| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| After partial deglycosylation of gp 130 , a 90 kD product arose which still bound to CD 4 . ^^^ Fully deglycosylated gp 130 of 60 kD was still immunoprecipitable , but had lost the CD 4 binding activity . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| The present study extends this observation to mouse myogenic cells and demonstrates that a tyrosine kinase associated gp 170 , very similar or identical to the receptor for the macrophage stimulating factor CSF 1 , is synthesized in myoblasts via a short lived precursor of 115 116 kD and an immature gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| We report here that an 80 kd single polypeptide chain ( IL 6 R ) is involved in IL 6 binding and that IL 6 triggers the association of this receptor with a non ligand binding membrane glycoprotein , gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Biosynthetic studies have shown that gp 130 is synthesized through two precursor forms : a 100 kD glycosylated species and an 80 kD unglycosylated species , presumably the primary translational product of the encoding mRNA . . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| CT 1 and LIF cross compete for binding to M 1 cells , Kd [ CT 1 ] approximately 0 . 7 nM , and this binding is inhibited by an anti gp 130 monoclonal antibody . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| When membrane protein fractions were prepared from PMNs and isolated human glomeruli , and immunoblotted with ANCA sera of NCGN patients , two bands with apparent molecular masses of 170 and 80 110 kD ( gp170 / 80 110 ) were labeled in PMNs , and a 130 kD glycoprotein ( gp 130 ) in glomeruli . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| The capacity to bind IL 11 with high affinity ( Kd = 300 800 pM ) appeared to require coexpression of both NR 1 and gp 130 , the common subunit of the IL 6 , leukaemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) and ciliary neurotrophic factor ( CNTF ) receptors . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Soluble forms of gp 130 ( sgp 130 ) with molecular weights of 90 and 110 Kd were found in human serum . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Interaction of the human IL 11R alpha with murine gp 130 was demonstrated : expression of the human IL 11R alpha in murine M 1 cells which constitutively express murine gp 130 ( and murine LIF receptor ) , resulted in the generation of specific high affinity binding sites for IL 11 ( Kd = 250 pM ) . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Soluble interleukin 6 receptor ( sIL 6R ) , a new prognostic factor in multiple myeloma . sIL 6R is a 55 kD soluble molecule mediating the interleukin 6 ( IL 6 ) signal through the IL 6 receptor associated transmembrane signal transducer , gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Scatchard plot analyses showed that mOSM bound to gp 130 with low affinity ( kd = 2 . 8 to 4 . 2 nmol / L ) and that the binding affinity did not increase in the presence of LIFRbeta . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Binding of sIL 11R to gp 130 was IL 11 dependent with intermediate affinity ( kd 1 . 5 to 3 . 0 nmol / L ) . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| It acts via a receptor consisting of two components , that besides the ligand specific chain also contains a second component of 130 kD ( gp 130 ) . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| To elucidate the molecular structure of the functional mOSM receptor , we cloned a cDNA encoding mOSMRbeta , which is 55 . 5 % identical to the hOSMRbeta at the amino acid level . mOSM responsive cell lines express high affinity mOSM receptors , as well as mOSMRbeta , whereas embryonic stem cells , which are responsive to LIF but not to mOSM , do not express mOSMRbeta . mOSMRbeta alone binds mOSM with low affinity ( kd = 13 . 0 nmol / L ) and forms a high affinity receptor ( kd = 606 pmol / L ) with gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Using the panel of specific antibodies the expression of cytokine receptors ( IL 1 , 2 , 3 , 6 , 7 , 8 , 10 , SCF , gp 130 , G CSF , GM CSF , EPO ) and Fas , Pgp and 24 34 kD multidrug resistance associated protein were examined . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| We previously found that the adapter protein Gab 1 ( 110 kD ) is tyrosine phosphorylated and forms a complex with SHP 2 and PI 3 kinase upon stimulation through either the interleukin 3 receptor ( IL 3R ) or gp 130 , the common receptor subunit of IL 6 family cytokines . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Soluble natural IL 6R and gp 130 were also found to interact with a Kd of 2 . 8 nM in the absence of IL 6 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Stimulation of macrophages with either CNTFRalpha in combination with CNTF or IL 6 alone resulted in tyrosine phosphorylation of an approximately 130 kD protein , presumed to be gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| The second nonligand binding chain of IL 6 receptor ( IL 6R ) , the membrane glycoprotein with 130 kD mol wt ( gp 130 ) , is responsible for the signal transduction of IL 6 biological activity . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| In addition , all three alpha ( 1 ) AR subtypes robustly stimulated the transcription of the prohypertrophic cytokine interleukin ( IL ) 6 , but differentially altered members of the IL 6 signaling pathway ( gp 130 and STAT 3 ) . ^^^ The alpha ( 1B ) AR also constitutively down regulated the protein levels of gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| In vivo and in vitro protein interaction assays suggested that androgen receptor ( AR ) can directly interact with IL 6 transducer gp 130 . ^^^ In addition , androgen treatment enhances the interaction between AR and gp 130 , interrupts the IL 6 induced gp 130 mediated PI3K activation , which may lead to inhibition of IL 6 mediated NE differentiation in LNCaP cells . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 is a multifunctional cytokine that exerts its biological activity through binding to an 80 Kd specific receptor ( IL 6Ralpha ) and a 130 Kd signal transducing unit ( gp 130 ) . ^^^ A 55 Kd soluble IL 6R ( IL 6sR ) has also been described which , after binding to IL 6 is also able to activate gp 130 . ^^^ |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40189 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|