| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , all of which use gp 130 as a signal transducer , significantly inhibited mouse placental lactogen 2 ( mPL 2 ) secretion by cultured placental cells from Days 7 , 9 , and 12 of pregnancy . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotropic factor , interleukin 11 , leukemia inhibitory factor , and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Identification of a 130 kilodalton tyrosine phosphorylated protein induced by interleukin 11 as JAK 2 tyrosine kinase , which associates with gp 130 signal transducer . ^^^ Interleukin 11 ( IL 11 ) shares the common signal transducer gp 130 with IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) and triggers activation of unknown tyrosine kinases as the early steps of signal transduction pathway . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| We used this model to investigate the role of two cytokines , interleukin 6 and interleukin 11 , which share the signal transducing subunit , gp 130 , of their respective receptors . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The role of gp 130 mediated signals in osteoclast development : regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) is a polyfunctional cytokine whose biological actions require a specific IL 11 receptor ( IL 11R ) and the transmembrane transducer gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Functional expression of soluble human interleukin 11 ( IL 11 ) receptor alpha and stoichiometry of in vitro IL 11 receptor complexes with gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 11 receptor alpha chain , a member of the hematopoietin receptor superfamily , forms , together with gp 130 , a functional high affinity receptor complex for interleukin 11 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Each of these cytokines induces the hetero oligomerization of LIF R with gp 130 , a signal transducing subunit shared with interleukin 6 and interleukin 11 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| We have expressed a soluble N glycosylated form of the murine interleukin 11 ( IL 11 ) receptor alpha chain ( sIL 11R ) and examined signaling in cells expressing the gp 130 molecule . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Activation of the signal transducer gp 130 by interleukin 11 and interleukin 6 is mediated by similar molecular interactions . ^^^ Interleukin 6 ( IL 6 ) and interleukin 11 ( IL 11 ) , in complex with their specific alpha receptors , homodimerize gp 130 and , as a consequence , activate the Janus kinase ( Jak ) / signal transducer and activator of transcription ( STAT ) signalling pathway in their target cells . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) is a member of the gp 130 family of cytokines . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| A fusion protein of interleukin 11 and soluble interleukin 11 receptor acts as a superagonist on cells expressing gp 130 . ^^^ Interleukin 11 is a hematopoietic cytokine that signals via the signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL 11 receptor alpha chain and signal transducing gp 130 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Astrocyte differentiation of fetal neuroepithelial cells by interleukin 11 via activation of a common cytokine signal transducer , gp 130 , and a transcription factor , STAT 3 . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| The gp 130 cytokines interleukin 11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) is a member of the gp 130 family of cytokines . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate the co expression of another member of this cytokine family , interleukin 11 ( IL 11 ) , and components of its receptor ( interleukin 11 receptor ; IL 11R ) , ie , IL 11Ralpha ( involved in ligand recognition ) , and gp 130 ( involved in signal transduction ) in cultured normal and malignant prostate derived epithelial cell lines . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| In liquid cultures , megakaryocytes from gp 130 ( delta ) / ( delta ) mice are smaller than those from wild type mice and do not increase in size upon stimulation with interleukin 6 or interleukin 11 . ^^^ Administration of either interleukin 6 or interleukin 11 to gp 130 ( delta ) / ( delta ) mice failed to increase platelet numbers , despite an increase in the production of megakaryocytes . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Recombinant human interleukin 11 ( rhIL 11 ) , a glycoprotein 130 ( gp 130 ) signaling cytokine approved for treatment of thrombocytopenia , also raises von Willebrand factor ( VWF ) and factor 8 ( FVIII ) by an unknown mechanism . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| OnM induced desensitization also prevents responses to other gp 130 signaling cytokines ( e . g . leukemia inhibitory factor and interleukin 11 ) . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signalling of interleukin ( IL ) 6 and interleukin 11 through gp 130 homodimeric receptor complexes has been analysed with respect to initiation and termination of signalling in great detail . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| Of known importance are members of the gp 130 family such as interleukin 11 ( IL 11 ) and leukaemia inhibitory factor ( LIF ) , the transforming growth factor beta ( TGFbeta ) superfamily including the activins , the colony stimulating factors ( CSF ) , the IL 1 system and IL 15 system . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| AIM : To explore the effect of recombinant human interleukin 11 ( rhIL 11 ) on the expressions of interleukin 11 receptor alpha chain ( IL 11Ralpha ) and an additional signal transducer glycoprotein 130 ( gp 130 ) in intestinal epithelium cell line 6 ( IEC 6 ) after neutron irradiation . ^^^ |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20809 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|