| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.73176946 |
| Oncostatin M binds directly to gp 130 and behaves as interleukin 6 antagonist on a cell line expressing gp 130 but lacking functional oncostatin M receptors . 0.73176946^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :1.0504775 |
| Interestingly , gp 130 binds directly to OSM , whereas complex formation with the other cytokines depends on additional receptor subunits . 1.0504775^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Other cytokines such as leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor have also been shown to utilize gp 130 as a signal transducer . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 signal transducer gp 130 mediates oncostatin M signaling . ^^^ Interleukin 6 signal transducer gp 130 mediates oncostatin M signaling . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we present data indicating that gp 130 functions as a common signal transducer for IL 6 , oncostatin M , leukemia inhibitory factor , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 6 signal transducer , gp 130 : an oncostatin M receptor and affinity converter for the LIF receptor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , all of which use gp 130 as a signal transducer , significantly inhibited mouse placental lactogen 2 ( mPL 2 ) secretion by cultured placental cells from Days 7 , 9 , and 12 of pregnancy . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation was also observed in response to other cytokines , such as leukemia inhibitory factor , oncostatin M , and ciliary neurotrophic factor , whose receptors share the IL 6 receptor signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase activity of the 72 kD molecule was enhanced by the stimulation through an IL 6 signal transducer , gp 130 , that was shared among the receptors for the IL 6 related cytokine subfamily , such as leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using c raf antisense oligonucleotides to block Raf 1 expression , we have established that Raf 1 is required for hematopoietic growth factor induced proliferation of murine cell lines stimulated by growth factors whose receptors are members of several different structural classes : ( a ) the hematopoietin receptor family , including interleukin ( IL ) 2 , IL 3 , IL 4 , granulocyte colony stimulating factor , granulocyte / macrophage colony stimulating factor ( GM CSF ) , and erythropoietin ; ( b ) the tyrosine kinase receptor class , including Steel factor and CSF 1 ; and ( c ) IL 6 , leukemia inhibitory factor , and oncostatin M , whose receptors include the gp 130 receptor subunit . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Extensive mutagenesis of residues between Q 153 and H 165 of human IL 6 , a region which is partly homologous in cytokines which also signal via gp 130 ( oncostatin M , ciliary neurotrophic factor , leukaemia inhibitory factor , IL 11 ) , did result in the isolation of a second antagonist for IL 6 activity on CESS and HepG 2 cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| It is now recognized that the beta subunit of the interleukin 6 ( IL 6 ) receptor , also known as gp 130 , is a common signal transducer shared by other cytokines , including ciliary neurotrophic factor , leukemia inhibitor factor , oncostatin M , and IL 11 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In addition to specific ligand binding elements , receptor assembly for interleukin ( IL ) 6 , oncostatin M , leukaemia inhibitory factor , ciliary neurotrophic factor and IL 11 includes an additional unit , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M belongs to the subfamily of hematopoietin cytokines that binds a receptor complex containing gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M , which all use gp 130 as a signal transducer , significantly inhibited mGHRF secretion by cultured placental cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The capacity to bind IL 11 with high affinity ( Kd = 300 800 pM ) appeared to require coexpression of both NR 1 and gp 130 , the common subunit of the IL 6 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) receptors . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In conclusion , IL 11 , along with IL 6 , leukemia inhibitory factor , oncostatin M and ciliary neurotrophic factor , belongs to the same family of cytokines , using gp 130 as a transducing protein . . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Previously it had been thought that the gp 130 alone is sufficient to bind ligand and transduce signal and that oncostatin M could bind to and activate the LIF receptor , but these data show this is not always the case . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| B 9 11 cells responded only to human IL 11 and IL 6 and not to other human cytokines using the same gp 130 transducer chain ( ciliary neurotrophic factor , leukemia inhibitory factor and oncostatin M ) or to other human interleukins ( interleukin 1 to interleukin 13 ) , human hematopoietic cytokines ( granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , colony stimulating factor 1 ) and various other human cytokines ( interferon alpha , tumor necrosis factor alpha , tumor necrosis factor beta , fibroblast growth factor and nerve growth factor ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interactions between oncostatin M and the IL 6 signal transducer , gp 130 . ^^^ Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Like other cytokines such as IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( ONC ) and ciliary neurotrophic factor ( CNTF ) , IL 11 has been shown to utilize IL 6 signal transducer , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 , leukemia inhibitory factor , and oncostatin M exert a broad range of similar biological activities through association of their receptors with the signal transducing component gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Ciliary neurotropic factor , interleukin 11 , leukemia inhibitory factor , and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130 . ^^^ Four cytokines , ciliary neurotropic factor ( CNTF ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) , use the same transducer chain ( signal transducer gp 130 ) as IL 6 and share numerous biological activities with this IL . