| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| However , cross linking of CNTF to LIFR beta and gp 130 is only observed in the presence of CNTFR alpha . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , expression of ciliary neurotrophic factor receptor alpha , leukemia inhibitory factor receptor , and gp 130 could be demonstrated in mRNA derived from murine corticotroph AtT 20 cells and murine pituitary tissue . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| By rational mutagenesis , receptor specific functional analysis , and visualization of complex formation in solution , we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor ( CNTF ) with CNTFR alpha and not with the beta components , gp 130 and LIFR . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The binding of 125I CNTF to sympathetic neurons involved all three components of the CNTF receptor complex , namely CNTFR alpha , LIFR , and gp 130 , as shown by cross linking experiments . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition to including a CNTF specific component , known as CNTFR alpha , the CNTF receptor complex utilizes two receptor components , gp 130 and LIFR beta , that are shared with members of a family of broadly acting cytokines , including leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^ CNTFR alpha does not play a direct role in signaling , but instead forms a complex with CNTF that promotes its binding to the signal transducing `` beta ' ' receptor components , gp 130 and LIFR beta . ^^^ CNTF first binds to CNTFR alpha , then recruits gp 130 , and finally complexes with LIFR beta . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The identity of the 80 kDa protein was determined by transient transfection experiments with the rat CNTF binding protein CNTFR alpha while the properties of the 140 kDa protein correspond to those of gp 130 . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Specific low affinity receptors for leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ; gp 130 ) , and ciliary neurotrophic factor ( CNTF ; receptor alpha , CNTFR alpha ) may be utilized in various combinations to generate high affinity binding sites and signal transduction . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| To begin defining whether NG neurons were capable of responding to CNTF and LIF in vivo , Northern blots were used to examine expression of mRNAs coding for CNTF and LIF receptor components ( CNTFR alpha , gp 130 , and LIFR beta ) in the intact ganglion . mRNAs for all three receptor components were present in both E16 . 5 and newborn ganglia , suggesting that LIF and CNTF receptors are expressed in the NG in vivo . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR alpha ) and the signal transducers gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^ Substitution of either F 152 or K 155 with alanine was found to specifically inhibit cytokine interaction with LIFR without affecting binding to CNTFR alpha or gp 130 . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signal transduction by CNTF requires that it bind first to CNTFR alpha , permitting the recruitment of gp 130 and LIFR beta , forming a tripartite receptor complex . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) in human peripheral neuropathies . ^^^ The mRNA levels of neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) , and their receptor components ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) were examined in seventy six patients with various peripheral neuropathies to determine the extent of expression of these cytokines and receptors , and their relationship to nerve fiber pathology and cell infiltration in the diseased nerves . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| For signal transduction , CNTF requires a receptor complex , composed of the IL 6 signal transducing molecule gp 130 , leukemia inhibitory factor receptor ( LIFR ) beta , and CNTFR alpha . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF activates membrane receptors ( CNTF Rs ) composed of one ligand specific binding subunit , defined CNTFR alpha , and two signal transducing subunits , termed leukaemia inhibitory factor receptor ( LIFR ) and gp 130 . ^^^ GT 1 7 cells were found to express CNTFR alpha , LIFR and gp 130 genes , as shown by reverse transcription polymerase chain reaction analysis , and the corresponding proteins , analysed by immunofluorescence and western blot . ^^^ CNTFR alpha , LIFR and gp 130 immunoreactive bands had an approximate size of 50 , 190 and 130 kDa , respectively . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| While IL 6 induces gp 130 dimerization , CNTF , after the initial interaction with the specific , non signalling receptor subunit , CNTFR , induces the formation of gp130 / LIF receptor heterodimers . ^^^ Furthermore , although gp 130 and LIFR are able to bind independently to the CNTF / CNTFR sub complex , they never form homodimers but only heterodimers . ^^^ We propose that CNTF assembles a hexameric receptor complex composed of two CNTF , two CNTFR , one gp 130 and one LIFR molecule , and present a model of the reciprocal interaction of these molecules based on similarities with the IL 6 hexameric complex . . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR ) and the signal transducing beta subunits gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^ Two new types of CNTF variants , characterized by weakened interactions with either CNTFR or both LIFR and gp 130 , were developed , and the biological activities of these and other mutants were determined in non neuronal versus neuronal cells , as well as in non neuronal cells transfected with an expression vector for CNTFR . ^^^ Membrane anchoring of CNTFR was found to render the CNTF receptor complex relatively insensitive to changes in agonist affinity for either alpha or beta receptor subunits and to promote a more efficient interaction with a gp 130 depleting antagonistic variant of CNTF . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^ Using in situ hybridization histochemistry , we examined spatiotemporal expression patterns of gp 130 , IL 6R , LIFR , and CNTFR mRNAs in regenerating muscles after muscle contusion . ^^^ At Day 7 post contusion , signals for gp 130 , LIFR , and IL 6R mRNAs were not detected in newly formed myotubes , whereas the CNTFR mRNA level was upregulated in myotubes . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Its receptor complex consists of a non signaling alpha chain , CNTFR , and two signaling beta chains , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains , gp 130 and the leukaemia inhibitory factor receptor ( LIFR ) , associated with a non signalling CNTF binding receptor alpha component ( CNTFR ) . ^^^ Co expression of CLC and CNTFR in mammalian cells generates a secreted composite cytokine , displaying activities on cells expressing the gp 130 LIFR complex on their surface . ^^^ Correspondingly , CLC CNTFR activates gp 130 , LIFR and STAT 3 signalling components , and enhances motor neuron survival . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Its receptor complex consists of a ligand binding component , CNTF receptor ( CNTFR ) , associated with two signaling receptor components , gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor complex of CNTF is composed of the CNTF receptor alpha ( CNTFR ) , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha receptor ( CNTFR ) , which is not involved in signal transduction , and the beta receptors gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor complex of ciliary neurotrophic factor ( CNTF ) , a member of the gp 130 family of cytokines , is composed of CNTF , the CNTF receptor alpha ( CNTFR ) , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^ To address this issue we have determined the solution structure of the C terminal or BC domain of CNTFR and studied the interactions of CNTFR with LIFR and gp 130 . ^^^ Substitution of residues in the gp 130 CBD , the LIFR CBD 1 , and the CNTFR BC domain that are expected to be involved in receptor receptor interactions significantly reduced their interactions . ^^^ An NMR chemical shift perturbation study of the interaction between the BC domains of CNTFR and gp 130 further mapped the interaction surface . ^^^ These data suggest that both the gp 130 CBD and the LIFR CBD 1 interact with CNTFR in a similar way and provide insights into the nature of the CNTF receptor complex . . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Remark : After preparation of this manuscript , another novel gp 130 cytokine named neuropoietin ( NP ) has been reported and shown to be a ligand of the CNTFR complex . . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| Rat and human CNTF differ in their fine specificities : in addition to CNTFR , rat CNTF has been shown to activate the LIFR ( a heterodimer of LIFRbeta and gp 130 ) , whereas human CNTF can bind and activate a tripartite receptor comprising the IL 6 receptor alpha chain ( IL 6Ralpha ) and LIFR . ^^^ |
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| Interacting proteins: P26992 and P40189 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^ |
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