| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.65231714 |
| CNTF first binds to CNTFR alpha , then recruits gp 130 , and finally complexes with LIFR beta . 0.65231714^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Other cytokines such as leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor have also been shown to utilize gp 130 as a signal transducer . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M , leukemia inhibitory factor , and ciliary neurotrophic factor . ^^^ Since leukemia inhibitory factor functions as a cholinergic differentiation factor in nerve cells , as does ciliary neurotrophic factor , these results suggest that gp 130 may also play a role in the nervous system . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) is a cytokine sharing structural and functional similarities with interleukin 6 ( IL 6 ) and other helical cytokines that utilize the common signalling chain gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation was also observed in response to other cytokines , such as leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor , whose receptors share the IL 6 receptor signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase activity of the 72 kD molecule was enhanced by the stimulation through an IL 6 signal transducer , gp 130 , that was shared among the receptors for the IL 6 related cytokine subfamily , such as leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| By rational mutagenesis , receptor specific functional analysis , and visualization of complex formation in solution , we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor ( CNTF ) with CNTFR alpha and not with the beta components , gp 130 and LIFR . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Extensive mutagenesis of residues between Q 153 and H 165 of human IL 6 , a region which is partly homologous in cytokines which also signal via gp 130 ( oncostatin M , ciliary neurotrophic factor , leukaemia inhibitory factor , IL 11 ) , did result in the isolation of a second antagonist for IL 6 activity on CESS and HepG 2 cells . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| It is now recognized that the beta subunit of the interleukin 6 ( IL 6 ) receptor , also known as gp 130 , is a common signal transducer shared by other cytokines , including ciliary neurotrophic factor , leukemia inhibitor factor , oncostatin M , and IL 11 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 6 receptor system consists of an 80 kDa IL 6 receptor and a gp 130 which functions as a signal transducer not only for IL 6R but also for LIF , OSM , ciliary neurotrophic factor ( CNTF ) , and IL 11 receptors . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition to specific ligand binding elements , receptor assembly for interleukin ( IL ) 6 , oncostatin M , leukaemia inhibitory factor , ciliary neurotrophic factor and IL 11 includes an additional unit , gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The capacity to bind IL 11 with high affinity ( Kd = 300 800 pM ) appeared to require coexpression of both NR 1 and gp 130 , the common subunit of the IL 6 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) receptors . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In conclusion , IL 11 , along with IL 6 , leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor , belongs to the same family of cytokines , using gp 130 as a transducing protein . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| B 9 11 cells responded only to human IL 11 and IL 6 and not to other human cytokines using the same gp 130 transducer chain ( ciliary neurotrophic factor , leukemia inhibitory factor and oncostatin M ) or to other human interleukins ( interleukin 1 to interleukin 13 ) , human hematopoietic cytokines ( granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , colony stimulating factor 1 ) and various other human cytokines ( interferon alpha , tumor necrosis factor alpha , tumor necrosis factor beta , fibroblast growth factor and nerve growth factor ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Like other cytokines such as IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( ONC ) and ciliary neurotrophic factor ( CNTF ) , IL 11 has been shown to utilize IL 6 signal transducer , gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| A fifth cytokine whose receptor complex shares the gp 130 protein , ciliary neurotrophic factor , did not significantly regulate stromal cell differentiation when added by itself . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Specific low affinity receptors for leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ; gp 130 ) , and ciliary neurotrophic factor ( CNTF ; receptor alpha , CNTFR alpha ) may be utilized in various combinations to generate high affinity binding sites and signal transduction . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 11 receptor belongs to a family of cytokine receptors which includes the receptors for IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , which are all capable of interacting with the signal transducing receptor gp 130 after ligand binding . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 6 induced gp 130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) and gp 130 in response to the LIF or ciliary neurotrophic factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The receptor of ciliary neurotrophic factor ( CNTF ) contains the signal transduction protein gp 130 , which is also a component of the receptors of cytokines such as interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 , and oncostatin M . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitor factor ( LIF ) , oncostatin M ( OSM ) and probably the recently cloned cytokine cardiotrophin 1 , signal , in combination with their specific receptors , through the common signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the expression of LIF , related members of this group of cytokines , oncostatin M and ciliary neurotrophic factor , and the LIF receptor beta and glycoprotein gp 130 in normal human tissues and in the endometrium of fertile women . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The gp 130 was originally identified as a signal transducing subunit of interleukin ( IL ) 6 and later also found to be a functional component of receptor complexes for other LIF related cytokines ( oncostatin M [ OSM ] , ciliary neurotrophic factor [ CNTF ] and IL 11 ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR alpha ) and the signal transducers gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) associates with an alpha subunit ( CNTFRalpha ) of the receptor complex to initiate signal transduction by facilitating heterodimerization of the gp 130 transducing protein and the leukemia inhibitory factor receptor ( LIFR ) beta . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The localization of gp 130 , the signal transducing receptor component used in common for interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , LIF and OSM , in the rat brain was demonstrated by immunohistochemistry using an antibody specific to gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a cytokine whose structural and functional features are similar to other members of the interleukin ( IL ) 6 family of cytokines ( IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , granulocyte colonystimulating factor , ciliary neurotrophic factor , and cardiotrophin 1 ) , many of which utilize gp 130 as a common receptor subunit . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Other cytokines oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) or ciliary neurotrophic factor ( CNTF ) also use the gp 130 transducer and induce its heterodimerization with LIF receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| A family of cytokines [ IL 6 , IL 11 , oncostatin M ( OM ) , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ] involved in various inflammatory or tumoral diseases share the same gp 130 signal transducer chain . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , along with other neuropoietic cytokines , signals through the shared receptor subunit gp 130 [ 1 3 ] , leading to the tyrosine phosphorylation of a number of substrates [ 4 , 5 ] , including the transcription factors STAT 1 and STAT 3 and the protein tyrosine phosphatase SHP 2 [ 6 , 7 ] [ 8 ] . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR ) and the signal transducing beta subunits gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| SHP 2 has more recently been shown to be tyrosine phosphorylated and recruited to the gp 130 component of the ciliary neurotrophic factor ( CNTF ) receptor complex upon stimulation with CNTF . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 family of cytokines : signaling mechanisms and thrombopoietic activities . gp 130 is a common signal transducing component of the functional receptor complexes for the interleukin ( IL ) 6 family of cytokines , ie , IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The family of cytokines signalling through the common receptor subunit gp 130 comprises interleukin ( IL ) 6 , IL 11 , leukaemia inhibitory factor , oncostatin M , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor for ciliary neurotrophic factor ( CNTF ) is comprised of a CNTF binding entity termed CNTF receptor alpha ( CNTFRalpha ) , and 2 signaling molecules called LIF receptor beta and gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we investigated 1 ) if the effects of IL 6 are mimicked by ciliary neurotrophic factor ( CNTF ) , another member of the IL 6 family of cytokines signaling via gp 130 , 2 ) the possible cellular mechanisms for these effects , and 3 ) if islet endocrine cells are a source of CNTF . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The pleiotrophic but overlapping functions of the cytokine family that includes interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are mediated by the cytokine receptor subunit gp 130 as the common signal transducer . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) signal through a receptor complex formed between two transmembrane proteins , gp 130 and LIFRbeta . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Glycoprotein 130 ( gp 130 ) belongs to the family of class 1 cytokine receptors and is the common signal transducing receptor subunit shared by the so called IL 6 type cytokines ( IL 6 , IL 11 , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and cardiotrophin 1 ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Several other cytokines including oncostatin M , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotropin 1 ( CT 1 ) use gp 130 as a common signal transducing molecule and therefore have similar biological activities . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a recently discovered member of the gp 130 cytokine family , which includes IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) and leukemia inhibitory factor ( LIF ) are members of a subfamily of related cytokines that share gp 130 as common signal transducing receptor component . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF ' s role as a lesion factor might be to promote the initial early recruitment of macrophages , which express the signal transducing receptor components , gp 130 and LIFRbeta . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) in human peripheral neuropathies . ^^^ The mRNA levels of neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) , and their receptor components ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) were examined in seventy six patients with various peripheral neuropathies to determine the extent of expression of these cytokines and receptors , and their relationship to nerve fiber pathology and cell infiltration in the diseased nerves . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , a gp 130 cytokine , regulates preovulatory surges of luteinizing hormone and prolactin in the rat . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) is a member of the gp 130 family of cytokines . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The heterodimeric cytokine composed of the soluble ciliary neurotrophic factor receptor ( sCNTFR ) and the IL 6 family member cardiotrophin like cytokine ( CLC ) was recently identified as a new ligand for gp 130 leukemia inhibitory factor receptor ( LIFR ) complex [ Plun Favreau , H . , Elson , G . , Chabbert , M . , Froger , J . , deLapeyriere , O . , Lelievre , E . , Guillet , C . , Hermann , J . , Gauchat , J . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The chimera induced increase of oligodendrocyte arborization was mimicked , although with lower efficacy , by ciliary neurotrophic factor ( CNTF ) but not by IL 6 and was reduced in the presence of a gp 130 soluble peptide which is able to inhibit the gp 130 mediated signals of the IL 6 / sIL 6R complex . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| These and others like IL 11 and ciliary neurotrophic factor are referred to as the gp 130 cytokines because they share the gp 130 glycoprotein as a common receptor initial signal transducer . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition to CNTF , the mRNAs of leukemia inhibitory factor , interleukin 6 , ciliary neurotrophic factor receptor component alpha and gp 130 were detected in the Schwann cells . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) activation of gp 130 in NSCs rapidly increased Notch 1 expression . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Novel neurotrophin 1 / B cell stimulating factor 3 ( NNT 1 / BSF 3 ) is a recently cloned gp 130 cytokine , acting through the tripartite ciliary neurotrophic factor receptor ( CNTFR ) alpha / leukemia inhibitory factor receptor ( LIFR ) / gp130 receptor complex . ^^^ Using RT PCR , expression of ciliary neurotrophic factor receptor alpha , leukemia inhibitory factor receptor , and gp 130 could be demonstrated in mRNA derived from murine corticotroph AtT 20 cells and murine pituitary tissue . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor complex of ciliary neurotrophic factor ( CNTF ) , a member of the gp 130 family of cytokines , is composed of CNTF , the CNTF receptor alpha ( CNTFR ) , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Peritoneal fluid concentrations of ciliary neurotrophic factor , a gp 130 cytokine , in women with endometriosis . ^^^ Ciliary neurotrophic factor ( CNTF ) is a gp 130 neuroregulatory cytokine belonging to the interleukin 6 type cytokine superfamily . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) signals via a tripartite receptor complex consisting of the glycosyl phosphatidylinositol ( GPI ) anchored CNTF receptor ( CNTF R ) , the leukaemia inhibitory factor receptor ( LIF R ) and the interleukin 6 ( IL 6 ) signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The relationship between circulating C reactive protein concentrations and potential cytokine and receptor mediators ( interleukin 6 , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , soluble IL 6 receptor , soluble gp 130 , soluble TNF receptor , interleukin 1 receptor antagonist and interleukin 8 ( IL 8 ) ) of this acute phase protein were examined in healthy subjects ( n=11 ) and patients with non small cell lung cancer ( n=50 ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) forms a functional receptor complex containing the CNTF receptor , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) is a member of the gp 130 receptor cytokine family recently identified as an antiobesity agent in rodents and humans by mechanisms that remain unclear . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The soluble receptors of the interleukin ( IL ) 6 family of cytokines ( sIL 6R , sIL 11R , soluble ciliary neurotrophic factor receptor ) are agonists capable of transmitting signals through interaction with the universal signal transducing receptor for all IL 6 family cytokines , gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL 6 signal transducing receptor component gp 130 . ^^^ We provide a basis for the overlapping actions of these three factors by demonstrating that the shared CNTF and LIF signaling pathways involve the IL 6 signal transducing receptor component gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| This complex consists of a CNTF binding protein ( CNTF R ) and two proteins important for signal transduction [ gp 130 and leukaemia inhibitory factor receptor ( LIF R ) ] . ^^^ Biological activities of the protein preparations were determined by their ability to induce proliferation of BAF / 3 cells that were stably transfected with CNTF R , gp 130 and LIF R cDNAs . