , and Akt kinases , as well as the STAT 3 transcription factor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Mammary gland remodeling depends on gp 130 signaling through Stat 3 and MAPK . ^^^ The interleukin 6 ( IL 6 ) family of cytokines signals through the common receptor subunit gp 130 , and subsequently activates Stat 3 , MAPK , and PI3K . ^^^ However , it is not clear whether Stat 3 activation is mediated solely through the gp 130 pathway or also through other receptors . ^^^ This question was explored in mice carrying two distinct mutations in the gp 130 gene ; one that resulted in the complete ablation of gp 130 and one that led to the loss of Stat 3 binding sites ( gp130Delta / Delta ) . ^^^ Deletion of gp 130 specifically from mammary epithelium resulted in a complete loss of Stat 3 activity and resistance to tissue remodeling comparable to that seen in the absence of Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Collectively , signals through gp 130 upregulate Wnt5a through STAT 3 , promoting the N cadherin mediated cell adhesion . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We detected gp 130 , JAK 1 and Ras but not STAT 3 and ERK 2 molecules in lipid rafts of NECs . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
In this study , we show that the LIFRbeta and the signaling subunit gp 130 are expressed in hESCs and that human LIF can induce STAT 3 phosphorylation and nuclear translocation in hESCs . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The leukemia inhibitory factor ( LIF ) / glycoprotein 130 ( gp 130 ) / signal transducer and activator of transcription 3 ( STAT 3 ) pathway plays an essential role in the maintenance of self renewal and pluripotency in mouse embryonic stem ( ES ) cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Gp 130 deleted mice had a totally abolished STAT 3 activation and acute phase response induction , but gp 130 deletion had no effect on the degree of acute liver injury and subsequent hepatocyte proliferation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We examined this effect further in knockin mice expressing mutant versions of the IL 6 signal transducer gp 130 , with defective signaling through either Src homology region 2 domain containing phosphatase 2 / Gab / MAPK ( gp 130 ( F759 / F759 ) ) or STAT 3 ( gp 130 ( FxxQ / FxxQ ) ) , and combined gp 130 and IL 6 defects ( gp 130 ( F759 / F759 ) / IL 6 KO mice ) . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
However , it has recently been found that STAT 3 may be negatively regulated by ERK1 / 2 in gp 130 dependent signaling . ^^^ Cardiotrophin 1 ( CT 1 ) , a potent novel hypertrophic cytokine , depends on gp 130 to induce signaling and depends on STAT 3 to exert hypertrophic effect . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Under basal conditions , the abundance of the IL 6 receptor , gp 130 , JAK 1 , STAT 1 , and STAT 3 proteins and levels of phosphorylation of ERK1 / 2 and p 38 were significantly increased in the liver in the 2 % casein group compared with the 20 % casein group . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Inhibition of gp 130 signaling in breast cancer blocks constitutive activation of Stat 3 and inhibits in vivo malignancy . ^^^ DN gp 130 inhibited constitutive Stat 3 activation in breast cancer cells . ^^^ Both gp 130 and epidermal growth factor receptor ( EGFR ) have been implicated in constitutive Stat 3 activation in breast cancer . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Ischemic preconditioning induced expression of gp 130 and STAT 3 in astrocytes of the rat hippocampus . ^^^ We investigated the distribution and time course of expression of both gp 130 mRNA and signal transducer and activator of transcription factor 3 ( STAT 3 ) in a rat model of ischemic tolerance induction . ^^^ Ischemic preconditioning induced STAT 3 activation , as revealed by nuclear translocation , resembled that of gp 130 expression . ^^^ Double labeling experiments revealed that the cells expressing gp 130 or STAT 3 were glial fibrillary acidic protein ( GFAP ) immunoreactive astrocytes . ^^^ These results demonstrate upregulation of gp 130 and STAT 3 in reactive astrocytes following ischemic preconditioning , indicating that this signal pathway is involved in the astroglial reaction to ischemic preconditioning in the rat hippocampus . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Inhibition of the cytokine receptor gp 130 using neutralizing antibodies reveals that gp 130 is required for both CNTF induced STAT 3 and ERK phosphorylation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