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M , leukemia inhibitory factor , and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp 130 . ^^^ We analyzed the stimulatory effect of oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , IL 11 , and the inhibitory effect of anti IL 6 antibody ( Ab ) , anti IL 6 receptor monoclonal antibody ( mAb ) , and anti gp 130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) shares the common signal transducer gp 130 with IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) and triggers activation of unknown tyrosine kinases as the early steps of signal transduction pathway . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Factors such as IL 11 , oncostatin M , and leukemia inhibitory factor , which are known to exert their functions through gp 130 ( the signal transducing chain of IL 6R ) , also induced MNC formation in our coculture system . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Specific low affinity receptors for leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ; gp 130 ) , and ciliary neurotrophic factor ( CNTF ; receptor alpha , CNTFR alpha ) may be utilized in various combinations to generate high affinity binding sites and signal transduction . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Recently , gp 130 has been shown to be involved in the signaling processes of oncostatin M , leukemia inhibitory factor , and ciliary neurotropic factor , in addition to those of IL 6 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Differentiation induction in murine M 1 leukemia cells by interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) is postulated to occur via a common receptor chain , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 11 receptor belongs to a family of cytokine receptors which includes the receptors for IL 6 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , which are all capable of interacting with the signal transducing receptor gp 130 after ligand binding . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The receptor of ciliary neurotrophic factor ( CNTF ) contains the signal transduction protein gp 130 , which is also a component of the receptors of cytokines such as interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitor factor ( LIF ) , oncostatin M ( OSM ) and probably the recently cloned cytokine cardiotrophin 1 , signal , in combination with their specific receptors , through the common signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cytokines oncostatin M and interleukin 1 regulate the expression of the IL 6 receptor ( gp 80 , gp 130 ) . ^^^ The steady state mRNA levels of the interleukin 6 receptor ( IL 6R , gp 80 ) and its signal transducing molecule , gp 130 , were examined in the rat hepatoma cell line , H 35 , stimulated by cytokines IL 6 , IL 1 , oncostatin M ( OSM ) and / or Dexamethasone ( Dex ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here , we describe the expression of LIF , related members of this group of cytokines , oncostatin M and ciliary neurotrophic factor , and the LIF receptor beta and glycoprotein gp 130 in normal human tissues and in the endometrium of fertile women . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The gp 130 was originally identified as a signal transducing subunit of interleukin ( IL ) 6 and later also found to be a functional component of receptor complexes for other LIF related cytokines ( oncostatin M [ OSM ] , ciliary neurotrophic factor [ CNTF ] and IL 11 ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a glycoprotein belonging to a new subfamily of cytokines related by sequence and structural homology and the use of the signal transducing receptor component gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| This was borne out in cellular assays since the extract inhibited activation of HepG 2 cells stimulated with oncostatin M or leukemia inhibitory factor , cytokines which also use gp 130 for signal transduction . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Growth of XG 4 CNTF cells using the gp 130 IL 6 transducer was also supported by other cytokines : IL 6 , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Some cytokines that stimulate megakaryopoiesis ( IL 6 , IL 11 , leukemia inhibitory factor , and oncostatin M ) bind to receptors that use gp 130 as a signal transduction subunit . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| METHODS : We incubated highly differentiated human hepatoma cells ( Hep G 2 ) and human umbilical vein endothelial cells ( HUVECs ) for 24 h with recombinant human leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) cytokines that are implicated in acute phase reactions during inflammation and which bind to the same cell surface receptor unit ( glycoprotein gp 130 ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a cytokine whose structural and functional features are similar to other members of the interleukin ( IL ) 6 family of cytokines ( IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , granulocyte colonystimulating factor , ciliary neurotrophic factor , and cardiotrophin 1 ) , many of which utilize gp 130 as a common receptor subunit . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Three cytokines , interleukin 6 ( IL 6 ) , leukaemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , that bind to composite receptors including a common signal transducer gp 130 suppressed proliferation of a mouse B cell hybridoma cell line 2E3 O cultured in serum free medium , while they enhanced antibody production of the cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a glycoprotein belonging to the same family of cytokines as IL 6 , to which it is related by sequence and structural homology and the use of the signal transducing receptor component gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| A family of cytokines [ IL 6 , IL 11 , oncostatin M ( OM ) , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ] involved in various inflammatory or tumoral diseases share the same gp 130 signal transducer chain . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 belongs to a family of related cytokines that includes leukemia inhibitory factor , oncostatin M , IL 11 , ciliary neurotropic factor , and cardiotropin 1 , all of which initiate signaling through a receptor associated gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The soluble IL 6R ( slL 6R alpha ) / IL 6 complex and oncostatin M ( OM ) , which exert biologic activities through the signal transducing protein gp 130 , are potent growth factors for AIDS associated Kaposi ' s sarcoma ( KS ) cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Two other cytokines which also utilize the gp 130 receptor , oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) , were also able to upregulate endothelial cell protein S . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) are members of the interleukin 6 ( IL 6 ) subfamily of cytokines that use a common signal transducer gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| We have shown recently that leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) , two members of the gp 130 dependent cytokine family , stimulate murine proopiomelanocortin ( POMC ) transcription and adrenocorticotropin hormone ( ACTH ) secretion . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| This synergy also extended to the inhibition of LIF or oncostatin M ( OSM ) induced proliferation of a Ba / F3 cell line co transfected with human gp 130 and gp 190 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) can be regulated by gp 130 cytokines such as IL 6 and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Serum levels of interleukin 6 ( IL 6 ) , oncostatin M , soluble IL 6 receptor , and soluble gp 130 in patients with systemic sclerosis . ^^^ OBJECTIVE : To determine whether serum interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) , and soluble gp 130 ( sgp 130 ) levels in patients with systemic sclerosis ( SSc ) are elevated and whether they are correlated with the clinical or serological features of the disease . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , a member of the gp 130 family of cytokines , has previously been shown to inhibit the growth of melanoma cell lines . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 family of cytokines : signaling mechanisms and thrombopoietic activities . gp 130 is a common signal transducing component of the functional receptor complexes for the interleukin ( IL ) 6 family of cytokines , ie , IL 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The transmembrane protein gp 130 is a shared component of the receptor complexes for the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The family of cytokines signalling through the common receptor subunit gp 130 comprises interleukin ( IL ) 6 , IL 11 , leukaemia inhibitory factor , oncostatin M , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The pleiotrophic but overlapping functions of the cytokine family that includes interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 are mediated by the cytokine receptor subunit gp 130 as the common signal transducer . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The interactions of the cytokine binding homology region and immunoglobulin like domains of gp 130 with oncostatin M : implications for receptor complex formation . ^^^ The receptor gp 130 is utilized by cytokines including interleukin 6 , leukemia inhibitory factor , oncostatin M , cilary neurotrophic factor and cardiotrophin . ^^^ Analysis by surface plasmon resonance of the binding of the immunoglobulin like and CHR domains of the extracellular portion of gp 130 to mutants of the cytokine oncostatin M reveal that the CHR forms the main binding site for oncostatin M by a classical site 2 interaction , but in addition a second interaction occurs involving the receptor ' s immunoglobulin like domain and the cytokine ' s site 3 at the N terminus of the D helix . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The specific binding of leukemia inhibitory factor ( LIF ) or oncostatin M ( OSM ) to transmembrane gp 190 or gp 130 leads to their oligomerization which is necessary for signal transduction . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 ( IL 6 ) family of cytokines that share the gp 130 receptor subunit . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Blocking signaling through the Gp 130 receptor chain by interleukin 6 and oncostatin M inhibits PC 3 cell growth and sensitizes the tumor cells to etoposide and cisplatin mediated cytotoxicity . ^^^ METHODS : The effects of oncostatin M ( OM ) , antiinterleukin 6 ( IL 6 ) treatment , or interference with the gp 130 mediated signaling on etoposide or cisplatin mediated cytotoxicity were investigated . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Glycoprotein 130 ( gp 130 ) belongs to the family of class 1 cytokine receptors and is the common signal transducing receptor subunit shared by the so called IL 6 type cytokines ( IL 6 , IL 11 , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M , and cardiotrophin 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Fetal liver development requires a paracrine action of oncostatin M through the gp 130 signal transducer . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Several other cytokines including oncostatin M , IL 11 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotropin 1 ( CT 1 ) use gp 130 as a common signal transducing molecule and therefore have similar biological activities . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The myeloma cell growth activity of IL 10 is mediated through a gp 130 cytokine , oncostatin M ( OSM ) , that is frequently produced by myeloma cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin 1 ( CT 1 ) is a recently discovered member of the gp 130 cytokine family , which includes IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , and oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| To assess the existence of IL 6 receptor complex ( including IL 6R and gp 130 ) with the treatment of PG cells by use of recombinant human IL 6 ( rhIL 6 ) , recombinant human oncostatin M ( rhOSM ) , and recombinant human leukemia inhibitory factor ( rhLIF ) , respectively . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Recently , it was demonstrated that the signal exerted by oncostatin M ( OSM ) through gp 130 plays a pivotal role in the maturation process of the liver both in vitro and in vivo . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In contrast , N terminal modification of the sgp 130 with the FLAG epitope did not interfere with the binding of leukemia inhibitory factor or oncostatin M ( other cytokines that signal through gp 130 ) to sgp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the IL 6 family cytokines that use gp 130 as a common signal transducer and exhibits both growth stimulatory as well as growth inhibitory activity depending on the cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To determine whether the spontaneous production of interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) from peripheral blood mononuclear cells ( PBMC ) is increased in patients with systemic sclerosis ( SSc ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Identification of a gp 130 cytokine receptor critical site involved in oncostatin M response . ^^^ Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Different epitopes are required for gp 130 activation by interleukin 6 , oncostatin M and leukemia inhibitory factor . ^^^ Gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor and cardiotrophin 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Following earlier findings that OM 85 BV induces the synthesis of IL 6 , a study was undertaken to investigate its possible effect on other gp 130 binding cytokines including IL 11 , IL 12 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neutrophil factor ( CNTF ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The Y 759 motif in gp 130 also attenuates gene induction mediated by the oncostatin M and leukemia inhibitory factor receptor complexes , which both contain gp 130 as the shared subunit . . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Removal of doxycycline from the culture medium elevated gp 130 expression and increased the responsiveness of a STAT responsive promoter luciferase construct to IL 6 complexed with its soluble receptor ( IL 6+sIL 6R ) , but diminished the responsiveness to oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Its mechanism of action is via specific binding to gp 130 and either the leukaemia inhibitory factor receptor ( LIFR ) or oncostatin M receptor ( OSMR ) systems at the cell surface to form an active signalling complex . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| We report that of four gp 130 cytokines tested , only oncostatin M ( OnM ) resulted in the activation of Stat molecules . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signalling of interleukin 6 type cytokines via gp 130 , leukemia inhibitory factor ( LIF ) receptor and oncostatin M receptor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| We have used measurements of extracellular acidification rate ( ECAR ) of HepG 2 cells cultured on microporous membranes to probe the coupling between signaling pathways for gp 130 family cytokines ( interleukin 6 , oncostatin M ) and IL 1 , each of which is considered to play a significant role in the hepatic acute phase response . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine whether other glycoprotein 130 ( gp 130 ) binding cytokines can mimic the effects of oncostatin M ( OSM ) in acting synergistically with interleukin 1alpha ( IL 1alpha ) to induce cartilage collagen breakdown and collagenase expression , and to determine which receptors mediate these effects . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M regulates the synthesis and turnover of gp 130 , leukemia inhibitory factor receptor alpha , and oncostatin M receptor beta by distinct mechanisms . ^^^ The cytokine receptor subunits gp 130 , leukemia inhibitory factor receptor alpha ( LIFRalpha ) , and oncostatin M receptor beta ( OSMRbeta ) transduce OSM signals that regulate gene expression and cell proliferation . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) , an interleukin 6 type cytokine , acts via the gp 130 signaling receptor to inhibit proliferation and induce differentiation of breast cancer cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the interleukin 6 / leukaemia inhibitory factor ( or gp 130 ) cytokine family , and its participation in inflammation and the regulation of ECM metabolism is supported by a number of activities identified in vitro , including regulation of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Thus , oncostatin M , an IL 6 type cytokine , stimulates membrane polarity development in HepG 2 cells via the gp 130 receptor unit , which activates a protein kinase A dependent and sphingomyelin marked membrane transport pathway from SAC to the apical membrane . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M ( OSM ) is a member of the IL 6 / LIF ( or gp 130 ) cytokine family , and its potential role in inflammation is supported by a number of activities identified in vitro . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , interleukin ( IL ) 6 , and IL 11 regulate hemopoiesis and LIF , OSM , and IL 6 also inhibit the proliferation of myeloid leukemic cell lines through the signal transducing subunit gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Here we report the purification and characterization of one of these down regulatory factors , the cytokine , oncostatin M ( OSM ) , which transmits its signal via the gp 130 cell surface receptor , resulting in the selective down modulation of the melanocyte lineage antigens : Melan A / MART 1 , gp 100 , tyrosinase , tyrosinase related proteins 1 and 2 , and the M isoform of microphthalmia transcription factor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Desensitization of signaling by oncostatin M in human vascular cells involves cytoplasmic Tyr residue 759 in gp 130 but is not mediated by either Src homology 2 domain containing tyrosine phosphatase 2 or suppressor of cytokine signaling 3 . ^^^ Oncostatin M ( OnM ) signals through cell surface receptors , which utilize the gp 130 subunit . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Because other members of the IL 6 family such as leukaemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) share gp 130 , the signal transduction subunit of their receptors , interpretation of the data without considering the expression of these cytokines and their specific receptor subunits could be misleading . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Thermal control of adhesion is maintained in IL 6 deficient mice through a gp 130 dependent compensatory mechanism mediated by IL 6 related cytokines ( i . e . , oncostatin M [ OSM ] , leukemia inhibitory factor [ LIF ] , and IL 11 ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| However , other components of the IL 6 pathway are intact , as demonstrated by rescue of STAT 3 activation and APP gene induction with recombinant soluble IL 6R linked to IL 6 cytokine ( Hyper IL 6 ) or with another gp 130 signaling cytokine , Oncostatin M . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Another gp 130 ligand , oncostatin M ( OSM ) , upregulates PAI 1 in cardiac myocytes , astrocytes , and endothelial cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Measurement of gp 130 cytokines oncostatin M and IL 6 in gingival crevicular fluid of patients with chronic periodontitis . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The gp 130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases 1 through ERK1 / 2 and p 38 in human adult cardiac myocytes and in human adult cardiac fibroblasts : a possible role for the gp130 / gp130 ligand system in the modulation of extracellular matrix degradation in the human heart . ^^^ Here we show that TIMP 1 was upregulated up to threefold after treatment with the inflammatory mediator and gp 130 ligand oncostatin M ( OSM ) in human adult cardiac myocytes and fibroblasts . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Among others , gp 130 is expressed in Gnv 4 cells , together with the ligand receptor subunits specific for IL 6 as well as oncostatin M ( OSM ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In the present study , we analyzed the effect of SOCS 3 on signal transduction by the proinflammatory cytokine oncostatin M ( OSM ) , which signals through a receptor complex of gp 130 and the OSM receptor ( OSMR ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The levels of OPG , RANKL and two gp 130 cytokines IL 6 and oncostatin M ( OSM ) in the GCF were determined by an enzyme linked immunosorbent assay ( ELISA ) and are expressed as total amounts ( pg / site ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The high affinity receptors for LIF , OSM and IL 6 share the common subunit , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The gp 130 family cytokines IL 6 , LIF and OSM but not IL 11 can reverse the anti proliferative effect of dexamethasone on human myeloma cells . ^^^ In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma ( MM ) , three IL 6 autocrine human myeloma cell lines , LP 1 , OPM 2 and L 363 , have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family : IL 6 , LIF , OSM and IL 11 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| While it has been proposed that the OSM receptor may include the gp 130 subunit of the IL 6 receptor and alpha chain of leukemia inhibitory factor ( LIF ) receptor , neither LIF nor r . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The IL 6 receptor system consists of an 80 kDa IL 6 receptor and a gp 130 which functions as a signal transducer not only for IL 6R but also for LIF , OSM , ciliary neurotrophic factor ( CNTF ) , and IL 11 receptors . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Moreover , in situ hybridization revealed an identical pattern of gene expression in cultivated KS spindle cells and KS spindle cells in vivo with respect to the above mentioned cytokines [ PDGF B , IL 1 beta , IL 1 alpha , IL 6 , OSM ] and their receptors [ PDGF beta receptor , gp 130 , IL 6 receptor , leukemia inhibitory factor ( LIF ) receptor ] . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| A 549 epithelial cells are subjected to growth inhibition only in the presence of OSM ( ED 50 = 6 ng / ml ) , even though they expressed LIF R and gp 130 transcripts . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In agreement with OSMs ability to directly bind gp 130 , preincubation of BMCs with OSM inhibits progenitor cell growth stimulated by the combination of LIF or IL 6 plus SLF . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Leukemia inhibitory factor ( LIF ) and oncastsin M ( OSM ) high affinity binding require additional receptor subunits besides GP 130 and GP 190 . ^^^ Heterodimerization of gp 190 and gp 130 has been proposed to form a high affinity receptor ( type 1 ) shared by LIF and OSM , while heterodimerization of gp 130 with an as yet unidentified subunit is proposed to form a high affinity OSM receptor ( type 2 ) not shared by LIF . ^^^ They indicate rather that third chains of 140 150 kDa molecular mass , in addition to the gp 130 and gp 190 subunits , enter in the structure of LIF and OSM high affinity receptors . ^^^ CHO cells co transfected with the human gp 190 and gp 130 cDNAs expressed high affinity LIF receptors but no high affinity OSM receptors , indicating that an additional component is required for high affinity OSM binding . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Characteristic localization of gp 130 ( the signal transducing receptor component used in common for IL 6 / IL 11 / CNTF / LIF / OSM ) in the rat brain . ^^^ The localization of gp 130 , the signal transducing receptor component used in common for interleukin ( IL ) 6 , IL 11 , ciliary neurotrophic factor ( CNTF ) , LIF and OSM , in the rat brain was demonstrated by immunohistochemistry using an antibody specific to gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Human OSM is known to exhibit biological activities similar to LIF , because they share the same functional receptor composed of the LIF receptor and gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| METHODS : Active transcription of LIF , IL 6 , and OSM , their related receptors ( LIF R , IL 6 R , and gp 130 ) , and the consecutive signal transducing molecules ( STAT 1 , STAT 3 , and STAT 5a ) were analyzed in reverse transcriptase polymerase chain reaction experiments . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| In NIH 3T3 cells ( which endogenously express gp 130 , LIF receptor beta [ LIFRbeta ] , and the protein product , c 12 , of the cDNA described here ) , mouse LIF , human LIF , and human OSM signaled through receptors containing the LIFRbeta and gp 130 but not through the mouse OSM receptor . ^^^ Binding studies demonstrated that mouse OSM associated directly with either the c 12 protein or gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The biological activities of OSM are mediated through two types of receptor complexes , the LIF / OSM shared receptor ( type 1 ) and OSM specific receptor ( OSM R , type 2 ) , which is composed of gp 130 as a binding subunit and a newly identified affinity conversion subunit , OSM R beta . ^^^ In these studies , the authors were able to examine expressions of gp 130 and OSM R beta . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Both mouse and human OSM engaged gp 130 with their respective OSMRbeta subunits , but only human OSM also acted through LIFR . ^^^ Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The regulated loss of LIFRalpha is specific since neither gp 130 nor OSM receptor beta shows a comparable change in turnover . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| ADR 58 has an affinity of 7 nm for human OSM , and it can antagonize OSM binding to the gp 130 receptor and specifically antagonize OSM mediated signaling . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| HCG release induced by recombinant human OSM was completely blocked by antibodies against OSM and the signal transducer , gp 130 , but only partially inhibited by antibodies against the leukaemia inhibiting factor ( LIF ) receptor . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Shc is recruited to the OSM receptor ( OSMR ) , but not to gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The livers from mice deficient for gp 130 , a signaling subunit of the OSM receptor , displayed reduced expression of hepatic differentiation marker and defective glycogenic function . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| OSM and LIF can bind to the same functional receptor complex ( LIF receptor beta and gp 130 heteromultidimers ) and thus mediate overlapping spectra of biological activities . ^^^ There is a second specific beta receptor that binds OSM with high affinity and also involves the subunit gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Soluble glycoprotein 130 ( gp 130 ) attenuates OSM and LIF induced cartilage proteoglycan catabolism . ^^^ The two cytokines bind with high affinity to the same receptor ( LIF / OSM receptor ) , which consists of the LIF receptor alpha chain ( LIFRalpha ) and the signal transduction unit gp 130 . ^^^ In this study , we sought to determine whether recombinant sgp 130 or anti gp 130 Ab could attenuate the resorption of proteoglycans induced by OSM and LIF in articular cartilage explants . ^^^ In contrast , anti gp 130 Ab selectively inhibited the stimulation of proteoglycan ( PG ) release by OSM , albeit minimally . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| All of these cell lines express the receptor components of OSM and leukemia inhibitory factor ( LIF ) gp 130 , LIFR and the OSM specific OSMRbeta . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Our results also suggested that OSM transduces differentiation signals through gp 130 , a common subunit of the interleukin ( IL ) 6 family cytokine receptors . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| We demonstrated expression of three components of the OSM receptor ; gp 130 , the leukemia inhibitory factor receptor ( LIFRbeta ) and the OSM specific receptor ( OSMRbeta ) . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The development of megakaryocytes is regulated by thrombopoietin ( TPO ) , which binds to the c mpl receptor , and by several other cytokines such as interleukin ( IL ) 6 , IL 11 , leukemia inhibitory factor ( LIF ) , cilliary neurotropic factor ( CNTF ) , and oncostatin ( OSM ) , which bind to gp 130 protein coupled receptors . ^^^ To our surprise , none of the other gp 130 protein related cytokines tested ( IL 11 , LIF , CNTF , and OSM ) activated these signaling pathways in CD34+ cells , megakaryoblasts , or platelets . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Stimulation of human peritoneal mesothelial cells with OSM induced phosphorylation of gp 130 and OSM receptor beta , which was accompanied by activation of STAT 3 and secretion of CC chemokine ligand 2 / monocyte chemoattractant protein 1 and IL 6 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| To effect synergy on the PGE ( 2 ) level , OSM signals in part through its gp130 / OSMRbeta receptor , since neutralizing antibodies against gp 130 and OSMRbeta , but not LIFRbeta , decrease PGE ( 2 ) production in response to OSM plus IL 1beta . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| The adult liver of these mice showed no abnormalities ; however , after IL 6 and OSM stimulation , gp 130 dependent pathways ( STAT 3 , APR gene expression ) were completely blocked in the liver of these animals . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| HACMs were treated with the gp 130 ligands CT 1 , IL 6 , LIF or OSM and VEGF 1 was determined by a specific ELISA in the conditioned media of these cells . ^^^ RT PCR and Western blot analysis was used in order to detect gp 130 , IL 6 receptor , LIF receptor or OSM receptor specific protein and mRNA in human adult cardiac myocytes and for detection of VEGF 1 specific mRNA in cardiac myocytes after incubation with OSM . ^^^ We detected high levels of mRNA for gp 130 and the OSM receptor in freshly isolated human cardiac myocytes but only low amounts of mRNA for the IL 6 receptor whereas mRNA for the LIF receptor was hardly detectable by RT PCR . ^^^ When pieces of human myocardial tissue were incubated with the gp 130 ligands in an ex vivo model only OSM resulted in an increase in VEGF 1 in the supernatants of these cultures . ^^^ CONCLUSION : The gp 130 gp130 ligand system is also involved in VEGF regulation in human cardiac myocytes and OSM is the gp 130 ligand responsible for this effect in the human system whereas LIF and CT 1 which had been shown to regulate VEGF expression in mouse and rat cardiac myocytes had no effect . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Specifically examining the OSM contribution to VEGF expression , neutralizing antibodies to OSM receptor subunits gp 130 and OSMRbeta , but not LIFRbeta , inhibited OSM induction of VEGF , indicating that the OSM specific receptor OSMRbeta / gp130 transduces the OSM signal for VEGF synthesis . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| IL 6 has many overlapping biological effects with the related gp 130 cytokines LIF and OSM that can be explained by the shared usage of the signalling receptor , gp 130 . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Using a dominant negative LIF mutant ( hLIF 05 ) , we showed that in RC cell cultures mouse OSM ( mOSM ) activates exclusively glycoprotein 130 ( gp 130 ) / OSMR . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| OSM signals through a gp 130 containing receptor complex over the JAK / STAT pathway . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that a subset of gp 130 cytokines , in particular CT 1 , LIF , and OSM , has the ability to impair subsequent signaling activity initiated by gp 130 cytokines . ^^^ |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13725 and P40189 |
Pubmed |
SVM Score :0.0 |
| NA |
|