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| We also compared the effect of CNTF with that of IL 6 , since the gp 130 receptor subunit for CNTF is shared with that of IL 6 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Consistent with this prediction , the CNTF receptor complex is composed of the CNTF alpha receptor , the LIF beta receptor and gp 130 a signalling molecule for LIF and interleukin 6 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The assay is based on the interaction between biotinylated human CNTF , soluble gp 130 , and soluble myc tagged CNTF receptor captured on a microtiter plate via an antibody against the myc epitope tag . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The binding of 125I CNTF to sympathetic neurons involved all three components of the CNTF receptor complex , namely CNTFR alpha , LIFR , and gp 130 , as shown by cross linking experiments . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 which , like CNTF , utilizes the gp 130 signal transducer , possesses similar inhibitory effects . ^^^ That CNTF and IL 6 share gp 130 as a receptor component suggests that gp 130 mediates these anti inflammatory responses . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Four cytokines , ciliary neurotropic factor ( CNTF ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , use the same transducer chain ( signal transducer gp 130 ) as IL 6 and share numerous biological activities with this IL . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The identity of the 80 kDa protein was determined by transient transfection experiments with the rat CNTF binding protein CNTFR alpha while the properties of the 140 kDa protein correspond to those of gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we show that the other CNTF receptor components , LIFR beta and gp 130 , are also expressed by skeletal muscle and that expression of all three CNTF receptor components is greatly increased in denervated muscle . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| To begin defining whether NG neurons were capable of responding to CNTF and LIF in vivo , Northern blots were used to examine expression of mRNAs coding for CNTF and LIF receptor components ( CNTFR alpha , gp 130 , and LIFR beta ) in the intact ganglion . mRNAs for all three receptor components were present in both E16 . 5 and newborn ganglia , suggesting that LIF and CNTF receptors are expressed in the NG in vivo . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Of the four endogenous pyrogens described to date ( interleukin 1 , tumor necrosis factor , interferon , and interleukin 6 ) , CNTF , like interleukin 6 , utilizes the cell surface gp 130 signal transduction apparatus . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| One of these proteins is the interleukin 6 signal transducing molecule gp 130 , which is required for signal transduction by both CNTF and LIF . ^^^ Cross linking experiments with iodinated factors were carried out on a cell line responsive to CNTF and LIF , as well as on COS cells that were cotransfected with various combinations of gp 130 , LIFR beta , and CNTF receptor ( CNTFR ) alpha , the previously cloned CNTF binding protein . ^^^ However , cross linking of CNTF to LIFR beta and gp 130 is only observed in the presence of CNTFR alpha . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The results showed that the heterocomplex CNTF / alpha CNTF receptor bound to gp 130 with an affinity of 3 5 10 10 ( 10 ) M , whereas LIF interacted mainly with gp 190 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF induced proliferation was completely inhibited by antibodies to gp 130 interleukin 6 ( IL 6 ) transducer , unlike antibodies to IL 6 or IL 6 receptor ( IL 6R ) . ^^^ Growth of XG 4 CNTF cells using the gp 130 IL 6 transducer was also supported by other cytokines : IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF causes the rapid tyrosine phosphorylation of LIFRbeta and gp 130 and the induction of the immediate early gene , tis 11 ; injection of CNTF 3 7 h after an initial exposure failed to re stimulate these immediate early responses , suggesting a biochemical desensitization to CNTF not accounted for by decreased receptor protein . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 triggers homodimerization of gp 130 , whereas CNTF and LIF induce heterodimerization of gp 130 and LIF receptor . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF and CNTF , which share the gp 130 transduction system , stimulate hepatic lipid metabolism in rats . ^^^ The combination of LIF plus CNTF showed no additive effects consistent with the action of both cytokines through the gp 130 transduction system . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition , levels of mRNA for both the CNTF receptor alpha and gp 130 subunits increased twofold as measured by RNase protection after treatment with retinoic acid for 30 h . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines IL 6 , LIF , CNTF , OSM , IL 11 , and CT 1 have been grouped into the family of IL 6 type cytokines , since they all require gp 130 for signal transduction . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| RT PCR analyses demonstrated that gp 130 was expressed in 12 / 12 breast cell lines and the specific receptor alpha chains for IL 6 , LIF , IL 11 and CNTF were expressed in the majority of these cell lines . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In absence of TpO , neither gp 130 activating cytokines ( IL 6 , IL 11 , LIF , CNTF ) nor the other hematopoietic growth factors or cytokines ( KL , IL 3 , GM CSF , EpO ) were able , when added alone , to stimulate the growth of human CFU Meg colonies . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Crest derived cells , immunoselected from the fetal rat gut ( E 14 ) with antibodies to p75NTR , were found by RT PCR and immunocytochemistry ( after culture ) to express both alpha ( CNTER alpha ) and beta components ( gp 130 and LIFR beta ) of the tripartite CNTF receptor . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition , cytokines or their receptors not known to be expressed in RPE were included to widen our picture of cytokine gene expression in the eye : stem cell factor ( SCF ) , its receptor ( SCF R ) , low affinity nerve growth factor receptor p 75 ( p 75 ( NGF R ) , ciliary neutrothropic factor ( CNTF ) , and its receptor ( CNTF R ) , glycoprotein 130 interleukin 6 transducer ( gp 130 ( IL 6 SD ) , leukemia inhibitory factor ( LIF ) , and its receptor ( LIF R ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The established glioma cell lines were also examined for expression of members of the neuropoietic cytokine family , CNTF and LIF , and their respective receptor components CNTFRalpha , LIFRbeta and gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of interleukin ( IL ) 6 , soluble IL 6 receptor , soluble gp 130 , leukemia inhibitory factor ( LIF ) , and ciliary neutrophic factor ( CNTF ) were analyzed in 32 patients with severe malaria . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| An antibody to gp 130 blocked the effects of LIF and CNTF , and both cytokines induced phosphorylation and nuclear translocation of stat 3 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF induced the tyrosine phosphorylation of LIFR and gp 130 , as well as of proteins with the molecular weights of 88 / 91 and 42 kDa . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 ) , whereas CNTF and leukemia inhibitory factor ( LIF ) signal via a heterodimer of gp 130 and LIF receptor ( LIFR ) . ^^^ Despite binding to the same receptor component ( gp 130 ) and a similar protein structure , IL 6 and CNTF share only 6 % sequence identity . ^^^ The resulting IL 6 / CNTF chimera lost the capacity to signal via gp 130 on cells without LIFR , but acquired the ability to signal via the gp130 / LIFR heterodimer and STAT 3 on responsive cells . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| To investigate the role of CNTF / LIF signaling in regenerative responses of motoneurons , we studied the expression of the three receptor components , CNTF receptor alpha ( CNTFRalpha ) , LIF receptor beta ( LIFRbeta ) , and gp 130 , and the activation of the STAT 3 signal transduction pathway in the rat facial nucleus following peripheral nerve transection . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Transcripts of the remaining two components of the CNTF receptor system , gp 130 and LIFR beta , were found by Northern blotting in 83 % and 70 % of the tumors , respectively . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signal transduction by CNTF requires that it bind first to CNTFR alpha , permitting the recruitment of gp 130 and LIFR beta , forming a tripartite receptor complex . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Following earlier findings that OM 85 BV induces the synthesis of IL 6 , a study was undertaken to investigate its possible effect on other gp 130 binding cytokines including IL 11 , IL 12 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neutrophil factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The CNTF receptor CNTFRalpha mRNA displayed only small changes , whereas the mRNA for membrane glycoprotein 130 ( gp 130 ) , which is a critical receptor component for LIF and CNTF transduction , was profoundly down regulated in motoneurons after ventral root avulsion . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains , gp 130 and the leukaemia inhibitory factor receptor ( LIFR ) , associated with a non signalling CNTF binding receptor alpha component ( CNTFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Its receptor complex consists of a ligand binding component , CNTF receptor ( CNTFR ) , associated with two signaling receptor components , gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In contrast , IL 6 enhanced the mRNA expression of gp 130 and CNTF . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Effects of the gp 130 cytokines ciliary neurotropic factor ( CNTF ) and interleukin 11 on pituitary cells : CNTF receptors on human pituitary adenomas and stimulation of prolactin and GH secretion in normal rat anterior pituitary aggregate cultures . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| For signal transduction , CNTF requires a receptor complex , composed of the IL 6 signal transducing molecule gp 130 , leukemia inhibitory factor receptor ( LIFR ) beta , and CNTFR alpha . ^^^ Tyrosine phosphorylation of gp 130 , Jak 1 , and STAT 3 was observed after CNTF stimulation in these three cell lines . ^^^ CONCLUSIONS : These results demonstrate that CNTF signaling is conserved in some of the neuroblastoma cell lines and suggest that not only a Jak STAT pathway but a MAPK pathway is activated by CNTF through gp 130 in neuroblastoma cell lines . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| The secondary structure of leptin has similarities to the long chain helical cytokines family , which includes interleukin 6 ( IL 6 ) , IL 11 , CNTF , and LIF , and the leptin receptor is homologous to the gp 130 signal transducing subunit of the IL 6 type cytokine receptors . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Inactivation to CNTF was not due to a decrease in CNTF receptor subunit gp 130 or in levels of Jak 1 or Jak 2 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here , we report the construction and expression of a CNTF / soluble CNTF receptor ( sCNTF R ) fusion protein ( Hyper CNTF ) with enhanced biological activity on cells expressing gp 130 and leukemia inhibitory factor receptor ( LIF R ) , but not membrane bound CNTF R . ^^^ Hyper CNTF efficiently induced dose dependent STAT 3 phosphorylation and proliferation of BAF 3 cells stably transfected with gp 130 and LIF R cDNAs . ^^^ These data indicate that although LIF and Hyper CNTF use the same heterodimeric receptor complex of gp 130 and LIFR , only Hyper CNTF induces neuronal differentiation . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) analysis showed that IL 11 and its receptor , CNTF and its receptor , LIFR , and gp 130 were constitutively expressed throughout the culture period . ^^^ Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The development of megakaryocytes is regulated by thrombopoietin ( TPO ) , which binds to the c mpl receptor , and by several other cytokines such as interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , cilliary neurotropic factor ( CNTF ) , and oncostatin ( OSM ) , which bind to gp 130 protein coupled receptors . ^^^ To our surprise , none of the other gp 130 protein related cytokines tested ( IL 11 , LIF , CNTF , and OSM ) activated these signaling pathways in CD34+ cells , megakaryoblasts , or platelets . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| In order to investigate the effects of CNTF on fat cells , we examined the expression of CNTF receptor complex proteins ( LIFR , gp 130 , and CNTFRalpha ) during adipocyte differentiation and the effects of CNTF on STAT , Akt , and MAPK activation . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha receptor ( CNTFR ) , which is not involved in signal transduction , and the beta receptors gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^ Previous studies with rat CNTF demonstrated that rat CNTF is unable to interact with the human interleukin 6 alpha receptor , whereas at high concentrations , it can directly induce a signaling heterodimer of human gp 130 and human LIFR in the absence of the CNTF receptor . ^^^ Here , we demonstrate that human CNTF can not directly induce a heterodimer of human gp 130 and LIFR . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signal transduction by CNTF requires that it bind first to CNTF R , permitting the recruitment of gp 130 and LIF R , forming a tripartite receptor complex . ^^^ Cells that only express gp 130 and LIF R , but not CNTF R are refractory to stimulation by CNTF . ^^^ The proliferative results confirmed that CNTF required homodimerization of the gp 130 , CNTF R and LIF R receptor subunit whereas Hyper CNTF required heterodimerization of the gp 130 and LIF R receptor subunit . ^^^ We concluded that the fusion protein Hyper CNTF had superagonistic activity on target cells expressing gp 130 and LIF R , but lacking membrane bound CNTF R . . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that lesion induces upregulation of CNTF related cytokines ( LIF , NNT 1 ) and , interestingly , a more pronounced upregulation of cytokine receptor components ( LIF receptor beta , gp 130 ) and TGFbeta in CNTF deficient animals . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression profiles of various cytokine signal transduction components , including receptor subunits CNTF receptor alpha ( CNTFRa ) and gp 130 , intracellular protein kinases , Jak 2 and Tyk 2 , as well as latent transcription factors , STAT 1 and STAT 3 , were determined by immunohistochemical staining of mouse retinal sections derived from different postnatal stages . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| It acts through a membrane receptor complex comprising CNTF receptor alpha component ( CNTFRalpha ) , gp 130 , and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Inhibition of the cytokine receptor gp 130 using neutralizing antibodies reveals that gp 130 is required for both CNTF induced STAT 3 and ERK phosphorylation . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain ( CNTFRalpha ) , the leukemia inhibitory factor receptor beta chain ( LIFRbeta ) and gp 130 . ^^^ Rat and human CNTF differ in their fine specificities : in addition to CNTFR , rat CNTF has been shown to activate the LIFR ( a heterodimer of LIFRbeta and gp 130 ) , whereas human CNTF can bind and activate a tripartite receptor comprising the IL 6 receptor alpha chain ( IL 6Ralpha ) and LIFR . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| CNTF activates membrane receptors ( CNTF Rs ) composed of one ligand specific binding subunit , defined CNTFR alpha , and two signal transducing subunits , termed leukaemia inhibitory factor receptor ( LIFR ) and gp 130 . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using Cre loxP mediated recombination in vivo , we have selectively ablated the common cytokine signaling chain gp 130 , which is required for functional CNTF signaling , in proopiomelanocortin ( POMC ) expressing neurons . ^^^ Strikingly , the anorectic effect of centrally administered CNTF was abolished in POMC specific gp 130 knockout mice . ^^^ |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|