We investigated the role of human IL 6 on p 53 null immortalized murine oval cell lines ( PIL ) , finding that they express transcripts for the IL 6 receptor and gp 130 , STAT 3 is phosphorylated upon IL 6 stimulation , IL 6 induces IL 6 production , and proliferation is induced by IL 6 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Signal transducer and activator of transcription 3 ( STAT 3 ) is widely expressed and activated by a variety of growth regulating signals as well as diverse cytokines that use gp 130 signaling receptors . ^^^ Signal transducer and activator of transcription 3 ( STAT 3 ) is widely expressed and activated by a variety of growth regulating signals as well as diverse cytokines that use gp 130 signaling receptors . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Activation of mouse melanoma and mast cells through gp 130 or c Kit receptors induced the mobilization of PIAS 3 from MITF to STAT 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Hypertrophic responses to cardiotrophin 1 are not mediated by STAT 3 , but via a MEK 5 ERK5 pathway in cultured cardiomyocytes . gp 130 dependent signaling is known to play a critical role in the onset of heart failure . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The threshold of gp 130 dependent STAT 3 signaling is critical for normal regulation of hematopoiesis . ^^^ To determine whether STAT 3 hyperactivation was responsible for the perturbed hematopoiesis in gp 130 ( Y757F / Y757F ) mice , we generated gp 130 ( Y757F / Y757F ) mice on a Stat 3 heterozygous ( Stat 3 ( + / ) ) background to specifically reduce gp 130 dependent activation of STAT 3 , but not STAT 1 . ^^^ Normal hematopoiesis was observed in gp 130 ( Y757F / Y757F ) : Stat 3 ( + / ) bone marrow and spleen , with no evidence of the splenomegaly and thrombocytosis displayed by gp 130 ( Y757F / Y757F ) mice . ^^^ The perturbed cellular composition of thymus and lymph nodes in gp 130 ( Y757F / Y757F ) mice was also alleviated in gp 130 ( Y757F / Y757F ) : Stat 3 ( + / ) mice . ^^^ Collectively , these data provide genetic evidence that gp 130 dependent STAT 3 hyperactivation during hematopoiesis has pathological consequences affecting multiple organs , and therefore identify the threshold of STAT 3 signaling elicited by IL 6 family cytokines as a critical determinant for hematopoietic homeostasis . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Expression of LIFR , gp 130 , and phosphorylated Stat 3 , Akt , and ERK1 / 2 was investigated by Western blot analysis and immunohistochemistry . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
More importantly , it was involved in a number of diseases , such as rheumatoid arthritis and Castleman ' s disease . 1 feel exceptionally fortunate that my work not only revealed the framework of cytokine signaling , including identification of the IL 6 receptor , gp 130 , NF IL 6 , STAT 3 , and SOCS 1 , but also led to the development of a new therapy for chronic inflammatory diseases . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
IL 6 induced activation of Stat 3 was suppressed by preincubation of the cells with OA , suggesting that the IL 6 signaling pathway was blocked by OA through degradation of gp 130 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Determinants governing the potency of STAT 3 activation via the individual STAT 3 recruiting motifs of gp 130 . ^^^ Here we investigated possible mechanisms underlying the different potency of the STAT 3 activating motifs of gp 130 after IL 6 stimulation . ^^^ Our data indicate that the extent of STAT 3 activation by the different receptor motifs is not influenced by structural features such as contacts between the two gp 130 chains . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
T cell migration was related to STAT 3 activity , because monoallelic deletion of Stat 3 in gp 130 ( Y757F / Y757F ) mice ( gp130Y757F / Y757F : Stat3+ / ) corrected the exaggerated responses observed in gp130Y757F / Y757F mice . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Increased levels of gp 130 signaling led to similar levels of STAT 3 activation in strain 129 and CBA ES cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The transcription factor Stat 3 is activated by multiple cytokines , including leptin and those signaling through the gp 130 receptor . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Hyperactivation of Stat 3 in gp 130 mutant mice promotes gastric hyperproliferation and desensitizes TGF beta signaling . ^^^ The latent transcription factor Stat 3 is activated by gp 130 , the common receptor for the interleukin ( IL ) 6 cytokine family and other growth factor and cytokine receptors . ^^^ Ligand induced dimerization of gp 130 leads to activation of the Stat 1 , Stat 3 and Shp 2 Ras Erk signaling pathways . ^^^ Here we assess genetically the contribution of exaggerated Stat 3 activation to the phenotype of gp 130 ( Y757F / Y757F ) mice , in which a knock in mutation disrupts the negative feedback mechanism on gp 130 dependent Stat signaling . ^^^ Compared to gp 130 ( Y757F / Y757F ) mice , reduced Stat 3 activation in gp 130 ( Y757F / Y757F ) Stat 3 ( + / ) mice increased their lifespan , prevented splenomegaly , normalized exaggerated hepatic acute phase response and lymphocyte trafficking , and suppressed the growth of spontaneously arising gastric adenomas in young mice . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The absence of SOCS 3 enhanced JAK STAT and extracellular signal related kinase 1 / 2 ( ERK 1 / 2 ) mitogen activated protein kinase ( MAPK ) signal transduction via gp 130 , with higher levels of phosphorylated STAT 1 , STAT 3 , SH 2 domain containing cytoplasmic protein tyrosine phosphatase 2 ( SHP 2 ) , and ERK 1 / 2 in steady state and in response to LIF stimulation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The increased formation of IL 6 sIL 6R complexes that interact with gp 130 on the membrane of CD4+T cells ( trans signaling ) lead to an increased expression and nuclear translocation of STAT 3 , which causes the induction of anti apoptotic genes , such as Bcl xl . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : We have shown that mice with a mutation in gp 130 ( gp 130 ( 757F / F ) ) , the signal transducing receptor for interleukin ( IL ) 6 family cytokines , have chronic gastric inflammation and develop distal stomach tumors associated with deregulated phosphorylated STAT 3 expression . ^^^ RESULTS : As a result of the gp 130 ( 757F / F ) mutation , expression of IL 6 and IL 11 was greatly up regulated concomitant with activation of STAT 3 and development of tumors . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Acute BDL resulted in increased IL 6 levels , Stat 3 activation , and an increase in acute phase proteins ( serum amyloid A [ SAA ] ) , which was blocked in gp 130 deleted animals . ^^^ During chronic cholestasis Stat 3 activation was dramatically reduced , while high SAA levels were maintained via gp 130 dependent signaling . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
LIF activates the JAK STAT 3 pathway through the class 1 cytokine receptor gp 130 , which forms a trimeric complex with LIF and the class 1 cytokine receptor LIF receptor beta . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Equivalent production of gp 130 was demonstrated in both cell types by Western blotting ; however , lower production of both IL 6 receptor and Stat 3 explains , in part , reduced activity of the gammaFBG promoter in lung cells . ^^^ By circumventing IL 6 receptor gp 130 coupled signaling with ectopic expression of the granulocyte colony stimulating factor receptor ( GCSFR ) gp 130 ( 133 ) chimeric receptor , overexpression of Stat 3 induced gammaFBG promoter activity 30 fold in A 549 cells . ^^^ Together , the data suggest tissue specific differences in IL 6 receptor gp 130 coupled signaling , thereby limiting the extent of Stat 3 activation and gammaFBG expression during lung inflammation . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Following IL 6 binding , the soluble IL 6R ( CD 126 ) IL 6 complex can directly activate cells that express the signal transducing gp 130 ( CD 130 ) molecule , which mediates two distinct signals , mitogenesis by mitogen activated protein kinase ( MAPK ) activation and anti apoptosis by signal transducer and activator of transcription 3 ( STAT 3 ) activation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Our data suggested that the introduction of HCV core protein results in an increase in expression of IL 6 , gp 130 , leptin receptor , and Stat 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Forced dimerization of gp 130 leads to constitutive STAT 3 activation , cytokine independent growth , and blockade of differentiation of embryonic stem cells . ^^^ Thus , L gp 130 can be used in vitro and in vivo to mimic constitutive and ligand independent activation of gp 130 and STAT 3 , the latter of which is frequently observed in neoplastic diseases . . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
A single intraarticular injection of gp 130 RAPS suppressed chronic antigen induced arthritis in association with a reduction in local activation of signal transducer and activator of transcription 3 . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Here , we report that gp 130 knock in mice gp 130 ( F759 / F759 ) , in which IL 6 family cytokine mediated Stat 3 activation is enhanced , showed an osteosclerotic phenotype . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The purified mini gp 130 ELP specifically inhibited sIL 6R mediated trans signalling as measured by binding to the IL 6 sIL 6R complex and through its ability to block sIL 6R mediated activation of STAT 3 ( signal transducer and activator of transcription 3 ) phosphorylation and proliferation in human hepatoma cells and murine pre B cells . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
Mutagenesis experiments show that cytokine stimulated activation of M ( 2 ) promoter activity requires tyrosine residues on glycoprotein 130 ( gp 130 ) that are also required for both STAT 1 and STAT 3 activation . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
The actions of the neuropoietic cytokines are mediated by the gp 130 receptor , which activates several signaling molecules including the transcription factor STAT 3 ( signal transducer and activator of transcription ) , which , in turn , is subject to feedback inhibition by SOCS 3 ( suppressor of cytokine signaling ) . ^^^ Activation of the gp 130 receptor has been implicated in axonal growth particularly during regeneration , but the specific contribution of STAT 3 is the subject of conflicting reports . ^^^
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40189 and P40763	Pubmed	SVM Score :0.0
NA